Antifibrogenic Effects of the Antimicrobial Peptide Cathelicidin in Murine Colitis-Associated Fibrosis

Cellular and Molecular Gastroenterology and Hepatology

Volumn 1, Issue 1, 2015, Pages 55-74.e1

  Yoo, Jun Hwan ^a,b   Ho, Samantha ^a   Tran, Deanna Hoang Yen ^a   Cheng, Michelle ^a   Bakirtzi, Kyriaki ^a   Kubota, Yuzu ^a   Ichikawa, Ryan ^a   Su, Bowei ^a   Tran, Diana Hoang Ngoc ^a   Hing, Tressia C ^a   Chang, Irene ^a   Shih, David Q ^c   Issacson, Richard E ^d   Gallo, Richard L ^e   Fiocchi, Claudio ^f   Pothoulakis, Charalabos ^a   Koon, Hon Wai ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHA University   (South Korea)

^c CEDARS SINAI MEDICAL CENTER   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Antimicrobial Peptide; Collagen; Inflammatory Bowel Disease

Indexed keywords

CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; COLLAGEN; COLLAGEN TYPE 1A2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA1; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIFIBROGENIC EFFECT; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG ACTIVITY; EXPERIMENTAL COLITIS; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINAL FIBROSIS; INTRACOLONIC DRUG ADMINISTRATION; LENTIVIRINAE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SALMONELLOSIS; TYPHLITIS; WESTERN BLOTTING;

EID: 84928189630     PISSN: None     EISSN: 2352345X     Source Type: Journal    
DOI: 10.1016/j.jcmgh.2014.08.001     Document Type: Article

References (28)

1. Fiocchi C. Genes and 'in-vironment': how will our concepts on the pathophysiology of inflammatory bowel disease develop in the future?. Dig Dis 2012, 30(Suppl 3):2-11.
2. Wettergren A., Christiansen J. Risk of recurrence and reoperation after resection for ileocolic Crohn's disease. Scand J Gastroenterol 1991, 26:1319-1322.
3. Spinelli A., Correale C., Szabo H., Montorsi M. Intestinal fibrosis in Crohn's disease: medical treatment or surgery?. Curr Drug Targets 2009, 11:242-248.
4. Sorrentino D., Avellini C., Beltrami C.A., et al. Selective effect of infliximab on the inflammatory component of a colonic stricture in Crohn's disease. Int J Colorectal Dis 2006, 21:276-281.
5. Ho S., Pothoulakis C., Koon H.W. Antimicrobial peptides and colitis. Curr Pharm Des 2013, 19:40-47.
6. Bergman P., Johansson L., Wan H., et al. Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infection. Infect Immun 2006, 74:6982-6991.
7. Koczulla R., von Degenfeld G., Kupatt C., et al. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. JClin Invest 2003, 111:1665-1672.
8. Shaykhiev R., Beisswenger C., Kandler K., et al. Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure. Am J Physiol Lung Cell Mol Physiol 2005, 289:L842-848.
9. Park H.J., Cho D.H., Kim H.J., et al. Collagen synthesis is suppressed in dermal fibroblasts by the human antimicrobial peptide LL-37. JInvest Dermatol 2009, 129:843-850.
10. Tai E.K., Wu W.K., Wong H.P., et al. Anew role for cathelicidin in ulcerative colitis in mice. Exp Biol Med (Maywood) 2007, 232:799-808.
11. Koon H.W., Shih D.Q., Chen J., et al. Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology 2011, 141:1852-1863. e1-3.
12. Hing T.C., Ho S., Shih D.Q., et al. The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice. Gut 2013, 62:1295-1305.
13. Grassl G.A., Valdez Y., Bergstrom K.S., et al. Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis. Gastroenterology 2008, 134:768-780.
14. Lawrance I.C., Wu F., Leite A.Z., et al. Amurine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-kappa B. Gastroenterology 2003, 125:1750-1761.
15. Koon H.W., Shih D., Karagiannides I., et al. Substance P modulates colitis-associated fibrosis. Am J Pathol 2010, 177:2300-2309.
16. Strong S.A., Pizarro T.T., Klein J.S., et al. Proinflammatory cytokines differentially modulate their own expression in human intestinal mucosal mesenchymal cells. Gastroenterology 1998, 114:1244-1256.
17. Naldini L., Blomer U., Gage F.H., et al. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci USA 1996, 93:11382-11388.
18. Chen C., Okayama H. High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 1987, 7:2745-2752.
19. Sakoda T., Kaibuchi K., Kishi K., et al. smg/rap1/Krev-1 p21s inhibit the signal pathway to the c-fos promoter/enhancer from c-Ki-ras p21 but not from c-raf-1 kinase in NIH3T3 cells. Oncogene 1992, 7:1705-1711.
20. Sakoda T., Kasahara N., Hamamori Y., Kedes L. Ahigh-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes. JMol Cell Cardiol 1999, 31:2037-2047.
21. Pfeifer A., Hofmann A. Lentiviral transgenesis. Methods Mol Biol 2009, 530:391-405.
22. Kruschewski M., Foitzik T., Perez-Canto A., et al. Changes of colonic mucosal microcirculation and histology in two colitis models: an experimental study using intravital microscopy and a new histological scoring system. Dig Dis Sci 2001, 46:2336-2343.
23. Johnson L.A., Luke A., Sauder K., et al. Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: impact of a "top-down" approach to intestinal fibrosis in mice. Inflamm Bowel Dis 2011, 18:460-471.
24. Mia M.M., Boersema M., Bank R.A. Interleukin-1β attenuates myofibroblast formation and extracellular matrix production in dermal and lung fibroblasts exposed to transforming growth factor-β1. PLoS One 2014, 9:e91559.
25. Marques C.C., Castelo-Branco M.T., Pacheco R.G., et al. Prophylactic systemic P2X7 receptor blockade prevents experimental colitis. Biochim Biophys Acta 2013, 1842:65-78.
26. Huang C., Yu W., Cui H., et al. P2X7 blockade attenuates mouse liver fibrosis. Mol Med Rep 2013, 9:57-62.
27. Sun C., Zhu M., Yang Z., et al. LL-37 secreted by epithelium promotes fibroblast collagen production: a potential mechanism of small airway remodeling in chronic obstructive pulmonary disease. Lab Invest 2014, 94:991-1002.
28. Schauber J., Rieger D., Weiler F., et al. Heterogeneous expression of human cathelicidin hCAP18/LL-37 in inflammatory bowel diseases. Eur J Gastroenterol Hepatol 2006, 18:615-621.