TNF-α levels in HIV-infected patients after long-term suppressive cART persist as high as in elderly, HIV-uninfected subjects

Journal of Antimicrobial Chemotherapy

Volumn 69, Issue 11, 2014, Pages 3041-3046

  De Pablo Bernal, R S ^a   Ruiz Mateos, E ^a   Rosado, I ^a   Dominguez Molina, B ^a   Alvarez Rios A I ^a   Carrillo Vico, A ^b   De La Rosa, R ^c   Delgado, J ^d   Munoz Fernandez M A ^d   Leal, M ^a   Ferrando Martinez S ^d  

^a HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

^c San Juan de Dios Hospital   (Spain)

^d HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

Author keywords

Ageing; HIV infection; Inflammation

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; C REACTIVE PROTEIN; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; RNA DIRECTED DNA POLYMERASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; ANTIRETROVIRUS AGENT;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONG TERM CARE; LONGITUDINAL STUDY; MALE; VIREMIA; AGED; BLOOD; DRUG COMBINATION; FOLLOW UP; HIV INFECTIONS; RETROSPECTIVE STUDY; TIME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTI-RETROVIRAL AGENTS; COHORT STUDIES; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HIV INFECTIONS; HUMANS; LONGITUDINAL STUDIES; MALE; RETROSPECTIVE STUDIES; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84928174960     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dku263     Document Type: Article

References (24)

1. Jamieson BD, Douek DC, Killian S et al. Generation of functional thymocytes in the human adult. Immunity 1999; 10:569-75.
2. Aldrovandi GM, Feuer G, Gao L et al. The SCID-hu mouse as a model for HIV-1 infection. Nature 1993; 363:732-6.
3. Kalayjian RC, Landay A, Pollard RB et al. Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes. J Infect Dis 2003; 187:1924-33.
4. Deeks SG. The end of AIDS: HIV infection as a chronic disease. Lancet 2013; 382:1525-33.
5. Haissman JM, Vestergaard LS, Sembuche S et al. Plasma cytokine levels in Tanzanian HIV-1-infected adults and the effect of antiretroviral treatment. J Acquir Immune Defic Syndr 2009; 52:493-7.
6. Franceschi C, Capri M, Monti D et al. Inflammaging and antiinflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007; 128:92-105.
7. Kuller LH, Tracy R, Belloso W et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med 2008; 5: e203.
8. Cesari M, Penninx BW, Newman AB et al. Inflammatory markers and onset of cardiovascular events: results from the Health ABC study. Circulation 2003; 108:2317-22.
9. Singh T, Newman AB. Inflammatory markers in population studies of aging. Ageing Res Rev 2011; 10:319-29.
10. Palella FJ Jr, Delaney KM, Moorman AC et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 1998; 339:405-6.
11. Muñoz A, Sabin CA, Phillips AN. The incubation period of AIDS. AIDS 1997; 11 Suppl A: S69-76.
12. Valdez H, Connick E, Smith KY et al. Limited immune restoration after 3 years' suppression of HIV-1 replication in patients with moderately advanced disease. AIDS 2002; 16:1859-66.
13. Rönsholt FF, Ullum H, Katzenstein TL et al. Persistent inflammation and endothelial activation in HIV-1 infected patients after 12 years of antiretroviral therapy. PLoS One 2013; 8: e65182.
14. Guaraldi G, Orlando G, Zona S et al. Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin Infect Dis 2011; 53:1120-6.
15. Ferrando-Martínez S, Romero-Sánchez MC, Solana R et al. Thymic function failure and C-reactive protein levels are independent predictors of all-cause mortality in healthy elderly humans. Age (Dordr) 2013; 35:251-9.
16. Keating SM, Golub ET, Nowicki M et al. The effect of HIV infection and HAART on inflammatory biomarkers in a population-based cohort of women. AIDS 2011; 24:1823-32.
17. Ferrando-Martínez S, Ruiz-Mateos E, Romero-Sánchez MC et al. HIV infection-related premature immunosenescence: high rates of immune exhaustion after short time of infection. Curr HIV Res 2011; 9:289-94.
18. Appay V, Sauce D. Immune activation and inflammation in HIV-1 infection: causes and consequences. J Pathol 2008; 214:231-41.
19. Ory Manchon F, Sanz Moreno JC, Castañeda López R et al. Seroepidemiologia frente a cytomegalovirus en la comunidad de Madrid. Rev Esp Salud Pú blica 2002; 75:55-62.
20. Stowe RP, Kozlova EV, Yetman DL et al. Chronic herpesvirus reactivation occurs in aging. Exp Gerontol 2007; 42:563-70.
21. Kaplan RC, Landay AL, Hodis HN et al. Potential cardiovascular disease risk markers among HIV-infected women initiating antiretroviral treatment. J Acquir Immune Defic Syndr 2012; 60:359e68.
22. Belge KU, Dayyani F, Horelt A et al. The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF. J Immunol 2002; 168:3536-42.
23. Méndez-Lagares G, Romero-Sánchez MC, Ruiz-Mateos E et al. Longterm suppressive combined antiretroviral treatment does not normalize the serum level of soluble CD14. J Infect Dis 2013; 207:1221-5.
24. Bruunsgaard H, Ladelund S, Pedersen AN et al. Predicting death from tumour necrosis factor-a and interleukin-6 in 80-year-old people. Clin Exp Immunol 2003; 132:24-31.