BQ-869, a novel NMDA receptor antagonist, protects against excitotoxicity and attenuates cerebral ischemic injury in stroke

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 2, 2015, Pages 1213-1225

  Yu, Guo ^a   Wu, Fei ^b   Wang, Er Song ^a  

^a FUDAN UNIVERSITY   (China)

^b TSINGHUA UNIVERSITY   (China)

Author keywords

BQ 869; Cerebral ischaemia; Excitotoxicity; MACO; NMDA receptor

Indexed keywords

AMINO ACID RECEPTOR BLOCKING AGENT; BQ-869; FUSED HETEROCYCLIC RINGS; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYLASPARTIC ACID; NEUROPROTECTIVE AGENT;

ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN ISCHEMIA; CELL CULTURE; CELL DEATH; DOSE RESPONSE; DRUG EFFECTS; HIPPOCAMPUS; PYRAMIDAL NERVE CELL; RAT; SPRAGUE DAWLEY RAT; STROKE;

ANIMALS; BRAIN ISCHEMIA; CELL DEATH; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; HETEROCYCLIC COMPOUNDS, 4 OR MORE RINGS; HIPPOCAMPUS; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; STROKE;

EID: 84928170009     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Sims NR and Muyderman H. Mitochondria, oxidative metabolism and cell death in stroke. Biochim Biophys Acta 2010; 1802: 80-91.
2. Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, Moran AE, Sacco RL, Anderson L, Truelsen T, O'Donnell M, Venketasubramanian N, Barker-Collo S, Lawes CM, Wang W, Shinohara Y, Witt E, Ezzati M, Naghavi M, Murray C; Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) and the GBD Stroke Experts Group. Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet 2014; 383: 245-254.
3. Mayer ML and Westbrook GL. The physiology of excitatory amino acids in the vertebrate central nervous system. Prog Neurobiol 1987; 28: 197-276.
4. Watkins JC and Evans RH. Excitatory amino acid transmitters. Annu Rev Pharmacol Toxicol 1981; 21: 165-204.
5. Greengard P. The neurobiology of slow synaptic transmission. Science 2001; 294: 1024-1030.
6. Morris RG, Steele RJ, Bell JE and Martin SJ. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci 2013; 37: 700-717.
7. Simon RP, Swan JH, Griffiths T and Meldrum BS. Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. Science 1984; 226: 850-852.
8. Lipton SA. Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat Rev Drug Discov 2006; 5: 160-170.
9. Lo EH, Dalkara T and Moskowitz MA. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 2003; 4: 399-415.
10. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA and Nicotera P. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 1995; 15: 961-973.
11. Choi DW and Rothman SM. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci 1990; 13: 171-182.
12. Ikonomidou C and Turski L. Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? Lancet Neurol 2002; 1: 383-386.
13. Davis SM, Lees KR, Albers GW, Diener HC, Markabi S, Karlsson G and Norris J. Selfotel in acute ischemic stroke: possible neurotoxic effects of an NMDA antagonist. Stroke 2000; 31: 347-54.
14. Sacco RL, DeRosa JT, Haley EC Jr, Levin B, Ordronneau P, Phillips SJ, Rundek T, Snipes RG and Thompson JL. Glycine antagonist in neuroprotection for patients with acute stroke: GAIN Americas: a randomized controlled trial. JAMA 2001; 285: 1719-28.
15. Kocaeli H, Korfali E, Oztürk H, Kahveci N and Yilmazlar S. MK-801 improves neurological and histological outcomes after spinal cord ischemia induced by transient aortic cross-clipping in rats. Surg Neurol 2005; 64: S22-26.
16. Kaech S and Banker G. Culturing hippocampal neurons. Nat Protoc 2006; 1: 2406-2415.
17. Hamill OP, Marty A, Neher E, Sakmann B and Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981; 391: 85-100.
18. O'Donnell ME, Tran L, Lam TI, Liu XB and Anderson SE. Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke. J Cereb Blood Flow Metab 2004; 24: 1046-1056.
19. Bederson JB, Pitts LH, Germano SM, Nishimura MC, Davis RL and Bartkowski HM. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 1986; 17: 1304-1308.
20. Feigin VL. Stroke epidemiology in the developing world. Lancet 2005; 365: 2160-2161.
21. The World health report 2004. Annex Table 2: Deaths by cause, sex and mortality stratum in WHO regions, estimates for 2002. Geneva: World Health Organization 2004.
22. Budd SL, Tenneti L, Lishnak T and Lipton SA. Mitochondrial and extramitochondrial apoptotic signaling pathways incerebrocortical neurons. Proc Natl Acad Sci U S A 2000; 97: 6161-6166.
23. Vannucci RC, Brucklacher RM and Vannucci SJ. Intracellular calcium accumulation during the evolution of hypoxic-ischemic brain damage in the immature rat. Brain Res Dev Brain Res 2001; 126: 117-120.
24. Palmer GC. Neuroprotection by NMDA receptor antagonists in a variety of neuropathologies. Curr Drug Targets 2001; 2: 241-271.
25. Coffey C. Edward, Cummings Jeffrey L, Starkstein Sergio and Robinson Robert. Stroke the American Psychiatric Press Textbook of Geriatric Neuropsychiatry. 2nd edition. Washington DC: American Psychiatric Press 2000; pp. 601-617.
26. Kobayashi S and Millhorn DE. Regulation of N-methyl-D-aspartate receptor expression and N-methyl-D-aspartate-induced cellular response during chronic hypoxia in differentiated rat PC12 cells. Neuroscience 2000; 101: 1153-1162.
27. Chung C and Kavalali ET. Seeking a function for spontaneous neurotransmission. Nat Neurosci 2006; 9: 989-9906.
28. Buchan A and Pulsinelli WA. Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia. J Neurosci 1990; 10: 311-316.
29. Lester RA and Jahr CE. NMDA channel behavior depends on agonist affinity. J Neurosci 1992; 12: 635-643.
30. Rogers DC, Campbell CA, Stretton JL and Mackay KB. Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat. Stroke 1997; 28: 2060-2065.