An eighteen-month helicobacter infection does not induce amyloid plaques or neuroinflammation in brains of wild type C57BL/6J mice

Journal of Alzheimer's Disease

Volumn 45, Issue 4, 2015, Pages 1045-1050

  Baudron, Claire Roubaud ^a,b,c   Chambonnier, Lucie ^a,b   Buissionnière, Alice ^a,b   Giese, Alban ^a,b   Macrez, Nathalie ^b,d   Cho, Yoon ^b,e   Fénelon, Valérie ^b,f   Blaszczyk, Lucie ^b,f   Dubus, Pierre ^a,b   Lehours, Philippe ^a,b   Mégraud, Francis ^a,b   Salles, Nathalie ^a,b,c   Varon, Christine ^a,b  

^a INSERM U853 ^*  (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c BORDEAUX UNIVERSITY HOSPITAL   (France)

^d INSTITUT DES MALADIES NEURODÉGÉNÉRATIVES   (France)

^e UMR 5287   (France)

^f INSTITUT FRANÇOIS MAGENDIE   (France)

Author keywords

Alzheimer's disease; dementia; GFAP; Helicobacter pylori; iba 1; neuroinflammation; thioflavin S

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DISEASE COURSE; GASTRITIS; HELICOBACTER FELIS; HELICOBACTER INFECTION; HELICOBACTER PYLORI; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BRAIN; C57BL MOUSE; DISEASE MODEL; IMMUNOLOGY; IMMUNOMODULATION; METABOLISM; PATHOLOGY;

AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; HELICOBACTER FELIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; MICE, INBRED C57BL; NEUROIMMUNOMODULATION; PLAQUE, AMYLOID;

EID: 84928156543     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-143129     Document Type: Article

References (36)

1. Lansbury PT, Lashuel HA (2006) A century-old debate on protein aggregation and neurodegeneration enters the clinic. Nature 443, 774-779.
2. Zlokovic BV (2008) The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57, 178-201.
3. GriffinWS,BargerSW(2010) Neuroinflammatory cytokinesthe common thread in Alzheimer's pathogenesis. US Neurology 6, 19-27.
4. Mawuenyega KG, Sigurdson W, Ovod V, Munsell L, Kasten T, Morris JC, Yarasheski KE, Bateman RJ (2010) Decreased clearance of CNS beta-amyloid in Alzheimer's disease. Science 330, 1774.
5. Krstic D, Madhusudan A, Doehner J,Vogel P, Notter T, Imhof C, Manalastas A, Hilfiker M, Pfister S, Schwerdel C, Riether C, Meyer U, Knuesel I (2012) Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice. J Neuroinflammation 9, 151.
6. Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM (2005) Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci 25, 8843-8853.
7. Miklossy J (2011) Emerging roles of pathogens in Alzheimer disease. Exp Rev Mol Med 13, e30.
8. Gerard HC, Dreses-Werringloer U,Wildt KS, Deka S, Oszust C, Balin BJ, Frey WH, 2nd, Bordayo EZ, Whittum-Hudson JA, Hudson AP (2006) Chlamydophila (Chlamydia) pneumoniae in the Alzheimer's brain. FEMS Immunol Med Microbiol 48, 355-366.
9. Miklossy J (1993) Alzheimer's disease - a spirochetosis? Neuroreport 4, 1069.
10. Wozniak MA, Mee AP, Itzhaki RF (2009) Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques. J Pathol 217, 131-138.
11. Miklossy J, Kis A, Radenovic A, Miller L, Forro L, Martins R, Reiss K, Darbinian N, Darekar P, Mihaly L, Khalili K (2006) Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes. Neurobiol Aging 27, 228-236.
12. Piacentini R, Civitelli L, Ripoli C, MarcocciME,De Chiara G, Garaci E, Azzena GB, Palamara AT, Grassi C (2010) HSV-1 promotes Ca2+-mediated APP phosphorylation and Abeta accumulation in rat cortical neurons. Neurobiol Aging 32, 2323 e2313-2326.
13. Little CS, Hammond CJ, MacIntyre A, Balin BJ, Appelt DM (2004) Chlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB/c mice. Neurobiol Aging 25, 419-429.
14. Wozniak MA, Itzhaki RF, Shipley SJ, Dobson CB (2007) Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation. Neurosci Lett 429, 95-100.
15. Boelen E, Stassen FR, van der Ven AJ, Lemmens MA, Steinbusch HP, Bruggeman CA, Schmitz C, Steinbusch HW (2007) Detection of amyloid beta aggregates in the brain of BALB/c mice after Chlamydia pneumoniae infection. Acta Neuropathol 114, 255-261.
16. Guzman-Sanchez F, Valdivieso F, Burgos JS (2012) Agingrelated neurostructural, neuropathological, and behavioral changes associated with herpes simplex virus type 1 brain infection in mice. J Alzheimers Dis 30, 779-790.
17. Kountouras J, Tsolaki M, Gavalas E, Boziki M, Zavos C, Karatzoglou P, Chatzopoulos D, Venizelos I (2006) Relationship between Helicobacter pylori infection and Alzheimer disease. Neurology 66, 938-940.
18. Malaguarnera M, Bella R, Alagona G, Ferri R, Carnemolla A, Pennisi G (2004) Helicobacter pylori and Alzheimer's disease: A possible link. Eur J Intern Med 15, 381-386.
19. Roubaud-Baudron C, Krolak-Salmon P, Quadrio I, Megraud F, Salles N (2012) Impact of chronic Helicobacter pylori infection on Alzheimer's disease: Preliminary results. Neurobiol Aging 33, 1009 e1011-1009.
20. Roubaud Baudron C, Letenneur L, Langlais A, Buissonniere A, Megraud F, Dartigues JF, Salles N (2013) Does Helicobacter pylori infection increase incidence of dementia? The Personnes Agees QUID Study. J Am Geriatr Soc 61, 74-78.
21. Suerbaum S, Michetti P (2002) Helicobacter pylori infection. N Engl J Med 347, 1175-1186.
22. Roubaud Baudron C, Franceschi F, Salles N, Gasbarrini A (2013) Extragastric diseases and Helicobacter pylori. Helicobacter 18(Suppl 1), 44-51.
23. Eisele YS, Obermuller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, Walker LC, Staufenbiel M, Heikenwalder M, Jucker M (2010) Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science 330, 980-982.
24. Wang XL, Zeng J, Feng J, Tian YT, Liu YJ, Qiu M, Yan X, Yang Y, Xiong Y, Zhang ZH, Wang Q, Wang JZ, Liu R (2014) Helicobacter pylori filtrate impairs spatial learning and memory in rats and increases beta-amyloid by enhancing expression of presenilin-2. Front Aging Neurosci 6, 66.
25. Wang XL, Zeng J,YangY, XiongY, Zhang ZH, Qiu M,YanX, Sun XY, Tuo QZ, Liu R,Wang JZ (2015) Helicobacter pylori filtrate induces Alzheimer-like tau hyperphosphorylation by activating glycogen synthase kinase-3beta. J Alzheimers Dis 43, 153-165.
26. Ameriso SF, Fridman EA, Leiguarda RC, Sevlever GE (2001) Detection of Helicobacter pylori in human carotid atherosclerotic plaques. Stroke 32, 385-391.
27. Kountouras J, Zavos C, Gavalas E, Boziki M, Chatzopoulos D, Katsinelos P (2007) Normal-tension glaucoma and Alzheimer's disease: Helicobacter pylori as a possible common underlying risk factor. Medical Hypotheses 68, 228-229.
28. Mohammadi M, Nedrud J, Redline R, Lycke N, Czinn SJ (1997) MurineCD4T-cell response to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load. Gastroenterology 113, 1848-1857.
29. Fox JG, Blanco M, Murphy JC, Taylor NS, Lee A, Kabok Z, Pappo J (1993) Local and systemic immune responses in murine Helicobacter felis active chronic gastritis. Infect Immun 61, 2309-2315.
30. Sofroniew MV, Vinters HV (2010) Astrocytes: Biology and pathology. Acta Neuropathol 119, 7-35.
31. Ladeby R, Wirenfeldt M, Garcia-Ovejero D, Fenger C, Dissing-Olesen L, Dalmau I, Finsen B (2005) Microglial cell population dynamics in the injured adult central nervous system. Brain Res Brain Res Rev 48, 196-206.
32. Varon C, Dubus P, Mazurier F, Asencio C, Chambonnier L, Ferrand J, Giese A, Senant-Dugot N, Carlotti M, Megraud F (2012) Helicobacter pylori infection recruits bone marrowderived cells that participate in gastric preneoplasia in mice. Gastroenterology 142, 281-291.
33. Fox JG, Rogers AB, Whary MT, Ge Z, Ohtani M, Jones EK, Wang TC (2007) Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2-/-C57BL6 x Sv129 Helicobacter pylori-infected mice. Am J Pathol 171, 1520-1528.
34. Paxinos G, Franklin K (2001) The mouse brain in stereotaxic coordinates. Academic Press.
35. Burkitt MD,Williams JM, Duckworth CA, O'Hara A, Hanedi A, Varro A, Caamano JH, Pritchard DM (2013) Signaling mediated by the NF-kappaB sub-units NF-kappaB1, NF-kappaB2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice. Oncogene 32, 5563-5573.
36. Oleastro M, Menard A, Santos A, Lamouliatte H, Monteiro L, Barthelemy P, Megraud F (2003) Real-time PCR assay for rapid and accurate detection of point mutations conferring resistance to clarithromycin in Helicobacter pylori. J Clin Microbiol 41, 397-402.