Fabrication of genistein-loaded biodegradable TPGS-b-PCL nanoparticles for improved therapeutic effects in cervical cancer cells

International Journal of Nanomedicine

Volumn 10, Issue , 2015, Pages 2461-2473

  Zhang, Hongling ^a   Liu, Gan ^a   Zeng, Xiaowei ^a   Wu, Yanping ^a   Yang, Chengming ^b   Mei, Lin ^a   Wang, Zhongyuan ^a,c   Huang, Laiqiang ^a  

^a TSINGHUA UNIVERSITY   (China)

^b Xili Hospital   (China)

^c Shenzhen University   (China)

Author keywords

Anticancer effect; Cytotoxicity; Drug delivery; Genistein; Nanomedicine; TPGS b PCL

Indexed keywords

COPOLYMER; GENISTEIN; NANOPARTICLE; POLYCAPROLACTONE; TOCOFERSOLAN; TOCOFERSOLAN B POLYCAPROLACTONE COPOLYMER; UNCLASSIFIED DRUG; ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; DRUG CARRIER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG STRUCTURE; FEMALE; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; MOUSE; NANOFABRICATION; NONHUMAN; PARTICLE SIZE; POLYMERIZATION; PRECIPITATION; PROTON NUCLEAR MAGNETIC RESONANCE; SCANNING ELECTRON MICROSCOPY; THERMOGRAVIMETRY; TRANSMISSION ELECTRON MICROSCOPY; TUMOR XENOGRAFT; UTERINE CERVIX CARCINOMA; ZETA POTENTIAL; ANIMAL; CHEMISTRY; DRUG SCREENING; HELA CELL LINE; NUDE MOUSE; UTERINE CERVIX TUMOR;

MUS MUSCULUS;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG CARRIERS; FEMALE; GENISTEIN; HELA CELLS; HUMANS; MICE; MICE, NUDE; NANOPARTICLES; UTERINE CERVICAL NEOPLASMS; VITAMIN E; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84928152577     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S78988     Document Type: Article

References (38)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69-90.
2. Li-Weber M. Targeting apoptosis pathways in cancer by Chinese medicine. Cancer Lett. 2013;332:304-312.
3. Buer CS, Imin N, Djordjevic MA. Flavonoids: new roles for old molecules. J Integr Plant Biol. 2010;52:98-111.
4. Spagnuolo C, Russo M, Bilotto S, Tedesco I, Laratta B, Russo GL. Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia. Ann N Y Acad Sci. 2012;1259:95-103.
5. Li QS, Li CY, Li ZL, Zhu HL. Genistein and its Synthetic Analogs as Anticancer Agents. Anticancer Agents Med Chem. 2012;12:271-281.
6. Ullah MF, Ahmad A, Zubair H, et al. Soy isoflavone genistein induces cell death in breast cancer cells through mobilization of endogenous copper ions and generation of reactive oxygen species. Mol Nutr Food Res. 2011;55:553-559.
7. Hussain A, Harish G, Prabhu SA, et al. Inhibitory effect of genistein on the invasive potential of human cervical cancer cells via modulation of matrix metalloproteinase-9 and tissue inhibitiors of matrix metalloproteinase-1 expression. Cancer Epidemiol. 2012;36:e387-e393.
8. Li HQ, Luo Y, Qiao CH. The mechanisms of anticancer agents by genistein and synthetic derivatives of isoflavone. Mini Rev Med Chem. 2012;12:350-362.
9. Ouyang G, Yao L, Ruan K, Song G, Mao Y, Bao S. Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways. Cell Biol Int. 2009;33:1237-1244.
10. Qi W, Weber CR,Wasland K, Savkovic SD. Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity. BMC Cancer. 2011;11:219.
11. Kim SH, Lee SC, Song YS. Involvement of both extrinsic and intrinsic apoptotic pathways in apoptosis induced by genistein in human cervical cancer cells. Ann N Y Acad Sci. 2009;1171:196-201.
12. Guo G, Fu S, Zhou L, et al. Preparation of curcumin loaded poly (ε-caprolactone)-poly (ethylene glycol)-poly (ε-caprolactone) nanofibers and their in vitro antitumor activity against Glioma 9L cells. Nanoscale. 2011;3:3825-3832.
13. Li X, Zhang Z, Li J, Sun S, Weng Y, Chen H. Diclofenac/biodegradable polymer micelles for ocular applications. Nanoscale. 2012;4:4667-4673.
14. Parrott MC, DeSimone JM. Relieving PEGylation. Nat Chem. 2012;4:13-14.
15. Tomasina J, Lheureux S, Gauduchon P, Rault S, Malzert-Freon A. Nanocarriers for the targeted treatment of ovarian cancers. Biomaterials. 2013;34:1073-1101.
16. Mi Y, Liu X, Zhao J, Ding J, Feng SS. Multimodality treatment of cancer with herceptin conjugated, thermomagnetic iron oxides and docetaxel loaded nanoparticles of biodegradable polymers. Biomaterials. 2012;33:7519-7529.
17. Mei L, Zhang Z, Zhao L, et al. Pharmaceutical nanotechnology for oral delivery of anticancer drugs. Adv Drug Deliv Rev. 2013;65:880-890.
18. Huang L, Chen H, Zheng Y, et al. Nanoformulation of d-α-tocopheryl polyethylene glycol 1000 succinate-b-poly (ε-caprolactone-ran-glycolide) diblock copolymer for breast cancer therapy. Integr Biol (Camb). 2011;3:993-1002.
19. Gao X, Wang B, Wei X, et al. Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer. Nanoscale. 2012;4:7021-7030.
20. Gong C, Deng S, Wu Q, et al. Improving antiangiogenesis and anti-tumor activity of curcumin by biodegradable polymeric micelles. Biomaterials. 2013;34:1413-1432.
21. Zhang Z, Mei L, Feng SS. Vitamin E D-α-tocopheryl polyethylene glycol 1000 succinate-based nanomedicine. Nanomedicine (London). 2012;7:1645-1647.
22. Youk HJ, Lee E, Choi MK, et al. Enhanced anticancer efficacy of α-tocopheryl succinate by conjugation with polyethylene glycol. J Control Release. 2005;107:43-52.
23. Collnot EM, Baldes C, Schaefer UF, Edgar KJ, Wempe MF, Lehr CM. Vitamin E TPGS P-glycoprotein inhibition mechanism: influence on conformational flexibility, intracellular ATP levels, and role of time and site of access. Mol Pharm. 2010;7:642-651.
24. Guo Y, Luo J, Tan S, Otieno BO, Zhang Z. The applications of Vitamin E TPGS in drug delivery. Eur J Pharm Sci. 2013;49:175-186.
25. Acharya S, Sahoo SK. PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect. Adv Drug Deliv Rev. 2011;63:170-183.
26. Zeng X, Tao W, Mei L, Huang L, Tan C, Feng SS. Cholic acid-functionalized nanoparticles of star-shaped PLGA-vitamin E TPGS copolymer for docetaxel delivery to cervical cancer. Biomaterials. 2013;34:6058-6067.
27. Valencia PM, Hanewich-Hollatz MH, Gao W, et al. Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles. Biomaterials. 2011;32:6226-6233.
28. Gou M, Men K, Shi H, et al. Curcumin-loaded biodegradable polymeric micelles.
29. Yan F, Zhang C, Zheng Y, et al. The effect of poloxamer 188 on nanoparticle morphology, size, cancer cell uptake, and cytotoxicity. Nanomedicine. 2010;6:170-178.
30. Mi Y, Liu Y, Feng SS. Formulation of docetaxel by folic acid-conjugated d-α-tocopheryl polyethylene glycol succinate 2000 (Vitamin E TPGS 2k) micelles for targeted and synergistic chemotherapy. Biomaterials. 2011;32:4058-4066.
31. Mi Y, Zhao J, Feng SS. Targeted co-delivery of docetaxel, cisplatin and herceptin by vitamin E TPGS-cisplatin prodrug nanoparticles for multimodality treatment of cancer. J Control Release. 2013;169:185-192.
32. Zhang Y, Tang L, Sun L, et al. A novel paclitaxel-loaded poly (ε-caprolactone)/poloxamer 188 blend nanoparticle overcoming multidrug resistance for cancer treatment. Acta Biomater. 2010;6:2045-2052.
33. Albanese A, Tang PS, Chan WC. The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu Rev Biomed Eng. 2012;14:1-16.
34. Petros RA, DeSimone JM. Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov. 2010;9:615-627.
35. Walkey CD, Olsen JB, Guo H, Emili A, Chan WC. Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake. J Am Chem Soc. 2012;134:2139-2147.
36. Kulkarni SA, Feng SS. Effects of particle size and surface modification on cellular uptake and biodistribution of polymeric nanoparticles for drug delivery. Pharm Res. 2013;30(10):2512-2522.
37. Van Eerdenbrugh B, Vermant J, Martens JA, et al. A screening study of surface stabilization during the production of drug nanocrystals. J Pharm Sci. 2009;98:2091-2103.
38. de Planque MR, Aghdaei S, Roose T, Morgan H. Electrophysiological characterization of membrane disruption by nanoparticles. ACS Nano. 2011;5:3599-3606.