Angiotensin-converting enzyme 2 inhibits apoptosis of pulmonary endothelial cells during acute lung injury through suppressing SMAD2 phosphorylation

Cellular Physiology and Biochemistry

Volumn 35, Issue 6, 2015, Pages 2203-2212

  Ji, Yong ^a   Gao, Fengying ^b   Sun, Bo ^a   Hao, Jing ^a   Liu, Zhenwei ^a  

^a SHANGHAI FIRST PEOPLE S HOSPITAL   (China)

^b Shanghai Jiangong Hospital   (China)

Author keywords

Acute lung injury (ALI); Angiotensin converting enzyme 2 (ACE2); Hydrolyzing angiotensin II (AngII); Nitric oxide (NO); SMAD2; SMAD7

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; CASPASE 9; CXCL1 CHEMOKINE; CYTOCHROME C; INTERLEUKIN 6; NITRIC OXIDE; PROTEIN BAD; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; PROTEIN P53; SMAD2 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; APOPTOSIS REGULATORY PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ACUTE LUNG INJURY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; LUNG; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ACUTE LUNG INJURY; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE; ENDOTHELIAL CELLS; HUMANS; LUNG; MICE; MICE, INBRED BALB C; NITRIC OXIDE; PEPTIDYL-DIPEPTIDASE A; PHOSPHORYLATION; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD7 PROTEIN;

EID: 84928139682     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000374025     Document Type: Article

References (24)

1. Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB: Is there still a role for the lung injury score in the era of the berlin definition ards? Ann Intensive Care 2014;4:4.
2. Khemani RG, Wilson DF, Esteban A, Ferguson ND: Evaluating the berlin definition in pediatric ards. Intensive Care Med 2013;39:2213-2216.
3. Thompson BT, Matthay MA: The berlin definition of ards versus pathological evidence of diffuse alveolar damage. Am J Respir Crit Care Med 2013;187:675-677.
4. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE: Acute respiratory distress in adults. Lancet 1967;2:319-323.
5. Herold S, Gabrielli NM, Vadasz I: Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction. Am J Physiol Lung Cell Mol Physiol 2013;305:L665-681.
6. Dengler V, Downey GP, Tuder RM, Eltzschig HK, Schmidt EP: Neutrophil intercellular communication in acute lung injury. Emerging roles of microparticles and gap junctions. Am J Respir Cell Mol Biol 2013;49:1-5.
7. Vlaar AP, Juffermans NP: Transfusion-related acute lung injury: A clinical review. Lancet 2013;382:984-994.
8. Imai Y, Kuba K, Penninger JM: The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice. Exp Physiol 2008;93:543-548.
9. Chen D, Jiao G, Ma T, Liu X, Yang C, Liu Z: The mechanism of rapamycin in the intervention of paraquatinduced acute lung injury in rats. Xenobiotica 2014:1-9.
10. Liu W, Shan LP, Dong XS, Liu Z: Toll-like receptor 4 implicated in acute lung injury induced by paraquat poisoning in mice. Int J Clin Exp Med 2014;7:3392-3397.
11. Liu F, Gao F, Li Q, Liu Z: The functional study of human umbilical cord mesenchymal stem cells harbouring angiotensin-converting enzyme 2 in rat acute lung ischemia-reperfusion injury model. Cell Biochem Funct 2014;32:580-589.
12. Gao F, Li Q, Hou L, Li Z, Min F, Liu Z: Mesenchymal stem cell-based angiotensin-converting enzyme 2 in treatment of acute lung injury rat induced by bleomycin. Exp Lung Res 2014;40:392-403.
13. Liu D, Dong Y, Liu Z, Niu B, Wang Y, Gao X: Impact of trem-2 gene silencing on inflammatory response of endotoxin-induced acute lung injury in mice. Mol Cell Biochem 2014;394:155-161.
14. Min F, Gao F, Li Q, Liu Z: Therapeutic effect of human umbilical cord mesenchymal stem cells modified by angiotensin-converting enzyme 2 gene on bleomycin-induced lung fibrosis injury. Mol Med Rep 2015;11:2387-2396.
15. Zhang X, Gao F, Li Q, Dong Z, Sun B, Hou L, Li Z, Liu Z: Mscs with ace ii gene affect apoptosis pathway of acute lung injury induced by bleomycin. Exp Lung Res 2015;41:32-43.
16. Boshier PR, Hanna GB, Marczin N: Exhaled nitric oxide as biomarker of acute lung injury: An unfulfilled promise? J Breath Res 2013;7:017118.
17. Mehta S: The effects of nitric oxide in acute lung injury. Vascul Pharmacol 2005;43:390-403.
18. Royall JA, Kooy NW, Beckman JS: Nitric oxide-related oxidants in acute lung injury. New Horizons 1995;3:113-122.
19. Stopa M, Anhuf D, Terstegen L, Gatsios P, Gressner AM, Dooley S: Participation of smad2, smad3, and smad4 in transforming growth factor beta (tgf-beta)-induced activation of smad7. The tgf-beta response element of the promoter requires functional smad binding element and e-box sequences for transcriptional regulation. J Biol Chem 2000;275:29308-29317.
20. Ulloa L, Doody J, Massague J: Inhibition of transforming growth factor-beta/smad signalling by the interferon-gamma/stat pathway. Nature 1999;397:710-713.
21. Xiao X, Gaffar I, Guo P, Wiersch J, Fischbach S, Peirish L, Song Z, El-Gohary Y, Prasadan K, Shiota C, Gittes GK: M2 macrophages promote beta-cell proliferation by up-regulation of smad7. Proc Natl Acad Sci U S A 2014;111:E1211-1220.
22. Goebl NA, Babbey CM, Datta-Mannan A, Witcher DR, Wroblewski VJ, Dunn KW: Neonatal fc receptor mediates internalization of fc in transfected human endothelial cells. Mol Biol Cell 2008;19:5490-5505.
23. Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA, Jr., Wrana JL, Falb D: The mad-related protein smad7 associates with the tgfbeta receptor and functions as an antagonist of tgfbeta signaling. Cell 1997;89:1165-1173.
24. Rodriguez-Vita J, Sanchez-Lopez E, Esteban V, Ruperez M, Egido J, Ruiz-Ortega M: Angiotensin ii activates the smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism. Circulation 2005;111:2509-2517.