Human systemic exposure to [14C]-paraphenylenediamine-containing oxidative hair dyes: Absorption, kinetics, metabolism, excretion and safety assessment

Food and Chemical Toxicology

Volumn 81, Issue , 2015, Pages 71-80

  Nohynek, Gerhard J ^a   Skare, Julie A ^b,f   Meuling, Wim J A ^c,f   Wehmeyer, Kenneth R ^b   de Bie, Albertus Th H J ^c   Vaes, Wouter H J ^c   Dufour, Eric K ^a   Fautz, Rolf ^d   Steiling, Winfried ^e   Bramante, Mario ^b   Toutain, Herve ^a  

^a L'Oréal Research Center   (France)

^b PROCTER AND GAMBLE COMPANY   (United States)

^c TNO   (Netherlands)

^d KAO GERMANY GMBH   (Germany)

^e HENKEL KGAA   (Germany)

^f Henkel AG and Co KGaA ^*  (Netherlands)

Author keywords

Consumer exposure; Hair dyes; Margin of safety; Paraphenylenediamine; TK based safety assessment; Toxicokinetics

Indexed keywords

CARBON PHENYLENEDIAMINE C 14; HAIR DYE; PHENYLENEDIAMINE; UNCLASSIFIED DRUG; 4-PHENYLENEDIAMINE; CARBON; PHENYLENEDIAMINE DERIVATIVE;

ABSORPTION; ADULT; ARTICLE; BLOOD ANALYSIS; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; METABOLISM; POPULATION EXPOSURE; RADIOACTIVITY; RISK ASSESSMENT; SKIN TEST; URINALYSIS; URINARY EXCRETION; AREA UNDER THE CURVE; BLOOD; CHEMISTRY; DRUG EFFECTS; HAIR; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PRODUCT SAFETY; TANDEM MASS SPECTROMETRY; URINE; YOUNG ADULT;

RATTUS;

ADULT; AREA UNDER CURVE; CARBON ISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONSUMER PRODUCT SAFETY; FEMALE; HAIR; HAIR DYES; HUMANS; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PHENYLENEDIAMINES; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 84928138169     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2015.04.003     Document Type: Article

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