메뉴 건너뛰기




Volumn 14, Issue 7, 2015, Pages 1046-1058

MiR-194, commonly repressed in colorectal cancer, suppresses tumor growth by regulating the MAP4K4/c- Jun/MDM2 signaling pathway

Author keywords

Apoptosis; C Jun; Colorectal cancer; MAP4K4; MDM2; MiR 194; Proliferation

Indexed keywords

MICRORNA; MICRORNA 194; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C JUN; PROTEIN MAP4K4; PROTEIN MDM2; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; MAP4K4 PROTEIN, HUMAN; MDM2 PROTEIN, HUMAN; MIRN194 MICRORNA, HUMAN; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

EID: 84928125704     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2015.1007767     Document Type: Article
Times cited : (76)

References (53)
  • 1
    • 84899438176 scopus 로고    scopus 로고
    • Colorectal cancer statistics, 2014
    • PMID:24639052
    • Siegel R, Desantis C, Jemal A. Colorectal cancer statistics, 2014. CA Cancer J Clin 2014; 64:104-17;  PMID:24639052; http://dx.doi.org/10.3322/caac.21220
    • (2014) CA Cancer J Clin , vol.64 , pp. 104-117
    • Siegel, R.1    Desantis, C.2    Jemal, A.3
  • 2
    • 84904736686 scopus 로고    scopus 로고
    • Identification of MicroRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression
    • PMID:24616020
    • Chen DL, Wang ZQ, Zeng ZL, Wu WJ, Zhang DS, Luo HY, Wang F, Qiu MZ, Wang DS, Ren C, et al. Identification of MicroRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression. Hepatology 2014; 60:598-609;  PMID:24616020; http://dx.doi.org/10.1002/hep.27118
    • (2014) Hepatology , vol.60 , pp. 598-609
    • Chen, D.L.1    Wang, Z.Q.2    Zeng, Z.L.3    Wu, W.J.4    Zhang, D.S.5    Luo, H.Y.6    Wang, F.7    Qiu, M.Z.8    Wang, D.S.9    Ren, C.10
  • 3
    • 84898430214 scopus 로고    scopus 로고
    • MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer
    • PMID:24735923
    • Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, et al. MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell 2014; 25:469-483; PMID:24735923; http://dx.doi.org/10.1016/j.ccr.2014.03.006
    • (2014) Cancer Cell , vol.25 , pp. 469-483
    • Valeri, N.1    Braconi, C.2    Gasparini, P.3    Murgia, C.4    Lampis, A.5    Paulus-Hock, V.6    Hart, J.R.7    Ueno, L.8    Grivennikov, S.I.9    Lovat, F.10
  • 5
    • 33749993417 scopus 로고    scopus 로고
    • PMID:16959974
    • breast and colorectal cancers. Science 2006; 314:268-274; PMID:16959974; http://dx.doi.org/10.1126/science.1133427
    • (2006) Breast and Colorectal Cancers. Science , vol.314 , pp. 268-274
  • 6
    • 79957523828 scopus 로고    scopus 로고
    • BRAF, PIK3CA, and PTEN mutations: Implications for targeted therapies in metastatic colorectal cancer
    • PMID:21163703
    • De Roock W, De Vriendt V, Normanno N, Ciardiello F, Tejpar S. KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol 2011; 12:594-603; PMID:21163703; http://dx.doi.org/10.1016/S1470-2045(10)70209-6
    • (2011) Lancet Oncol , vol.12 , pp. 594-603
    • De Roock, W.1    De Vriendt, V.2    Normanno, N.3    Ciardiello, F.4    Tejpar, S.5
  • 7
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • PMID:14744438
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-97; PMID:14744438; http://dx.doi.org/10.1016/S0092-8674(04)00045-5
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 8
    • 61849137222 scopus 로고    scopus 로고
    • Many roads to maturity: MicroRNA biogenesis pathways and their regulation
    • PMID:19255566
    • Winter J, Jung S, Keller S, Gregory RI, Diederichs S. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 2009; 11:228-234; PMID:19255566; http://dx.doi.org/10.1038/ncb0309-228
    • (2009) Nat Cell Biol , vol.11 , pp. 228-234
    • Winter, J.1    Jung, S.2    Keller, S.3    Gregory, R.I.4    Diederichs, S.5
  • 10
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • PMID:17060945
    • Calin GA, Croce CM. MicroRNA signatures in human cancers. Nature Reviews Cancer 2006; 6:857-66; PMID:17060945; http://dx.doi.org/10.1038/nrc1997
    • (2006) Nature Reviews Cancer , vol.6 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 11
    • 84907879102 scopus 로고    scopus 로고
    • MicroRNA-194 Inhibits the Epithelial-Mesenchymal Transition in Gastric Cancer Cells by Targeting FoxM1
    • Li Z, Ying X, Chen H, Ye P, Shen Y, Pan W, Zhang L MicroRNA-194 Inhibits the Epithelial-Mesenchymal Transition in Gastric Cancer Cells by Targeting FoxM1. Dig Dis Sci 2014; 59:2145-52;
    • (2014) Dig Dis Sci , vol.59 , pp. 2145-2152
    • Li, Z.1    Ying, X.2    Chen, H.3    Ye, P.4    Shen, Y.5    Pan, W.6    Zhang, L.7
  • 12
    • 84928144141 scopus 로고    scopus 로고
    • PMID:24748184
    • PMID:24748184; http://dx.doi.org/10.1007/s10620-014-3159-6
  • 13
    • 84880168568 scopus 로고    scopus 로고
    • Prognostic significance of miR-194 in endometrial cancer
    • PMID:24040515
    • Zhai H, Karaayvaz M, Dong P, Sakuragi N, Ju J. Prognostic significance of miR-194 in endometrial cancer. Biomark Res 2013; 1;  PMID:24040515; http://dx.doi.org/10.1186/2050-7771-1-12
    • (2013) Biomark Res , pp. 1
    • Zhai, H.1    Karaayvaz, M.2    Dong, P.3    Sakuragi, N.4    Ju, J.5
  • 15
    • 84897056701 scopus 로고    scopus 로고
    • Luo Z. MiR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27kip1
    • PMID:23584484
    • Wu X, Liu T, Fang O, Leach LJ, Hu X, Luo Z. miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27kip1. Oncogene 2014; 33:1506-14;  PMID:23584484; http://dx.doi.org/10.1038/onc.2013.108
    • (2014) Oncogene , vol.33 , pp. 1506-1514
    • Wu, X.1    Liu, T.2    Fang, O.3    Leach, L.J.4    Hu, X.5
  • 16
    • 84864072975 scopus 로고    scopus 로고
    • Modulation of MicroRNA-194 and cell migration by HER2-targeting trastuzumab in breast cancer
    • PMID:22829924
    • Le XF, Almeida MI, Mao W, Spizzo R, Rossi S, Nicoloso MS, Zhang S, Wu Y, Calin GA, Bast RC Jr. Modulation of MicroRNA-194 and cell migration by HER2-targeting trastuzumab in breast cancer. PLoS One 2012; 7:e41170;  PMID:22829924; http://dx.doi.org/10.1371/journal.pone.0041170
    • (2012) Plos One , vol.7
    • Le, X.F.1    Almeida, M.I.2    Mao, W.3    Spizzo, R.4    Rossi, S.5    Nicoloso, M.S.6    Zhang, S.7    Wu, Y.8    Calin, G.A.9    Bast, R.C.10
  • 17
    • 84896737787 scopus 로고    scopus 로고
    • Upregulation of miR-194 contributes to tumor growth and progression in pancreatic ductal adenocarcinoma
    • PMID:24398877
    • Zhang J, Zhao CY, Zhang SH, Yu DH, Chen Y, Liu QH, Shi M, Ni CR, Zhu MH. Upregulation of miR-194 contributes to tumor growth and progression in pancreatic ductal adenocarcinoma. Oncol Rep 2014;31:1157-1164; PMID:24398877
    • (2014) Oncol Rep , vol.31 , pp. 1157-1164
    • Zhang, J.1    Zhao, C.Y.2    Zhang, S.H.3    Yu, D.H.4    Chen, Y.5    Liu, Q.H.6    Shi, M.7    Ni, C.R.8    Zhu, M.H.9
  • 18
    • 84862932892 scopus 로고    scopus 로고
    • MicroRNA-192, -194 and -215 are frequently downregulated in colorectal cancer
    • PMID:22969930
    • Chiang Y, Song Y, Wang Z, Liu Z, Gao P, Liang J, Zhu J, Xing C, Xu H. microRNA-192, -194 and -215 are frequently downregulated in colorectal cancer. Exp Ther Med 2012; 3:560-6; PMID:22969930
    • (2012) Exp Ther Med , vol.3 , pp. 560-566
    • Chiang, Y.1    Song, Y.2    Wang, Z.3    Liu, Z.4    Gao, P.5    Liang, J.6    Zhu, J.7    Xing, C.8    Xu, H.9
  • 19
    • 84903552631 scopus 로고    scopus 로고
    • MiR-194 as a predictor for adenoma recurrence in patients with advanced colorectal adenoma after polypectomy
    • PMID:24691499
    • Wang ZH, Ren LL, Zheng P, Zheng HM, Yu YN, Wang JL, Lin YW, Chen YX, Ge ZZ, Chen XY, et al. MiR-194 as a predictor for adenoma recurrence in patients with advanced colorectal adenoma after polypectomy. Cancer Prev Res (Phila) 2014; 7:607-616; PMID:24691499; http://dx.doi.org/10.1158/1940-6207.CAPR-13-0426
    • (2014) Cancer Prev Res (Phila) , vol.7 , pp. 607-616
    • Wang, Z.H.1    Ren, L.L.2    Zheng, P.3    Zheng, H.M.4    Yu, Y.N.5    Wang, J.L.6    Lin, Y.W.7    Chen, Y.X.8    Ge, Z.Z.9    Chen, X.Y.10
  • 20
    • 84255170428 scopus 로고    scopus 로고
    • Volpert OV, et al. P53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers
    • PMID:22028325
    • Sundaram P, Hultine S, Smith LM, Dews M, Fox JL, Biyashev D, Schelter JM, Huang Q, Cleary MA, Volpert OV, et al. p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers. Cancer Res 2011; 71:7490-501; PMID:22028325; http://dx.doi.org/10.1158/0008-5472.CAN-11-1124
    • (2011) Cancer Res , vol.71 , pp. 7490-7501
    • Sundaram, P.1    Hultine, S.2    Smith, L.M.3    Dews, M.4    Fox, J.L.5    Biyashev, D.6    Schelter, J.M.7    Huang, Q.8    Cleary, M.A.9
  • 21
    • 0037372198 scopus 로고    scopus 로고
    • The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion
    • PMID:12612079
    • Wright JH, Wang X, Manning G, LaMere BJ, Le P, Zhu S, Khatry D, Flanagan PM, Buckley SD, Whyte DB, et al. The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. Mol Cell Biol 2003; 23:2068-82; PMID:12612079; http://dx.doi.org/10.1128/MCB.23.6.2068-2082.2003
    • (2003) Mol Cell Biol , vol.23 , pp. 2068-2082
    • Wright, J.H.1    Wang, X.2    Manning, G.3    Lamere, B.J.4    Le, P.5    Zhu, S.6    Khatry, D.7    Flanagan, P.M.8    Buckley, S.D.9    Whyte, D.B.10
  • 23
    • 79951819984 scopus 로고    scopus 로고
    • ShRNA-targeted MAP4K4 inhibits hepatocellular carcinoma growth
    • PMID:21196414
    • Liu AW, Cai J, Zhao XL, Jiang TH, He TF, Fu HQ, Zhu MH, Zhang SH. ShRNA-targeted MAP4K4 inhibits hepatocellular carcinoma growth. Clin Cancer Res 2011; 17:710-720; PMID:21196414; http://dx.doi.org/10.1158/1078-0432.CCR-10-0331
    • (2011) Clin Cancer Res , vol.17 , pp. 710-720
    • Liu, A.W.1    Cai, J.2    Zhao, X.L.3    Jiang, T.H.4    He, T.F.5    Fu, H.Q.6    Zhu, M.H.7    Zhang, S.H.8
  • 24
    • 84865296967 scopus 로고    scopus 로고
    • Expression and prognostic significance of MAP4K4 in lung adenocarcinoma
    • PMID:22824148
    • Qiu MH, Qian YM, Zhao XL, Wang SM, Feng XJ, Chen XF, Zhang SH. Expression and prognostic significance of MAP4K4 in lung adenocarcinoma. Pathol Res Pract 2012; 208:541-8;  PMID:22824148; http://dx.doi.org/10.1016/j.prp.2012.06.001
    • (2012) Pathol Res Pract , vol.208 , pp. 541-548
    • Qiu, M.H.1    Qian, Y.M.2    Zhao, X.L.3    Wang, S.M.4    Feng, X.J.5    Chen, X.F.6    Zhang, S.H.7
  • 25
    • 84887486620 scopus 로고    scopus 로고
    • Niu Y, et al. MiRNA-141, downregulated in pancreatic cancer, inhibits cell proliferation and invasion by directly targeting MAP4K4
    • PMID:24013097
    • Zhao G, Wang B, Liu Y, Zhang JG, Deng SC, Qin Q, Tian K, Li X, Zhu S, Niu Y, et al. miRNA-141, downregulated in pancreatic cancer, inhibits cell proliferation and invasion by directly targeting MAP4K4. Mol Cancer Ther 2013; 12:2569-80;  PMID:24013097; http://dx.doi.org/10.1158/1535-7163.MCT-13-0296
    • (2013) Mol Cancer Ther , vol.12 , pp. 2569-2580
    • Zhao, G.1    Wang, B.2    Liu, Y.3    Zhang, J.G.4    Deng, S.C.5    Qin, Q.6    Tian, K.7    Li, X.8    Zhu, S.9
  • 26
    • 0036655060 scopus 로고    scopus 로고
    • Alternative and aberrant splicing of MDM2 mRNA in human cancer
    • PMID:12150820
    • Bartel F, Taubert H, Harris LC. Alternative and aberrant splicing of MDM2 mRNA in human cancer. Cancer Cell 2002; 2:9-15; PMID:12150820; http://dx.doi.org/10.1016/S1535-6108(02)00091-0
    • (2002) Cancer Cell , vol.2 , pp. 9-15
    • Bartel, F.1    Taubert, H.2    Harris, L.C.3
  • 27
    • 84873055344 scopus 로고    scopus 로고
    • MDMX and p53 in oncogenesis and cancer therapy
    • PMID:23303139
    • Wade M, Li YC, Wahl GM. MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer 2013; 13:83-96; PMID:23303139; http://dx.doi.org/10.1038/nrc3430
    • (2013) Nat Rev Cancer , vol.13 , pp. 83-96
    • Wade, M.1    Li, Y.C.2    Mdm2, W.G.3
  • 28
    • 84874100498 scopus 로고    scopus 로고
    • Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway
    • PMID:23243057
    • Huang M, Zhang H, Liu T, Tian D, Gu L, Zhou M. Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway. Mol Cancer Ther 2013; 12:184-94;  PMID:23243057; http://dx.doi.org/10.1158/1535-7163.MCT-12-0425
    • (2013) Mol Cancer Ther , vol.12 , pp. 184-194
    • Huang, M.1    Zhang, H.2    Liu, T.3    Tian, D.4    Gu, L.5    Zhou, M.6
  • 29
    • 84878293248 scopus 로고    scopus 로고
    • Mdm2 increases cellular invasiveness by binding to and stabilizing the Slug mRNA
    • PMID:23438693
    • Jung CH, Kim J, Park JK, Hwang SG, Moon SK, Kim WJ, Um HD. Mdm2 increases cellular invasiveness by binding to and stabilizing the Slug mRNA. Cancer Lett 2013; 335:270-7;  PMID:23438693; http://dx.doi.org/10.1016/j.canlet.2013.02.035
    • (2013) Cancer Lett , vol.335 , pp. 270-277
    • Jung, C.H.1    Kim, J.2    Park, J.K.3    Hwang, S.G.4    Moon, S.K.5    Kim, W.J.6    Um, H.D.7
  • 31
    • 16444380911 scopus 로고    scopus 로고
    • Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors
    • PMID:15753391
    • Carvajal D, Tovar C, Yang H, Vu BT, Heimbrook DC, Vassilev LT. Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors. Cancer Res 2005; 65:1918-1924; PMID:15753391; http://dx.doi.org/10.1158/0008-5472.CAN-04-3576
    • (2005) Cancer Res , vol.65 , pp. 1918-1924
    • Carvajal, D.1    Tovar, C.2    Yang, H.3    Vu, B.T.4    Heimbrook, D.C.5    Vassilev, L.T.6
  • 32
    • 84876984880 scopus 로고    scopus 로고
    • Relationship between MDM2 and p53 alterations in colorectal cancer and their involvement and prognostic value in the Tunisian population
    • PMID:22914606
    • Chaar I, Amara S, Khiari M, Ounissi D, Dhraif M, Ben HAE, Gharbi L, Mzabi S, Bouraoui S. Relationship between MDM2 and p53 alterations in colorectal cancer and their involvement and prognostic value in the Tunisian population. Appl mmunohistochem Mol Morphol 2013; 21:228-236; PMID:22914606
    • (2013) Appl Mmunohistochemmol Morphol , vol.21 , pp. 228-236
    • Chaar, I.1    Amara, S.2    Khiari, M.3    Ounissi, D.4    Dhraif, M.5    Ben, H.6    Gharbi, L.7    Mzabi, S.8    Bouraoui, S.9
  • 33
    • 34547106324 scopus 로고    scopus 로고
    • Czech MP. Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2
    • PMID:17500068
    • Tesz GJ, Guilherme A, Guntur KV, Hubbard AC, Tang X, Chawla A, Czech MP. Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem 2007; 282:19302-19312; PMID:17500068; http://dx.doi.org/10.1074/jbc.M700665200
    • (2007) J Biol Chem , vol.282 , pp. 19302-19312
    • Tesz, G.J.1    Guilherme, A.2    Guntur, K.V.3    Hubbard, A.C.4    Tang, X.5    Chawla, A.6
  • 34
    • 1842850704 scopus 로고    scopus 로고
    • Phosphorylation of JNK is involved in regulation of H (+)-induced c-Jun expression
    • PMID:15093613
    • Shimokawa N, Qiu CH, Seki T, Dikic I, Koibuchi N. Phosphorylation of JNK is involved in regulation of H (+)-induced c-Jun expression. Cell Signal 2004; 16:723-729; PMID:15093613; http://dx.doi.org/10.1016/j.cellsig.2003.11.005
    • (2004) Cell Signal , pp. 723-729
    • Shimokawa, N.1    Qiu, C.H.2    Seki, T.3    Dikic, I.4    Koibuchi, N.5
  • 35
    • 7244240783 scopus 로고    scopus 로고
    • C-Jun regulates the stability and activity of the p53 homologue, p73
    • PMID:15302867
    • Toh WH, Siddique MM, Boominathan L, Lin KW, Sabapathy K. c-Jun regulates the stability and activity of the p53 homologue, p73. J Biol Chem 2004; 279:44713-44722; PMID:15302867; http://dx.doi.org/10.1074/jbc.M407672200
    • (2004) J Biol Chem , vol.279 , pp. 44713-44722
    • Toh, W.H.1    Siddique, M.M.2    Boominathan, L.3    Lin, K.W.4    Sabapathy, K.5
  • 36
    • 77951087217 scopus 로고    scopus 로고
    • . Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer
    • PMID:20395206
    • Xu YM, Zhu F, Cho YY, Carper A, Peng C, Zheng D, Yao K, Lau AT, Zykova TA, Kim HG, et al. Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer. Cancer Res 2010; 70:3218-3227; PMID:20395206; http://dx.doi.org/10.1158/0008-5472.CAN-09-4306
    • (2010) Cancer Res , vol.70 , pp. 3218-3227
    • Xu, Y.M.1    Zhu, F.2    Cho, Y.Y.3    Carper, A.4    Peng, C.5    Zheng, D.6    Yao, K.7    Lau, A.T.8    Zykova, T.A.9    Kim, H.G.10
  • 37
    • 84903767171 scopus 로고    scopus 로고
    • MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis
    • PMID:24911147
    • Chao CH, Chang CC,Wu MJ, Ko HW,Wang D,Hung MC, Yang JY, Chang CJ. MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis. J Clin Invest 2014; 124:3093-3106; PMID:24911147; http://dx.doi.org/10.1172/JCI73351
    • (2014) J Clin Inves , pp. 3093-3106
    • Chao, C.H.1    Chang, C.C.2    Wu, M.J.3    Ko, H.W.4    Wang, D.5    Hung, M.C.6    Yang, J.Y.7    Chang, C.J.8
  • 38
    • 84920995604 scopus 로고    scopus 로고
    • MicroRNA-29c mediates initiation of gastric carcinogenesis by directly targeting ITGB1
    • PMID:24870620
    • Han TS, Hur K, AUID Oho, Xu G, Choi B, Okugawa Y, Toiyama Y, Oshima H, Oshima M, Lee HJ, et al. MicroRNA-29c mediates initiation of gastric carcinogenesis by directly targeting ITGB1. Gut 2014; 64:203-214; PMID:24870620; http://dx.doi.org/10.1136/gutjnl-2013-306640
    • (2014) Gut , vol.64 , pp. 203-214
    • Han, T.S.1    Hur, K.2    Oho, A.3    Xu, G.4    Choi, B.5    Okugawa, Y.6    Toiyama, Y.7    Oshima, H.8    Oshima, M.9    Lee, H.J.10
  • 39
    • 84921683452 scopus 로고    scopus 로고
    • A microRNA 221-and222-Mediated Feedback Loop, via PDLIM2, Maintains Constitutive Activation of NFkappaB and STAT3 in Colorectal Cancer Cells
    • PMID:24931456
    • Liu S, Sun X, Wang M, Hou Y, Zhan Y, Jiang Y, Liu S, Sun X, Wang M, Hou Y, et al. A microRNA 221-and222-Mediated Feedback Loop, via PDLIM2, Maintains Constitutive Activation of NFkappaB and STAT3 in Colorectal Cancer Cells. Gastroenterology 2014; 147:847-859; PMID:24931456; http://dx.doi.org/10.1053/j.gastro.2014.06.006
    • (2014) Gastroenterology , vol.147 , pp. 847-859
    • Liu, S.1    Sun, X.2    Wang, M.3    Hou, Y.4    Zhan, Y.5    Jiang, Y.6    Liu, S.7    Sun, X.8    Wang, M.9    Hou, Y.10
  • 40
    • 84886909055 scopus 로고    scopus 로고
    • Screening of differentially expressed microRNA in ulcerative colitis related colorectal cancer
    • PMID:24144030
    • Tan YG, Zhang YF, Guo CJ, Yang M, Chen MY. Screening of differentially expressed microRNA in ulcerative colitis related colorectal cancer. Asian Pac J Trop Med 2013; 6:972-6; PMID:24144030; http://dx.doi.org/10.1016/S1995-7645(13)60174-1
    • (2013) Asian Pac J Trop Med , vol.6 , pp. 972-976
    • Tan, Y.G.1    Zhang, Y.F.2    Guo, C.J.3    Yang, M.4    Chen, M.Y.5
  • 41
    • 78649588750 scopus 로고    scopus 로고
    • HuangW. MiR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice
    • PMID:20979124
    • Meng Z, Fu X, Chen X, Zeng S, Tian Y, Jove R, Xu R, HuangW. miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice. Hepatology 2010; 52:2148-57; PMID:20979124; http://dx.doi.org/10.1002/hep.23915
    • (2010) Hepatology , vol.52 , pp. 2148-2157
    • Meng, Z.1    Fu, X.2    Chen, X.3    Zeng, S.4    Tian, Y.5    Jove, R.6    Xu, R.7
  • 43
    • 0037372198 scopus 로고    scopus 로고
    • The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion
    • PMID:12612079
    • Wright JH, Wang X, Manning G, LaMere BJ, Le P, Zhu S, Khatry D, Flanagan PM, Buckley SD, Whyte DB, et al. The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. Mol Cell Biol 2003; 23:2068-82; PMID:12612079; http://dx.doi.org/10.1128/MCB.23.6.2068-2082.2003
    • (2003) Mol Cell Biol , vol.23 , pp. 2068-2082
    • Wright, J.H.1    Wang, X.2    Manning, G.3    Lamere, B.J.4    Le, P.5    Zhu, S.6    Khatry, D.7    Flanagan, P.M.8    Buckley, S.D.9    Whyte, D.B.10
  • 44
    • 84865296967 scopus 로고    scopus 로고
    • Expression and prognostic significance of MAP4K4 in lung adenocarcinoma
    • PMID:22824148
    • Qiu MH, Qian YM, Zhao XL, Wang SM, Feng XJ, Chen XF, Zhang SH. Expression and prognostic significance of MAP4K4 in lung adenocarcinoma. Pathol Res Pract 2012; 208:541-8; PMID:22824148; http://dx.doi.org/10.1016/j.prp.2012.06.001
    • (2012) Pathol Res Pract , vol.208 , pp. 541-548
    • Qiu, M.H.1    Qian, Y.M.2    Zhao, X.L.3    Wang, S.M.4    Feng, X.J.5    Chen, X.F.6    Zhang, S.H.7
  • 45
    • 84876413303 scopus 로고    scopus 로고
    • MDM2 is a useful prognostic biomarker for resectable gastric cancer
    • PMID:23347235;
    • Ye Y, Li X, Yang J, Miao S, Wang S, Chen Y, Xia X, Wu X, Zhang J, Zhou Y, et al. MDM2 is a useful prognostic biomarker for resectable gastric cancer. Cancer Sci 2013; 104:590-8 ;PMID:23347235; http://dx.doi.org/10.1111/cas.12111
    • (2013) Cancer Sci , vol.104 , pp. 590-598
    • Ye, Y.1    Li, X.2    Yang, J.3    Miao, S.4    Wang, S.5    Chen, Y.6    Xia, X.7    Wu, X.8    Zhang, J.9    Zhou, Y.10
  • 46
    • 84899501190 scopus 로고    scopus 로고
    • Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations
    • PMID:24667108
    • Yu Q, Li Y, Mu K, Li Z, Meng Q, Wu X, Wang Y, Li L. Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations. Diagn Pathol 2014; 9:71; PMID:24667108; http://dx.doi.org/10.1186/1746-1596-9-71
    • (2014) Diagn Pathol , vol.9 , pp. 71
    • Yu, Q.1    Li, Y.2    Mu, K.3    Li, Z.4    Meng, Q.5    Wu, X.6    Wang, Y.7    Li, L.8
  • 47
    • 11844283981 scopus 로고    scopus 로고
    • Stage-specific expression of micro- RNAs during Xenopus development
    • PMID:15642338
    • Watanabe T, Takeda A, Mise K, Okuno T, Suzuki T, Minami N, Imai H. Stage-specific expression of micro- RNAs during Xenopus development. FEBS Lett 2005; 579:318-24; PMID:15642338; http://dx.doi.org/10.1016/j.febslet.2004.11.067
    • (2005) FEBS Lett , vol.579 , pp. 318-324
    • Watanabe, T.1    Takeda, A.2    Mise, K.3    Okuno, T.4    Suzuki, T.5    Minami, N.6    Imai, H.7
  • 48
    • 13944262052 scopus 로고    scopus 로고
    • A custom microarray platform for analysis of microRNA gene expression
    • PMID:15782152
    • Thomson JM, Parker J, Perou CM, Hammond SM. A custom microarray platform for analysis of microRNA gene expression. Nat Methods 2004; 1:47-53; PMID:15782152; http://dx.doi.org/10.1038/nmeth704
    • (2004) Nat Methods , vol.1 , pp. 47-53
    • Thomson, J.M.1    Parker, J.2    Perou, C.M.3    Hammond, S.M.4
  • 49
    • 33644849221 scopus 로고    scopus 로고
    • A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase
    • PMID:16537454
    • Collins CS, Hong J, Sapinoso L, Zhou Y, Liu Z, Micklash K, Schultz PG, Hampton GM. A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. Proc Natl Acad Sci U S A 2006; 103:3775-80; PMID:16537454; http://dx.doi.org/10.1073/pnas.0600040103
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3775-3780
    • Collins, C.S.1    Hong, J.2    Sapinoso, L.3    Zhou, Y.4    Liu, Z.5    Micklash, K.6    Schultz, P.G.7    Hampton, G.M.8
  • 50
    • 77956296766 scopus 로고    scopus 로고
    • Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer
    • PMID:20498843
    • Hwang JH, Voortman J, Giovannetti E, Steinberg SM, Leon LG, Kim YT, Funel N, Park JK, Kim MA, Kang GH, et al. Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer. PLoS One 2010; 5:e10630; PMID:20498843; http://dx.doi.org/10.1371/journal.pone.0010630
    • (2010) Plos One , vol.5
    • Hwang, J.H.1    Voortman, J.2    Giovannetti, E.3    Steinberg, S.M.4    Leon, L.G.5    Kim, Y.T.6    Funel, N.7    Park, J.K.8    Kim, M.A.9    Kang, G.H.10
  • 52
    • 17644400134 scopus 로고    scopus 로고
    • In human gastric cancer
    • PMID:15814628
    • in human gastric cancer. Clinical cancer research 2005; 11:2518-25; PMID:15814628; http://dx.doi.org/10.1158/1078-0432.CCR-04-1282
    • (2005) Clinical Cancer Research , vol.11 , pp. 2518-2525
  • 53
    • 84898856724 scopus 로고    scopus 로고
    • Critical role of histonedemethylase RBP2 in human gastric cancer angiogenesis
    • PMID:24716659
    • Li L, Wang L, Song P, Geng X, Liang X, Zhou M, Wang Y, Chen C, Jia J, Zeng J. Critical role of histonedemethylase RBP2 in human gastric cancer angiogenesis. Mol Cancer 2014; 13:81; PMID:24716659; http://dx.doi.org/10.1186/1476-4598-13-81
    • (2014) Mol Cancer , vol.13 , pp. 81
    • Li, L.1    Wang, L.2    Song, P.3    Geng, X.4    Liang, X.5    Zhou, M.6    Wang, Y.7    Chen, C.8    Jia, J.9    Zeng, J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.