Inhibition of porcine reproductive and respiratory syndrome virus infection by recombinant adenovirus- and/or exosome-delivered the artificial microRNAs targeting sialoadhesin and CD163 receptors

Virology Journal

Volumn 11, Issue 1, 2014, Pages

  Zhu, Li ^a   Song, Hongqin ^a   Zhang, Xinyu ^a   Xia, Xiaoli ^a   Sun, Huaichang ^a  

^a YANGZHOU UNIVERSITY   (China)

Author keywords

Anti viral effect; Artificial microRNAS; Porcine reproductive and respiratory syndrome virus; Receptors

Indexed keywords

ADENOVIRUS VECTOR; CD163 RECEPTOR; MICRORNA; RECEPTOR; SIALOADHESIN RECEPTOR; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; CD163 ANTIGEN; CELL SURFACE RECEPTOR; DIFFERENTIATION ANTIGEN; DRUG CARRIER; LEUKOCYTE ANTIGEN; SIALOADHESIN; VIRUS RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG TARGETING; EXOSOME; GENE DOSAGE; GENE EXPRESSION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; ORF7 GENE; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS; PREDICTION; PROTEIN RNA BINDING; RNA SEQUENCE; VIRAL GENE DELIVERY SYSTEM; VIRUS RECOMBINANT; VIRUS STRAIN; ADENOVIRIDAE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE SILENCING; GENETIC TRANSDUCTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; MACROPHAGE; METABOLISM; PIG; REAL TIME POLYMERASE CHAIN REACTION; VIROLOGY; VIRUS LOAD;

ADENOVIRIDAE; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUIDAE; SUS;

ADENOVIRIDAE; ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ANTIVIRAL AGENTS; CELLS, CULTURED; DRUG CARRIERS; EXOSOMES; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; MACROPHAGES; MICRORNAS; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CELL SURFACE; RECEPTORS, VIRUS; SIALIC ACID BINDING IG-LIKE LECTIN 1; SWINE; TRANSDUCTION, GENETIC; VIRAL LOAD;

EID: 84928114467     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/s12985-014-0225-9     Document Type: Article

References (38)

1. Done SH, Paton DJ: Porcine reproductive and respiratory syndrome: clinical disease, pathology and immunosuppression. Vet Rec 1995, 136:32 35.
2. Neumann EJ, Kliebenstein JB, Johnson CD, Mabry JW, Bush EJ, Seitzinger AH, Green AL, Zimmerman JJ: Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States. J Am Vet Med Assoc 2005, 227:385 392.
3. Lunney JK, Benfield D, Rowland RR: Porcine reproductive and respiratory syndrome virus: an update on an emerging and re-emerging viral disease of swine. Virus Res 2010, 154:1 6.
4. Kimman TG, Cornelissen LA, Moormann RJ, Rebel JM, Stockhofe-Zurwieden N: Challenges for porcine reproductive and respiratory syndrome virus (PRRSV) vaccinology. Vaccine 2009, 27(28):3704 3718.
5. Snijder EJ, Meulenberg JJ: The molecular biology of arteriviruses. J Gen Virol 1998, 79:961 979.
6. Dokland T: The structural biology of PRRSV. Virus Res 2010, 154(1 2):86 97.
7. Duan X, Nauwynck HJ, Pensaert MB: Effects of origin and state of differentiation and activation of monocytes/macrophages on their susceptibility to porcine reproductive and respiratory syndrome virus (PRRSV). Arch Virol 1997, 142(12):2483 2497.
8. Lee YJ, Park CK, Nam E, Kim SH, Lee OS, Lee du S, Lee C: Generation of a porcine alveolar macrophage cell line for the growth of porcine reproductive and respiratory syndrome virus. J Virol Methods 2010, 163(2):410 415.
9. Nauwynck HJ, Duan X, Favoreel HW, Van Oostveldt P, Pensaert MB: Entry of porcine reproductive and respiratory syndrome virus into porcine alveolar macrophages via receptor-mediated endocytosis. J Gen Virol 1999, 80(Pt 2):297 305.
10. Van Breedam W, Verbeeck M, Christiaens I, Van Gorp H, Nauwynck HJ: Porcine, murine and human sialoadhesin (Sn/Siglec-1/CD169): portals for porcine reproductive and respiratory syndrome virus entry into target cells. J Gen Virol 2013, 94(Pt 9):1955 1960.
11. Van Gorp H, Van Breedam W, Delputte PL, Neuwynck HI: Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratorysyndrome virus. J Gen Virol 2008, 89(Pt 12):2943 2953.
12. Chen Y, Guo R, He S, Zhang XY, Xia XL, Sun HC: Additive inhibition of porcine reproductive and respiratory syndrome virus infection with the soluble sialoadhesin and CD163 receptors. Virus Res 2014, 179:85 92.
13. Fire A: RNA triggered gene silencing. TIG 1999, 15:358 363.
14. Zhou J, Rossi JJ: Progress in RNAi-based antiviral therapeutics. Methods Mol Biol 2011, 721:67 75.
15. Terasawa K, Shimizu K, Tsujimoto G: Synthetic pre-miRNA-based shRNA as potent RNAi triggers. J Nucleic Acids 2011, 2011:1 6.
16. Boden D, Pusch O, Silbermann R, Lee F, Tucker L, Ramratnam B: Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins. Nucleic Acids Res 2004, 32:1154 1158.
17. Liu YP, Haasnoot J, ter Brake O, Berkhout B, Konstantinova P: Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron. Nucleic Acids Res 2008, 36:2811 2824.
18. Khare R, Khare R, Chen CY, Weaver EA, Barry MA: Advances and futher challenges in adenoviral vector pharmacology and targeting. Curr Gene Ther 2011, 11(4):241 258.
19. Li G, Jiang P, Li Y, Wang X, Huang J, Bai J, Cao J, Wu B, Chen N, Zeshan B: Inhibition of porcine reproductive and respiratory syndrome virus replication by adenovirus-mediated RNA interference both in porcine alveolar macrophages and swine. Antiviral Res 2009, 82(3):157 165.
20. Kaner RJ, Worgall S, Leopold PL, Stolze E, Milano E, Hidaka C, Ramalingam R, Hackett NR, Singh R, Bergelson J, Finberg R, Falck-Pedersen E, Crystal RG: Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor. Am J Respir Cell Mol Biol 1999, 20(3):361 370.
21. Valadi H, Ekstrm K, Bossios A, Sjstrand M, Lee JJ, Ltvall JO: Exosome mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007, 9(6):654 659.
22. Zhang H, Li HC, Miao XX: Feasibility, limitation and possible solutions of RNAi-based technology for insect pest control. Insect Sci 2013, 20(1):15 30.
23. Shanmukhappa K, Kim JK, Kapil S: Role of CD151, A tetraspanin, in porcine reproductive and respiratory syndrome virus infection. Virol J 2007, 4:62.
24. Huang Y, Guo R, Zhang Y, Zhang X, Xia X, Sun H: Establishment of a porcine CD151 transgenic PK-15 cell line susceptible to porcine reproductive and respiratory syndrome virus. Wei Sheng Wu Xue Bao 2013, 53(5):507 514.
25. Chang YC, Olson J, Louie A, Crocker PR, Varki A, Nizet V: Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus. J Mol Med (Berl) 2014, 92(9):951 959.
26. Komori H, Watanabe H, Shuto T, Kodama A, Maeda H, Watanabe K, Kai H, Otagiri M, Maruyama T: α(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress. J Biol Chem 2012, 287(36):30688 30700.
27. Lee YJ, Park CK, Nam E, Kim SH, Lee OS, du Lee S, Lee C: Generation of a porcine alveolar macrophage cell line for the growth of porcine reproductive and respiratory syndrome virus. J Virol Methods 2010, 163(2):410 415.
28. Collins JE, Benfield DA, Christianson WT, Harris L, Hennings JC, Shaw DP, Goyal SM, McCullough S, Morrison RB, Joo HS, Gorcyca D, Chladek D: Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR-2332) in North America and experimental reproduction of the disease in gnotobiotic pigs. J Vet Diagn Invest 1992, 4(2):117 126.
29. Hu S, Zhang Z, Cai X, Tian Z, Liu Y, An T, Wu D: Valuation of protective efficacy of PRRS attenuated vaccine and inactivated mutant PRRSV strains. Chin J Prev Vet Med 2009, 31(5):392 396.
30. Tian K, Yu X, Zhao T, Feng Y, Cao Z, Wang C, Hu Y, Chen X, Hu D, Tian X, Liu D, Zhang S, Deng X, Ding Y, Yang L, Zhang Y, Xiao H, Qiao M, Wang B, Hou L, Wan X, Yang X, Kang L, Sun M, Jin P, Wang S, Kitamura Y, Yan J, Gao GF: Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS One 2007, 2(6):e526.
31. Xia B, Song H, Chen Y, Zhang X, Xia X, Sun H: Efficient inhibition of porcine reproductive and respiratory syndrome virus replication by artificial microRNAs targeting the untranslated regions. Arch Virol 2013, 158(1):55 61.
32. Benihoud K, Yeh P, Perricaudet M: Adenovirus vectors for gene delivery. Curr Opin Biotechnol 1999, 10(5):440 447.
33. Mayne GC, Borowicz RA, Greeneklee KV, Finlay-Jones JJ, Williams KA, Hart PH: Centrifugation facilitates transduction of green fluorescent protein in human monocytes and macrophages by adenovirus at low multiplicity of infection. J Immunol Methods 2003, 278(1 2):45 56.
34. Lasse C, Eldh M, Lotvall J: Isolation and characterization of RNA-containing exosomes. J Vis Exp 2012, 59:e3037.
35. Wang L, Zhang H, Suo X, Zheng S, Feng WH: Increase of CD163 but not sialoadhesin on cultured peripheral blood monocytes is coordinated with enhanced susceptibility to porcine reproductive and respiratory syndrome virus infection. Vet Immunol Immunopathol 2011, 141:209 220.
36. Han X, Fan S, Patel D, Zhang YJ: Enhanced inhibition of porcine reproductive and respiratory syndrome virus replication by combination of morpholino oligomers. Antiviral Res 2009, 82:59 66.
37. Van Gorp H, Van Breedam W, Delputte PL, Nauwynck HJ: Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus. J Gen Virol 2008, 89:2943 2953.
38. Zimmerman JJ, Jacobs AC, Hermann JR, Muoz-Zanzi C, Prickett JR, Roof MB, Yoon KJ: Stability of Porcine reproductive and respiratory syndrome virus at ambient temperatures. J Vet Diagn Invest 2010, 22(2):257 260.