Reprogramming the fate of human glioma cells to impede brain tumor development

Cell Death and Disease

Volumn 5, Issue 10, 2014, Pages

  Su, Z ^a   Zang, T ^a   Liu, M L ^a   Wang, L L ^a   Niu, W ^a   Zhang, C L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROGENIN 2; PROTEIN; TRANSCRIPTION FACTOR SOX11; UNCLASSIFIED DRUG; Y BOX BINDING PROTEIN 11; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; NERVE PROTEIN; NEUROG2 PROTEIN, HUMAN; SOX11 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TUMOR; CANCER SURVIVAL; CELL CULTURE; CELL CYCLE; CELL FATE; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; MOUSE; NERVE CELL; NONHUMAN; NUCLEAR REPROGRAMMING; ORTHOTOPIC TRANSPLANTATION; PRIORITY JOURNAL; TUMOR GROWTH; VIRUS; ANIMAL; CARCINOGENESIS; CELL LINEAGE; GLIOMA; HEK293 CELL LINE; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

MUS;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN NEOPLASMS; CARCINOGENESIS; CELL CYCLE; CELL LINE, TUMOR; CELL LINEAGE; CELL PROLIFERATION; CELLULAR REPROGRAMMING; GLIOMA; HEK293 CELLS; HUMANS; MICE; NERVE TISSUE PROTEINS; NEURONS; SOXC TRANSCRIPTION FACTORS;

EID: 84928034248     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.425     Document Type: Article

References (43)

1. Sukhdeo K, Hambardzumyan D, Rich JN. Glioma development: where did it all go wrong? Cell 2011; 146: 187-188.
2. Chen J, McKay RM, Parada LF. Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell 2012; 149: 36-47.
3. Bleeker FE, Molenaar RJ, Leenstra S. Recent advances in the molecular understanding of glioblastoma. J Neurooncol 2012; 108: 11-27.
4. Mei J, Bachoo R, Zhang CL. MicroRNA-146a inhibits glioma development by targeting Notch1. Mol Cell Biol 2011; 31: 3584-3592.
5. Guessous F, Zhang Y, Kofman A, Catania A, Li Y, Schiff D et al. microRNA-34a is tumor suppressive in brain tumors and glioma stem cells. Cell Cycle 2010; 9: 1031-1036.
6. Srikanth M, Kim J, Das S, Kessler JA. BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells. Mol Cancer Res 2014; 12: 283-294.
7. Piccirillo SG, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G et al. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumourinitiating cells. Nature 2006; 444: 761-765.
8. Campos B, Wan F, Farhadi M, Ernst A, Zeppernick F, Tagscherer KE et al. Differentiation therapy exerts antitumor effects on stem-like glioma cells. Clin Cancer Res 2010; 16: 2715-2728.
9. Rohle D, Popovici-Muller J, Palaskas N, Turcan S, Grommes C, Campos C et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 2013; 340: 626-630.
10. Tchoghandjian A, Jennewein C, Eckhardt I, Momma S, Figarella-Branger D, Fulda S. Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-kappaB. Cell Death Differ 2014; 21: 735-747.
11. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M et al. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med 2008; 6: 14.
12. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676.
13. Heinrich C, Blum R, Gascon S, Masserdotti G, Tripathi P, Sanchez R et al. Directing astroglia from the cerebral cortex into subtype specific functional neurons. PLoS Biol 2010; 8: e1000373.
14. Karow M, Sanchez R, Schichor C, Masserdotti G, Ortega F, Heinrich C et al. Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells. Cell Stem Cell 2012; 11: 471-476.
15. Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Sudhof TC, Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010; 463: 1035-1041.
16. Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, Woolf CJ et al. Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell 2011; 9: 205-218.
17. Heins N, Malatesta P, Cecconi F, Nakafuku M, Tucker KL, Hack MA et al. Glial cells generate neurons: the role of the transcription factor Pax6. Nat Neurosci 2002; 5: 308-315.
18. Addis RC, Hsu FC, Wright RL, Dichter MA, Coulter DA, Gearhart JD. Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector. PLoS One 2011; 6: e28719.
19. Corti S, Nizzardo M, Simone C, Falcone M, Donadoni C, Salani S et al. Direct reprogramming of human astrocytes into neural stem cells and neurons. Exp Cell Res 2012; 318: 1528-1541.
20. Torper O, Pfisterer U, Wolf DA, Pereira M, Lau S, Jakobsson J et al. Generation of induced neurons via direct conversion in vivo. Proc Natl Acad Sci USA 2013; 110: 7038-7043.
21. Niu W, Zang T, Zou Y, Fang S, Smith DK, Bachoo R et al. In vivo reprogramming of astrocytes to neuroblasts in the adult brain. Nat Cell Biol 2013; 15: 1164-1175.
22. Su Z, Niu W, Liu ML, Zou Y, Zhang CL. In vivo conversion of astrocytes to neurons in the injured adult spinal cord. Nat Commun 2014; 5: 3338.
23. Zhao J, He H, Zhou K, Ren Y, Shi Z, Wu Z et al. Neuronal transcription factors induce conversion of human glioma cells to neurons and inhibit tumorigenesis. PLoS One 2012; 7: e41506.
24. Liu ML, Zang T, Zou Y, Chang JC, Gibson JR, Huber KM et al. Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons. Nat Commun 2013; 4: 2183.
25. Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X et al. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell 2001; 104: 365-376.
26. Ross SE, Greenberg ME, Stiles CD. Basic helix-loop-helix factors in cortical development. Neuron 2003; 39: 13-25.
27. Berninger B, Costa MR, Koch U, Schroeder T, Sutor B, Grothe B et al. Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia. J Neurosci 2007; 27: 8654-8664.
28. Guichet PO, Bieche I, Teigell M, Serguera C, Rothhut B, Rigau V et al. Cell death and neuronal differentiation of glioblastoma stem-like cells induced by neurogenic transcription factors. Glia 2013; 61: 225-239.
29. Heinrich C, Gascon S, Masserdotti G, Lepier A, Sanchez R, Simon-Ebert T et al. Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex. Nat Protoc 2011; 6: 214-228.
30. Bergsland M, Werme M, Malewicz M, Perlmann T, Muhr J. The establishment of neuronal properties is controlled by Sox4 and Sox11. Genes Dev 2006; 20: 3475-3486.
31. Mu L, Berti L, Masserdotti G, Covic M, Michaelidis TM, Doberauer K et al. SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis. J Neurosci 2012; 32: 3067-3080.
32. Hide T, Takezaki T, Nakatani Y, Nakamura H, Kuratsu J, Kondo T. Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation. Cancer Res 2009; 69: 7953-7959.
33. Guo Z, Zhang L, Wu Z, Chen Y, Wang F, Chen G. In Vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model. Cell Stem Cell 2014; 14: 188-202.
34. Shultz LD, Lyons BL, Burzenski LM, Gott B, Chen X, Chaleff S et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 2005; 174: 6477-6489.
35. Gleeson JG, Lin PT, Flanagan LA, Walsh CA. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron 1999; 23: 257-271.
36. Brown JP, Couillard-Despres S, Cooper-Kuhn CM, Winkler J, Aigner L, Kuhn HG. Transient expression of doublecortin during adult neurogenesis. J Comp Neurol 2003; 467: 1-10.
37. Santra M, Santra S, Roberts C, Zhang RL, Chopp M. Doublecortin induces mitotic microtubule catastrophe and inhibits glioma cell invasion. J Neurochem 2009; 108: 231-245.
38. Santra M, Zhang X, Santra S, Jiang F, Chopp M. Ectopic doublecortin gene expression suppresses the malignant phenotype in glioblastoma cells. Cancer Res 2006; 66: 11726-11735.
39. Rich JN, Hans C, Jones B, Iversen ES, McLendon RE, Rasheed BK et al. Gene expression profiling and genetic markers in glioblastoma survival. Cancer Res 2005; 65: 4051-4058.
40. Kay MA, Glorioso JC, Naldini L. Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat Med 2001; 7: 33-40.
41. Azzouz M, Martin-Rendon E, Barber RD, Mitrophanous KA, Carter EE, Rohll JB et al. Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease. J Neurosci 2002; 22: 10302-10312.
42. Widdowson P, Ralph S, Mitrophanous K Delivery of lentiviral vectors to the brain. Google Patents 2011.
43. Niu W, Zou Y, Shen C, Zhang CL. Activation of postnatal neural stem cells requires nuclear receptor TLX. J Neurosci 2011; 31: 13816-13828.