Cutaneous iontophoresis of treprostinil, a prostacyclin analog, increases microvascular blood flux in diabetic malleolus area

European Journal of Pharmacology

Volumn 758, Issue , 2015, Pages 123-128

  Hellmann, Marcin ^a,b   Roustit, Matthieu ^a,c,d   Gaillard Bigot, Florence ^a   Cracowski, Jean Luc ^a,c,d  

^a GRENOBLE UNIVERSITY HOSPITAL   (France)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

^c University Grenoble Alpes   (France)

^d UNIV GRENOBLE ALPES   (France)

Author keywords

Diabetic foot ulcers; Iontophoresis; Laser speckle contrast imaging; Microcirculation; Prostacyclin; Treprostinil

Indexed keywords

GLICLAZIDE; INSULIN; METFORMIN; PLACEBO; TREPROSTINIL; PROSTACYCLIN;

ADULT; ARTICLE; BLOOD VESSEL PARAMETERS; CLINICAL ARTICLE; CONTROLLED STUDY; CUTANEOUS VASCULAR CONDUCTANCE; DIABETIC FOOT; DIAGNOSTIC IMAGING; DOUBLE BLIND PROCEDURE; DRUG DELIVERY SYSTEM; ERYTHEMA; FEMALE; HUMAN; HYPEREMIA; IONTOPHORESIS; LASER SPECKLE CONTRAST IMAGING; LEG; MALE; MALLEOLUS; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT SAFETY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN BLOOD FLOW; SKIN HYPEREMIA; ANALOGS AND DERIVATIVES; ANKLE; BLOOD; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; INTRADERMAL DRUG ADMINISTRATION; MICROCIRCULATION; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; SKIN; VASCULARIZATION; YOUNG ADULT;

ADMINISTRATION, CUTANEOUS; ADULT; ANKLE; DIABETES MELLITUS, TYPE 2; DOUBLE-BLIND METHOD; EPOPROSTENOL; FEMALE; HUMANS; IONTOPHORESIS; MALE; MICROCIRCULATION; MIDDLE AGED; SKIN; YOUNG ADULT;

EID: 84928016077     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.03.066     Document Type: Article

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