Nalfurafine suppresses pruritogen- and touch-evoked scratching behavior in models of acute and chronic itch in mice

Acta Dermato-Venereologica

Volumn 95, Issue 2, 2015, Pages 147-150

  Akiyama, Tasuku ^a   Carstens, Mirela Iodi ^a   Piecha, Dorothea ^b   Steppan, Sonja ^b   Carstens, Earl ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b FRESENIUS MEDICAL CARE   (Germany)

Author keywords

Alloknesis; Dry skin; Itch; Mouse; Nalfurafine (TRK 820)

Indexed keywords

CHLOROQUINE; HISTAMINE; NALFURAFINE; ANTIPRURITIC AGENT; MORPHINAN DERIVATIVE; SPIRO COMPOUND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRY SKIN; HINDLIMB; MALE; MECHANICAL STIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PRURITUS; SCRATCHING; SKIN WATER LOSS; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; CHEMICALLY INDUCED; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; ICHTHYOSIS; MECHANOTRANSDUCTION; PATHOPHYSIOLOGY; PRESSURE; PSYCHOLOGY; SKIN; TIME;

ANIMALS; ANTIPRURITICS; BEHAVIOR, ANIMAL; CHLOROQUINE; DISEASE MODELS, ANIMAL; HISTAMINE; ICHTHYOSIS; MALE; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, INBRED C57BL; MORPHINANS; PRESSURE; PRURITUS; SKIN; SPIRO COMPOUNDS; TIME FACTORS;

EID: 84928007739     PISSN: 00015555     EISSN: 16512057     Source Type: Journal    
DOI: 10.2340/00015555-1879     Document Type: Article

References (23)

1. Ständer S, Weisshaar E, Mettang T, Szepietowski J, Carstens E, Ikoma A, et al. Clinical classification of itch: a position paper of the International Forum for the Study of Itch. Acta Derm Venereol 2007; 87: 291–294.
2. Akiyama T, Carstens E. Neural processing of itch. Neurosci 2013; 250: 697–714.
3. Matterne U, Apfelbacher C, Vogelgsang L, Loerbroks A, Weisshaar E. Incidence and determinants of chronic pruritus: A population-based cohort study. Acta Derm Venereol 2013; 93: 532–537.
4. Chen SC. Pruritus. Dermatol Clin 2012; 30: 309–321, ix.
5. Akiyama T, Carstens MI, Ikoma A, Cevikbas F, Steinhoff M, Carstens E. Mouse model of touch-evoked itch (Alloknesis). J Invest Dermatol 2012; 132: 1886–1891.
6. Inan S, Cowan A. Kappa opioid agonists suppress chloroquine- induced scratching in mice. Eur J Pharmacol 2004; 502: 233–237.
7. Inan S, Cowan A. Nalfurafine, a kappa opioid receptor agonist, inhibits scratching behavior secondary to cholestasis induced by chronic ethynylestradiol injections in rats. Pharmacol Biochem Behav 2006; 85: 39–43.
8. Inan S, Dun NJ, Cowan A. Nalfurafine prevents 5’-guanidinonaltrindole- and compound 48/80-induced spinal c-fos expression and attenuates 5’-guanidinonaltrindole-elicited scratching behavior in mice. Neurosci 2009; 163: 23–33.
9. Umeuchi H, Kawashima Y, Aoki CA, Kurokawa T, Nakao K, Itoh M, et al. Spontaneous scratching behavior in MRL/ lpr mice, a possible model for pruritus in autoimmune diseases, and antipruritic activity of a novel kappa-opioid receptor agonist nalfurafine hydrochloride. Eur J Pharmacol 2005; 518: 133–139.
10. Togashi Y, Umeuchi H, Okano K, Ando N, Yoshizawa Y, Honda T, et al. Antipruritic activity of the kappa-opioid receptor agonist, TRK-820. Eur J Pharmacol 2002; 435: 259–264.
11. Umeuchi H, Togashi Y, Honda T, Nakao K, Okano K, Tanaka T, et al. Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system. Eur J Pharmacol 2003; 477: 29–35.
12. Ko MC, Husbands SM. Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. J Pharmacol Exp Ther 2009; 328: 193–200.
13. Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, et al. Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell 2009; 139: 1353–1365.
14. Szepietowski JC, Balaskas E, Taube KM, Taberly A, Dupuy P. Quality of life in patients with uraemic xerosis and pruritus. Acta Derm Venereol 2011; 91: 313–317.
15. Manenti L, Tansinda P, Vaglio A. Uraemic pruritus: clinical characteristics, pathophysiology and treatment. Drugs 2009; 69: 251–263.
16. Akiyama T, Carstens MI, Carstens E. Enhanced scratching evoked by PAR-2 agonist and 5-HT but not histamine in a mouse model of chronic dry skin itch. Pain 2010; 151: 378–383.
17. Akiyama T, Tominaga M, Davoodi A, Nagamine M, Blansit K, Horwitz A, et al. Cross-sensitization of histamine-independent itch in mouse primary sensory neurons. Neurosci 2012; 226: 305–312.
18. Akiyama T, Tominaga M, Takamori K, Carstens MI, Carstens E. Roles of glutamate, substance P, and gastrinreleasing peptide as spinal neurotransmitters of histaminergic and nonhistaminergic itch. Pain 2013; 155: 80–92.
19. Roberson DP, Gudes S, Sprague JM, Patoski HA, Robson VK, Blasl F, et al. Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nature Neurosci 2013; 16: 910–918.
20. Tominaga M, Ozawa S, Tengara S, Ogawa H, Takamori K. Intraepidermal nerve fibers increase in dry skin of acetonetreated mice. J Dermatol Sci 2007; 48: 103–111.
21. Heyer G, Dotzer M, Diepgen TL, Handwerker HO. Opiate and H1 antagonist effects on histamine induced pruritus and alloknesis. Pain 1997; 73: 239–243.
22. Miraucourt LS, Moisset X, Dallel R, Voisin DL. Glycine inhibitory dysfunction induces a selectively dynamic, morphine-resistant, and neurokinin 1 receptor-independent mechanical allodynia. J Neurosci 2009; 29: 2519–2527.
23. Lu Y, Dong H, Gao Y, Gong Y, Ren Y, Gu N, et al. A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia. J Clin Invest 2013; 123: 4050–4062.