Synthesis, physicochemical and biological evaluation of 2-amino-5-chlorobenzophenone derivatives as potent skeletal muscle relaxants

Arabian Journal of Chemistry

Volumn 8, Issue 3, 2015, Pages 307-312

  Singh, Rajesh K ^a   Devi, Sonia ^a,b   Prasad, D N ^a  

^a Nangal   (India)

^b Laureate Institute of Pharmacy Kathog   (India)

Author keywords

2 Aminobenzophenone; Central nervous system; LogP; Physicochemical parameters; Rotarod test; Skeletal muscle relaxant activity

Indexed keywords

ANILINE;

2-AMINOBENZOPHENONE; CENTRAL NERVOUS SYSTEMS; LOGP; PHYSICOCHEMICAL PARAMETERS; SKELETAL MUSCLE;

MUSCLE;

EID: 84927967022     PISSN: 18785352     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arabjc.2011.11.013     Document Type: Article

References (16)

1. Bodor N., Sloan K.B., Higuchi T. J. Med. Chem. 1977, 20:1435.
2. Coombs R.V., Danna R.P., Denzer M., Hardtmann G.E., Huegi B., Koletar G., Koletar J., Ott H., Jukniewicz E. J. Med. Chem. 1973, 16:1237.
3. Felix A.M., Winter D.P., Wang S.S., Kulesha I.D., Pool W.R., Hane D.L., Sheppard H. J. Med. Chem. 1974, 17:422.
4. Fujita T., Iwasa J., Hansch C. J. Am. Chem. Soc. 1964, 86:5175.
5. Hirai K., Ishiba T., Sugimoto H., Sasakura K., Fujishita T., Toyoda T., Tsukinoki Y., Joyama H., Hatakeyama H., Hirose K. J. Med. Chem. 1980, 23:764.
6. Kulkarni S.K. Hand Book of Experimental Pharmacology 1993, Vallabh Prakashan, New Delhi, p. 122. second ed.
7. Liou J.P., Chang C.W., Song J.S., Yang Y.N., Yeh C.F., Tseng H.Y., Lo Y.K., Chang Y.L., Chang C.M., Hsieh H.P. J. Med. Chem. 2002, 45(12):2556.
8. Moriguchi I., Hirono S., Liu Q., Nakagome I., Matsushita Y. Chem. Pharm. Bull. 1992, 40(1):127-130.
9. Ottosen E.R., Sorenson M.D., Bjorkiing F., Nielsen T.S., Fjording M.S., Aaes H., Binderup L. J. Med. Chem. 2003, 46(26):5651.
10. Sternbach L.H., Fryer R.I., Metlesics W., Reeder E., Sach G., Saucy G., Stempel A. J. Org. Chem. 1962, 27:3788.
11. Sternbach L.H., Reeder E., Keller O., Metlesics W. J. Org. Chem. 1961, 26:4488.
12. Su D-S., Lim J.L., Tinney E., Wan B-L., Murphy K.L., Reiss D.R., Harrell M., O'Malley S.S., Ransom R.W., Chang R.S.L., Pettibone D.J., Yu J., Tang C., Freidionger R.M., Bock M.G., Anthony N.J. J. Med. Chem. 2008, 51(13):3946.
13. Walsh D.A. Synthesis 1980, 677.
14. Welstead W.J., Moran J.H.W., Stauffer H.F., Turnbull L.B., Sancilio L.F. Amer. Chem. Soc. 1979, 22:1074.
15. http://www.molinspiration.com/cgi-bin/properties.
16. http://www.chemsilico.com/cs_products/products.html.