Vitamin B12 deficiency - A 21st century perspective

Clinical Medicine, Journal of the Royal College of Physicians of London

Volumn 15, Issue 2, 2015, Pages 145-150

  Shipton, Michael J ^a   Thachil, Jecko ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

B12; Cobalamin; Deficiency; Vitamin

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HAPTOCORRIN; HISTAMINE H2 RECEPTOR ANTAGONIST; HOMOCYSTEINE; HYDROXOCOBALAMIN; METFORMIN; ORAL CONTRACEPTIVE AGENT; PROTON PUMP INHIBITOR; TRANSCOBALAMIN II;

ANTIBODY TITER; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL FEATURE; CYANOCOBALAMIN DEFICIENCY; DISEASE ASSOCIATION; FOLIC ACID BLOOD LEVEL; FOOD BOUND COBALAMIN MALABSORPTION; HEMATOLOGIC DISEASE; HUMAN; LIVER DISEASE; MACROCYTIC ANEMIA; MALABSORPTION; MEGALOCYTOSIS; NEUROLOGIC DISEASE; PANCYTOPENIA; PERNICIOUS ANEMIA; REVIEW; SPINAL CORD ATROPHY; SUBSTITUTION THERAPY; VITAMIN BLOOD LEVEL; VITAMIN METABOLISM; BLOOD; PHYSIOLOGY; VITAMIN B 12 DEFICIENCY;

HUMANS; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 84927949196     PISSN: 14702118     EISSN: 14734893     Source Type: Journal    
DOI: 10.7861/clinmedicine.15-2-145     Document Type: Review

References (31)

1. 12 deficiency in adults. Q J Med 2009;102:17-28.
2. Devalia V, Hamilton MS, Molloy AM; The British Committee for Standards in Haematology. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Brit J Haematol 2014;166:496-513.
3. Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr 2009;89:693S-696S.
4. Antony AC. Vegetarianism and vitamin B-12 (cobalamin) deficiency. Am J Clin Nutr 2003;78:3-6.
5. 12) deficiency. Blood 2008;112:2214-21.
6. 12 transport from food to the body's cells - A sophisticated, multistep pathway. Nat Rev Gastroenterol Hepatol 2012;9:345-54.
7. th edn. New York: WH Freeman, 2003.
8. 12 (cobalamin) deficiency in elderly patients. Can Med Assoc J 2004;171:251-9.
9. Toh BH, van Driel IR, Gleeson PA. Pernicious anaemia. N Eng J Med 1997;337:1441-8.
10. Stabler SP. Vitamin B12 deficiency. N Eng J Med 2013;368:149-60.
11. 12 deficiency. J Am Med Assoc 2013;310:2435-42.
12. de Jager J, Kooy A, Lehert P et al. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: Randomised placebo controlled trial. Brit Med J 2010;340:c2181.
13. 12 status in metformin treated patients: Systematic review. PLoS One. 2014;9:e100379.
14. 12 deficiency in elderly patients. J Neuropsychiatry Clin Neurosci 2012;24:5-15.
15. 12 in neurology and ageing: Clinical and genetic aspects. Biochimie 2013;95:1066-76.
16. 12 is associated with lower BMD: The Framingham Osteoporosis study. J Bone Miner Res 2005;20:152-8.
17. 12 deficiency: The long-term effects in cardiovascular disease. Cardiology 2007;107:57-62.
18. 12) deficiency and its application. J Nutr Health Aging 2011;15:227-31.
19. Arendt JF, Nexø E. Unexpected high plasma cobalamin - Proposal for diagnostic strategy. Clin Chem Lab Med 2013;51:489-96.
20. Carmel R. Subclinical cobalamin deficiency. Curr Opin Gastroenterol 2012;28:151-8.
21. 12 and folate deficiency. NICE Clinical Knowledge Summaries, November 2014. Available online at http://cks.nice.org.uk/anaemia-b12-and-folate-deficiency [Accessed 4 December 2014].
22. Kuzminski AM, Del Giacco EJ, Allen RH, Stabler SP, Lindenbaum J. Effective treatment of cobalamin deficiency with oral cobalamin. Blood 1998;92:1191-8.
23. Andrès E, Kurtz J, Perrin A et al. Oral cobalamin therapy for the treatment of patients with food-cobalamin malabsorption. Am J Med 2001;111:126-9.
24. Andrès E, Loukili NH, Noel E et al. Effects of oral crystalline cobalamin 1000 μg/d in the treatment of pernicious anemia: An open-label, prospective study in ten patients. Curr Ther Res 2005;66:13-22.
25. 12 in normalizing low cobalamin levels: A randomized, open-label, parallel-group study. Clin Ther 2011;33:358-71.
26. 12 deficiency: A systematic review of randomized controlled trials. Fam Pract 2006;23:279-85.
27. 12 deficiency: A pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting (Project OB12). BMC Public Health 2012;12:394-404.
28. 12 in clinical practice. Q J Med 2013;106:505-15.
29. 12 levels and mortality in hospitalized older adults. J Am Geriatr Soc 2010;58:523-6.
30. 12. J Am Med Assoc 2009;302:2119-26.
31. 12 levels are associated with mortality in critically ill medical patients. Clin Nutr 2012;31:53-9.