Transmission of pruriceptive signals

Handbook of Experimental Pharmacology

Volumn 226, Issue , 2015, Pages 151-162

  Mishra, Santosh K ^a   Hoon, Mark A ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Dynorphin; Grp; Grpr; Itch; Neurotransmitters; Nppb; Pruritic; Receptors; Somatostatin

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; DYNORPHIN; GASTRIN RELEASING PEPTIDE; GASTRIN RELEASING PEPTIDE RECEPTOR; GLUTAMIC ACID; HORMONE RECEPTOR; KAPPA OPIATE RECEPTOR; NATRIURETIC PEPTIDE RECEPTOR 1; NATRIURETIC PEPTIDE RECEPTOR A; NEUROMEDIN B; NEUROTRANSMITTER; ORPHAN NUCLEAR RECEPTOR; SOMATOSTATIN; SOMATOSTATIN RECEPTOR; SOMATOSTATIN RECEPTOR 2; SUBSTANCE P; SUBSTANCE P RECEPTOR; TESTICULAR ORPHAN NUCLEAR RECEPTOR 4; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1; VESICULAR GLUTAMATE TRANSPORTER 2;

ARTICLE; CELL ACTIVATION; HUMAN; ITCH SENSORY CELL; NERVE CELL; NERVE CELL STIMULATION; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PRURICEPTIVE TRANSMISSION; PRURITUS; SENSORY NERVE CELL; SPINAL CORD CELL; SPINAL CORD DORSAL HORN; SPINAL GANGLION; AMINO ACID SEQUENCE; ANIMAL; MOLECULAR GENETICS; PATHOPHYSIOLOGY; PHYSIOLOGY; SPINAL CORD; SYNAPTIC TRANSMISSION;

AMINO ACID SEQUENCE; ANIMALS; HUMANS; MOLECULAR SEQUENCE DATA; PRURITUS; SPINAL CORD; SYNAPTIC TRANSMISSION;

EID: 84927931779     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-662-44605-8_8     Document Type: Article

References (57)

1. Akiyama T, Iodi Carstens M, Carstens E (2011) Transmitters and pathways mediating inhibition of spinal itch-signaling neurons by scratching and other counterstimuli. PLoS One 6:e22665
2. Akiyama T, Tominaga M, Takamori K, Carstens MI, Carstens E (2014) Roles of glutamate, substance P, and gastrin-releasing peptide as spinal neurotransmitters of histaminergic and nonhistaminergic itch. Pain 155:80–92
3. Atlas SA, Kleinert HD, Camargo MJ, Volpe M, Laragh JH, Lewicki JA, Maack T (1985) Atrial natriuretic factor (auriculin): structure and biological effects. J Clin Hypertens 1:187–198
4. Bass RT, Buckwalter BL, Patel BP, Pausch MH, Price LA, Strnad J, Hadcock JR (1996) Identification and characterization of novel somatostatin antagonists. Mol Pharmacol 50:709–715
5. Bromm B, Scharein E, Darsow U, Ring J (1995) Effects of menthol and cold on histamine-induced itch and skin reactions in man. Neurosci Lett 187:157–160
6. Carstens EE, Carstens MI, Simons CT, Jinks SL (2010) Dorsal horn neurons expressing NK-1 receptors mediate scratching in rats. Neuroreport 21:303–308
7. Coy D, Wang LH, Jiang NY, Jensen R (1990) Short chain bombesin pseudopeptides with potent bombesin receptor antagonist activity in rat and guinea pig pancreatic acinar cells. Eur J Pharmacol 190:31–38
8. Cuellar JM, Jinks SL, Simons CT, Carstens E (2003) Deletion of the preprotachykinin A gene in mice does not reduce scratching behavior elicited by intradermal serotonin. Neurosci Lett 339:72–76
9. Davidson S, Zhang X, Khasabov SG, Simone DA, Giesler GJ Jr (2009) Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons. Nat Neurosci 12:544–546
10. Davidson S, Zhang X, Khasabov SG, Moser HR, Honda CN, Simone DA, Giesler GJ Jr (2012) Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate. J Neurophysiol 108:1711–1723
11. Dhawan BN, Cesselin F, Raghubir R, Reisine T, Bradley PB, Portoghese PS, Hamon M (1996) International Union of Pharmacology. XII. Classification of opioid receptors. Pharmacol Rev 48:567–592
12. Fleming MS, Ramos D, Han SB, Zhao J, Son YJ, Luo W (2012) The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons. Mol Pain 8:52
13. Garbers DL, Lowe DG (1994) Guanylyl cyclase receptors. J Biol Chem 269:30741–30744
14. Han SK, Mancino V, Simon MI (2006) Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons. Neuron 52:691–703
15. Hellmich MR, Battey JF, Northup JK (1997) Selective reconstitution of gastrin-releasing peptide receptor with G alpha q. Proc Natl Acad Sci U S A 94:751–756
16. Hou C, Gilbert RL, Barber DL (1994) Subtype-specific signaling mechanisms of somatostatin receptors SSTR1 and SSTR2. J Biol Chem 269:10357–10362
17. Imamachi N, Park GH, Lee H, Anderson DJ, Simon MI, Basbaum AI, Han SK (2009) TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proc Natl Acad Sci U S A 106:11330–11335
18. Inan S, Cowan A (2006) Nalfurafine, a kappa opioid receptor agonist, inhibits scratching behavior secondary to cholestasis induced by chronic ethynylestradiol injections in rats. Pharmacol Biochem Behav 85:39–43
19. Inan S, Dun NJ, Cowan A (2011) Investigation of gastrin-releasing peptide as a mediator for 50-guanidinonaltrindole-induced compulsive scratching in mice. Peptides 32:286–292
20. Jensen RT, Battey JF, Spindel ER, Benya RV (2008) International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev 60:1–42
21. Kardon AP, Polgar E, Hachisuka J, Snyder LM, Cameron D, Savage S, Cai X, Karnup S, Fan CR, Hemenway GM, Bernard CS, Schwartz ES, Nagase H, Schwarzer C, Watanabe M, Furuta T, Kaneko T, Koerber HR, Todd AJ, Ross SE (2014) Dynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord. Neuron 82:573–586
22. Koga K, Chen T, Li XY, Descalzi G, Ling J, Gu J, Zhuo M (2011) Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord. Mol Pain 7:47
23. Kumagai H, Ebata T, Takamori K, Miyasato K, Muramatsu T, Nakamoto H, Kurihara M, Yanagita T, Suzuki H (2012) Efficacy and safety of a novel k-agonist for managing intractable pruritus in dialysis patients. Am J Nephrol 36:175–183
24. Lagerstrom MC, Rogoz K, Abrahamsen B, Persson E, Reinius B, Nordenankar K, Olund C, Smith C, Mendez JA, Chen ZF, Wood JN, Wallen-Mackenzie A, Kullander K (2010) VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch. Neuron 68:529–542
25. Li MZ, Wang JS, Jiang DJ, Xiang CX, Wang FY, Zhang KH, Williams PR, Chen ZF (2006) Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening. Dev Biol 292:555–564
26. Liu Q, Tang Z, Surdenikova L, Kim S, Patel KN, Kim A, Ru F, Guan Y, Weng HJ, Geng Y, Undem BJ, Kollarik M, Chen ZF, Anderson DJ, Dong X (2009) Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus. Cell 139:1353–1365
27. Liu Y, Abdel Samad O, Zhang L, Duan B, Tong Q, Lopes C, Ji RR, Lowell BB, Ma Q (2010) VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron 68:543–556
28. Liu Q, Weng HJ, Patel KN, Tang Z, Bai H, Steinhoff M, Dong X (2011) The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia. Sci Signal 4:45
29. Mantyh PW, Rogers SD, Honore P, Allen BJ, Ghilardi JR, Li J, Daughters RS, Lappi DA, Wiley RG, Simone DA (1997) Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. Science 278:275–279
30. Mishra SK, Hoon MA (2013) The cells and circuitry for itch responses in mice. Science 340:968–971
31. Mishra SK, Tisel SM, Orestes P, Bhangoo SK, Hoon MA (2011) TRPV1-lineage neurons are required for thermal sensation. EMBO J 30:582–593
32. Mishra SK, Holzman S, Hoon MA (2012) A nociceptive signaling role for neuromedin B. J Neurosci 32:8686–8695
33. Morgan MM, Christie MJ (2011) Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human. Br J Pharmacol 164:1322–1334
34. Polgar E, Durrieux C, Hughes DI, Todd AJ (2013) A quantitative study of inhibitory interneurons in laminae I-III of the mouse spinal dorsal horn. PLoS One 8:e78309
35. Raynor K, Murphy WA, Coy DH, Taylor JE, Moreau JP, Yasuda K, Bell GI, Reisine T (1993) Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. Mol Pharmacol 43:838–844
36. Ross SE, Mardinly AR, McCord AE, Zurawski J, Cohen S, Jung C, Hu L, Mok SI, Shah A, Savner EM, Tolias C, Corfas R, Chen S, Inquimbert P, Xu Y, McInnes RR, Rice FL, Corfas G, Ma Q, Woolf CJ, Greenberg ME (2010) Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron 65:886–898
37. Scherrer G, Low SA, Wang X, Zhang J, Yamanaka H, Urban R, Solorzano C, Harper B, Hnasko TS, Edwards RH, Basbaum AI (2010) VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity. Proc Natl Acad Sci U S A 107:22296–22301
38. Seilhamer JJ, Arfsten A, Miller JA, Lundquist P, Scarborough RM, Lewicki JA, Porter JG (1989) Human and canine gene homologs of porcine brain natriuretic peptide. Biochem Biophys Res Commun 165:650–658
39. Shi TJ, Xiang Q, Zhang MD, Barde S, Kai-Larsen Y, Fried K, Josephson A, Gluck L, Deyev SM, Zvyagin AV, Schulz S, Hokfelt T (2014) Somatostatin and its 2A receptor in dorsal root ganglia and dorsal horn of mouse and human: expression, trafficking and possible role in pain. Mol Pain 10:12
40. Stander S, Siepmann D, Herrgott I, Sunderkotter C, Luger TA (2010) Targeting the neurokinin receptor 1 with aprepitant: a novel antipruritic strategy. PLoS One 5:e10968
41. Su J, Sandor K, Skold K, Hokfelt T, Svensson CI, Kultima K (2014) Identification and quantification of neuropeptides in naive mouse spinal cord using mass spectrometry reveals [des-Ser1]-cerebellin as a novel modulator of nociception. J Neurochem 130:199–214
42. Sukhtankar DD, Ko MC (2013) Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice. PLoS One 8:e67422
43. Sun YG, Chen ZF (2007) A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 448:700–703
44. Sun YG, Zhao ZQ, Meng XL, Yin J, Liu XY, Chen ZF (2009) Cellular basis of itch sensation. Science 325:1531–1534
45. Takeda M, Kadoi J, Takahashi M, Nasu M, Matsumoto S (2007) Somatostatin inhibits the excitability of rat small-diameter trigeminal ganglion neurons that innervate nasal mucosa and project to the upper cervical dorsal horn via activation of somatostatin 2a receptor. Neuroscience 148:744–756
46. Todd AJ, McGill MM, Shehab SA (2000) Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem. Eur J Neurosci 12:689–700
47. Trivedi M, Bergasa NV (2010) Serum concentrations of substance P in cholestasis. Ann Hepatol 9:177–180
48. Tse MY, Watson JD, Sarda IR, Flynn TG, Pang SC (2001) Expression of B-type natriuretic peptide in atrial natriuretic peptide gene disrupted mice. Mol Cell Biochem 219:99–105
49. Wada E, Way J, Lebacq-Verheyden AM, Battey JF (1990) Neuromedin B and gastrin-releasing peptide mRNAs are differentially distributed in the rat nervous system. J Neurosci 10:2917–2930
50. Wang X, Zhang J, Eberhart D, Urban R, Meda K, Solorzano C, Yamanaka H, Rice D, Basbaum AI (2013) Excitatory superficial dorsal horn interneurons are functionally heterogeneous and required for the full behavioral expression of pain and itch. Neuron 78:312–324
51. Wikst€rom B, Gellert R, Ladefoged SD, Danda Y, Akai M, Ide K, Ogasawara M, Kawashima Y, Ueno K, Mori A, Ueno Y (2005) Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies. J Am Soc Nephrol 16:3742–3747
52. Wyss DF, Lahm HW, Manneberg M, Labhardt AM (1991) Anantin—a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments. J Antibiot 44:172–180
53. Xu Y, Lopes C, Wende H, Guo Z, Cheng L, Birchmeier C, Ma Q (2013) Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities. J Neurosci 33:14738–14748
54. Yasaka T, Tiong SY, Hughes DI, Riddell JS, Todd AJ (2010) Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach. Pain 151:475–488
55. Yosipovitch G, Duque MI, Fast K, Dawn AG, Coghill RC (2007) Scratching and noxious heat stimuli inhibit itch in humans: a psychophysical study. Br J Dermatol 156:629–634
56. Zhang FX, Liu XJ, Gong LQ, Yao JR, Li KC, Li ZY, Lin LB, Lu YJ, Xiao HS, Bao L, Zhang XH, Zhang X (2010) Inhibition of inflammatory pain by activating B-type natriuretic peptide signal pathway in nociceptive sensory neurons. J Neurosci 30:10927–10938
57. Zhao ZQ, Huo FQ, Jeffry J, Hampton L, Demehri S, Kim S, Liu XY, Barry DM, Wan L, Liu ZC, Li H, Turkoz A, Ma K, Cornelius LA, Kopan R, Battey JF Jr, Zhong J, Chen ZF (2013) Chronic itch development in sensory neurons requires BRAF signaling pathways. J Clin Invest 123:4769–4780