Regulation of TLR2 and NLRP3 in primary murine renal tubular epithelial cells

Nephron - Clinical Practice

Volumn 127, Issue 1-4, 2014, Pages 119-123

  Kasimsetty, Sashi G ^a   Dewolf, Sean E ^a   Shigeoka, Alana A ^a   McKay, Dianne B ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Pattern recognition receptors; Regulation; Renal tubular epithelial cells

Indexed keywords

CRYOPYRIN; INTERLEUKIN 1BETA; TOLL LIKE RECEPTOR 2; ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; INFLAMMASOME; LIGAND; LIPOPROTEIN; N-PALMITOYL-S-(2,3-BIS(PALMITOYLOXY)PROPYL)CYSTEINYL-SERYL-LYSYL-LYSYL-LYSYL-LYSINE; NIGERICIN; TLR2 PROTEIN, MOUSE;

ADULT; ANIMAL CELL; CELL DEATH; CELL LYSATE; CONFERENCE PAPER; CONTROLLED STUDY; KIDNEY TUBULE CELL; KIDNEY TUBULE NECROSIS; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; APOPTOSIS; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CYTOLOGY; EPITHELIUM CELL; GENETICS; KIDNEY TUBULE; METABOLISM; NECROSIS; PHYSIOLOGY; PRIMARY CELL CULTURE;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELLS, CULTURED; EPITHELIAL CELLS; INFLAMMASOMES; INTERLEUKIN-1BETA; KIDNEY TUBULES; LIGANDS; LIPOPROTEINS; MALE; MICE; MICE, INBRED C57BL; NECROSIS; NIGERICIN; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; UP-REGULATION;

EID: 84927743237     PISSN: None     EISSN: 16602110     Source Type: Journal    
DOI: 10.1159/000363208     Document Type: Conference Paper

References (15)

1. Shigeoka AA, et al: TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and-independent pathways. J Immunol 2007; 178: 6252-6258.
2. Segovia J, et al: TLR2/MyD88/NF-kappaB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. PLoS One 2012; 7:e29695.
3. Zager RA, Burkhart KM: Differential effects of glutathione and cysteine on Fe 2+ , Fe 3+ , H 2 O 2 and myoglobin-induced proximal tubular cell attack. Kidney Int 1998; 53: 1661-1672.
4. Shigeoka AA, et al: Nod1 and nod2 are expressed in human and murine renal tubular epithelial cells and participate in renal ischemia reperfusion injury. J Immunol 2010; 184: 2297-2304.
5. Shigeoka AA, et al: An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury. J Immunol 2010; 185: 6277-6285.
6. Snodgrass RG, Huang S, Choi IW, Rutledge JC, Hwang DH: Inflammasome-mediated secretion of IL-1beta in human monocytes through TLR2 activation; modulation by dietary fatty acids. J Immunol 2013; 191: 4337-4347.
7. Bauernfeind FG, et al: Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 2009; 183: 787-791.
8. Iyer SS, et al: Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci USA 2009; 106: 20388-20393.
9. Leemans JC, et al; Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 2005; 115: 2894-2903.
10. Tian J, et al: Extracellular HSP60 induces inflammation through activating and up-regulating TLRs in cardiomyocytes. Cardiovasc Res 2013; 98: 391-401.
11. Zhang J, et al: TLR2 mRNA upregulation in ischemic lobes in mouse partial hepatic ischemia/ reperfusion injury model. J Huazhong Univ Sci Technolog Med Sci 2004; 24: 144-146.
12. Wolfs TG, et al: In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFNgamma and TNF-alpha mediated up-regulation during inflammation. J Immunol 2002; 168: 1286-1293.
13. Sandanger O, et al: The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury. Cardiovasc Res 2013; 99: 164-174.
14. Turner CM, Arulkumaran N, Singer M, Unwin RJ, Tam FW: Is the inflammasome a potential therapeutic target in renal disease? BMC Nephrol 2014; 15: 21.
15. Lin KM, et al: IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation. Proc Natl Acad Sci USA 2014; 111: 775-780.