Prediction models for neonatal health care-associated sepsis: A meta-analysis

Pediatrics

Volumn 135, Issue 4, 2015, Pages e1002-e1014

  Verstraete, Evelien Hilde ^a   Blot, Koen ^a   Mahieu, Ludo ^b,c   Vogelaers, Dirk ^a,d   Blot, Stijn ^a,e  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^d GHENT UNIVERSITY HOSPITAL   (Belgium)

^e UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; BIOLOGICAL MARKER;

APNEA; BLOODSTREAM INFECTION; BRADYCARDIA; DIAGNOSTIC ACCURACY; HUMAN; LETHARGY; MOTTLING; NEWBORN; NEWBORN CARE; NEWBORN SEPSIS; PALLOR; PERFUSION; PHYSICAL DISEASE BY BODY FUNCTION; POOR PERIPHERAL PERFUSION; POPULATION RESEARCH; POST HOC ANALYSIS; POSTNATAL CARE; PREDICTION; PRIORITY JOURNAL; QUALITY CONTROL; REVIEW; SYSTEMATIC REVIEW; TOTAL PARENTERAL NUTRITION; BACTEREMIA; CROSS INFECTION; DIFFERENTIAL DIAGNOSIS; GESTATIONAL AGE; META ANALYSIS; MICROBIOLOGICAL EXAMINATION; NEWBORN INTENSIVE CARE; SEPSIS; STATISTICAL MODEL;

BACTEREMIA; BACTERIOLOGICAL TECHNIQUES; BIOLOGICAL MARKERS; CROSS INFECTION; DIAGNOSIS, DIFFERENTIAL; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; MODELS, STATISTICAL; SEPSIS;

EID: 84927728380     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2014-3226     Document Type: Review

References (70)

1. Verstraete E, Boelens J, De Coen K, et al. Healthcare-associated bloodstream infections in a neonatal intensive care unit over a 20-year period (1992-2011): trends in incidence, pathogens, and mortality. Infect Control Hosp Epidemiol. 2014;35(5):511-518
2. Stoll BJ, Hansen N, Fanaroff AA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 2002;110(2 pt 1):285-291
3. Brodie SB, Sands KE, Gray JE, et al. Occurrence of nosocomial bloodstream infections in six neonatal intensive care units. Pediatr Infect Dis J. 2000;19(1):56-65
4. Gupta N, Crockett DC, Anthony M, Webster DP. Late onset bloodstream infections in a tertiary neonatal intensive care unit. Arch Dis Child Fetal Neonatal Ed. 2011;96(3):F234-F237
5. Mahieu LM, Buitenweg N, Beutels P, De Dooy JJ. Additional hospital stay and charges due to hospital-acquired infections in a neonatal intensive care unit. J Hosp Infect. 2001;47(3):223-229
6. Fanaroff AA, Korones SB, Wright LL, et al; The National Institute of Child Health and Human Development Neonatal Research Network. Incidence, presenting features, risk factors and significance of late onset septicemia in very low birth weight infants. Pediatr Infect Dis J. 1998;17(7):593-598
7. Stoll BJ, Hansen NI, Adams-Chapman I, et al; National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA. 2004;292(19):2357-2365
8. Pessoa-Silva CL, Miyasaki CH, De Almeida MF, Kopelman BI, Raggio RL, Wey SB. Neonatal late-onset bloodstream infection: attributable mortality, excess of length of stay and risk factors. Eur J Epidemiol. 2001;17(8):715-720
9. Adams-Chapman I. Long-term impact of infection on the preterm neonate. Semin Perinatol. 2012;36(6):462-470
10. Stoll BJ, Hansen N. Infections in VLBW infants: studies from the NICHD Neonatal Research Network. Semin Perinatol. 2003;27(4):293-301
11. Gray JW. A 7-year study of bloodstream infections in an English children's hospital. Eur J Pediatr. 2004;163(9):530-535
12. Blot S, Cankurtaran M, Petrovic M, et al. Epidemiology and outcome of nosocomial bloodstream infection in elderly critically ill patients: a comparison between middle-aged, old, and very old patients. Crit Care Med. 2009;37(5):1634-1641
13. Gastmeier P, Behnke M, Breier AC, et al. Healthcare-associated infection rates: measuring and comparing. Experiences from the German National Nosocomial Infection Surveillance System (KISS) and from other surveillance systems [in German]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012;55(11-12):1363-1369
14. Paolucci M, Landini MP, Sambri V. How can the microbiologist help in diagnosing neonatal sepsis? Int J Pediatr. 2012;2012:120139. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272815. Accessed February 5, 2015
15. Pammi M, Flores A, Leeflang M, Versalovic J. Molecular assays in the diagnosis of neonatal sepsis: a systematic review and meta-analysis. Pediatrics. 2011;128 (4). Available at: www.pediatrics.org/cgi/content/full/128/4/e973
16. Chiesa C, Panero A, Osborn JF, Simonetti AF, Pacifico L. Diagnosis of neonatal sepsis: a clinical and laboratory challenge. Clin Chem. 2004;50(2):279-287
17. Fowlie PW, Schmidt B. Diagnostic tests for bacterial infection from birth to 90 days-a systematic review. Arch Dis Child Fetal Neonatal Ed. 1998;78(2):F92-F98
18. Beekmann SE, Diekema DJ, Doern GV. Determining the clinical significance of coagulase-negative staphylococci isolated from blood cultures. Infect Control Hosp Epidemiol. 2005;26(6):559-566
19. Fischer JE, Ramser M, Altermatt S, Nadal D, Waldvogel K. Rational utilization of antibiotics in critically ill children [in German]. Schweiz Med Wochenschr. 2000;130(42):1564-1571
20. Apisarnthanarak A, Holzmann-Pazgal G, Hamvas A, Olsen MA, Fraser VJ. Antimicrobial use and the influence of inadequate empiric antimicrobial therapy on the outcomes of nosocomial bloodstream infections in a neonatal intensive care unit. Infect Control Hosp Epidemiol. 2004;25(9):735-741
21. Gordon A, Jeffery HE. Antibiotic regimens for suspected late onset sepsis in newborn infants. Cochrane Database Syst Rev. 2005; (3): CD004501
22. Whiting PF, Rutjes AW, Westwood ME, et al; QUADAS-2 Group. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 2011;155(8):529-536
23. Laupacis A, Sekar N, Stiell IG. Clinical prediction rules. A review and suggested modifications of methodological standards. JAMA. 1997;277(6):488-494
24. Altman DG, Vergouwe Y, Royston P, Moons KG. Prognosis and prognostic research: validating a prognostic model. BMJ. 2009;338:b605
25. Royston P, Moons KG, Altman DG, Vergouwe Y. Prognosis and prognostic research: Developing a prognostic model. BMJ. 2009;338:b604
26. Schwartz A. Diagnostic test calculator. 2002-2006. Available at: http://araw. mede.uic.edu/cgi-bin/testcalc.pl. Accessed October 11, 2014
27. Mahieu LM, De Muynck AO, De Dooy JJ, Laroche SM, Van Acker KJ. Prediction of nosocomial sepsis in neonates by means of a computer-weighted bedside scoring system (NOSEP score). Crit Care Med. 2000;28(6):2026-2033
28. Mahieu LM, De Dooy JJ, Cossey VR, et al. Internal and external validation of the NOSEP prediction score for nosocomial sepsis in neonates. Crit Care Med. 2002;30(7):1459-1466
29. Bekhof J, Reitsma JB, Kok JH, Van Straaten IH. Clinical signs to identify late-onset sepsis in preterm infants. Eur J Pediatr. 2013;172(4):501-508
30. Singh SA, Dutta S, Narang A. Predictive clinical scores for diagnosis of late onset neonatal septicemia. J Trop Pediatr. 2003;49(4):235-239
31. Okascharoen C, Sirinavin S, Thakkinstian A, Kitayaporn D, Supapanachart S. A bedside prediction-scoring model for late-onset neonatal sepsis. J Perinatol. 2005;25(12):778-783
32. Kudawla M, Dutta S, Narang A. Validation of a clinical score for the diagnosis of late onset neonatal septicemia in babies weighing 1000-2500 g. J Trop Pediatr. 2008;54(1):66-69
33. Rosenberg RE, Ahmed AS, Saha SK, et al. Nosocomial sepsis risk score for preterm infants in low-resource settings. J Trop Pediatr. 2010;56(2):82-89
34. Okascharoen C, Hui C, Cairnie J, Morris AM, Kirpalani H. External validation of bedside prediction score for diagnosis of late-onset neonatal sepsis. J Perinatol. 2007;27(8):496-501
35. Dalgic N, Ergenekon E, Koc E, Atalay Y. NOSEP and clinical scores for nosocomial sepsis in a neonatal intensive care unit. J Trop Pediatr. 2006;52(3):226-227
36. Rodwell RL, Leslie AL, Tudehope DI. Early diagnosis of neonatal sepsis using a hematologic scoring system. J Pediatr. 1988;112(5):761-767
37. Wang K, Bhandari V, Chepustanova S, et al. Which biomarkers reveal neonatal sepsis? PLoS ONE. 2013;8(12):e82700
38. Zeitoun AA, Gad SS, Attia FM, Abu Maziad AS, Bell EF. Evaluation of neutrophilic CD64, interleukin 10 and procalcitonin as diagnostic markers of early- and late-onset neonatal sepsis. Scand J Infect Dis. 2010;42(4):299-305
39. Harrell FE Jr, Margolis PA, Gove S, et al; WHO/ARI Young Infant Multicentre Study Group. Development of a clinical prediction model for an ordinal outcome: the World Health Organization Multicentre Study of Clinical Signs and Etiological agents of Pneumonia, Sepsis and Meningitis in Young Infants. Stat Med. 1998;17(8):909-944
40. Bachur RG, Harper MB. Predictive model for serious bacterial infections among infants younger than 3 months of age. Pediatrics. 2001;108(2):311-316
41. Weber MW, Carlin JB, Gatchalian S, Lehmann D, Muhe L, Mulholland EK; WHO Young Infants Study Group. Predictors of neonatal sepsis in developing countries. Pediatr Infect Dis J. 2003;22(8):711-717
42. Griffin MP, O'Shea TM, Bissonette EA, Harrell FE Jr, Lake DE, Moorman JR. Abnormal heart rate characteristics preceding neonatal sepsis and sepsis-like illness. Pediatr Res. 2003;53(6):920-926
43. Griffin MP, Lake DE, Moorman JR. Heart rate characteristics and laboratory tests in neonatal sepsis. Pediatrics. 2005;115(4):937-941
44. Griffin MP, Lake DE, O'Shea TM, Moorman JR. Heart rate characteristics and clinical signs in neonatal sepsis. Pediatr Res. 2007;61(2):222-227
45. Modi N, Doré CJ, Saraswatula A, et al. A case definition for national and international neonatal bloodstream infection surveillance. Arch Dis Child Fetal Neonatal Ed. 2009;94(1):F8-F12
46. Yang YN, Tseng HI, Yang SN, Lu CC, Chen HL, Chen CJ. A strategy for reduction of antibiotic use in new patients admitted to a neonatal intensive care unit. Pediatr Neonatol. 2012;53(4):245-251
47. Patel SJ, Saiman L. Principles and strategies of antimicrobial stewardship in the neonatal intensive care unit. Semin Perinatol. 2012;36(6):431-436
48. Fischer JE, Harbarth S, Agthe AG, et al. Quantifying uncertainty: physicians' estimates of infection in critically ill neonates and children. Clin Infect Dis. 2004;38(10):1383-1390
49. Dewhurst CJ, Cooke RW, Turner MA. Clinician observation of physiological trend monitoring to identify late-onset sepsis in preterm infants. Acta Paediatr. 2008;97(9):1187-1191
50. Holmes A, Doré CJ, Saraswatula A, et al. Risk factors and recommendations for rate stratification for surveillance of neonatal healthcare-associated bloodstream infection. J Hosp Infect. 2008;68(1):66-72
51. Auriti C, Ronchetti MP, Pezzotti P, et al. Determinants of nosocomial infection in 6 neonatal intensive care units: an Italian multicenter prospective cohort study. Infect Control Hosp Epidemiol. 2010;31(9):926-933
52. Ohlin A, Björkqvist M, Montgomery SM, Schollin J. Clinical signs and CRP values associated with blood culture results in neonates evaluated for suspected sepsis. Acta Paediatr. 2010;99(11):1635-1640
53. Phillips P, Cortina-Borja M, Millar M, Gilbert R. Risk-adjusted surveillance of hospital-acquired infections in neonatal intensive care units: a systematic review. J Hosp Infect. 2008;70(3):203-211
54. Bang AT, Bang RA, Reddy MH, et al. Simple clinical criteria to identify sepsis or pneumonia in neonates in the community needing treatment or referral. Pediatr Infect Dis J. 2005;24(4):335-341
55. Healy CM, Baker CJ, Palazzi DL, Campbell JR, Edwards MS. Distinguishing true coagulase-negative Staphylococcus infections from contaminants in the neonatal intensive care unit. J Perinatol. 2013;33(1):52-58
56. Gonzalez BE, Mercado CK, Johnson L, Brodsky NL, Bhandari V. Early markers of late-onset sepsis in premature neonates: clinical, hematological and cytokine profile. J Perinat Med. 2003;31(1):60-68
57. Van Den Bruel A, Haj-Hassan T, Thompson M, Buntinx F, Mant D; European Research Network on Recognising Serious Infection investigators. Diagnostic value of clinical features at presentation to identify serious infection in children in developed countries: a systematic review. Lancet. 2010;375(9717):834-845
58. Avila-Figueroa C, Goldmann DA, Richardson DK, Gray JE, Ferrari A, Freeman J. Intravenous lipid emulsions are the major determinant of coagulasenegative staphylococcal bacteremia in very low birth weight newborns. Pediatr Infect Dis J. 1998;17(1):10-17
59. Freeman J, Goldmann DA, Smith NE, Sidebottom DG, Epstein MF, Platt R. Association of intravenous lipid emulsion and coagulase-negative staphylococcal bacteremia in neonatal intensive care units. N Engl J Med. 1990;323(5):301-308
60. Samanta S, Farrer K, Breathnach A, Heath PT. Risk factors for late onset gram-negative infections: a case-control study. Arch Dis Child Fetal Neonatal Ed. 2011;96(1):F15-F18
61. Perlman SE, Saiman L, Larson EL. Risk factors for late-onset health careassociated bloodstream infections in patients in neonatal intensive care units. Am J Infect Control. 2007;35(3):177-182
62. Anderson-Berry A, Brinton B, Lyden E, Faix RG. Risk factors associated with development of persistent coagulasenegative staphylococci bacteremia in the neonate and associated short-term and discharge morbidities. Neonatology. 2011;99(1):23-31
63. Auriti C, Maccallini A, Di Liso G, Di Ciommo V, Ronchetti MP, Orzalesi M. Risk factors for nosocomial infections in a neonatal intensive-care unit. J Hosp Infect. 2003;53(1):25-30
64. Lake DE, Fairchild KD, Moorman JR. Complex signals bioinformatics: evaluation of heart rate characteristics monitoring as a novel risk marker for neonatal sepsis. J Clin Monit Comput. 2014;28(4):329-339
65. Griffin MP, Lake DE, Bissonette EA, Harrell FE Jr, O'Shea TM, Moorman JR. Heart rate characteristics: novel physiomarkers to predict neonatal infection and death. Pediatrics. 2005;116(5):1070-1074
66. Moorman JR, Lake DE, Griffin MP. Heart rate characteristics monitoring for neonatal sepsis. IEEE Trans Biomed Eng. 2006;53(1):126-132
67. Kovatchev BP, Farhy LS, Cao H, Griffin MP, Lake DE, Moorman JR. Sample asymmetry analysis of heart rate characteristics with application to neonatal sepsis and systemic inflammatory response syndrome. Pediatr Res. 2003;54(6):892-898
68. Fairchild KD, O'Shea TM. Heart rate characteristics: physiomarkers for detection of late-onset neonatal sepsis. Clin Perinatol. 2010;37(3):581-598
69. Goldstein B. Heart rate characteristics in neonatal sepsis: a promising test that is still premature. Pediatrics. 2005;115(4):1070-1072
70. Fairchild KD. Predictive monitoring for early detection of sepsis in neonatal ICU patients. Curr Opin Pediatr. 2013;25(2):172-179