Mitochondrial biogenesis in the acutely injured kidney

Nephron - Clinical Practice

Volumn 127, Issue 1-4, 2014, Pages 42-45

  Tran, Mei ^a   Parikh, Samir M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Acute kidney injury; Biogenesis; Mitochondrial function; Mitophagy; Renal recovery

Indexed keywords

ACUTE KIDNEY FAILURE; APOPTOSIS; BIOGENESIS; CONFERENCE PAPER; ENERGY METABOLISM; HOMEOSTASIS; HUMAN; KIDNEY FUNCTION; MITOCHONDRION; MITOCHONDRION SWELLING; MITOPHAGY; NITROSATIVE STRESS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY CHAIN; UPREGULATION; ACUTE KIDNEY INJURY; ANIMAL; ANTAGONISTS AND INHIBITORS; COMPLICATION; DEFICIENCY; DRUG EFFECTS; ENDOTOXEMIA; EPITHELIUM CELL; KIDNEY PROXIMAL TUBULE; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRIAL DYNAMICS; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RENAL REPLACEMENT THERAPY; SEPSIS;

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PPARGC1A PROTEIN, HUMAN; PPARGC1A PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ACUTE KIDNEY INJURY; ANIMALS; ENDOTOXEMIA; ENERGY METABOLISM; EPITHELIAL CELLS; HUMANS; KIDNEY TUBULES, PROXIMAL; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL TURNOVER; MOLECULAR TARGETED THERAPY; PPAR GAMMA; RENAL REPLACEMENT THERAPY; SEPSIS; TRANSCRIPTION FACTORS;

EID: 84927725521     PISSN: None     EISSN: 16602110     Source Type: Journal    
DOI: 10.1159/000363715     Document Type: Conference Paper

References (18)

1. Vafai SB, Mootha VK: Mitochondrial disorders as windows into an ancient organelle. Nature 2012; 491: 374-383.
2. Weinberg JM, Venkatachalam MA, Roeser NF, Nissim I: Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates. Proc Natl Acad Sci USA 2000; 97: 2826-2831.
3. Mukhopadhyay P, Horváth B, Zsengellér Z, et al: Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. Free Radic Biol Med 2012; 52: 497-506.
4. Parekh DJ, Weinberg JM, Ercole B, Torkko KC, Hilton W, Bennett M, Devarajan P, Venkatachalam MA: Tolerance of the human kidney to isolated controlled ischemia. J Am Soc Nephrol 2013; 24: 506-517.
5. Takasu O, Gaut JP, Watanabe E, To K, Fagley RE, Sato B, Jarman S, Efimov IR, Janks DL, Srivastava A, Bhayani SB, Drewry A, Swanson PE, Hotchkiss RS: Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med 2013; 187: 509-517.
6. Tran M, Tam D, Bardia A, et al: PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest 2011; 121: 4003-4014.
7. Brooks C, Wei Q, Cho SG, Dong Z: Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest 2009; 119: 1275-1285.
8. Wei Q, Dong G, Chen JK, Ramesh G, Dong Z: Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models. Kidney Int 2013; 84: 138-148.
9. Jiang M, Wei Q, Dong G, Komatsu M, Su Y, Dong Z: Autophagy in proximal tubules protects against acute kidney injury. Kidney Int 2012; 82: 1271-1283.
10. Weinberg JM: Mitochondrial biogenesis in kidney disease. J Am Soc Nephrol 2011; 22: 431-436.
11. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM: Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 1999; 98: 115-124.
12. Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM: Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem 2002; 277: 1645-1648.
13. Funk JA, Schnellmann RG: Persistent disruption of mitochondrial homeostasis after acute kidney injury. Am J Physiol Renal Physiol 2012; 302:F853-F864.
14. Rasbach KA, Schnellmann RG: PGC-1alpha over-expression promotes recovery from mitochondrial dysfunction and cell injury. Biochem Biophys Res Commun 2007; 355: 734-739.
15. Rasbach KA, Schnellmann RG: Signaling of mitochondrial biogenesis following oxidant injury. J Biol Chem 2007; 282: 2355-2362.
16. Lempiainen J, Finckenberg P, Levijoki J, Mervaala E: AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney. Br J Pharmacol 2012; 166: 1905-1915.
17. Funk JA, Odejinmi S, Schnellmann RG: SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells. J Pharmacol Exp Ther 2010; 333: 593-601.
18. Jesinkey SR, Funk JA, Stallons LJ, et al: Formoterol restores mitochondrial and renal function after ischemia-reperfusion injury. J Am Soc Nephrol 2014; 25: 1157-1162.