Mitochondrial dysfunction confers albumin-induced NLRP3 inflammasome activation and renal tubular injury

American Journal of Physiology - Renal Physiology

Volumn 308, Issue 8, 2015, Pages F857-F866

  Zhuang, Yibo ^a,b   Yasinta, Marchella ^a,b   Hu, Caiyu ^a,b   Zhao, Min ^a,b   Ding, Guixia ^a   Bai, Mi ^b   Yang, Lingyun ^b   Ni, Jiajia ^b   Wang, Rong ^b   Jia, Zhanjun ^a,b   Huang, Songming ^a,b   Zhang, Aihua ^a,b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Jiangsu Key Laboratory of Pediatric Respiratory Disease   (China)

Author keywords

Domain containing 3; Mitochondria; NOD like receptor family; Proteinuria; Pyrin; Renal tubular injury

Indexed keywords

ALBUMIN; ALPHA SMOOTH MUSCLE ACTIN; BETA ACTIN; CRYOPYRIN; CYCLOSPORIN A; CYTOCHROME C; CYTOKINE; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; MANGANESE DERIVATIVE; MANGANESE TETRAKIS (4 BENZOIC ACID)PORPHYRIN; MITOCHONDRIAL DNA; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; CYCLOSPORIN; MANGANESE(III)-TETRAKIS(4-BENZOIC ACID)PORPHYRIN; METALLOPORPHYRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME RELEASE; IN VIVO STUDY; KIDNEY TUBULE CELL; KIDNEY TUBULE DAMAGE; KIDNEY TUBULE EPITHELIUM; MALE; MORPHOLOGY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; 129 MOUSE; ALBUMINURIA; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL PROTECTION; DISEASE MODEL; DRUG EFFECTS; EPITHELIUM CELL; IMMUNOLOGY; KIDNEY PROXIMAL TUBULE; METABOLISM; MITOCHONDRION; PATHOLOGY; PHENOTYPE; SIGNAL TRANSDUCTION; TIME;

ALBUMINURIA; ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELL LINE; CYCLOSPORINE; CYTOPROTECTION; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; INFLAMMASOMES; KIDNEY TUBULES, PROXIMAL; MALE; METALLOPORPHYRINS; MICE, 129 STRAIN; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OXIDATIVE STRESS; PHENOTYPE; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84927723589     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00203.2014     Document Type: Article

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