Transcutaneous delivery of leflunomide nanoemulgel: Mechanistic investigation into physicomechanical characteristics, in vitro anti-psoriatic and anti-melanoma activity

International Journal of Pharmaceutics

Volumn 487, Issue 1-2, 2015, Pages 148-156

  Pund, Swati ^a   Pawar, Satish ^a   Gangurde, Shashikant ^a   Divate, Deepali ^a  

^a Sinhgad Institute of Pharmacy   (India)

Author keywords

Ex vivo permeation; Leflunomide; Melanoma; Nanoemulgel; Psoriasis; Texture profile analysis

Indexed keywords

ACRYSOL K150; CAPMUL PG12; CAPRYOL 90; CAPTEX 170; CAPTEX 355; CREMOPHOR; DIETHYLENE GLYCOL MONOETHYL ETHER; EXCIPIENT; LABRAFAC; LABRAFIL; LABRASOL; LEFLUNOMIDE; MACROGOL 400; MYRISTIC ACID ISOPROPYL ESTER; OLEIC ACID ETHYL ESTER; PALMITIC ACID ISOPROPYL ESTER; POLOXAMER; POLYSORBATE 20; POLYSORBATE 80; PROPYLENE GLYCOL; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; EMULSION; GEL; ISOXAZOLE DERIVATIVE; NANOMATERIAL;

ADHESION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COLLOID; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; EX VIVO STUDY; GELATION; HARDNESS; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; MELANOCYTE; MELANOMA; NANOEMULGEL; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PSORIASIS; PSORIATIC ARTHRITIS; RAT; STEADY STATE; THERMODYNAMICS; VISCOSITY; CUTANEOUS DRUG ADMINISTRATION; DRUG STABILITY; EMULSION; GEL; MEDICINAL CHEMISTRY; SKIN ABSORPTION; TUMOR CELL LINE;

ADHESIVENESS; ADMINISTRATION, CUTANEOUS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; EMULSIONS; EXCIPIENTS; GELS; HARDNESS TESTS; HUMANS; ISOXAZOLES; MELANOMA; NANOSTRUCTURES; PARTICLE SIZE; PSORIASIS; SKIN ABSORPTION; VISCOSITY;

EID: 84927720410     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.04.015     Document Type: Article

References (33)

1. A. Azeem, M. Rizwan, F.J. Ahmad, Z. Iqbal, R.K. Khar, M. Aquil, and S. Talegaonkar Nanoemulsion components screening and selection: a technical note AAPS PharmSciTech 10 2009 69 76
2. M.V.L.B. Bentley, J.M. Marchetti, N. Ricardo, Z. Ali-Abi, and J.H. Collett Influence of lecithin on some physical chemical properties of poloxamer gels: rheological, microscopic and in vitro permeation studies Int. J. Pharm. 193 1999 49 55
3. A. Bhatia, B. Singh, K. Raza, S. Wadhwa, and O.P. Katare Tamoxifen-loaded lecithin organogel (LO) for topical application: development, optimization and characterization Int. J. Pharm. 444 2013 47 59
4. F.C. Breedveld, and J.-M. Dayer Leflunomide: mode of action in the treatment of rheumatoid arthritis Ann. Rheum. Dis. 59 2000 841 849
5. A.M. Boyd Leflunomide in dermatology J. Am. Acad. Dermatol. 66 2012 673 679
6. S. Ekins, V. Kholodovych, N. Ai, M. Sinz, J. Gal, L. Gera, W.J. Welsh, K. Bachmann, and S. Mani Computational discovery of novel low micromolar human pregnane × receptor antagonists Mol. Pharmacol. 74 2008 662 672
7. J.E. Harrison, A.C. Watkinson, D.M. Green, J. Hadgraft, and K. Brain The relative effect of Azone and Transcutol on permeant diffusivity and solubility in human stratum corneum Pharm. Res. 13 1996 542 546
8. M.L. Herrmann, R. Schleyerbach, and B.J. Kirschbaum Leflunomide: an immuno-modulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases Immunopharmacology 47 2000 273 289
9. M. Huang, J.F. Kennedy, B. Li, X. Xu, and B.J. Xie Characters of rice starch gel modifed by gellan, carrageenan,and glucomannan: a texture profile analysis study Carbohydr. Polym. 69 2007 411 418
10. A.F. Jerant, J.T. Johnson, C.D. Sheridan, and T.J. Caffrey Early detection and treatment of skin cancer Am. Family Phys. 62 2000 357 368
11. D.S. Jones, A.D. Woolfson, and J. Djokic Texture profile analysis of bioadhesive polymeric semisolids: mechanical characterization and investigation of interactions between formulation components J. Appl. Polym. Sci. 61 1996 2229 2234
12. J.O. Kaltwasser, P. Nash, D. Gladman, C.F. Rosen, F. Behrens, P. Jones, J. Wollenhaupt, F.G. Falk, and P. Mease Efficacy and safety of leflunomide in the treatment of psoriatic arthritis and psoriasis Arthritis Rheum. 50 2004 1939 1950
13. J.P. Kaltwasser Leflunomide in psoriatic arthritis Autoimmun. Rev. 6 2007 511 514
14. S. Khurana, N.K. Jain, and M.S. Bedi Nanoemulsion based gel for transdermal delivery of meloxicam: physico-chemical, mechanistic investigation Life Sci. 92 2013 383 392
15. E.F. O'Donnell, P.R. Kopparapu, D.C. Koch, H.S. Jang, J.L. Phillips, R.L. Tanguay, N.I. Kerkvliet, and S.K. Kolluri The aryl hydrocarbon receptor mediates leflunomide-induced growth inhibition of melanoma cells PLoS One 7 2012 e40926
16. Y. Okubo, and M. Koga Peripheral blood monocytes in psoriatic patients overproduce cytokines J. Dermatol. Sci. 17 1998 223 232
17. J. Pardeike, A. Hommoss, and R. Muller Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products Int. J. Pharm. 366 2009 170 184
18. P. Pinto, and M. Dougados Leflunomide in clinical practice Acta Reumatol. Port. 31 2006 215 224
19. D. Pooja, H. Kulhari, M.K. Singh, S. Mukherjee, S.S. Rachamalla, and R. Sistla Dendrimer-TPGS mixed micelles for enhanced solubility and cellular toxicity of taxanes Colloids Surf. B. Biointerfaces 121 2014 461 468
20. M. Pradhan, D. Singh, and M.R. Singh Novel colloidal carriers for psoriasis: current issues, mechanistic insight and novel delivery approaches J. Controlled Release 170 2013 380 395
21. E.P. Prens, T. van Joost, J.P. Hegmans, K.t. Hooft-Benne, O.E. Ysselmuiden, and R. Benner Effects of cyclosporine on cytokines and cytokine receptors in psoriasis J. Am. Acad. Dermatol. 33 1995 947 953
22. L. Puig, A. Julià, and S. Marsal The pathogenesis and genetics of psoriasis Acta Dermosifiliogr. 105 2014 535 545
23. S. Pund, G. Rasve, and G. Borade Ex vivo permeation characteristics of venlafaxine through sheep nasal mucosa Eur. J. Pharm. Sci. 48 2013 195 201
24. S. Pund, R. Thankur, U. More, and A. Joshi Lipid based nanoemulsifying resveratrol for improved physicochemical characteristics, in vitro cytotoxicity and in vivo antiangiogenic efficacy Colloids Surf. B Biointerfaces 120 2014 110 117
25. V. Saino, D. Monti, S. Burgalassi, S. Tampucci, S. Palma, D. Allemandi, and P. Chetoni Optimization of skin permeation and distribution of ibuprofen by using nanostructures (coagels) based on alkyl vitamin C derivatives Eur. J. Pharm. Biopharm. 76 2010 443 449
26. P. Severino, J.F. Fangueiro, S.V. Ferreira, R. Basso, M.V. Chaud, M.H. Santana, A. Rosmaninho, and E.B. Souto Nanoemulsions and nanoparticles for non-melanoma skin cancer: effects of lipid materials Clin. Transl. Oncol. 15 2013 417 424
27. P. Skehn, R. Storeng, D. Scudiero, A. Monks, J. McMohan, D. Vistica, J.T. Warren, H. Bokesch, S. Kenney, and M.R. Boyd New colorimetric cytotoxicity assay for anticancer-drug screening J. Natl. Cancer Inst. 82 1990 1107 1112
28. J.-B. Tagne, S. Kakumanu, and R.J. Nicolosi Nanoemulsion preparations of the anticancer drug dacarbazine significantly increase its efficacy in a xenograft mouse melanoma model Mol. Pharm. 5 2008 1055 1063
29. R.M. White, J. Cech, S. Ratanasirintrawoot, C.Y. Lin, B. Rahl, C.J. Burke, E. Langdon, M.L. Tomlinson, J. Mosher, C. Kaufman, F. Chen, H.K. Long, M. Kramer, S. Datta, D. Neuberg, S. Granter, R.A. Young, S. Morrison, G.N. Wheeler, and L.I. Zon DHODH modulates transcriptional elongation in the neural crest and melanoma Nature 471 2011 518 522
30. F. Yang, N. Kamiya, and M. Goto Transdermal delivery of the anti-rheumatic agent methotrexate using a solid-in-oil nanocarrier Eur. J. Pharm. Biopharm. 82 2012 158 163
31. E.N. van Roon, T.L.T.A. Jansen, N.M. Houtman, P. Spoelstra, and J.R. Brouwers Leflunomide for the treatment of rheumatoid arthritis in clinical practice- incidence and severity of hepatotoxicity Drug Saf. 27 2004 345 352
32. D. Vega, A. Petragalli, D. Fernandez, and J.A. Ellena Polymorphism on leflunomide: stability and crystal structures J. Pharm. Sci. 95 2006 1075 1083
33. M.H. Zulfa.M.nd C.M. Heard The effectsft samples of Captex 170, Capmul PG 12, Capmul MCM, Acrysol K-150 and Pluronic1 F127. Author DD is thankful to AICTE, India for providing Junior Research Fellowship.