A neonatal gnotobiotic pig model of human enterovirus 71 infection and associated immune responses

Emerging Microbes and Infections

Volumn 3, Issue 5, 2014, Pages

  Yang, Xingdong ^a   Li, Guohua ^a   Wen, Ke ^a   Bui, Tammy ^a   Liu, Fangning ^a   Kocher, Jacob ^a   Jortner, Bernard S ^a   Vonck, Marlice ^a   Pelzer, Kevin ^a   Deng, Jie ^b   Zhu, Runan ^b   Li, Yuyun ^b   Qian, Yuan ^b   Yuan, Lijuan ^a  

^a VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^b CAPITAL INSTITUTE OF PEDIATRICS   (China)

Author keywords

adaptive immune responses; animal model; human enterovirus 71; neonatal gnotobiotic pigs; pathogenesis; vaccine evaluation

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; NEUTRALIZING ANTIBODY; VIRUS PROTEIN; VIRUS RNA;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; BRAIN CELL; BREATHING DISORDER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENTEROVIRUS 71; ENTEROVIRUS 71 INFECTION; ENTEROVIRUS INFECTION; FEVER; FLOW CYTOMETRY; GENOTYPE; GNOTOBIOTICS; HAND FOOT AND MOUTH DISEASE; HEART MUSCLE; HISTOPATHOLOGY; IMMUNE RESPONSE; IN VITRO STUDY; INTESTINE EPITHELIUM CELL; LIMB WEAKNESS; LUNG PARENCHYMA; MOUTH INFECTION; MUSCLE TISSUE; NERVE CELL; NONHUMAN; NOSE INFECTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PORCINE MODEL; PRIORITY JOURNAL; RNA VIRUS; SMALL INTESTINE; T LYMPHOCYTE; TISSUE DISTRIBUTION; VIRUS CAPSID; VIRUS SHEDDING; VIRUS STRAIN;

ANIMALIA; HUMAN ENTEROVIRUS 71; MIRIDAE; SUIDAE; SUS;

EID: 84927712960     PISSN: None     EISSN: 22221751     Source Type: Journal    
DOI: 10.1038/emi.2014.35     Document Type: Article

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