메뉴 건너뛰기




Volumn 13, Issue , 2015, Pages 49-54

Pexa-Vec double agent engineered vaccinia: Oncolytic and active immunotherapeutic

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PEXASTIMOGENE DEVACIREPVEC; ONCOLYTIC VIRUS;

EID: 84927699457     PISSN: 18796257     EISSN: 18796265     Source Type: Journal    
DOI: 10.1016/j.coviro.2015.03.016     Document Type: Review
Times cited : (41)

References (50)
  • 1
    • 0034077666 scopus 로고    scopus 로고
    • Replication-selective adenoviruses as oncolytic agents
    • C. Heise, and D.H. Kirn Replication-selective adenoviruses as oncolytic agents J Clin Invest 105 2000 847 851
    • (2000) J Clin Invest , vol.105 , pp. 847-851
    • Heise, C.1    Kirn, D.H.2
  • 2
    • 28844444483 scopus 로고    scopus 로고
    • Recent progress in the battle between oncolytic viruses and tumours
    • K.A. Parato, D. Senger, P.A. Forsyth, and J.C. Bell Recent progress in the battle between oncolytic viruses and tumours Nat Rev Cancer 5 2005 965 976
    • (2005) Nat Rev Cancer , vol.5 , pp. 965-976
    • Parato, K.A.1    Senger, D.2    Forsyth, P.A.3    Bell, J.C.4
  • 3
    • 57749201655 scopus 로고    scopus 로고
    • Targeted and armed oncolytic poxviruses: A novel multi-mechanistic therapeutic class for cancer
    • D.H. Kirn, and S.H. Thorne Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer Nat Rev Cancer 9 2009 64 71
    • (2009) Nat Rev Cancer , vol.9 , pp. 64-71
    • Kirn, D.H.1    Thorne, S.H.2
  • 5
    • 79961166449 scopus 로고    scopus 로고
    • Immunotherapeutic potential of oncolytic vaccinia virus
    • S.H. Thorne Immunotherapeutic potential of oncolytic vaccinia virus Immunol Res 50 2011 286 293
    • (2011) Immunol Res , vol.50 , pp. 286-293
    • Thorne, S.H.1
  • 6
    • 80555144261 scopus 로고    scopus 로고
    • Next-generation oncolytic vaccinia vectors
    • S.H. Thorne Next-generation oncolytic vaccinia vectors Methods Mol Biol 797 2012 205 215
    • (2012) Methods Mol Biol , vol.797 , pp. 205-215
    • Thorne, S.H.1
  • 7
    • 80455178699 scopus 로고    scopus 로고
    • An intravenous stimulus package for oncolytic virotherapy
    • R. Vile, and A. Melcher An intravenous stimulus package for oncolytic virotherapy Mol Ther 19 2011 1930 1932
    • (2011) Mol Ther , vol.19 , pp. 1930-1932
    • Vile, R.1    Melcher, A.2
  • 8
    • 79953865759 scopus 로고    scopus 로고
    • Oncolytic vaccinia virus for the treatment of cancer
    • K. Guse, V. Cerullo, and A. Hemminki Oncolytic vaccinia virus for the treatment of cancer Expert Opin Biol Ther 11 2011 595 608
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 595-608
    • Guse, K.1    Cerullo, V.2    Hemminki, A.3
  • 10
    • 0037444281 scopus 로고    scopus 로고
    • Validation and analysis of a mathematical model of a replication-competent oncolytic virus for cancer treatment: Implications for virus design and delivery
    • L.M. Wein, J.T. Wu, and D.H. Kirn Validation and analysis of a mathematical model of a replication-competent oncolytic virus for cancer treatment: implications for virus design and delivery Cancer Res 63 2003 1317 1324
    • (2003) Cancer Res , vol.63 , pp. 1317-1324
    • Wein, L.M.1    Wu, J.T.2    Kirn, D.H.3
  • 12
  • 13
    • 74549226667 scopus 로고    scopus 로고
    • Oncolytic and immunostimulatory efficacy of a targeted oncolytic poxvirus expressing human GM-CSF following intravenous administration in a rabbit tumor model
    • J.H. Lee, M.S. Roh, Y.K. Lee, M.K. Kim, J.Y. Han, B.H. Park, P. Trown, D.H. Kirn, and T.H. Hwang Oncolytic and immunostimulatory efficacy of a targeted oncolytic poxvirus expressing human GM-CSF following intravenous administration in a rabbit tumor model Cancer Gene Ther 17 2010 73 79
    • (2010) Cancer Gene Ther , vol.17 , pp. 73-79
    • Lee, J.H.1    Roh, M.S.2    Lee, Y.K.3    Kim, M.K.4    Han, J.Y.5    Park, B.H.6    Trown, P.7    Kirn, D.H.8    Hwang, T.H.9
  • 14
    • 0025815449 scopus 로고
    • Vaccinia virus: A tool for research and vaccine development
    • B. Moss Vaccinia virus: a tool for research and vaccine development Science 252 1991 1662 1667
    • (1991) Science , vol.252 , pp. 1662-1667
    • Moss, B.1
  • 16
    • 45849104841 scopus 로고    scopus 로고
    • The poxvirus vectors MVA and NYVAC as gene delivery systems for vaccination against infectious diseases and cancer
    • C.E. Gomez, J.L. Najera, M. Krupa, and M. Esteban The poxvirus vectors MVA and NYVAC as gene delivery systems for vaccination against infectious diseases and cancer Curr Gene Ther 8 2008 97 120
    • (2008) Curr Gene Ther , vol.8 , pp. 97-120
    • Gomez, C.E.1    Najera, J.L.2    Krupa, M.3    Esteban, M.4
  • 18
    • 77953537985 scopus 로고    scopus 로고
    • GM-CSF-armed, replication-competent viruses for cancer
    • J.M. Burke GM-CSF-armed, replication-competent viruses for cancer Cytokine Growth Factor Rev 21 2010 149 151
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 149-151
    • Burke, J.M.1
  • 19
    • 0036813199 scopus 로고    scopus 로고
    • GM-CSF-based cancer vaccines
    • G. Dranoff GM-CSF-based cancer vaccines Immunol Rev 188 2002 147 154
    • (2002) Immunol Rev , vol.188 , pp. 147-154
    • Dranoff, G.1
  • 20
    • 79151482353 scopus 로고    scopus 로고
    • GM-CSF-secreting vaccines for solid tumors: Moving forward
    • R. Gupta, and L.A. Emens GM-CSF-secreting vaccines for solid tumors: moving forward Discov Med 10 2010 52 60
    • (2010) Discov Med , vol.10 , pp. 52-60
    • Gupta, R.1    Emens, L.A.2
  • 21
    • 44249100151 scopus 로고    scopus 로고
    • Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: A phase i trial
    • B.H. Park, T. Hwang, T.C. Liu, D.Y. Sze, J.S. Kim, H.C. Kwon, S.Y. Oh, S.Y. Han, J.H. Yoon, and S.H. Hong Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial Lancet Oncol 9 2008 533 542
    • (2008) Lancet Oncol , vol.9 , pp. 533-542
    • Park, B.H.1    Hwang, T.2    Liu, T.C.3    Sze, D.Y.4    Kim, J.S.5    Kwon, H.C.6    Oh, S.Y.7    Han, S.Y.8    Yoon, J.H.9    Hong, S.H.10
  • 25
    • 71249157377 scopus 로고    scopus 로고
    • JX-594, a targeted oncolytic poxvirus for the treatment of cancer
    • A.E. Merrick, E.J. Ilett, and A.A. Melcher JX-594, a targeted oncolytic poxvirus for the treatment of cancer Curr Opin Invest Drugs 10 2009 1372 1382
    • (2009) Curr Opin Invest Drugs , vol.10 , pp. 1372-1382
    • Merrick, A.E.1    Ilett, E.J.2    Melcher, A.A.3
  • 27
    • 50549091297 scopus 로고    scopus 로고
    • The targeted oncolytic poxvirus JX-594 demonstrates antitumoral, antivascular, and anti-HBV activities in patients with hepatocellular carcinoma
    • T.C. Liu, T. Hwang, B.H. Park, J. Bell, and D.H. Kirn The targeted oncolytic poxvirus JX-594 demonstrates antitumoral, antivascular, and anti-HBV activities in patients with hepatocellular carcinoma Mol Ther 16 2008 1637 1642
    • (2008) Mol Ther , vol.16 , pp. 1637-1642
    • Liu, T.C.1    Hwang, T.2    Park, B.H.3    Bell, J.4    Kirn, D.H.5
  • 28
    • 79957902460 scopus 로고    scopus 로고
    • Sequential therapy with JX-594, a targeted oncolytic poxvirus followed by sorafenib in hepatocellular carcinoma: Preclinical and clinical demonstration of combination efficacy
    • J. Heo, C.J. Breitbach, A. Moon, C.W. Kim, R. Patt, M.K. Kim, Y.K. Lee, S.Y. Oh, H.Y. Woo, and K. Parato Sequential therapy with JX-594, a targeted oncolytic poxvirus followed by sorafenib in hepatocellular carcinoma: preclinical and clinical demonstration of combination efficacy Mol Ther: J Am Soc Gene Ther 19 2011 1170 1179
    • (2011) Mol Ther: J Am Soc Gene Ther , vol.19 , pp. 1170-1179
    • Heo, J.1    Breitbach, C.J.2    Moon, A.3    Kim, C.W.4    Patt, R.5    Kim, M.K.6    Lee, Y.K.7    Oh, S.Y.8    Woo, H.Y.9    Parato, K.10
  • 29
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
    • R.D. Schreiber, L.J. Old, and M.J. Smyth Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion Science 331 2011 1565 1570
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 32
    • 74349092805 scopus 로고    scopus 로고
    • Mechanisms of T-cell inhibition: Implications for cancer immunotherapy
    • E.A. Mittendorf, and P. Sharma Mechanisms of T-cell inhibition: implications for cancer immunotherapy Expert Rev Vaccines 9 2010 89 105
    • (2010) Expert Rev Vaccines , vol.9 , pp. 89-105
    • Mittendorf, E.A.1    Sharma, P.2
  • 33
    • 33846212288 scopus 로고    scopus 로고
    • Phase I/II study of topical imiquimod and intralesional interleukin-2 in the treatment of accessible metastases in malignant melanoma
    • D.S. Green, M.D. Bodman-Smith, A.G. Dalgleish, and M.D. Fischer Phase I/II study of topical imiquimod and intralesional interleukin-2 in the treatment of accessible metastases in malignant melanoma Br J Dermatol 156 2007 337 345
    • (2007) Br J Dermatol , vol.156 , pp. 337-345
    • Green, D.S.1    Bodman-Smith, M.D.2    Dalgleish, A.G.3    Fischer, M.D.4
  • 34
    • 33846993355 scopus 로고    scopus 로고
    • The in vivo antitumoral effects of lipopolysaccharide against glioblastoma multiforme are mediated in part by Toll-like receptor 4
    • (discussion 381)
    • M.R. Chicoine, M. Zahner, E.K. Won, R.R. Kalra, T. Kitamura, A. Perry, and R. Higashikubo The in vivo antitumoral effects of lipopolysaccharide against glioblastoma multiforme are mediated in part by Toll-like receptor 4 Neurosurgery 60 2007 372 380 (discussion 381)
    • (2007) Neurosurgery , vol.60 , pp. 372-380
    • Chicoine, M.R.1    Zahner, M.2    Won, E.K.3    Kalra, R.R.4    Kitamura, T.5    Perry, A.6    Higashikubo, R.7
  • 35
    • 0035098241 scopus 로고    scopus 로고
    • Intratumoral injection of lipopolysaccharide causes regression of subcutaneously implanted mouse glioblastoma multiforme
    • (discussion 614-605)
    • M.R. Chicoine, E.K. Won, and M.C. Zahner Intratumoral injection of lipopolysaccharide causes regression of subcutaneously implanted mouse glioblastoma multiforme Neurosurgery 48 2001 607 614 (discussion 614-605)
    • (2001) Neurosurgery , vol.48 , pp. 607-614
    • Chicoine, M.R.1    Won, E.K.2    Zahner, M.C.3
  • 36
    • 1842486876 scopus 로고    scopus 로고
    • Induction of potent antitumor immunity by in situ targeting of intratumoral DCs
    • K. Furumoto, L. Soares, E.G. Engleman, and M. Merad Induction of potent antitumor immunity by in situ targeting of intratumoral DCs J Clin Invest 113 2004 774 783
    • (2004) J Clin Invest , vol.113 , pp. 774-783
    • Furumoto, K.1    Soares, L.2    Engleman, E.G.3    Merad, M.4
  • 38
    • 33846232145 scopus 로고    scopus 로고
    • Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta
    • J. Zhu, J. Martinez, X. Huang, and Y. Yang Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta Blood 109 2007 619 625
    • (2007) Blood , vol.109 , pp. 619-625
    • Zhu, J.1    Martinez, J.2    Huang, X.3    Yang, Y.4
  • 39
    • 63849167957 scopus 로고    scopus 로고
    • A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection
    • M. Quigley, J. Martinez, X. Huang, and Y. Yang A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection Blood 113 2009 2256 2264
    • (2009) Blood , vol.113 , pp. 2256-2264
    • Quigley, M.1    Martinez, J.2    Huang, X.3    Yang, Y.4
  • 40
    • 77950373214 scopus 로고    scopus 로고
    • Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection
    • J. Martinez, X. Huang, and Y. Yang Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection PLoS Pathog 6 2010 e1000811
    • (2010) PLoS Pathog , vol.6 , pp. e1000811
    • Martinez, J.1    Huang, X.2    Yang, Y.3
  • 41
    • 77950883727 scopus 로고    scopus 로고
    • Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA
    • J. Martinez, X. Huang, and Y. Yang Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA Proc Natl Acad Sci USA 107 2010 6442 6447
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 6442-6447
    • Martinez, J.1    Huang, X.2    Yang, Y.3
  • 42
    • 77956267058 scopus 로고    scopus 로고
    • Targeting localized immune suppression within the tumor through repeat cycles of immune cell-oncolytic virus combination therapy
    • S.H. Thorne, W. Liang, P. Sampath, T. Schmidt, R. Sikorski, A. Beilhack, and C.H. Contag Targeting localized immune suppression within the tumor through repeat cycles of immune cell-oncolytic virus combination therapy Mol Ther: J Am Soc Gene Ther 18 2010 1698 1705
    • (2010) Mol Ther: J Am Soc Gene Ther , vol.18 , pp. 1698-1705
    • Thorne, S.H.1    Liang, W.2    Sampath, P.3    Schmidt, T.4    Sikorski, R.5    Beilhack, A.6    Contag, C.H.7
  • 43
    • 2442655250 scopus 로고    scopus 로고
    • Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance
    • Y. Yang, C.T. Huang, X. Huang, and D.M. Pardoll Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance Nat Immunol 5 2004 508 515
    • (2004) Nat Immunol , vol.5 , pp. 508-515
    • Yang, Y.1    Huang, C.T.2    Huang, X.3    Pardoll, D.M.4
  • 44
    • 78650578440 scopus 로고    scopus 로고
    • Smallpox vaccines: Targets of protective immunity
    • B. Moss Smallpox vaccines: targets of protective immunity Immunol Rev 239 2011 8 26
    • (2011) Immunol Rev , vol.239 , pp. 8-26
    • Moss, B.1
  • 47
    • 0035893770 scopus 로고    scopus 로고
    • Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes
    • J.A. McCart, J.M. Ward, J. Lee, Y. Hu, H.R. Alexander, S.K. Libutti, B. Moss, and D.L. Bartlett Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes Cancer Res 61 2001 8751 8757
    • (2001) Cancer Res , vol.61 , pp. 8751-8757
    • McCart, J.A.1    Ward, J.M.2    Lee, J.3    Hu, Y.4    Alexander, H.R.5    Libutti, S.K.6    Moss, B.7    Bartlett, D.L.8
  • 49
    • 38049017526 scopus 로고    scopus 로고
    • Targeting of interferon-beta to produce a specific, multi-mechanistic oncolytic vaccinia virus
    • D.H. Kirn, Y. Wang, F. Le Boeuf, J. Bell, and S.H. Thorne Targeting of interferon-beta to produce a specific, multi-mechanistic oncolytic vaccinia virus PLoS Med 4 2007 e353
    • (2007) PLoS Med , vol.4 , pp. e353
    • Kirn, D.H.1    Wang, Y.2    Le Boeuf, F.3    Bell, J.4    Thorne, S.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.