Development of Fecal Microbiota Transplantation Suitable for Mainstream Medicine

Clinical Gastroenterology and Hepatology

Volumn 13, Issue 2, 2015, Pages 246-250

  Khoruts, Alexander ^a,b   Sadowsky, Michael J ^b   Hamilton, Matthew J ^b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Clostridium difficile infection; Fecal Transplant; Microbiome; Microbiota

Indexed keywords

ANTIBIOTIC THERAPY; ARTICLE; CLINICAL PRACTICE; CLOSTRIDIUM DIFFICILE INFECTION; DONOR SELECTION; FECAL MICROBIOTA TRANSPLANTATION; FECES; FECES MICROFLORA; HUMAN; INTESTINE FLORA; MICROBIAL CONSORTIUM; NONHUMAN; PATIENT SAFETY; PHYSICAL EXAMINATION; TISSUE TRANSPLANTATION; TRANSPLANTATION; UNRELATED DONORS; CLOSTRIDIUM INFECTIONS; GASTROINTESTINAL DISEASES; GASTROINTESTINAL TRACT; ISOLATION AND PURIFICATION; MEDICAL RESEARCH; MICROBIOLOGY; PEPTOCLOSTRIDIUM DIFFICILE; PROCEDURES; TRENDS;

BIOMEDICAL RESEARCH; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; FECAL MICROBIOTA TRANSPLANTATION; GASTROINTESTINAL DISEASES; GASTROINTESTINAL MICROBIOME; GASTROINTESTINAL TRACT; HUMANS;

EID: 84927698882     PISSN: 15423565     EISSN: 15427714     Source Type: Journal    
DOI: 10.1016/j.cgh.2014.11.014     Document Type: Review

References (27)

1. Hamilton M.J., Weingarden A.R., Unno T., et al. High-throughput DNA sequence analysis reveals stable engraftment of gut microbiota following transplantation of previously frozen fecal bacteria. Gut Microbes 2013, 4:125-135.
2. Shahinas D., Silverman M., Sittler T., et al. Toward an understanding of changes in diversity associated with fecal microbiome transplantation based on 16S rRNA gene deep sequencing. MBio 2012, 3.
3. van Nood E., Vrieze A., Nieuwdorp M., et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. NEngl J Med 2013, 368:407-415.
4. Weingarden A.R., Chen C., Bobr A., et al. Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection. Am J Physiol Gastrointest Liver Physiol 2014, 306:G310-G319.
5. Fuentes S., van Nood E., Tims S., et al. Reset of a critically disturbed microbial ecosystem: faecal transplant in recurrent Clostridium difficile infection. ISME J 2014, 8:1621-1633.
6. Shankar V., Hamilton M.J., Khoruts A., et al. Species and genus level resolution analysis of gut microbiota in Clostridium difficile patients following fecal microbiota transplantation. Microbiome 2014, 2:13.
7. Gough E., Shaikh H., Manges A.R. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection. Clin Infect Dis 2011, 53:994-1002.
8. Kassam Z., Lee C.H., Yuan Y., et al. Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysis. Am J Gastroenterol 2013, 108:500-508.
9. Surawicz C.M., Brandt L.J., Binion D.G., et al. Guidelines fordiagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol 2013, 108:478-498. quiz 499.
10. Backhed F., Ley R.E., Sonnenburg J.L., et al. Host-bacterial mutualism in the human intestine. Science 2005, 307:1915-1920.
11. Aroniadis O.C., Brandt L.J. Fecal microbiota transplantation: past, present and future. Curr Opin Gastroenterol 2013, 29:79-84.
12. Smits L.P., Bouter K.E., de Vos W.M., et al. Therapeutic potential of fecal microbiota transplantation. Gastroenterology 2013, 145:946-953.
13. Starkey J.M., MacPherson J.L., Bolgiano D.C., et al. Markers for transfusion-transmitted disease in different groups of blood donors. JAMA 1989, 262:3452-3454.
14. Hamilton M.J., Weingarden A.R., Sadowsky M.J., et al. Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection. Am J Gastroenterol 2012, 107:761-767.
15. Bakken J.S., Borody T., Brandt L.J., et al. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol 2011, 9:1044-1049.
16. Youngster I., Russell G.H., Pindar C., et al. Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA 2014, 312:1772-1778.
17. Guarino A., Giannattasio A. New molecular approaches in the diagnosis of acute diarrhea: advantages for clinicians and researchers. Curr Opin Gastroenterol 2011, 27:24-29.
18. Lamendella R., VerBerkmoes N., Jansson J.K. 'Omics' of the mammalian gut-new insights into function. Curr Opin Biotechnol 2012, 23:491-500.
19. Lawley T.D., Clare S., Walker A.W., et al. Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. PLoS Pathog 2012, 8:e1002995.
20. Petrof E.O., Gloor G.B., Vanner S.J., et al. Stool substitute transplant therapy for the eradication of Clostridium difficile infection: 'RePOOPulating' the gut. Microbiome 2013, 1:3.
21. Buffie C.G., Bucci V., Stein R.R., et al. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature 2014, Epub ahead of print.
22. Olle B. Medicines from microbiota. Nat Biotechnol 2013, 31:309-315.
23. Guidance for Industry: Enforcement Policy Regarding Investigational New Drug Requirements for Use of Fecal Microbiota for Transplantation to Treat Clostridium difficile Infection Not Responsive to Standard Therapies. Available from: . http://www.fda.gov/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/Vaccines/ucm361379.htm.
24. Ratner M. Fecal transplantation poses dilemma for FDA. Nat Biotechnol 2014, 32:401-402.
25. David L.A., Maurice C.F., Carmody R.N., et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 2014, 505:559-563.
26. Ochman H., Worobey M., Kuo C.H., et al. Evolutionary relationships of wild hominids recapitulated by gut microbial communities. PLoS Biol 2010, 8:e1000546.
27. Smith M.B., Kelly C., Alm E.J. Policy: how to regulate faecal transplants. Nature 2014, 506:290-291.