NAIP inflammasomes give the NOD to bacterial ligands

Trends in Immunology

Volumn 35, Issue 11, 2014, Pages 503-504

  Maltez, Vivien I ^a   Miao, Edward A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; INFLAMMASOME; NEURONAL APOPTOSIS INHIBITORY PROTEIN; APOPTOSIS REGULATORY PROTEIN; CALCIUM BINDING PROTEIN;

ARTICLE; LIGAND BINDING; NONHUMAN; OLIGOMERIZATION; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; TYPE III SECRETION SYSTEM; ANIMAL; HUMAN; METABOLISM;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BACTERIAL PROTEINS; CALCIUM-BINDING PROTEINS; HUMANS; INFLAMMASOMES; NEURONAL APOPTOSIS-INHIBITORY PROTEIN;

EID: 84927693271     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2014.10.002     Document Type: Short Survey

References (10)

1. Wen H., et al. Mechanisms of NOD-like receptor-associated inflammasome activation. Immunity 2013, 39:432-441.
2. Bonardi V., et al. A new eye on NLR proteins: focused on clarity or diffused by complexity?. Curr. Opin. Immunol. 2012, 24:41-50.
3. Tenthorey J.L., et al. Molecular Basis for Specific Recognition of Bacterial Ligands by NAIP/NLRC4 Inflammasomes. Mol. Cell 2014, 54:17-29.
4. Bonardi V., et al. Expanded functions for a family of plant intracellular immune receptors beyond specific recognition of pathogen effectors. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:16463-16468.
5. Zhao Y., et al. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 2011, 477:596-600.
6. Kofoed E.M., Vance R.E. Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 2011, 477:592-595.
7. Hu Z., et al. Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism. Science 2013, 341:172-175.
8. Qu Y., et al. Phosphorylation of NLRC4 is critical for inflammasome activation. Nature 2012, 490:539-542.
9. Suzuki S., et al. Shigella Type III Secretion Protein MxiI Is Recognized by Naip2 to Induce Nlrc4 Inflammasome Activation Independently of Pkcδ. PLoS Pathog. 2014, 10:e1003926.
10. Halff E.F., et al. Formation and Structure of a NAIP5-NLRC4 Inflammasome Induced by Direct Interactions with Conserved N- and C-terminal Regions of Flagellin. J. Biol. Chem. 2012, 287:38460-38472.