Iron and carbon monoxide enhance coagulation and attenuate fibrinolysis by different mechanisms

Blood Coagulation and Fibrinolysis

Volumn 25, Issue 7, 2014, Pages 695-702

  Nielsen, Vance G ^a   Pretorius, Etheresia ^b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

Carbon monoxide; Coagulation; Fibrinogen; Fibrinolysis; Iron

Indexed keywords

CARBON MONOXIDE; FERRIC CHLORIDE; FIBRIN; HEME OXYGENASE 1; IRON;

ARTICLE; BLOOD CLOTTING; CATABOLISM; CELL ULTRASTRUCTURE; CONTROLLED STUDY; FIBRINOLYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; VISCOELASTICITY; ADULT; DRUG EFFECTS; FEMALE;

ADULT; BLOOD COAGULATION; CARBON MONOXIDE; FEMALE; FIBRINOLYSIS; HUMANS; IRON;

EID: 84927691106     PISSN: 09575235     EISSN: 14735733     Source Type: Journal    
DOI: 10.1097/MBC.0000000000000128     Document Type: Article

References (32)

1. Lipinski B. Modification of fibrin structure as a possible cause of thrombolytic resistance. J Thromb Thrombolysis 2010; 29:296-298.
2. Lipinski B, Pretorius E. Novel pathway of iron-induced blood coagulation: implications for diabetes mellitus and its complications. Pol Arch Med Wewn 2012; 122:115-122.
3. Lipinski B, Pretorius E, Oberholzer HM, van der Spuy WJ. Iron enhances generation of fibrin fibers in human blood: implications for pathogenesis of stroke. Microsc Res Tech 2012; 75:1185-1190.
4. Pretorius E, Vermeulen N, Bester J, Lipinski B. Novel use of scanning electron microscopy for detection of iron-induced morphological changes in human blood. Microsc Res Tech 2013; 76:268-271.
5. Lipinski B, Pretorius E. Iron-induced fibrin in cardiovascular disease. Curr Neurovasc Res 2013; 10:269-274.
6. Pretorius E, Vermeulen N, Bester J, Lipinski B, Kell DB. A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy. Toxicol Mech Methods 2013; 23:352-359.
7. Pretorius E, Lipinski B. Differences in morphology of fibrin clots induced with thrombin and ferric ions and its pathophysiological consequences. Heart Lung Circ 2013; 22:447-449.
8. Nielsen VG, Kirklin JK, George JF. Carbon monoxide releasing molecule-2 increases the velocity of thrombus growth and strength in human plasma. Blood Coagul Fibrinolysis 2009; 20:377-380.
9. Nielsen VG, Kirklin JK, George JF, Messinger JD. Carbon monoxide releasing molecule-2 decreases thick diameter fibrin fibre formation in normal and factor XIII deficient plasma. Blood Coagul Fibrinolysis 2010; 21:101-105.
10. Machovec KA, Ushakumari DS, Welsby IJ, Nielsen VG. The procoagulant properties of purified fibrinogen concentrate are enhanced by carbon monoxide releasing molecule-2. Thromb Res 2012; 129:793-796.
11. Nielsen VG, Cohen JB, Malayaman SN, Nowak M, Vosseller K. Fibrinogen is a heme-associated, carbon monoxide sensing molecule: a preliminary report. Blood Coagul Fibrinolysis 2011; 22:443-447.
12. Nielsen VG, Kirklin JK, George JF. Carbon monoxide releasing molecule-2 (CORM-2) decreases fibrinolysis in human plasma. Blood Coagul Fibrinolysis 2009; 20:448-455.
13. Arkebauer MR, Kanaparthy SS, Malayaman SN, Vosseller K, Nielsen VG. Carbon monoxide and nitric oxide modulate alpha-2-antiplasmin and plasmin activity: role of heme. Blood Coagul Fibrinolysis 2011; 22:712-719.
14. Nielsen VG, Arkebauer MR, Vosseller K. Redox-based thrombelastographic method to detect carboxyhemefibrinogen mediated hypercoagulability. Blood Coagul Fibrinolysis 2011; 22:657-661.
15. Nielsen VG, Chawla N, Mangla D, Gomes SB, Arkebauer MR, Wasko KA, et al. Carbon monoxide releasing molecule-2 enhances coagulation in rabbit plasma and decreases bleeding time in clopidogrel/aspirin treated rabbits. Blood Coagul Fibrinolysis 2011; 22:756-759.
16. Nielsen VG, Arkebauer MR, Wasko KA, Malayaman SN, Vosseller K. Carbon monoxide releasing molecule-2 decreases fibrinolysis in vitro and in vivo in the rabbit. Blood Coagul Fibrinolysis 2012; 23:104-107.
17. Balla J, Vercellotti GM, Jeney V, Yachie A, Varga Z, Eaton JW, Balla G. Heme, heme oxygenase and ferritin in vascular endothelial cell injury. Mol Nutr Food Res 2005; 49:1030-1043.
18. Nielsen VG, Pearson T, Smith MC. Increased carbon monoxide production by hemeoxygenase-1 caused by device-mediated hemolysis: thrombotic phantom menace? Artif Organs 2013; 37:1008-1014.
19. Lipinski B, Pretorius E. Hydroxyl radical-modified fibrinogen as a marker of thrombosis: the role of iron. Hematology 2012; 17:241-247.
20. Orino K. Functional binding analysis of human fibrinogen as an iron- and heme-binding protein. Biometals 2013; 26:789-794.
21. Bao W, Song F, Li X, Rong S, Yang W, Zhang M, et al. Plasma heme oxygenase-1 concentration is elevated in individuals with type 2 diabetes mellitus. PLoS One 2010; 5:e12371.
22. Takhashi A, Mori M, Naruto T, Nakajima S, Miyamae T, Imagawa T, Yokota S. The role of heme oxygenase-1 in systemic-onset juvenile idiopathic arthritis. Mod Rheumatol 2009; 19:302-308.
23. Pretorius E, Oberholzer HM, van der Spuy WJ, Swanepoel AC, Soma P. Qualitative scanning electron microscopy analysis of fibrin networks and platelet abnormalities in diabetes. Blood Coagul Fibrinolysis 2011; 22:463-467.
24. Pretorius E, Oberholzer HM, van der Spuy WJ, Swanepoel AC, Soma P. Scanning electron microscopy of fibrin networks in rheumatoid arthritis: a qualitative analysis. Rheumatol Int 2012; 32:1611-1615.
25. Nielsen VG, Hafner DT, Steinbrenner EB. Tobacco smoke induced hypercoagulation in human plasma: role of carbon monoxide. Blood Coagul Fibrinolysis 2013; 24:405-410.
26. Smith MC, Nielsen VG. Detection of carboxyhemefibrinogen and methemefibrinogen in a patient with thrombosis of a Heartmate II ventricular assist device. ASAIO J 2013; 59:93-95.
27. Nielsen VG, Garol BD, Zelman EA, Guerrero MA. Hemeoxygenase-1 mediated hypercoagulability in a patient with thyroid cancer. Blood Coagul Fibrinolysis 2013; 24:663-665.
28. Nielsen VG, Ley MLB, Waer AL, Alger PW, Matika RW, Steinbrenner EB. Plasmatic hypercoagulation in patients with breast cancer: role of hemeoxygenase-1. Blood Coagul Fibrinolysis 2013; 24:809-813.
29. Nielsen VG, Lemole GM Jr, Weinand ME, Baaj AA, Hussaini S, Steinbrenner EB. Brain tumors enhance plasmatic coagulation: role of hemeoxygenase-1. Anesth Analg (in press).
30. Nielsen VG, Gharagozloo F, Matika RW, Kim S, Zelman EA, Steinbrenner EB. Lung tumor effects on plasmatic coagulation: role of hemeoxygenase- 1. Lung Cancer 2014; 83:288-291.
31. Nielsen VG, Nfonsam VN, Matika RW, Ong ES, Jie T, Warneke JA, Steinbrenner EB. Colon and pancreas tumors enhance plasma coagulation kinetics: role of hemeoxygenase-1. Blood Coagul Fibrinolysis (in press).
32. Pretorius E, Oberholzer HM, van der Spuy WJ, Meiring JH. The changed ultrastructure of fibrin networks during use of oral contraception and hormone replacement. J Thromb Thrombolysis 2010; 30:502-506.