-
1
-
-
84860215480
-
Correlation of Alzheimer's disease neuropathologic changes with cognitive status: A review of the literature
-
Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns N, Davies P, Tredici KD, Duyckaerts C, Frosch MP, Hof PR, Hulette C, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kovari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee A, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG: Correlation of Alzheimer's disease neuropathologic changes with cognitive status: a review of the literature. J Neuropath Exp Neurol 2012;71:362-381.
-
(2012)
J Neuropath Exp Neurol
, vol.71
, pp. 362-381
-
-
Nelson, P.T.1
Alafuzoff, I.2
Bigio, E.H.3
Bouras, C.4
Braak, H.5
Cairns, N.6
Davies, P.7
Tredici, K.D.8
Duyckaerts, C.9
Frosch, M.P.10
Hof, P.R.11
Hulette, C.12
Hyman, B.T.13
Iwatsubo, T.14
Jellinger, K.A.15
Jicha, G.A.16
Kovari, E.17
Kukull, W.A.18
Leverenz, J.B.19
Love, S.20
Mackenzie, I.R.21
Mann, D.M.22
Masliah, E.23
McKee, A.24
Montine, T.J.25
Morris, J.C.26
Schneider, J.A.27
Sonnen, J.A.28
Thal, D.R.29
Trojanowski, J.Q.30
Troncoso, J.C.31
Wisniewski, T.32
Woltjer, R.L.33
Beach, T.G.34
more..
-
2
-
-
84874638938
-
Prions, prionoids and pathogenic proteins in Alzheimer disease
-
Ashe KH, Aguzzi A: Prions, prionoids and pathogenic proteins in Alzheimer disease. Prion 2013;7:55-59.
-
(2013)
Prion
, vol.7
, pp. 55-59
-
-
Ashe, K.H.1
Aguzzi, A.2
-
3
-
-
84889639581
-
-
Alzheimer's Disease Association
-
Gaugler J, James B, Johnson T, Scholz K, Weuve J: Alzheimer's Disease Facts and Figures 2013. Alzheimer's Disease Association, 2013.
-
(2013)
Alzheimer's Disease Facts and Figures 2013
-
-
Gaugler, J.1
James, B.2
Johnson, T.3
Scholz, K.4
Weuve, J.5
-
4
-
-
84897954317
-
Immunotherapy for Alzheimer's disease
-
Wisniewski T, Goni F: Immunotherapy for Alzheimer's disease. Biochem Pharmacol 2014;88:499-507.
-
(2014)
Biochem Pharmacol
, vol.88
, pp. 499-507
-
-
Wisniewski, T.1
Goni, F.2
-
5
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002;297:353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
7
-
-
11444267243
-
Evaluation of the safety and immunogenicity of synthetic Aβ42 (AN1792) in patients with AD
-
Bayer AJ, Bullock R, Jones RW, Wilkinson D, Paterson KR, Jenkins L, Millais SB, Donoghue S: Evaluation of the safety and immunogenicity of synthetic Aβ42 (AN1792) in patients with AD. Neurol 2005;64:94-101.
-
(2005)
Neurol
, vol.64
, pp. 94-101
-
-
Bayer, A.J.1
Bullock, R.2
Jones, R.W.3
Wilkinson, D.4
Paterson, K.R.5
Jenkins, L.6
Millais, S.B.7
Donoghue, S.8
-
8
-
-
47149112621
-
Long-term effects of Aβ42 immunization in Alzheimer's disease: Immune response, plaque removal and clinical function
-
Holmes C, Boche D, Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, Jones RW, Bullock R, Love S, Neal JW, Zotova E, Nicoll JA: Long-term effects of Aβ42 immunization in Alzheimer's disease: immune response, plaque removal and clinical function. Lancet 2008;372:216-223.
-
(2008)
Lancet
, vol.372
, pp. 216-223
-
-
Holmes, C.1
Boche, D.2
Wilkinson, D.3
Yadegarfar, G.4
Hopkins, V.5
Bayer, A.6
Jones, R.W.7
Bullock, R.8
Love, S.9
Neal, J.W.10
Zotova, E.11
Nicoll, J.A.12
-
9
-
-
84881025664
-
Immunotherapy for Alzheimer's disease
-
Farlow MR, Brosch JR: Immunotherapy for Alzheimer's disease. Neurol Clin 2013;31:869-878.
-
(2013)
Neurol Clin
, vol.31
, pp. 869-878
-
-
Farlow, M.R.1
Brosch, J.R.2
-
11
-
-
84888170295
-
Recent developments of protein kinase inhibitors as potential AD therapeutics
-
Tell V, Hilgeroth A: Recent developments of protein kinase inhibitors as potential AD therapeutics. Front Cell Neurosci 2013;7:189.
-
(2013)
Front Cell Neurosci
, vol.7
, pp. 189
-
-
Tell, V.1
Hilgeroth, A.2
-
12
-
-
84886600387
-
Therapeutics of Alzheimer's disease: Past, present and future
-
Anand R, Gill KD, Mahdi AA: Therapeutics of Alzheimer's disease: past, present and future. Neuropharmacology 2014;76(Pt A):27-50.
-
(2014)
Neuropharmacology
, vol.76
, pp. 27-50
-
-
Anand, R.1
Gill, K.D.2
Mahdi, A.A.3
-
13
-
-
33845530335
-
Chronic lithium administration to FTDP-17 tau and GSK-3β overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but preformed neurofibrillary tangles do not revert
-
Engel T, Goni-Oliver P, Lucas JJ, Avila J, Hernandez F: Chronic lithium administration to FTDP-17 tau and GSK-3β overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but preformed neurofibrillary tangles do not revert. J Neurochem 2006;99:1445-1455.
-
(2006)
J Neurochem
, vol.99
, pp. 1445-1455
-
-
Engel, T.1
Goni-Oliver, P.2
Lucas, J.J.3
Avila, J.4
Hernandez, F.5
-
14
-
-
67649206084
-
Lithium trial in Alzheimer's disease: A randomized, single-blind, placebo-controlled, multicenter 10-week study
-
Hampel H, Ewers M, Burger K, Annas P, Mortberg A, Bogstedt A, Frolich L, Schroder J, Schonknecht P, Riepe MW, Kraft I, Gasser T, Leyhe T, Moller HJ, Kurz A, Basun H: Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study. J Clin Psychiatry 2009;70:922-931.
-
(2009)
J Clin Psychiatry
, vol.70
, pp. 922-931
-
-
Hampel, H.1
Ewers, M.2
Burger, K.3
Annas, P.4
Mortberg, A.5
Bogstedt, A.6
Frolich, L.7
Schroder, J.8
Schonknecht, P.9
Riepe, M.W.10
Kraft, I.11
Gasser, T.12
Leyhe, T.13
Moller, H.J.14
Kurz, A.15
Basun, H.16
-
15
-
-
67649199941
-
Can lithium or valproate untie tangles in Alzheimer's disease?
-
Tariot PN, Aisen PS: Can lithium or valproate untie tangles in Alzheimer's disease? J Clin Psychiatry 2009;70:919-921.
-
(2009)
J Clin Psychiatry
, vol.70
, pp. 919-921
-
-
Tariot, P.N.1
Aisen, P.S.2
-
16
-
-
84872470005
-
Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: A pilot study
-
Del ST, Steinwachs KC, Gertz HJ, Andres MV, Gomez-Carrillo B, Medina M, Vericat JA, Redondo P, Fleet D, Leon T: Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study. J Alzheimers Dis 2013;33:205-215.
-
(2013)
J Alzheimers Dis
, vol.33
, pp. 205-215
-
-
Del, S.T.1
Steinwachs, K.C.2
Gertz, H.J.3
Andres, M.V.4
Gomez-Carrillo, B.5
Medina, M.6
Vericat, J.A.7
Redondo, P.8
Fleet, D.9
Leon, T.10
-
17
-
-
84879040199
-
Progress and developments in tau aggregation inhibitors for Alzheimer disease
-
Bulic B, Pickhardt M, Mandelkow E: Progress and developments in tau aggregation inhibitors for Alzheimer disease. J Med Chem 2013;56:4135-4155.
-
(2013)
J Med Chem
, vol.56
, pp. 4135-4155
-
-
Bulic, B.1
Pickhardt, M.2
Mandelkow, E.3
-
18
-
-
0029742937
-
Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines
-
Wischik CM, Edwards PC, Lai RY, Roth M, Harrington CR: Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. Proc Natl Acad Sci USA 1996;93:11213-11218.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 11213-11218
-
-
Wischik, C.M.1
Edwards, P.C.2
Lai, R.Y.3
Roth, M.4
Harrington, C.R.5
-
19
-
-
77949503424
-
The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition
-
Giommarelli C, Zuco V, Favini E, Pisano C, Dal PF, De TN, Zunino F: The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition. Cell Mol Life Sci 2010;67:995-1004.
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 995-1004
-
-
Giommarelli, C.1
Zuco, V.2
Favini, E.3
Pisano, C.4
Dal, P.F.5
De, T.N.6
Zunino, F.7
-
20
-
-
84873687399
-
Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice
-
Ma QL, Zuo X, Yang F, Ubeda OJ, Gant DJ, Alaverdyan M, Teng E, Hu S, Chen PP, Maiti P, Teter B, Cole GM, Frautschy SA: Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice. J Biol Chem 2013;288:4056-4065.
-
(2013)
J Biol Chem
, vol.288
, pp. 4056-4065
-
-
Ma, Q.L.1
Zuo, X.2
Yang, F.3
Ubeda, O.J.4
Gant, D.J.5
Alaverdyan, M.6
Teng, E.7
Hu, S.8
Chen, P.P.9
Maiti, P.10
Teter, B.11
Cole, G.M.12
Frautschy, S.A.13
-
21
-
-
34548146119
-
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
-
Asuni AA, Boutajangout A, Quartermain D, Sigurdsson EM: Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J Neurosci 2007;27:9115-9129.
-
(2007)
J Neurosci
, vol.27
, pp. 9115-9129
-
-
Asuni, A.A.1
Boutajangout, A.2
Quartermain, D.3
Sigurdsson, E.M.4
-
22
-
-
77956062142
-
Influence of presenilin mutation on tau pathology in novel Alzheimer's disease mouse model
-
Boutajangout A, Frangione B, Wisniewski T, Brion JP, Sigurdsson EM: Influence of presenilin mutation on tau pathology in novel Alzheimer's disease mouse model. Alzheimers Dement 2009;5:P445-P446.
-
(2009)
Alzheimers Dement
, vol.5
, pp. 445-P446
-
-
Boutajangout, A.1
Frangione, B.2
Wisniewski, T.3
Brion, J.P.4
Sigurdsson, E.M.5
-
23
-
-
78650065372
-
Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model
-
Boutajangout A, Quartermain D, Sigurdsson EM: Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. J Neurosci 2010;30:16559-16566.
-
(2010)
J Neurosci
, vol.30
, pp. 16559-16566
-
-
Boutajangout, A.1
Quartermain, D.2
Sigurdsson, E.M.3
-
24
-
-
77954656871
-
Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice
-
Boimel M, Grigoriadis N, Lourbopoulos A, Haber E, Abramsky O, Rosenmann H: Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice. Exp Neurol 2010;224:472-485.
-
(2010)
Exp Neurol
, vol.224
, pp. 472-485
-
-
Boimel, M.1
Grigoriadis, N.2
Lourbopoulos, A.3
Haber, E.4
Abramsky, O.5
Rosenmann, H.6
-
25
-
-
84860531636
-
Targeting phospho-Ser422 by active tau immunotherapy in the THY-Tau22 mouse model: A suitable therapeutic approach
-
Troquier L, Caillierez R, Burnouf S, Fernandez-Gomez FJ, Grosjean ME, Zommer N, Sergeant N, Schraen-Maschke S, Blum D, Buee L: Targeting phospho-Ser422 by active tau immunotherapy in the THY-Tau22 mouse model: a suitable therapeutic approach. Curr Alzheimer Res 2012;9:397-405.
-
(2012)
Curr Alzheimer Res
, vol.9
, pp. 397-405
-
-
Troquier, L.1
Caillierez, R.2
Burnouf, S.3
Fernandez-Gomez, F.J.4
Grosjean, M.E.5
Zommer, N.6
Sergeant, N.7
Schraen-Maschke, S.8
Blum, D.9
Buee, L.10
-
26
-
-
79960563632
-
Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
-
Boutajangout A, Ingadottir J, Davies P, Sigurdsson EM: Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain. J Neurochem 2011;118:658-667.
-
(2011)
J Neurochem
, vol.118
, pp. 658-667
-
-
Boutajangout, A.1
Ingadottir, J.2
Davies, P.3
Sigurdsson, E.M.4
-
27
-
-
80053202160
-
Passive immunization with anti-Tau antibodies in two transgenic models: Reduction of Tau pathology and delay of disease progression
-
Chai X, Wu S, Murray TK, Kinley R, Cella CV, Sims H, Buckner N, Hanmer J, Davies P, O'Neill MJ, Hutton ML, Citron M: Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression. J Biol Chem 2011;286:34457-34467.
-
(2011)
J Biol Chem
, vol.286
, pp. 34457-34467
-
-
Chai, X.1
Wu, S.2
Murray, T.K.3
Kinley, R.4
Cella, C.V.5
Sims, H.6
Buckner, N.7
Hanmer, J.8
Davies, P.9
O'Neill, M.J.10
Hutton, M.L.11
Citron, M.12
-
28
-
-
84876908676
-
Tau passive immunotherapy in mutant P301L mice: Antibody affinity versus specificity
-
d'Abramo C, Acker CM, Jimenez HT, Davies P: Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity. PLoS One 2013;8:e62402.
-
(2013)
PLoS One
, vol.8
, pp. e62402
-
-
D'Abramo, C.1
Acker, C.M.2
Jimenez, H.T.3
Davies, P.4
-
29
-
-
84885783467
-
Anti-tau antibodies that block tau aggregate seeding In vitro markedly decrease pathology and improve cognition in vivo
-
Yanamandra K, Kfoury N, Jiang H, Mahan TE, Ma S, Maloney SE, Wozniak DF, Diamond MI, Holtzman DM: Anti-tau antibodies that block tau aggregate seeding In vitro markedly decrease pathology and improve cognition in vivo. Neuron 2013;80:402-414.
-
(2013)
Neuron
, vol.80
, pp. 402-414
-
-
Yanamandra, K.1
Kfoury, N.2
Jiang, H.3
Mahan, T.E.4
Ma, S.5
Maloney, S.E.6
Wozniak, D.F.7
Diamond, M.I.8
Holtzman, D.M.9
-
30
-
-
84889992513
-
Immunomodulation targeting both Aβ and tau pathological conformers ameliorates Alzheimer's disease pathology in TgSwDI and 3xTg mouse models
-
Goni F, Herline K, Peyser D, Wong K, Ji Y, Sun Y, Mehta PD, Wisniewski T: Immunomodulation targeting both Aβ and tau pathological conformers ameliorates Alzheimer's disease pathology in TgSwDI and 3xTg mouse models. J Neuroinflammation 2013;10:150.
-
(2013)
J Neuroinflammation
, vol.10
, pp. 150
-
-
Goni, F.1
Herline, K.2
Peyser, D.3
Wong, K.4
Ji, Y.5
Sun, Y.6
Mehta, P.D.7
Wisniewski, T.8
-
31
-
-
84890282160
-
Antibody uptake into neurons occurs primarily via clathrin-dependent fcγ receptor endocytosis, and is a prerequisite for acute tau clearance
-
Congdon EE, Gu J, Sait HB, Sigurdsson EM: Antibody uptake into neurons occurs primarily via clathrin-dependent fcγ receptor endocytosis, and is a prerequisite for acute tau clearance. J Biol Chem 2013;288:35452-35465.
-
(2013)
J Biol Chem
, vol.288
, pp. 35452-35465
-
-
Congdon, E.E.1
Gu, J.2
Sait, H.B.3
Sigurdsson, E.M.4
-
32
-
-
67650077008
-
Transmission and spreading of tauopathy in transgenic mouse brain
-
Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M: Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol 2009;11:909-913.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 909-913
-
-
Clavaguera, F.1
Bolmont, T.2
Crowther, R.A.3
Abramowski, D.4
Frank, S.5
Probst, A.6
Fraser, G.7
Stalder, A.K.8
Beibel, M.9
Staufenbiel, M.10
Jucker, M.11
Goedert, M.12
Tolnay, M.13
|