메뉴 건너뛰기




Volumn 40, Issue 7, 2013, Pages 1069-1073

Sustained clinical remission and rate of relapse after tocilizumab withdrawal in patients with rheumatoid arthritis

Author keywords

Biological Agent; Relapse; Remission; Rheumatoid Arthritis; Tocilizumab; Withdrawal

Indexed keywords

ANTIINFLAMMATORY AGENT; DISEASE MODIFYING ANTIRHEUMATIC DRUG; GLUCOCORTICOID; METHOTREXATE; RITUXIMAB; TOCILIZUMAB; TUMOR NECROSIS FACTOR INHIBITOR;

EID: 84879941145     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.121427     Document Type: Article
Times cited : (43)

References (27)
  • 1
    • 38149047494 scopus 로고    scopus 로고
    • Rheumatic diseases: The unnoticed elephant in the room
    • Badley EM. Rheumatic diseases: The unnoticed elephant in the room. J Rheumatol 2008;35:6-7.
    • (2008) J Rheumatol , vol.35 , pp. 6-7
    • Badley, E.M.1
  • 2
    • 38149110381 scopus 로고    scopus 로고
    • Burden of disease across chronic diseases: A health survey that measured prevalence, function, and quality of life
    • EPISER Study Group
    • Loza E, Abasolo L, Jover JA, Carmona L; EPISER Study Group. Burden of disease across chronic diseases: A health survey that measured prevalence, function, and quality of life. J Rheumatol 2008;35:159-65.
    • (2008) J Rheumatol , vol.35 , pp. 159-65
    • Loza, E.1    Abasolo, L.2    Jover, J.A.3    Carmona, L.4
  • 4
    • 79956289882 scopus 로고    scopus 로고
    • When to initiate and discontinue biologic treatments for rheumatoid arthritis?
    • Chatzidionysiou K, van Vollenhoven RF. When to initiate and discontinue biologic treatments for rheumatoid arthritis? J Intern Med 2011;269:614-25.
    • (2011) J Intern Med , vol.269 , pp. 614-25
    • Chatzidionysiou, K.1    Van Vollenhoven, R.F.2
  • 5
    • 77956042108 scopus 로고    scopus 로고
    • Patients with RA in remission on TNF blockers: When and in whom can TNF blocker therapy be stopped?
    • Saleem B, Keen H, Goeb V, Parmar R, Nizam S, Hensor EM, et al. Patients with RA in remission on TNF blockers: When and in whom can TNF blocker therapy be stopped? Ann Rheum Dis 2010;69:1636-42.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1636-42
    • Saleem, B.1    Keen, H.2    Goeb, V.3    Parmar, R.4    Nizam, S.5    Hensor, E.M.6
  • 6
    • 84870257368 scopus 로고    scopus 로고
    • Do we need guidelines to stop as well as to start biological therapies for rheumatoid arthritis?
    • van den Broek M, Lems WF, Allaart CF. Do we need guidelines to stop as well as to start biological therapies for rheumatoid arthritis? Clin Exp Rheumatol 2012;30 Suppl 73:S21-6.
    • (2012) Clin Exp Rheumatol , vol.30 , Issue.SUPPL. 73
    • Van Den Broek, M.1    Lems, W.F.2    Allaart, C.F.3
  • 7
    • 84859832981 scopus 로고    scopus 로고
    • 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis
    • Singh JA, Furst DE, Bharat A, Curtis JR, Kavanaugh AF, Kremer JM, et al. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res 2012;64:625-39.
    • (2012) Arthritis Care Res , vol.64 , pp. 625-639
    • Singh, J.A.1    Furst, D.E.2    Bharat, A.3    Curtis, J.R.4    Kavanaugh, A.F.5    Kremer, J.M.6
  • 8
    • 19944431840 scopus 로고    scopus 로고
    • Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: Results from a twelve-month randomized, double-blind, placebo-controlled trial
    • Quinn MA, Conaghan PG, O'Connor PJ, Karim Z, Greenstein A, Brown A, et al. Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: Results from a twelve-month randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2005;52:27-35.
    • (2005) Arthritis Rheum , vol.52 , pp. 27-35
    • Quinn, M.A.1    Conaghan, P.G.2    O'Connor, P.J.3    Karim, Z.4    Greenstein, A.5    Brown, A.6
  • 9
    • 79959795633 scopus 로고    scopus 로고
    • Discontinuation of infliximab and potential predictors of persistent low disease activity in patients with early rheumatoid arthritis and Disease Activity Score-steered therapy: Subanalysis of the BeSt study
    • van den Broek M, Klarenbeek NB, Dirven L, van Schaardenburg D, Hulsmans HM, Kerstens PJ, et al. Discontinuation of infliximab and potential predictors of persistent low disease activity in patients with early rheumatoid arthritis and Disease Activity Score-steered therapy: Subanalysis of the BeSt study. Ann Rheum Dis 2011;70:1389-94.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1389-94
    • Van Den Broek, M.1    Klarenbeek, N.B.2    Dirven, L.3    Van Schaardenburg, D.4    Hulsmans, H.M.5    Kerstens, P.J.6
  • 10
    • 77954973766 scopus 로고    scopus 로고
    • Discontinuation of infliximab after attaining low disease activity in patients with rheumatoid arthritis, RRR (remission induction by remicade in RA) Study
    • Tanaka Y, Takeuchi T, Mimori T, Saito K, Nawata M, Kameda H, et al. Discontinuation of infliximab after attaining low disease activity in patients with rheumatoid arthritis, RRR (remission induction by remicade in RA) Study. Ann Rheum Dis 2010;69:1286-91.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1286-1291
    • Tanaka, Y.1    Takeuchi, T.2    Mimori, T.3    Saito, K.4    Nawata, M.5    Kameda, H.6
  • 11
    • 84867398615 scopus 로고    scopus 로고
    • Down-titration and discontinuation of infliximab in rheumatoid arthritis patients with stable low disease activity and stable treatment: An observational cohort study
    • van der Maas A, Kievit W, van den Bemt BJ, van den Hoogen FH, van Riel PL, den Broeder AA. Down-titration and discontinuation of infliximab in rheumatoid arthritis patients with stable low disease activity and stable treatment: An observational cohort study. Ann Rheum Dis 2012;71:1849-54.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1849-54
    • Van Der Maas, A.1    Kievit, W.2    Van Den Bemt, B.J.3    Van Den Hoogen, F.H.4    Van Riel, P.L.5    Den Broeder, A.A.6
  • 12
    • 84863963952 scopus 로고    scopus 로고
    • Withdrawal of adalimumab in early rheumatoid arthritis patients who attained stable low disease activity with adalimumab plus methotrexate: Results of a phase 4, double-blind, placebo-controlled study [abstract]
    • Kavanaugh A, Emery P, Fleischmann R, van Vollenhoven RF, Pavelka K, Durez P, et al. Withdrawal of adalimumab in early rheumatoid arthritis patients who attained stable low disease activity with adalimumab plus methotrexate: Results of a phase 4, double-blind, placebo-controlled study [abstract]. Arthritis Rheum 2011;63 Suppl:665-6.
    • (2011) Arthritis Rheum , vol.63 , Issue.SUPPL. , pp. 665-6
    • Kavanaugh, A.1    Emery, P.2    Fleischmann, R.3    Van Vollenhoven, R.F.4    Pavelka, K.5    Durez, P.6
  • 13
    • 84870322518 scopus 로고    scopus 로고
    • Discontinuation of adalimumab treatment in rheumatoid arthritis patients after achieving low disease activity
    • Harigai M, Takeuchi T, Tanaka Y, Matsubara T, Yamanaka H, Miyasaka N. Discontinuation of adalimumab treatment in rheumatoid arthritis patients after achieving low disease activity. Mod Rheumatol 2012;22:814-22.
    • (2012) Mod Rheumatol , vol.22 , pp. 814-22
    • Harigai, M.1    Takeuchi, T.2    Tanaka, Y.3    Matsubara, T.4    Yamanaka, H.5    Miyasaka, N.6
  • 14
    • 84871407614 scopus 로고    scopus 로고
    • Discontinuation of adalimumab without functional and structural progress after attaining remission in patients with rheumatoid arthritis [abstract]
    • Tanaka Y, Hirata S, Fukuyo S, Nawata M, Kubo S, Yamaoka K. Discontinuation of adalimumab without functional and structural progress after attaining remission in patients with rheumatoid arthritis [abstract]. Arthritis Rheum 2011;63 Suppl:962.
    • (2011) Arthritis Rheum , vol.63 , Issue.SUPPL. , pp. 962
    • Tanaka, Y.1    Hirata, S.2    Fukuyo, S.3    Nawata, M.4    Kubo, S.5    Yamaoka, K.6
  • 15
    • 80155163979 scopus 로고    scopus 로고
    • Drug free remission after cessation of actemra monotherapy (DREAM study) [abstract]
    • Nishimoto N. Drug free remission after cessation of actemra monotherapy (DREAM study) [abstract]. Ann Rheum Dis Suppl 2010;69 Suppl 3:98.
    • (2010) Ann Rheum Dis Suppl , vol.69 , Issue.SUPPL. 3 , pp. 98
    • Nishimoto, N.1
  • 16
    • 1242342194 scopus 로고    scopus 로고
    • Long-term treatment of rheumatoid arthritis with tumor necrosis factor alpha blockade: Outcome of ceasing and restarting biologicals
    • Buch MH, Marzo-Ortega H, Bingham SJ, Emery P. Long-term treatment of rheumatoid arthritis with tumor necrosis factor alpha blockade: Outcome of ceasing and restarting biologicals. Rheumatology 2004;43:243-4.
    • (2004) Rheumatology , vol.43 , pp. 243-4
    • Buch, M.H.1    Marzo-Ortega, H.2    Bingham, S.J.3    Emery, P.4
  • 17
    • 67649755653 scopus 로고    scopus 로고
    • Effect of discontinuing TNF-alpha antagonist therapy in patients with remission of rheumatoid arthritis
    • Brocq O, Millasseau E, Albert C, Grisot C, Flory P, Roux CH, et al. Effect of discontinuing TNF-alpha antagonist therapy in patients with remission of rheumatoid arthritis. Joint Bone Spine 2009;76:350-5.
    • (2009) Joint Bone Spine , vol.76 , pp. 350-5
    • Brocq, O.1    Millasseau, E.2    Albert, C.3    Grisot, C.4    Flory, P.5    Roux, C.H.6
  • 18
    • 82955189834 scopus 로고    scopus 로고
    • Evaluation of abatacept administered subcutaneously in adults with active rheumatoid arthritis: Impact of withdrawal and reintroduction on immunogenicity, efficacy and safety (phase Iiib ALLOW study)
    • Kaine J, Gladstein G, Strusberg I, Robles M, Louw I, Gujrathi S, et al. Evaluation of abatacept administered subcutaneously in adults with active rheumatoid arthritis: Impact of withdrawal and reintroduction on immunogenicity, efficacy and safety (phase Iiib ALLOW study). Ann Rheum Dis 2012;71:38-44.
    • (2012) Ann Rheum Dis , vol.71 , pp. 38-44
    • Kaine, J.1    Gladstein, G.2    Strusberg, I.3    Robles, M.4    Louw, I.5    Gujrathi, S.6
  • 19
    • 84877602545 scopus 로고    scopus 로고
    • Induction therapy with adalimumab plus methotrexate for 24 weeks followed by methotrexate monotherapy up to week 48 versus methotrexate therapy alone for DMARD-naive patients with early rheumatoid arthritis: HIT HARD, an investigator-initiated study
    • Jul 10. [E-pub ahead of print]
    • Detert J, Bastian H, Listing J, Weiss A, Wassenberg S, Liebhaber A, et al. Induction therapy with adalimumab plus methotrexate for 24 weeks followed by methotrexate monotherapy up to week 48 versus methotrexate therapy alone for DMARD-naive patients with early rheumatoid arthritis: HIT HARD, an investigator-initiated study. Ann Rheum Dis 2012 Jul 10. [E-pub ahead of print]
    • (2012) Ann Rheum Dis
    • Detert, J.1    Bastian, H.2    Listing, J.3    Weiss, A.4    Wassenberg, S.5    Liebhaber, A.6
  • 20
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumor necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial
    • Emery P, Keystone E, Tony HP, Cantagrel A, van Vollenhoven R, Sanchez A, et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumor necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial. Ann Rheum Dis 2008;67:1516-23.
    • (2008) Ann Rheum Dis , vol.67 , pp. 1516-23
    • Emery, P.1    Keystone, E.2    Tony, H.P.3    Cantagrel, A.4    Van Vollenhoven, R.5    Sanchez, A.6
  • 21
    • 84855351178 scopus 로고    scopus 로고
    • Efficacy of tocilizumab in patients with moderate to severe active rheumatoid arthritis and a previous inadequate response to disease-modifying antirheumatic drugs: The ROSE study
    • Yazici Y, Curtis JR, Ince A, Baraf H, Malamet RL, Teng LL, et al. Efficacy of tocilizumab in patients with moderate to severe active rheumatoid arthritis and a previous inadequate response to disease-modifying antirheumatic drugs: The ROSE study. Ann Rheum Dis 2012;71:198-205.
    • (2012) Ann Rheum Dis , vol.71 , pp. 198-205
    • Yazici, Y.1    Curtis, J.R.2    Ince, A.3    Baraf, H.4    Malamet, R.L.5    Teng, L.L.6
  • 22
    • 73449118587 scopus 로고    scopus 로고
    • Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: The AMBITION study
    • Jones G, Sebba A, Gu J, Lowenstein MB, Calvo A, Gomez-Reino JJ, et al. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: The AMBITION study. Ann Rheum Dis 2010;69:88-96.
    • (2010) Ann Rheum Dis , vol.69 , pp. 88-96
    • Jones, G.1    Sebba, A.2    Gu, J.3    Lowenstein, M.B.4    Calvo, A.5    Gomez-Reino, J.J.6
  • 23
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial
    • Smolen JS, Beaulieu A, Rubbert-Roth A, Ramos-Remus C, Rovensky J, Alecock E, et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomised trial. Lancet 2008;371:989-97.
    • (2008) Lancet , vol.371 , pp. 989-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3    Ramos-Remus, C.4    Rovensky, J.5    Alecock, E.6
  • 24
    • 84879935653 scopus 로고    scopus 로고
    • Hoffmann-La Roche. Long-term extension study of safety during treatment with tocilizumab in rheumatoid arthritis patients completing treatment in WA17822. [Internet. Accessed April 2, 2013.] Available from
    • Hoffmann-La Roche. Long-term extension study of safety during treatment with tocilizumab in rheumatoid arthritis patients completing treatment in WA17822. [Internet. Accessed April 2, 2013.] Available from: Http://clinicaltrials.gov/show/NCT00721123
  • 25
    • 84879951331 scopus 로고    scopus 로고
    • Hoffmann-La Roche; Long-term extension study of safety during treatment with tocilizumab in rheumatoid arthritis patients completing treatment in tocilizumab core studies WA18062, WA18063 and WA17824. [Internet. Accessed April 2, 2013.] Available from
    • Hoffmann-La Roche; Long-term extension study of safety during treatment with tocilizumab in rheumatoid arthritis patients completing treatment in tocilizumab core studies WA18062, WA18063 and WA17824. [Internet. Accessed April 2, 2013.] Available from: Http://clinicaltrials.gov/show/NCT00720798
  • 26
    • 78650860381 scopus 로고    scopus 로고
    • Validity of the COPCORD core questionnaire as a classification tool for rheumatic diseases
    • Grupo de Estudio Epidemiolóico de Enfermedades Mculo Articulares (GEEMA) Jan
    • Goycochea-Robles MV, Sanin LH, Moreno-Montoya J, Alvarez-Nemegyei J, Burgos-Vargas R, Garza-Elizondo M, et al; Grupo de Estudio Epidemiolóico de Enfermedades Mculo Articulares (GEEMA). Validity of the COPCORD core questionnaire as a classification tool for rheumatic diseases. J Rheumatol Suppl. 2011 Jan;86:31-5.
    • (2011) J Rheumatol Suppl. , vol.86 , pp. 31-5
    • Goycochea-Robles, M.V.1    Sanin, L.H.2    Moreno-Montoya, J.3    Alvarez-Nemegyei, J.4    Burgos-Vargas, R.5    Garza-Elizondo, M.6
  • 27
    • 83255161975 scopus 로고    scopus 로고
    • The efficacy and safety of reinstitution of tocilizumab in patients with relapsed active rheumatoid arthritis after long-term withdrawal of tocilizumab: Retreatment of patients with rheumatoid arthritis with a novel anti-IL-6 receptor antibody after a long-term interval following SAMURAI: The RONIN study
    • Sagawa A. The efficacy and safety of reinstitution of tocilizumab in patients with relapsed active rheumatoid arthritis after long-term withdrawal of tocilizumab: Retreatment of patients with rheumatoid arthritis with a novel anti-IL-6 receptor antibody after a long-term interval following SAMURAI: The RONIN study. Mod Rheumatol 2011;21:352-8.
    • (2011) Mod Rheumatol , vol.21 , pp. 352-8
    • Sagawa, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.