Ex vivo cytosolic delivery of functional macromolecules to immune cells

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Sharei, Armon ^a,b,c   Trifonova, Radiana ^d   Jhunjhunwala, Siddharth ^b   Hartoularos, George C ^a   Eyerman, Alexandra T ^a   Lytton Jean, Abigail ^b   Angin, Mathieu ^b   Sharma, Siddhartha ^b   Poceviciute, Roberta ^a   Mao, Shirley ^a   Heimann, Megan ^a   Liu, Sophia ^a   Talkar, Tanya ^a   Khan, Omar F ^b   Addo, Marylyn ^b   Von Andrian, Ulrich H ^b,c   Anderson, Daniel G ^a,b   Langer, Robert ^a,b   Lieberman, Judy ^d   Jensen, Klavs F ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; DEXTRAN; PROTEIN; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ENGINEERING; CELL FUNCTION; CONTROLLED STUDY; CYTOSOL; DRUG DELIVERY SYSTEM; EX VIVO STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOCOMPETENT CELL; INTRACELLULAR DELIVERY; LYMPHOCYTE; MACROMOLECULE; MALE; MEMBRANE DAMAGE; MICROFLUIDICS; MOUSE; NONHUMAN; ANIMAL; B LYMPHOCYTE; C57BL MOUSE; CELL CULTURE; DENDRITIC CELL; DEVICES; GENETICS; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS; LAB ON A CHIP; METABOLISM; RNAI THERAPEUTICS; T LYMPHOCYTE; VIROLOGY;

ANIMALS; ANTIBODIES; B-LYMPHOCYTES; CELLS, CULTURED; DENDRITIC CELLS; DEXTRANS; DRUG DELIVERY SYSTEMS; HIV; HIV INFECTIONS; HUMANS; LAB-ON-A-CHIP DEVICES; MICE; MICE, INBRED C57BL; RNA, SMALL INTERFERING; RNAI THERAPEUTICS; T-LYMPHOCYTES;

EID: 84927631037     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0118803     Document Type: Article

References (26)

1. Kalos M, Levine BL, Porter DL, Katz S, Grupp SA, Bagg A, et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Science translational medicine. 2011; 3(95):95ra73-95ra73. doi: 10.1126/scitranslmed.3002842 PMID: 21832238
2. Small EJ, Schellhammer PF, Higano CS, Redfern CH, Nemunaitis JJ, Valone FH, et al. Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer. Journal of Clinical Oncology. 2006; 24(19):3089-94. PMID: 16809734
3. Joliot A, Prochiantz A. Transduction peptides: from technology to physiology. Nature cell biology. 2004; 6(3):189-96. Epub 2004/03/25. doi: 10.1038/ncb0304-189 PubMed PMID: 15039791.
4. Zorko M, Langel Ü. Cell-penetrating peptides: mechanism and kinetics of cargo delivery. Advanced Drug Delivery Reviews. 2005; 57(4):529-45. PMID: 15722162
5. Song E, Zhu P, Lee S-K, Chowdhury D, Kussman S, Dykxhoorn DM, et al. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nature biotechnology. 2005; 23(6):709-17. PMID: 15908939
6. McNamara JO, Andrechek ER, Wang Y, Viles KD, Rempel RE, Gilboa E, et al. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nature biotechnology. 2006; 24(8):1005-15. PMID: 16823371
7. Wheeler LA, Trifonova R, Vrbanac V, Basar E, McKernan S, Xu Z, et al. Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. The Journal of Clinical Investigation. 2011; 121(6):2401-12. doi: 10.1172/JCI45876 PMID: 21576818
8. Koshkaryev A, Sawant R, Deshpande M, Torchilin V. Immunoconjugates and long circulating systems: origins, current state of the art and future directions. Advanced Drug Delivery Reviews. 2013; 65(1):24-35. doi: 10.1016/j.addr.2012.08.009 PMID: 22964425
9. Irvine DJ, Swartz MA, Szeto GL. Engineering synthetic vaccines using cues from natural immunity. Nature materials. 2013; 12(11):978-90. PubMed Central PMCID: PMCPMC3928825. doi: 10.1038/ nmat3775 PMID: 24150416
10. Yoo JW, Irvine DJ, Discher DE, Mitragotri S. Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nature reviews Drug discovery. 2011; 10(7):521-35. Epub 2011/07/02. doi: 10.1038/nrd3499 PubMed PMID: 21720407.
11. Jhunjhunwala S, Raimondi G, Thomson AW, Little SR. Delivery of rapamycin to dendritic cells using degradable microparticles. Journal of Controlled Release. 2009; 133(3):191-7. PubMed Central PMCID: PMCPMC2925512. doi: 10.1016/j.jconrel.2008.10.011 PMID: 19000726
12. Sahay G, Querbes W, Alabi C, Eltoukhy A, Sarkar S, Zurenko C, et al. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nature biotechnology. 2013; 31(7):653-U119. doi: 10.1038/Nbt.2614 PubMed ISI:000321579700023. PMID: 23792629
13. Gilleron J, Querbes W, Zeigerer A, Borodovsky A, Marsico G, Schubert U, et al. Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape. Nature biotechnology. 2013; 31(7):638-46. doi: 10.1038/nbt.2612 PMID: 23792630
14. Sharei A, Zoldan J, Adamo A, Sim WY, Cho N, Jackson E, et al. A vector-free microfluidic platform for intracellular delivery. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(6):2082-7. Epub 2013/01/24. doi: 10.1073/pnas.1218705110 PubMed PMID: 23341631; PubMed Central PMCID: PMC3568376.
15. Lee J, Sharei A, Sim WY, Adamo A, Langer R, Jensen KF, et al. Nonendocytic delivery of functional engineered nanoparticles into the cytoplasm of live cells using a novel, high-throughput microfluidic device. Nano letters. 2012; 12(12):6322-7. Epub 2012/11/14. doi: 10.1021/nl303421h PubMed PMID: 23145796; PubMed Central PMCID: PMC3521073.
16. Sharei A, Poceviciute R, Jackson EL, Cho N, Mao S, Hartoularos GC, et al. Plasma membrane recovery kinetics of a microfluidic intracellular delivery platform. Integrative biology: quantitative biosciences from nano to macro. 2014; 6(4):470-5. Epub 2014/02/06. doi: 10.1039/c3ib40215k PubMed PMID: 24496115; PubMed Central PMCID: PMC3966949.
17. Lambert H, Pankov R, Gauthier J, Hancock R. Electroporation-mediated uptake of proteins into mammalian cells. Biochemistry and Cell Biology. 1990; 68(4):729-34. doi: 10.1139/o90-105 PMID: 2222997
18. Marrero MB, Schieffer B, Paxton WG, Schieffer E, Bernstein KE. Electroporation of pp60 Antibodies Inhibits the Angiotensin II Activation of Phospholipase C-1 in Rat Aortic Smooth Muscle Cells. Journal of Biological Chemistry. 1995; 270(26):15734-8. doi: 10.1074/jbc.270.26.15734 PMID: 7541047
19. Huang L, Jin J, Deighan P, Kiner E, McReynolds L, Lieberman J. Efficient and specific gene knockdown by small interfering RNAs produced in bacteria. Nature biotechnology. 2013; 31(4):350-6. doi: 10. 1038/nbt.2537 PMID: 23475073
20. Bonehill A, Tuyaerts S, Van Nuffel AM, Heirman C, Bos TJ, Fostier K, et al. Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA. Molecular Therapy. 2008; 16(6):1170-80. doi: 10.1038/mt.2008.77 PMID: 18431362
21. Schaft N, Dörrie J, Müller I, Beck V, Baumann S, Schunder T, et al. A new way to generate cytolytic tumor-specific T cells: electroporation of RNA coding for a T cell receptor into T lymphocytes. Cancer Immunology, Immunotherapy. 2006; 55(9):1132-41. PMID: 16344988
22. Derfus AM, Chan WCW, Bhatia SN. Intracellular Delivery of Quantum Dots for Live Cell Labeling and Organelle Tracking. Advanced Materials. 2004; 16(12):961-6. doi: 10.1002/adma.200306111
23. Angin M, King M, Addo MM. New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals. JoVE (Journal of Visualized Experiments). 2013;(75:) :e50244-e. doi: 10.3791/50244 PMID: 23748671
24. Angin M, Kwon DS, Streeck H, Wen F, King M, Rezai A, et al. Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue. Journal of Infectious Diseases. 2012; 205(10):1495-500. doi: 10.1093/infdis/jis236 PMID: 22427677
25. Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science. 2008; 319(5865):921-6. doi: 10.1126/science.1152725 PMID: 18187620
26. O'Doherty U, Swiggard WJ, Malim MH. Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding. Journal of virology. 2000; 74(21):10074-80. PMID: 11024136