Alteration of Urothelial Inflammation, Apoptosis, and Junction Protein in Patients with Various Bladder Conditions and Storage Bladder Symptoms Suggest Common Pathway Involved in Underlying Pathophysiology

LUTS: Lower Urinary Tract Symptoms

Volumn 7, Issue 2, 2015, Pages 102-107

  Liu, Hsin Tzu ^a   Jiang, Yuan Hong ^a   Kuo, Hann Chorng ^a  

^a TZU CHI UNIVERSITY   (Taiwan)

Author keywords

Bladder dysfunction; Inflammation; Urothelium

Indexed keywords

GAP JUNCTION PROTEIN; UVOMORULIN; BIOLOGICAL MARKER; CADHERIN;

ADULT; AGED; APOPTOSIS; ARTICLE; BLADDER DISEASE; BLADDER NECK STENOSIS; CELL INFILTRATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; INTERSTITIAL CYSTITIS; KETAMINE RELATED CYSTITIS; LOWER URINARY TRACT SYMPTOM; MAJOR CLINICAL STUDY; MALE; MAST CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD INJURY; URINARY TRACT INFECTION; UROTHELIUM; BLADDER; CASE CONTROL STUDY; CHRONIC DISEASE; INFLAMMATION; METABOLISM; MIDDLE AGED; PHYSIOLOGY; TUNEL ASSAY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; BIOMARKERS; CADHERINS; CASE-CONTROL STUDIES; CHRONIC DISEASE; FEMALE; HUMANS; IN SITU NICK-END LABELING; INFLAMMATION; LOWER URINARY TRACT SYMPTOMS; MALE; MAST CELLS; MIDDLE AGED; URINARY BLADDER; URINARY BLADDER DISEASES; UROTHELIUM;

EID: 84927619019     PISSN: 17575664     EISSN: 17575672     Source Type: Journal    
DOI: 10.1111/luts.12062     Document Type: Article

References (36)

1. Steers WD. Pathophysiology of overactive bladder and urge urinary incontinence. Rev Urol 2002; 4(Suppl 4): S7-18.
2. Birder L, Andersson KE. Urothelial signaling. Physiol Rev 2013; 93: 653-80.
3. Daly DM, Collins VM, Chapple CR, Grundy D. The afferent system and its role in lower urinary tract dysfunction. Curr Opin Urol 2011; 21: 268-74.
4. Birder LA, Ruggieri M, Takeda M, van Koeveringe G, Veltkamp S. How does the urothelium affect bladder function in health and disease? ICI-RS 2011. Neurourol Urodyn 2012; 31: 293-9.
5. Everaerts W, Zhen X, Ghosh D, Vriens J, Gevaert T. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A 2010; 107: 19084-9.
6. Liu HT, Jiang YH, Kuo HC. Increased serum adipokines implicate chronic inflammation in the pathogenesis of overactive bladder syndrome refractory to antimuscarinic therapy. PLoS One 2013; 8: e76706.
7. Tyagi P, Barclay D, Zamora R et al. Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study. Int Urol Nephrol 2010; 42: 629-35.
8. Liu HT, Chen CY, Kuo HC. Urinary nerve growth factor levels in overactive bladder syndrome and lower urinary tract disorders. J Formos Med Assoc 2010; 109: 862-78.
9. Liu HT, Chancellor MB, Kuo HC. Urinary nerve growth factor levels are elevated in patients with detrusor overactivity and decreased in responders to detrusor botulinum toxin-A injection. Eur Urol 2009; 56: 700-6.
10. Shie JH, Kuo HC. Higher levels of cell apoptosis and abnormal E-cadherin expression in the urothelium are associated with inflammation in patients with interstitial cystitis/painful bladder syndrome. BJU Int 2011; 108: E136-41.
11. Shie JH, Liu HT, Kuo HC. Increased cell apoptosis of urothelium mediated by inflammation in interstitial cystitis/painful bladder syndrome. Urology 2012; 79: 484.e7-13.
12. Chuang FC, Kuo HC. Increased urothelial cell apoptosis and chronic inflammation are associated with recurrent urinary tract infection in women. PLoS One 2013; 8: e63760.
13. Liu HT, Shie JH, Chen SH, Wang YS, Kuo HC. Differences in mast cell infiltration, E-cadherin, and zonula occludens-1 expression between patients with overactive bladder and interstitial cystitis/bladder pain syndrome. Urology 2012; 80: 225.e13-8.
14. Lee CL, Jiang YH, Kuo HC. Increased apoptosis and suburothelial inflammation in patients with ketamine-related cystitis: a comparison with non-ulcerative interstitial cystitis and controls. BJU Int 2013; 112: 1156-62.
15. Kaczmarek E, Gorna A, Majewski P. Techniques of image analysis for quantitative immunohistochemistry. Rocz Akad Med Bialymst 2004; 49(Suppl 1): 155-8.
16. Steers WD, Ciambotti J, Etzel B et al. Alterations in afferent pathways from the urinary bladder of the rat in response to partial urethral obstruction. J Comp Neurol 1991; 310: 401-10.
17. Chertin B, Rolle U, Solari V, Cascio S, Puri P. The role of nitric oxide in bladder urothelial injury after bladder outlet obstruction. BJU Int 2004; 94: 392-9.
18. Vaidyanathan S, Krishnan KR, Mansour P et al. P75 nerve growth factor receptor in the vesical urothelium of patients with neuropathic bladder: an immunohistochemical study. Spinal Cord 1998; 36: 541-7.
19. Chu PS, Ma WK, Wong SC et al. The destruction of the lower urinary tract by ketamine abuse: a new syndrome? BJU Int 2008; 102: 1616-22.
20. Furuta A, Suzuki Y, Hayashi N et al. Transient receptor potential A1 receptor-mediated neural cross-talk and afferent sensitization induced by oxidative stress: implication for the pathogenesis of interstitial cystitis/bladder pain syndrome. Int J Urol 2012; 19: 429-36.
21. Arya LA, Northington GM, Asfaw T et al. Evidence of bladder oversensitivity in the absence of an infection in premenopausal women with a history of recurrent urinary tract infection. BJU Int 2012; 110: 247-51.
22. Metcalfe PD, Wang J, Jiao H et al. Bladder outlet obstruction: progression from inflammation to fibrosis. BJU Int 2010; 106: 1686-94.
23. Herrera JJ, Haywood-Watson RJ II, Grill RJ. Acute and chronic defivits in the urinary bladder after spinal contusion injury in the adult rat. J Neurotrauma 2010; 27: 423-31.
24. Balsara ZR, Ross SS, Dolber PC et al. Enhanced susceptibility to urinary tract infection in the spinal cord injured host with neurogenic bladder. Infect Immun 2013; 81: 3018-26.
25. Wognum S, Lagoa CE, Nagatomi J et al. An exploratory pathways analysis of temporal changes induced by spinal cord injury in the bladder wall: inside on remodeling and inflammation. PLoS One 2009; 4: e5852.
26. Birder LA, Ruan HZ, Chopra B et al. Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis. Am J Physiol Renal Physiol 2004; 287: F1084-91.
27. Meng E, Chang HY, Chang SY et al. Involvement of purinergic neurotransmission in ketamine induced bladder dysfunction. J Urol 2011; 186: 1134-41.
28. Kim JC, Yoo JS, Park EY et al. Muscarinic and purinergic receptor expression in the urothelium of rats with detrusor overactivity induced by bladder outlet obstruction. BJU Int 2008; 101: 371-5.
29. Li Y, Xue L, Miao Q et al. Expression and electrophysiological characteristics of P2X3 receptors in interstitial cells of Cajal in rats with partial bladder outlet obstruction. BJU Int 2013; 111: 843-51.
30. Munoz A, Smith CP, Boone TB, Somogyi GT. Overactive and underactive bladder dysfunction is reflected by alterations in urothelial ATP and NO release. Neurochem Int 2011; 58: 295-300.
31. Munoz A, Somogyi GT, Boone TB, Ford AP, Smith CP. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3 receptors. BJU Int 2012; 110: E409-14.
32. Cruz CD, Cruz F. Spinal cord injury and bladder dysfunction: new ideas about an old problem. Scientific World Journal 2011; 11: 214-34.
33. Vaidyanathan S, McDicken IW, Ikin AJ et al. A study of cytokeratin 20 immunostaining in the urothelium of neuropathic bladder of patients with spinal cord injury. BMC Urol 2002; 2: 7.
34. Vaidyanathan S, McDicken I, Soni BM, Sett P, Krishnan KR. Possible role of denervation-induced changes in the urothelium in the pathophysiology of cystitis in patients with spinal cord injury: a hypothesis. Spinal Cord 1997; 35: 708-9.
35. Chuang SM, Liu KM, Li YL et al. Dual involvements of cyclooxygenase and nitric oxide synthase expressions in ketamine-induced ulcerative cystitis in rat bladder. Neurourol Urodyn 2013; 32: 1137-43.
36. Celik-Ozenci C, Ustunel I, Erdogru T et al. Ultrastructural and immunohistochemical analysis of rat uroepithelial cell junctions after partial bladder outlet obstruction and selective COX-2 inhibitor treatment. Acta Histochem 2006; 107: 443-51.