Increased Serum Adipokines Implicate Chronic Inflammation in the Pathogenesis of Overactive Bladder Syndrome Refractory to Antimuscarinic Therapy

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Liu, Hsin Tzu ^a,b   Jiang, Yuan Hong ^a   Kuo, Hann Chorng ^a  

^a BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^b TZU CHI UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; C REACTIVE PROTEIN; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; MUSCARINIC RECEPTOR BLOCKING AGENT; NERVE GROWTH FACTOR; TOLTERODINE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CHRONIC INFLAMMATION; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; FEMALE; HUMAN; LOWER URINARY TRACT SYMPTOM; MALE; OVERACTIVE BLADDER; PATHOGENESIS; PILOT STUDY; PROTEIN BLOOD LEVEL;

ADIPOKINES; ADULT; AGED; BENZHYDRYL COMPOUNDS; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; CRESOLS; DRUG RESISTANCE; FEMALE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; MUSCARINIC ANTAGONISTS; NERVE GROWTH FACTOR; PHENYLPROPANOLAMINE; PROSPECTIVE STUDIES; URINARY BLADDER, OVERACTIVE;

EID: 84884843018     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076706     Document Type: Article

References (39)

1. Abrams P, Kelleher CJ, Kerr LA, Rogers RG, (2000) Overactive bladder significantly affects quality of life. Am J Manag Care (Suppl 11): pp. S580-590.
2. Melville JL, Walker E, Katon W, Lentz G, Miller J, et al. (2002) Prevalence of comorbid psychiatric illness and its impact on symptom perception, quality of life, and functional status in women with urinary incontinence. Am J Obstet Gynecol 187: 80-87.
3. Brown JS, McGhan WF, Chokroverty S (2000) Comorbidities associated with overactive bladder. Am J Manage Care 6(11 Suppl): S574-579.
4. Rodríguez MA, Afari N, Buchwald DS, (2009) National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Urological Chronic Pelvic Pain. Evidence for overlap between urological and nonurological unexplained clinical conditions. J Urol 182: 2123-2131.
5. Apostolidis A, Jacques TS, Freeman A, Freeman A, Kalsi V, et al. (2008) Histological changes in the urothelium and suburothelium of human overactive bladder following intradetrusor injections of botulinum neurotoxin type A for the treatment of neurogenic or idiopathic detrusor overactivity. Eur Urol 53: 1245-1253.
6. Yiangou Y, Facer P, Ford A, Brady C, Wiseman O, et al. (2001) Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder. BJU Int 87: 774-779.
7. Avelino A, Cruz C, Nagy I, Cruz F, (2002) Vanilloid receptor 1 expression in the rat urinary tract. Neuroscience 109: 787-798.
8. Chapple CR (2000) Muscarinic receptor antagonist in the treatment of overactive bladder. Urology (Suppl 3): 33-46.
9. Gormley EA, Lightner DJ, Burgio KL, Chai TC, Clemens JQ, et al. (2012) Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline. J Urol 188(6 Suppl): 2455-2463.
10. Chung SD, Liu HT, Lin H, Kuo HC, (2011) Elevation of serum C-reactive protein in patients with OAB and IC/BPS implies chronic inflammation in the urinary bladder. Neurourol Urodyn 30: 417-420.
11. Liao CH, Chung SD, Kuo HC, (2011) Serum C-reactive protein levels are associated with residual urgency symptoms in patients with benign prostatic hyperplasia after medical treatment. Urology 78: 1373-1378.
12. Steers WD, Tuttle JB, (2006) Mechanisms of Disease: the role of nerve growth factor in the pathophysiology of bladder disorders. Nat Clin Pract Urol 3: 101-110.
13. Wang W, Zhang N, Zhu XH, He ZS, Wahafu W, et al. (2012) Involvement of TL1A and DR3 in induction of ischaemia and inflammation in urinary bladder dysfunction in the elderly. Mol Med Rep 6: 434-438.
14. Nomiya M, Sagawa K, Yazaki J, Takahashi N, Kushida N, et al. (2012) Increased bladder activity is associated with elevated oxidative stress markers and proinflammatory cytokines in a rat model of atherosclerosis-induced chronic bladder ischemia. Neurourol Urodyn 31: 185-189.
15. Apostolidis A, Popat R, Yiangou Y, Cockayne D, Ford AP, et al. (2005) Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity. J Urol 174: 977-983.
16. Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, et al. (1999) Myofibroblasts. II. Intestinal subepithelial myofibroblasts. Am J Physiol 277: C183-201.
17. Dupont MC, Spitsberegen JM, Kim KB, Tuttle JB, Steers WD, (2001) Histological and neurotrophic changes triggered by varying models of bladder inflammation. J Urol 166: 1111-1118.
18. Tuttle JB, Steers WD, Albo M, Nataluk E, (1994) Neural input regulates tissue NGF and growth of the adult urinary bladder. J Auton Nerv Syst 49: 147-158.
19. Steers WD, Kolbeck S, Creedon D, Tuttle JB, (1991) Nerve growth factor in the urinary bladder of the adult regulates neuronal form and function. J Clin Invest 88: 1709-1715.
20. Lowe EM, Anand P, Terenghi G, Williams-Chestnut RE, Sinicropi DV, et al. (1997) Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis. Br J Urol 79: 572-577.
21. Liu HT, Kuo HC, (2008) Urinary nerve growth factor levels are increased in patients with bladder outlet obstruction with overactive bladder symptoms and reduced after successful medical treatment. Urology 72: 104-108.
22. Kupelian V, Rosen RC, Roehrborn CG, Tyagi P, Chancellor MB, et al. (2012) Association of overactive bladder and C-reactive protein levels. Results from the Boston Area Community Health (BACH) Survey. BJU Int 110: 401-407.
23. Seki S, Sasaki K, Fraser MO, Igawa Y, Nishizawa O, et al. (2002) Immunoneutralization of nerve growth factor in lumbosacral spinal cord reduces bladder hyperreflexia in spinal cord injured rats. J Urol 168: 2269-2274.
24. Bonini S, Lambiase A, Bonini S, Angelucci F, Magrini L, et al. (1996) Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma. Proc Natl Acad Sci USA 93: 10955-10960.
25. Serrano-Sánchez T, Robinson-Agramonte MA, Lorigados-Pedre L, (2001) Endogenous nerve growth factor in patients with Alzheimer s disease. Rev Neurol 32: 825-828.
26. Stanzani L, Zoia C, Sala G, Appollonio I, Frattola L, et al. (2001) Nerve growth factor and transforming growth factor-beta serum levels in acute stroke patients. Possible involvement of neurotrophins in cerebrovascular disease. Cerebrovasc Dis 12: 240-244.
27. Liu HT, Lin H, Kuo HC, (2011) Increased serum nerve growth factor levels in patients with overactive bladder syndrome refractory to antimuscarinic therapy. Neurourol Urodyn 30: 1525-1529.
28. Vizzard MA, (2000) Changes in urinary bladder neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction. Exp Neurol 161: 273-284.
29. Tyagi P, Barclay D, Zamora R, Yoshimura N, Peters K, et al. (2010) Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study. Int Urol Nephrol 42: 629-635.
30. Tyagi P, Killinger K, Tyagi V, Nirmal J, Chancellor M, et al. (2012) Urinary chemokines as noninvasive predictors of ulcerative interstitial cystitis. J Urol 187: 2243-2248.
31. Heinrich M, Oberbach A, Schlichting N, Stolzenburg JU, Neuhaus J, (2011) Cytokine effects on gap junction communication and connexin expression in human bladder smooth muscle cells and suburothelial myofibroblasts. PLoS One 6: e20792.
32. Davidoff R, Yamaguchi R, Leach GE, Park E, Lad PM, (1997) Multiple urinary cytokine levels of bacterial cystitis. J Urol 157: 1980-1985.
33. Jacobson SH, Hylander B, Wretlind B, Brauner A, (1994) Interleukin-6 and interleukin-8 in serum and urine in patients with acute pyelonephritis in relation to bacterial-virulence-associated traits and renal function. Nephron 67: 172-179.
34. Liu HT, Kuo HC (2012) Increased pro-inflammatory cytokine and chemokine expressions in serum of patients with interstitial cystitis/bladder pain syndrome. ICS Abstract 480.
35. Bouchelouche K, Alvarez S, Andersen L, Nordling J, Hom T, et al. (2004) Monocyte chemoattractant protein-1 production by human detrusor smooth muscle cells. J Urol 171: 462-466.
36. Zhang Z, Cherryholmes G, Mao A, Marek C, Longmate J, et al. (2008) High plasma levels of MCP-1 and eotaxin provide evidence for an immunological basis of fibromyalgia. Exp Biol Med (Maywood) 233: 1171-1180.
37. Segerer S, Nelson PJ, (2005) Chemokines in renal diseases. Scientific World Journal 5: 835-844.
38. Ley K, (2003) Arrest chemokines. Microcirculation 10: 289-295.
39. Wennberg AL, Molander U, Fall M, Edlund C, Peeker R, et al. (2009) A longitudinal population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in women. Eur Urol 55: 783-791.