Increased Urothelial Cell Apoptosis and Chronic Inflammation Are Associated with Recurrent Urinary Tract Infection in Women

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Chuang, Fei Chi ^a,b   Kuo, Hann Chorng ^c,d  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^d TZU CHI UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAX; SYNAPTOPHYSIN; TRYPTASE; UVOMORULIN;

APOPTOSIS; ARTICLE; BLADDER BIOPSY; BLADDER MUCOSA; CHRONIC INFLAMMATION; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; MAST CELL; NICK END LABELING; RECURRENT INFECTION; URINALYSIS; URINARY TRACT INFECTION; URINE CULTURE; UROTHELIUM CELL; WESTERN BLOTTING;

APOPTOSIS; CASE-CONTROL STUDIES; CHRONIC DISEASE; FEMALE; HUMANS; IN SITU NICK-END LABELING; INFLAMMATION; RECURRENCE; URINARY TRACT INFECTIONS; UROTHELIUM;

EID: 84877779794     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063760     Document Type: Article

References (27)

1. Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, et al. (2010) An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodynam 29: 4-20.
2. Van De Merwe JP, Arendsen HJ, (2000) Interstitial cystitis: a review of immunological aspects of the aetiology and pathogenesis, with a hypothesis. BJU Int 85: 995-999.
3. Sant GR, Kempuraj D, Marchand JE, Theoharides TC (2007) The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis. Urology 69 (4 Suppl): 34-40.
4. Graham E, Chai TC, (2006) Dysfunction of bladder urothelium and bladder urothelial cells in interstitial cystitis. Current urology reports 7: 440-446.
5. Shie JH, Kuo HC, (2011) Higher levels of cell apoptosis and abnormal E-cadherin expression in the urothelium are associated with inflammation in patients with interstitial cystitis/painful bladder syndrome. BJU Int 108: E136-141.
6. Liu HT, Chen CY, Kuo HC, (2010) Urinary nerve growth factor levels in overactive bladder syndrome and lower urinary tract disorders. J Formosan Med Assoc 109: 862-878.
7. Liu HT, Chancellor MB, Kuo HC, (2009) Urinary nerve growth factor levels are elevated in patients with detrusor overactivity and decreased in responders to detrusor botulinum toxin-A injection. Eur Urol 56: 700-706.
8. Liu HT, Chancellor MB, Kuo HC, (2008) Urinary nerve growth factor level could be a biomarker in the differential diagnosis of mixed urinary incontinence in women. BJU Int 102: 1440-1444.
9. Kuo HC, Liu HT, Chancellor MB, (2010) Can urinary nerve growth factor be a biomarker for overactive bladder? Rev Urol 12: e69-77.
10. Liu HT, Chancellor MB, Kuo HC, (2009) Decrease of urinary nerve growth factor levels after antimuscarinic therapy in patients with overactive bladder. BJU Int 103: 1668-1672.
11. Lowe EM, Anand P, Terenghi G, Williams-Chestnut RE, Sinicropi DV, et al. (1997) Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis. BJU 79: 572-577.
12. Chung SD, Liu HT, Lin H, Kuo HC, (2011) Elevation of serum c-reactive protein in patients with OAB and IC/BPS implies chronic inflammation in the urinary bladder. Neurourol Urodynam 30: 417-420.
13. Kaczmarek E, Gorna A, Majewski P, (2004) Techniques of image analysis for quantitative immunohistochemistry. Rocz Akad Med Bialyms 49(Suppl 1): 155-158.
14. Janssen DA, Hoenderop JG, Jansen KC, Kemp AW, Heesakkers JP, et al. (2011) The mechanoreceptor TRPV4 is localized in adherence junctions of the human bladder urothelium: a morphological study. J Urol 186: 1121-1127.
15. Zhang S, Zeng X, Yang H, Hu G, He S, (2012) Mast cell tryptase induces microglia activation via protease-activated receptor 2 signaling. Cell Physiol Biochem 29: 931-940.
16. Lynes WL, Flynn SD, Shortliffe LD, Lemmers M, Zipser R, et al. (1987) Mast cell involvement in interstitial cystitis. J Urol138: 746-752.
17. Liu HT, Shie JH, Chen SH, Wang YS, Kuo HC (2012) Differences in mast cell infiltration, E-cadherin, and zonula occludens-1 expression between patients with overactive bladder and interstitial cystitis/bladder pain syndrome. Urology 80: 225 e213-228.
18. Chan CY, St John AL, Abraham SN, (2013) Mast cell interleukin-10 drives localized tolerance in chronic bladder infection. Immunity 38: 349-359.
19. Sylvester PW, (2007) Vitamin E and apoptosis. Vitam Horm 76: 329-356.
20. Khan MA, Thompson CS, Calvert RC, Mikhailidis DP, Morgan RJ, (2002) Decreased urinary bladder apoptosis in a rabbit model of diabetes mellitus. Urol Res 30: 79-83.
21. Shie JH, Liu HT, Kuo HC (2012) Increased cell apoptosis of urothelium mediated by inflammation in interstitial cystitis/painful bladder syndrome. Urology 79: 484 e7-13.
22. Rozniecki JJ, Hauser SL, Stein M, Lincoln R, Theoharides TC, (1995) Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients. Ann Neurol 37: 63-66.
23. Cai B, Chang SH, Becker EB, Bonni A, Xia Z, (2006) p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. J Biol Chem 281: 25215-25222.
24. Kawasaki H, Morooka T, Shimohama S, Kimura J, Hirano T, et al. (1997) Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. J Biol Chem 272: 18518-18521.
25. Ma FY, Tesch GH, Flavell RA, Davis RJ, Nikolic-Paterson DJ, (2007) MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney. Am J Physiol Renal Physiol 293: F1556-F1563.
26. Jiang P, Du W, Wu M, (2007) p53 and Bad: remote strangers become close friends. Cell Res 17: 283-285.
27. Wang H, Wang Z, Chen J, Wu J, (2007) Apoptosis induced by NO via phosphorylation of p38 MAPK that stimulates NF-kappaB, p53 and caspase-3 activation in rabbit articular chondrocytes. Cell Biol Int 31: 1027-1035.