Arterial norepinephrine concentration is inversely and independently associated with insulin clearance in obese individuals with metabolic syndrome

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 4, 2015, Pages 1544-1550

  Straznicky, Nora E ^a   Grima, Mariee T ^a   Lambert, Elisabeth A ^a   Sari, Carolina I ^a   Eikelis, Nina ^a   Nestel, Paul J ^a   Phillips, Sarah E ^a   Hering, Dagmara ^a   Karapanagiotidis, Sofie ^a   Dixon, John B ^a   Schlaich, Markus P ^a   Lambert, Gavin W ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; NORADRENALIN; GLUCOSE BLOOD LEVEL;

ADRENERGIC SYSTEM; ADULT; AGE; ARTICLE; AUGMENTATION INDEX; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DOPPLER ECHOCARDIOGRAPHY; FEMALE; HEART OUTPUT; HUMAN; INSULIN CLEARANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NORADRENALIN BLOOD LEVEL; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PREDICTION; PRIORITY JOURNAL; SEX DIFFERENCE; TONOMETRY; ARTERY; BLOOD; CLINICAL TRIAL; COMPLICATION; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; METABOLISM;

ARTERIES; BLOOD GLUCOSE; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NOREPINEPHRINE; OBESITY;

EID: 84927615542     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-3796     Document Type: Article

References (40)

1. Peiris AN, Mueller RA, Smith GA, Struve MF, Kissebah AH. Splanchnic insulin metabolism in obesity. Influence of body fat distribution. J Clin Invest. 1986;78:1648-1657.
2. Bonora E, Zavaroni I, Bruschi F, et al. Peripheral hyperinsulinemia of simple obesity: Pancreatic hypersecretion or impaired insulin metabolism? J Clin Endocrinol Metab. 1984;59:1121-1127.
3. Marini MA, Frontoni S, Succurro E, et al. Differences in insulin clearance between metabolically healthy and unhealthy obese subjects. Acta Diabetol. 2014;51:257-261.
4. Lender D, Arauz-Pacheco C, Adams-Huet B, Raskin P. Essential hypertension is associated with decreased insulin clearance and insulin resistance. Hypertension. 1997;29:111-114.
5. Kotronen A, Vehkavaara S, Seppälä-Lindroos A, Bergholm R, Yki-Järvinen H. Effect of liver fat on insulin clearance. Am J Physiol Endocrinol Metab. 2007;293:E1709-E1715.
6. Mittelman SD, Van Citters GW, Kim SP, et al. Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced β-cell response. Diabetes. 2000;49:2116-2125.
7. Jones CN, Abbasi F, Carantoni M, Polonsky KS, Reaven GM. Roles of insulin resistance and obesity in regulation of plasma insulin concentrations. Am J Physiol Endocrinol Metab. 2000;278:E501-E508.
8. Kim SH, Abbasi F, Chu JW, et al. Rosiglitazone reduces glucose-stimulated insulin secretion rate and increases insulin clearance in nondiabetic, insulin-resistant individuals. Diabetes. 2005;54:2447-2452.
9. Grassi G, Dell'Oro R, Quarti-Trevano F, et al. Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome. Diabetologia. 2005;48:1359-1365.
10. Straznicky NE, Eikelis N, Lambert EA, Esler MD. Mediators of sympathetic activation in metabolic syndrome obesity. Curr Hypertens Rep. 2008;10:440-447.
11. Flaa A, Aksnes TA, Kjeldsen SE, Eide I, Rostrup M. Increased sympathetic reactivity may predict insulin resistance: an 18-year followup study. Metabolism. 2008;57:1422-1427.
12. Jamerson KA, Julius S, Gudbrandsson T, Andersson O, Brant DO. Reflex sympathetic activation induces acute insulin resistance in the human forearm. Hypertension. 1993;21:618-623.
13. Valera Mora ME, Scarfone A, Calvani M, Greco AV, Mingrone G. Insulin clearance in obesity. J Am Coll Nutr. 2003;22:487-493.
14. Ferrannini E, Wahren J, Faber OK, Felig P, Binder C, DeFronzo RA. Splanchnic and renal metabolism of insulin in human subjects: a dose-response study. Am J Physiol. 1983;244:E517-E527.
15. O'Callaghan CJ, Komersova K, Louis WJ. Acute effects of blood pressure elevation on insulin clearance in normotensive healthy subjects. Hypertension. 1998;31:104-109.
16. Richardson PD, Withrington PG. The role of β-adrenoceptors in the responses of the hepatic arterial vascular bed of the dog to phenylephrine, isoprenaline, noradrenaline and adrenaline. Br J Pharmacol. 1977;60:239-249.
17. Schmetterer L, Müller M, Fasching P, et al. Renal and ocular hemodynamic effects of insulin. Diabetes. 1997;46:1868-1874.
18. Klein HH, Matthaei S, Drenkhan M, Ries W, Scriba PC. The relationship between insulin binding, insulin activation of insulin-receptor tyrosine kinase, and insulin stimulation of glucose uptake in isolated rat adipocytes. Effects of isoprenaline. Biochem J. 1991;274:787-792.
19. Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640-1645.
20. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 1999;22:1462-1470.
21. Esler M, Jackman G, Bobik A, et al. Determination of norepinephrine apparent release rate and clearance in humans. Life Sci. 1979;25:1461-1470.
22. Hamburg NM, Keyes MJ, Larson MG, et al. Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study. Circulation. 2008;117:2467-2474.
23. Goodarzi MO, Cui J, Chen YD, Hsueh WA, Guo X, Rotter JI. Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance. Am J Physiol Endocrinol Metab. 2011;301:E402-E408.
24. Goodarzi MO, Taylor KD, Guo X, et al. Variation in the gene for muscle-specificAMPdeaminase is associated with insulin clearance, a highly heritable trait. Diabetes. 2005;54:1222-1227.
25. Oshida Y, Yamanouchi K, Hayamizu S, Sato Y. Long-term mild jogging increases insulin action despite no influence on body mass index or VO2 max. J Appl Physiol. 1989;66:2206-2210.
26. Xun P, Wu Y, He Q, He K. Fasting insulin concentrations and incidence of hypertension, stroke, and coronary heart disease: a metaanalysis of prospective cohort studies. Am J Clin Nutr. 2013;98:1543-1554.
27. Lee CC, Haffner SM, Wagenknecht LE, et al. Insulin clearance and the incidence of type 2 diabetes in Hispanics and African Americans: the IRAS Family Study. Diabetes Care. 2013;36:901-907.
28. Rothe CF, Maass-Moreno R. Active and passive liver microvascular responses from angiotensin, endothelin, norepinephrine, and vasopressin. AmJ Physiol Heart Circ Physiol. 2000;279:H1147-H1156.
29. Desoye G, Ertl-Stockinger U, Porta S. Prolonged administration in vivo of alpha and beta adrenergic agonists decreases insulin binding to rat myocardial membranes in vitro by different mechanisms. Life Sci. 1991;48:2249-2258.
30. Joost HG, Quentin SH. Effects of chemical sympathectomy on insulin receptors and insulin action in isolated rat adipocytes. J Pharmacol Exp Ther. 1984;229:839-844.
31. Egan BM. Neurohumoral, hemodynamic and microvascular changes as mechanisms of insulin resistance in hypertension: a provocative but partial picture. Int J Obes. 1991;15:133-139.
32. Casey DP, Curry TB, Joyner MJ, Charkoudian N, Hart EC. Relationship between muscle sympathetic nerve activity and aortic wave reflection characteristics in young men and women. Hypertension. 2011;57:421-427.
33. Sugawara J, Brothers RM, Raven PB, Okazaki K, Ogoh S. Effect of systemic β1-adrenergic receptor blockade on central blood pressure response during exercise. J Physiol Sci. 2013;63:389-393.
34. Florian JP, Pawelczyk JA. Non-esterified fatty acids increase arterial pressure via central sympathetic activation in humans. Clin Sci. 2010;118:61-69.
35. Stepniakowski KT, Goodfriend TL, Egan BM. Fatty acids enhance vascular β-adrenergic sensitivity. Hypertension. 1995;25:774-778.
36. Wiesenthal SR, Sandhu H, McCall RH, et al. Free fatty acids impair hepatic insulin extraction in vivo. Diabetes. 1999;48:766-774.
37. Rahmouni K, Morgan DA, Morgan GM, et al. Hypothalamic PI3K and MAPKdifferentially mediate regional sympathetic activation to insulin. J Clin Invest. 2004;114:652-658.
38. Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation. 2006;113:1888-1904.
39. Lindgren K, Hagelin E, Hansén N, Lind L. Baroreceptor sensitivity is impaired in elderly subjects with metabolic syndrome and insulin resistance. J Hypertens. 2006;24:143-150.
40. Kolterman OG, Gray RS, Griffin J, et al. Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus. J Clin Invest. 1981;68:957-969.