Protective effect of Wuzhi tablet (Schisandra sphenanthera extract) against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response

Phytomedicine

Volumn 22, Issue 5, 2015, Pages 528-535

  Jin, Jing ^a   Li, Mei ^a   Zhao, Zhongxiang ^b   Sun, Xiaozhe ^a   Li, Jia ^c   Wang, Wenwen ^a   Huang, Min ^a   Huang, Zhiying ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cisplatin; Nephrotoxicity; Nrf2; Schisandra sphenanthera; Wuzhi tablet

Indexed keywords

ALCOHOL; CISPLATIN; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE 1; MALONALDEHYDE; NEUROPROTECTIVE AGENT; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SCHISANDRA SPHENANTHERA EXTRACT; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; HERBACEOUS AGENT; TABLET; WUZHI;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; HISTOPATHOLOGY; KIDNEY DISEASE; KIDNEY INJURY; MALE; MEMBRANE DAMAGE; MOUSE; NEPHROTOXICITY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; SCHISANDRA; TABLET; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING; ANIMAL; CELL LINE; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; HUMAN; KIDNEY; LIPID PEROXIDATION; METABOLISM; PATHOLOGY;

MUS; SCHISANDRA SPHENANTHERA;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CISPLATIN; DRUGS, CHINESE HERBAL; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE-1; HUMANS; KIDNEY; KIDNEY DISEASES; LIPID PEROXIDATION; MALE; MICE; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SCHISANDRA; TABLETS;

EID: 84927586451     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2015.03.003     Document Type: Article

References (26)

1. Ahmad S.T., Sultana S. Tannic acid mitigates cisplatin-induced nephrotoxicity in mice Hum. Exp. Toxicol. 31 2012 145 156
2. Aleksunes L.M., Goedken M.J., Rockwell C.E., Thomale J., Manautou J.E., Klaassen C.D. Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity J. Pharmacol. Exp. Ther. 335 2010 2 12
3. Bi H., Li F., Krausz K.W., Qu A., Johnson C.H., Gonzalez F.J. Targeted metabolomics of serum acylcarnitines evaluates hepatoprotective effect of Wuzhi Tablet (Schisandra sphenanthera extract) against acute acetaminophen toxicity Evidence-Based Complementary Alternat. Med. 2013 2013 985257
4. Cheng N., Ren N., Gao H., Lei X., Zheng J., Cao W. Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice Food Chem. Toxicol. 55 2013 234 240
5. Chirino Y.I., Sanchez-Gonzalez D.J., Martinez-Martinez C.M., Cruz C., Pedraza-Chaverri J. Protective effects of apocynin against cisplatin-induced oxidative stress and nephrotoxicity Toxicology 245 2008 18 23
6. Gao X.M., Wang R.R., Niu D.Y., Meng C.Y., Yang L.M., Zheng Y.T., Yang G.Y., Hu Q.F., Sun H.D., Xiao W.L. Bioactive dibenzocyclooctadiene lignans from the stems of Schisandra neglecta J. Nat. Prod. 76 2013 1052 1057
7. Guerrero-Beltran C.E., Calderon-Oliver M., Tapia E., Medina-Campos O.N., Sanchez-Gonzalez D.J., Martinez-Martinez C.M., Ortiz-Vega K.M., Franco M., Pedraza-Chaverri J. Sulforaphane protects against cisplatin-induced nephrotoxicity Toxicol. Lett. 192 2010 278 285
8. Hsin Y.H., Cheng C.H., Tzen J.T., Wu M.J., Shu K.H., Chen H.C. Effect of aristolochic acid on intracellular calcium concentration and its links with apoptosis in renal tubular cells Apoptosis 11 2006 2167 2177
9. Huang M., Jin J., Sun H., Liu G.T. Reversal of P-glycoprotein-mediated multidrug resistance of cancer cells by five schizandrins isolated from the Chinese herb Fructus Schizandrae Cancer Chemother. Pharmacol. 62 2008 1015 1026
10. Huyke C., Engel K., Simon-Haarhaus B., Quirin K.W., Schempp C.M. Composition and biological activity of different extracts from Schisandra sphenanthera and Schisandra chinensis Planta Med 73 2007 1116 1126
11. Jin J., Bi H., Hu J., Zeng H., Zhong G., Zhao L., Huang Z., Huang M. Effect of Wuzhi tablet (Schisandra sphenanthera extract) on the pharmacokinetics of paclitaxel in rats Phytother. Res. 25 2011 1250 1253
12. Korzeniewski C., Callewaert D.M. An enzyme-release assay for natural cytotoxicity J. Immunol. Methods 64 1983 313 320
13. Li J., Jin J., Li M., Guan C., Wang W., Zhu S., Qiu Y., Huang M., Huang Z. Role of Nrf2 in protection against triptolide-induced toxicity in rat kidney cells Toxicol. Lett. 213 2012 194 202
14. Li Y., Paonessa J.D., Zhang Y. Mechanism of chemical activation of Nrf2 PLoS One 7 2012 e35122
15. Min H.Y., Park E.J., Hong J.Y., Kang Y.J., Kim S.J., Chung H.J., Woo E.R., Hung T.M., Youn U.J., Kim Y.S., Kang S.S., Bae K., Lee S.K. Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells Biorg. Med. Chem. Lett. 18 2008 523 526
16. Moon J.H., Shin J.S., Kim J.B., Baek N.I., Cho Y.W., Lee Y.S., Kay H.Y., Kim S.D., Lee K.T. Protective effects of 6-hydroxy-1-methylindole-3-acetonitrile on cisplatin-induced oxidative nephrotoxicity via Nrf2 inactivation Food Chem. Toxicol. 62C 2013 159 166
17. Pabla N., Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies Kidney Int. 73 2008 994 1007
18. Pan H., Mukhopadhyay P., Rajesh M., Patel V., Mukhopadhyay B., Gao B., Hasko G., Pacher P. Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death J. Pharmacol. Exp. Ther. 328 2009 708 714
19. Perez-Rojas J.M., Cruz C., Garcia-Lopez P., Sanchez-Gonzalez D.J., Martinez-Martinez C.M., Ceballos G., Espinosa M., Melendez-Zajgla J., Pedraza-Chaverri J. Renoprotection by alpha-Mangostin is related to the attenuation in renal oxidative/nitrosative stress induced by cisplatin nephrotoxicity Free Radical Res. 43 2009 1122 1132
20. Qin X.-L., Yu T., Li L.-J., Wang Y., Gu H.-M., Wang Y.-T., Huang M., Bi H.-C. Effect of long-term co-administration of Wuzhi tablet (Schisandra sphenanthera extract) and prednisone on the pharmacokinetics of tacrolimus Phytomedicine 20 2013 375 379
21. Qin X.L., Bi H.C., Wang X.D., Li J.L., Wang Y., Xue X.P., Chen X., Wang C.X., Xu le J., Wang Y.T., Huang M. Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506) Int. J. Pharm. 389 2010 114 121
22. Qin X.L., Chen X., Zhong G.P., Fan X.M., Wang Y., Xue X.P., Huang M., Bi H.C. Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp Phytomedicine 21 2014 766 772
23. Wilmes A., Crean D., Aydin S., Pfaller W., Jennings P., Leonard M.O. Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity Toxicol. In Vitro 25 2011 613 622
24. Yu F.Y., Wu T.S., Chen T.W., Liu B.H. Aristolochic acid I induced oxidative DNA damage associated with glutathione depletion and ERK1/2 activation in human cells Toxicol. In Vitro 25 2011 810 816
25. Yu Y.N., Chen H., Li Y. Protect effect of bicyclol on cisplatin-induced nephrotoxicity in mice Arch. Toxicol. 83 2009 381 387
26. Zuniga-Toala A., Zatarain-Barron Z.L., Hernandez-Pando R., Negrette-Guzman M., Huerta-Yepez S., Torres I., Pinzon E., Tapia E., Pedraza-Chaverri J. Nordihydroguaiaretic acid induces Nrf2 nuclear translocation in vivo and attenuates renal damage and apoptosis in the ischemia and reperfusion model Phytomedicine 20 2013 775 779