Anticancer drug 2-methoxyestradiol protects against renal ischemia/reperfusion injury by reducing inflammatory cytokines expression

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Chen, Ying Yin ^a,b   Yeh, Ching Hua ^c   So, Edmund Cheung ^d   Sun, Ding Ping ^a   Wang, Li Yun ^a   Hsing, Chung Hsi ^a,e  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b NATIONAL FORMOSA UNIVERSITY   (Taiwan)

^c DA YEH UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL; ANTIMYCIN A1; CASPASE 3; CASPASE 9; CREATININE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BNIP3; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; UREA; 2-METHOXYESTRADIOL; CYTOKINE; ESTRADIOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ENZYME ACTIVATION; GENE EXPRESSION; IMMUNOBLOTTING; IN VITRO STUDY; KIDNEY FUNCTION; KIDNEY ISCHEMIA; KIDNEY MASS; KIDNEY PARENCHYMA; KIDNEY TUBULE CELL; MESANGIUM CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UREA NITROGEN BLOOD LEVEL; ACUTE KIDNEY FAILURE; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INFLAMMATION; KIDNEY TRANSPLANTATION; PATHOLOGY;

ADENOVIRIDAE; MUS;

ACUTE KIDNEY INJURY; ANIMALS; CYTOKINES; ESTRADIOL; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; KIDNEY TRANSPLANTATION; MICE; REPERFUSION INJURY; RNA, MESSENGER;

EID: 84927566102     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/431524     Document Type: Article

References (27)

1. C. Sadis, G. Teske, G. Stokman et al., "Nicotine protects kidney fromrenal ischemia/reperfusion injury through the cholinergic anti-inflammatory pathway, " PLoS ONE, vol. 2, no. 5, article e469, 2007.
2. R. Munshi, C. Hsu, and J. Himmelfarb, "Advances in understanding ischemic acute kidney injury, " BMC Medicine, vol. 9, article 11, 2011.
3. A. T. Burns, D. R. Davies, A. J. Mclaren, L. Cerundolo, P. J. Morris, and S. V. Fuggle, "Apoptosis in ischemia/reperfusion injury of human renal allografts, " Transplantation, vol. 66, no. 7, pp. 872-876, 1998.
4. T. Hayashi, Y. Saitou, K. Nose, T. Nishioka, T. Ishii, and H. Uemura, "Efficacy of carvedilol for ischemia/reperfusioninduced oxidative renal injury in rats, " Transplantation Proceedings, vol. 40, no. 7, pp. 2139-2141, 2008.
5. A. Kher, K. K. Meldrum, K. L. Hile et al., "Aprotinin improves kidney function and decreases tubular cell apoptosis and proapoptotic signaling after renal ischemia-reperfusion, " Journal of Thoracic and Cardiovascular Surgery, vol. 130, no. 3, pp. 662. e1-669. e1, 2005.
6. J. Kim, Y. M. Seok, K. Jung, and K. M. Park, "Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice, " The American Journal of Physiology: Renal Physiology, vol. 297, no. 2, pp. F461-F470, 2009.
7. M. E. Sabbahy and V. S. Vaidya, "Ischemic kidney injury and mechanisms of tissue repair, " Wiley Interdisciplinary Reviews: Systems Biology and Medicine, vol. 3, no. 5, pp. 606-618, 2011.
8. K. J. Johnson and J. M. Weinberg, "Postischemic renal injury due to oxygen radicals, " Current Opinion in Nephrology and Hypertension, vol. 2, no. 4, pp. 625-635, 1993.
9. K. Dobashi, B. Ghosh, J. K. Orak, I. Singh, and A. K. Singh, "Kidney ischemia-reperfusion: modulation of antioxidant defenses, " Molecular and Cellular Biochemistry, vol. 205, no. 1-2, pp. 1-11, 2000.
10. J. L. Ricker, Z. Chen, X. P. Yang, V. S. Pribluda, G. M. Swartz, and C. van Waes, "2-Methoxyestradiol inhibits hypoxia-inducible factor 1α, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma, " Clinical Cancer Research, vol. 10, no. 24, pp. 8665-8673, 2004.
11. V. S. Pribluda, E. R. J. Gubish, T. M. LaVallee, A. Treston, G. M. Swartz, and S. J. Green, "2-Methoxyestradiol: an endogenous antiangiogenic and antiproliferative drug candidate, " Cancer and Metastasis Reviews, vol. 19, no. 1-2, pp. 173-179, 2000.
12. A. J. Tevaarwerk, K. D. Holen, D. B. Alberti et al., "Phase i trialof 2-methoxyestradioI NanoCrystal dispersion in advanced solid malignancies, " Clinical Cancer Research, vol. 15, no. 4, pp. 1460-1465, 2009.
13. Y. S. Chua, Y. L. Chua, and T. Hagen, "Structure activity analysis of 2-methoxyestradiol analogues reveals targeting of microtubules as the major mechanism of antiproliferative and proapoptotic activity, "Molecular CancerTherapeutics, vol. 9, no. 1, pp. 224-235, 2010.
14. N. J. Mabjeesh, D. Escuin, T. M. LaVallee et al., "2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF, " Cancer Cell, vol. 3, no. 4, pp. 363-375, 2003.
15. Y. Li, Z. Xia, and L. Chen, "HIF-1-alpha and survivin involved in the antiapoptotic effect of 2ME2 after global ischemia in rats, " Neurological Research, vol. 33, no. 6, pp. 583-592, 2011.
16. S. Yeh, L. Ou, P. Gean, J. Hung, and W. Chang, "Selective inhibition of early-but not late-expressed HIF-1α is neuroprotective in rats after focal ischemic brain damage, " Brain Pathology, vol. 21, no. 3, pp. 249-262, 2011.
17. C. Chen, Q. Hu, J. Yan et al., "Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1α and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model, " Journal of Neurochemistry, vol. 102, no. 6, pp. 1831-1841, 2007.
18. C.-H. Yeh, W. Chou, C.-C. Chu et al., "Anticancer agent 2-methoxyestradiol improves survival in septic mice by reducing the production of cytokines and nitric oxide, " Shock, vol. 36, no. 5, pp. 510-516, 2011.
19. R. Helton, J. Cui, J. R. Scheel et al., "Brain-specific knock-out of hypoxia-inducible factor-1α reduces rather than increases hypoxic-ischemic damage, " Journal of Neuroscience, vol. 25, no. 16, pp. 4099-4107, 2005.
20. C. Rosenberger, S. Mandriota, J. S. Jürgensen et al., "Expression of hypoxia-inducible factor-1α and-2α in hypoxic and ischemic rat kidneys, " Journal of the American Society of Nephrology, vol. 13, no. 7, pp. 1721-1732, 2002.
21. J. Lee, S. Bae, J. Jeong, S. Kim, and K. Kim, "Hypoxia-inducible factor (HIF-1)α: Its protein stability and biological functions, " Experimental and Molecular Medicine, vol. 36, no. 1, pp. 1-12, 2004.
22. M. Matsumoto, Y. Makino, T. Tanaka et al., "Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats, " Journal of the American Society of Nephrology, vol. 14, no. 7, pp. 1825-1832, 2003.
23. W. M. Bernhardt, C. Warnecke, C. Willam, T. Tanaka, M. S. Wiesener, and K. Eckardt, "Organ protection by hypoxia and hypoxia-inducible factors, "Methods in Enzymology, vol. 435, pp. 219-245, 2007.
24. J. W. Calvert, J. Cahill, M. Yamaguchi-Okada, and J. H. Zhang, "Oxygen treatment after experimental hypoxia-ischemia in neonatal rats alters the expression ofHIF-1α and its downstream target genes, " Journal of Applied Physiology, vol. 101, no. 3, pp. 853-865, 2006.
25. C.-H. Yeh, W. Cho, E. C. So et al., "Propofol inhibits lipopolysaccharide-induced lung epithelial cell injury by reducing hypoxia-inducible factor-1α expression, " British Journal of Anaesthesia, vol. 106, no. 4, pp. 590-599, 2011.
26. Y. Li, C. Zhou, J. W. Calvert, A. R. T. Colohan, and J. H. Zhang, "Multiple effects of hyperbaric oxygen on the expression of HIF-1α and apoptotic genes in a global ischemia-hypotension rat model, " Experimental Neurology, vol. 191, no. 1, pp. 198-210, 2005.
27. W. Chen, V. Jadhav, J. Tang, and J. H. Zhang, "HIF-1α inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model, " Neurobiology ofDisease, vol. 31, no. 3, pp. 433-441, 2008.