Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-α/PGC-1α signaling mediated energy biosynthesis

Environmental Toxicology and Pharmacology

Volumn 39, Issue 3, 2015, Pages 1081-1090

  Luan, Aina ^a   Tang, Futian ^a   Yang, Yuhong ^a   Lu, Meili ^a   Wang, Hongxin ^a   Zhang, Yingjie ^a  

^a JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Astragalus polysaccharide; Cardiac hypertrophy; Energy biosynthesis; Hemodynamics; TNF PGC 1 signaling

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ASTRAGALUS POLYSACCHARIDE; ATRIAL NATRIURETIC FACTOR; FATTY ACID; ISOPRENALINE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; POLYSACCHARIDE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PYRUVATE DEHYDROGENASE KINASE 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; HERBACEOUS AGENT; PPARGC1A PROTEIN, RAT; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HEART HEMODYNAMICS; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; HISTOLOGY; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; ASTRAGALUS MEMBRANACEUS; CARDIOMEGALY; CELL CULTURE; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENETICS; INJECTION; MALE; METABOLISM; NEWBORN;

ASTRAGALUS MEMBRANACEUS; RATTUS;

ANIMALS; ANIMALS, NEWBORN; ASTRAGALUS MEMBRANACEUS; CARDIOMEGALY; CELLS, CULTURED; DRUGS, CHINESE HERBAL; ENERGY METABOLISM; GENE EXPRESSION REGULATION; INJECTIONS; ISOPROTERENOL; MALE; POLYSACCHARIDES; RATS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84927553867     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2015.03.014     Document Type: Article

References (28)

1. Alvarez-Guardia D., Palomer X., Coll T., Davidson M.M., Chan T.O., Feldman A.M., Laguna J.C., Vazquez-Carrera M. The p65 subunit of NF-kappaB binds to PGC-1alpha, linking inflammation and metabolic disturbances in cardiac cells. Cardiovasc. Res. 2010, 87:449-458.
2. Arany Z., Novikov M., Chin S., Ma Y., Rosenzweig A., Spiegelman B.M. Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:10086-10091.
3. Bagattin A., Hugendubler L., Mueller E. Transcriptional coactivator PGC-1alpha promotes peroxisomal remodeling and biogenesis. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:20376-20381.
4. Cai R., Gu J., Sun H., Liu X., Mei W., Qi Y., Xue S., Ren S., Rabinowitz J.E., Wang Y., Yeh E.T., Cheng J. Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy. J. Mol. Cell. Cardiol. 2015, 79:115-122.
5. Chen W., Yu M.H., Li Y.M., Chen W.J., Xia Y.P. Beneficial effects of astragalus polysaccharides treatment on cardiac chymase activities and cardiomyopathy in diabetic hamsters. Acta Diabetol. 2010, 47(Suppl. 1):35L 46.
6. Connaughton S., Chowdhury F., Attia R.R., Song S., Zhang Y., Elam M.B., Cook G.A., Park E.A. Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin. Mol. Cell. Endocrinol. 2010, 315:159-167.
7. Cox E.J., Marsh S.A. A systematic review of fetal genes as biomarkers of cardiac hypertrophy in rodent models of diabetes. PLOS ONE 2014, 9:e92903.
8. Dai H., Jia G., Liu X., Liu Z., Wang H. Astragalus polysaccharide inhibits isoprenaline-induced cardiac hypertrophy via suppressing Ca(2)(+)-mediated calcineurin/NFATc3 and CaMKII signaling cascades. Environ. Toxicol. Pharmacol. 2014, 38:263-271.
9. Ding G., Cheng L., Qin Q., Frontin S., Yang Q. PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes. J. Mol. Cell. Cardiol. 2006, 40:821-828.
10. Finck B.N., Kelly D.P. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. Circulation 2007, 115:2540-2548.
11. Gao F., Ni Y., Luo Z., Liang Y., Yan Z., Xu X., Liu D., Wang J., Zhu S., Zhu Z. Atorvastatin attenuates TNF-alpha-induced increase of glucose oxidation through PGC-1alpha upregulation in cardiomyocytes. J. Cardiovasc. Pharmacol. 2012, 59:500-506.
12. He K., Yan L., Pan C.S., Liu Y.Y., Cui Y.C., Hu B.H., Chang X., Li Q., Sun K., Mao X.W., Fan J.Y., Han J.Y. ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia/reperfusion-induced myocardial injury. Am. J. Physiol. Heart Circ. Physiol. 2014, 10.1152/ajpheart.00259.2014:ajpheart 00259 02014.
13. Jaswal J.S., Keung W., Wang W., Ussher J.R., Lopaschuk G.D. Targeting fatty acid and carbohydrate oxidation - a novel therapeutic intervention in the ischemic and failing heart. Biochim. Biophys. Acta 2011, 1813:1333-1350.
14. Jobe L.J., Melendez G.C., Levick S.P., Du Y., Brower G.L., Janicki J.S. TNF-alpha inhibition attenuates adverse myocardial remodeling in a rat model of volume overload. Am. J. Physiol. Heart Circ. Physiol. 2009, 297:H1462-H1468.
15. Kolwicz S.C., Tian R. Glucose metabolism and cardiac hypertrophy. Cardiovasc. Res. 2011, 90:194-201.
16. Lopaschuk G.D., Jaswal J.S. Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation. J. Cardiovasc. Pharmacol. 2010, 56:130-140.
17. Osadchii O.E. Cardiac hypertrophy induced by sustained beta-adrenoreceptor activation: pathophysiological aspects. Heart Fail. Rev. 2007, 12:66-86.
18. Palomer X., Alvarez-Guardia D., Rodriguez-Calvo R., Coll T., Laguna J.C., Davidson M.M., Chan T.O., Feldman A.M., Vazquez-Carrera M. TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model. Cardiovasc. Res. 2009, 81:703-712.
19. Rowe G.C., Jiang A., Arany Z. PGC-1 coactivators in cardiac development and disease. Circ. Res. 2010, 107:825-838.
20. Schilling J., Kelly D.P. The PGC-1 cascade as a therapeutic target for heart failure. J. Mol. Cell. Cardiol. 2011, 51:578-583.
21. Schultheiss H.P. Dysfunction of the ADP/ATP carrier as a causative factor for the disturbance of the myocardial energy metabolism in dilated cardiomyopathy. Basic Res. Cardiol. 1992, 87(Suppl. 1):311-320.
22. Siddiqi N., Singh S., Beadle R., Dawson D., Frenneaux M. Cardiac metabolism in hypertrophy and heart failure: implications for therapy. Heart Fail. Rev. 2013, 18:595-606.
23. Stefanon I., Valero-Munoz M., Fernandes A.A., Ribeiro R.F., Rodriguez C., Miana M., Martinez-Gonzalez J., Spalenza J.S., Lahera V., Vassallo P.F., Cachofeiro V. Left and right ventricle late remodeling following myocardial infarction in rats. PLOS ONE 2013, 8:e64986.
24. Tan X., Li J., Wang X., Chen N., Cai B., Wang G., Shan H., Dong D., Liu Y., Li X., Yang F., Li X., Zhang P., Li X., Yang B., Lu Y. Tanshinone IIA protects against cardiac hypertrophy via inhibiting calcineurin/NFATc3 pathway. Int. J. Biol. Sci. 2011, 7:383-389.
25. Tang K., Wagner P.D., Breen E.C. TNF-alpha-mediated reduction in PGC-1alpha may impair skeletal muscle function after cigarette smoke exposure. J. Cell. Physiol. 2010, 222:320-327.
26. Ventura-Clapier R., Garnier A., Veksler V. Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. Cardiovasc. Res. 2008, 79:208-217.
27. Zhang L., Yang Y., Wang Y., Gao X. Astragalus membranaceus extract promotes neovascularisation by VEGF pathway in rat model of ischemic injury. Pharmazie 2011, 66:144-150.
28. Zhang S., Tang F., Yang Y., Lu M., Luan A., Zhang J., Yang J., Wang H. Astragaloside IV protects against isoproterenol-induced cardiac hypertrophy by regulating NF-kappaB/PGC-1alpha signaling mediated energy biosynthesis. PLOS ONE 2015, 10:e0118759.