Characterization and rapid identification of chemical constituents of NaoXinTong capsules by UHPLC-linear ion trap/Orbitrap mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 111, Issue , 2015, Pages 104-118

  Songsong, Wang ^a,b   Haiyu, Xu ^a   Yan, Ma ^a   Xuguang, Wang ^c   Yang, Shi ^d   Bin, Huang ^a   Shihuan, Tang ^a   Yi, Zhang ^a   Defeng, Li ^a   Rixin, Liang ^a   Hongjun, Yang ^a  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^d SHAANXI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Flavones; Monoterpene glycosides; NaoXinTong capsule; Tanshinones; UHPLC LTQ Orbitrap

Indexed keywords

ALBIFLORIN; AMYGDALIN; BUCHANG NAOXINTONG; BUTYLPHTHALIDE; CATECHIN; CHIKUSETSU SAPONIN; CHINESE DRUG; CINNAMIC ACID; COUMARIN; DAIDZEIN; ECDYSTERONE; FERULIC ACID; FORMONONETIN; GALLIC ACID; GENISTEIN; ISOLIQUIRITIGENIN; KAEMPFEROL; LIGUSTILIDE; LITHOSPERMIC ACID; LUTEOLIN; MANDELIC ACID; NICOTIFLORIN; ONONIN; PAEONIFLORIN; PROLINE; QUERCETIN; RUTOSIDE; SALVIANOLIC ACID B; SCOPOLETIN; SOYASAPONIN I; UNCLASSIFIED DRUG; FLAVONE; FLAVONE DERIVATIVE; GLYCOSIDE; HERBACEOUS AGENT; ION; MICROCAPSULE;

ARTICLE; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; HIGH THROUGHPUT SCREENING; ION TRAP MASS SPECTROMETRY; MICROCAPSULE; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROCEDURES;

CAPSULES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; FLAVONES; GLYCOSIDES; IONS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84927553761     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2015.01.020     Document Type: Article

References (17)

1. Mendis S. Cardiovascular risk assessment and management in developing countries. Vasc. Health Risk Manage. 2005, 1:15-18.
2. Luo J., Xu H., Chen K.J. Potential benefits of Chinese Herbal Medicine for elderly patients with cardiovascular diseases. J. Geriatr. Cardiol. 2013, 10:305-309.
3. Zhang H., Wang W.R., Lin R., Zhang J.Y., Ji Q.L., Lin Q.Q., Yang L.N. Buyang Huanwu decoction ameliorates coronary heart disease with Qi deficiency and blood stasis syndrome by reducing CRP and CD40 in rats. J. Ethnopharmacol. 2010, 130:98-102.
4. Zhao J., Zhu H., Wang S., Ma X., Liu X., Wang C., Zhao H., Fan S., Jin X., Zhao B., Zhao T., Jia L., Wang K., Zou Y., Hu K., Sun A., Ge J. Naoxintong protects against atherosclerosis through lipid-lowering and inhibiting maturation of dendritic cells in LDL receptor knockoutmice fed a high-fat diet. Curr. Pharm. Des. 2013, 19:5891-5896.
5. 2-induced oxidative injury through ERK1/2 signaling pathway. Evid. Based Complement. Alternat. Med. 2013, 2013:802784.
6. Chen D., Lu P., Zhang F.B., Tang S.H., Yang H.J. Molecular mechanism research on simultaneous therapy of brain and heart based on data mining and network analysis. Zhongguo Zhong Yao Za Zhi 2013, 38:91-98.
7. Shaw L.H., Lin L.C., Tsai T.H. HPLC-MS/MS analysis of a traditional Chinese medical formulation of Bu-Yang-Huan-Wu-Tang and its pharmacokinetics after oral administration to rats. PLOS ONE 2012, 7:e43848.
8. Li G., Meng F.Y., Yang H.J., Fang J., Liu F., Fu M.H. UPLC simultaneous determination of five components in Naoxintong capsules. Chin. J. Pharm. Anal. 2013, 33:414-418.
9. Yang M., Sun J., Lu Z., Chen G. Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry. J. Chromatogr. A 2009, 1216:2045-2062.
10. Theodoridis G.A., Gika H.G., Want E.J., Wilson I.D. Liquid chromatography-mass spectrometry based global metabolite profiling: a review. Anal. Chim. Acta 2012, 711:7-16.
11. Qiu X., Zhang J., Huang Z., Zhu D., Xu W. Profiling of phenolic constituents in Polygonum multiflorum Thunb. by combination of ultra-high-pressure liquid chromatography with linear ion trap-Orbitrap mass spectrometry. J. Chromatogr. A 2013, 1292:121-131.
12. Ko Y.C., Feng H.T., Lee R.J., Lee M.R. The determination of flavonoids in Wikstroemia indica C. A. Mey. by liquid chromatography with photo-diode array detection and negative electrospray ionization tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2013, 27:59-67.
13. n. Molecules 2014, 19:5650-5673.
14. Zhou Y., Xu G., Choi F.F., Ding L.S., Han Q.B., Song J.Z., Qiao C.F., Zhao Q.S., Xu H.X. Qualitative and quantitative analysis of diterpenoids in Salvia species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. J. Chromatogr. A 2009, 1216:4847-4858.
15. Ma Z., Zhang M., Song Z. Characterization of tanshinones with quinone reductase induction activity from Radix Salvia miltiorrhiza by liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2009, 23:2857-2866.
16. Xu X., Li F., Zhang X. In vitro synergistic antioxidant activity and identification of antioxidant components from Astragalus membranaceus and Paeonia lactiflora. PLOS ONE 2014, 9:e96780.
17. Yan Z., Chen C., Xie X., Fu B., Yang X. Rapid screening and quantification of sulfonate derivatives in white peony root by UHPLC-MS-MS. Anal. Bioanal. Chem. 2012, 402:2173-2182.