Generation of suppressive blood cells for control of allograft rejection

Clinical Science

Volumn 128, Issue 9, 2015, Pages 593-607

  Kleist, Christian ^a   Sandra Petrescu, Flavius ^a   Jiga, Lucian ^b   Dittmar, Laura ^a   Mohr, Elisabeth ^a   Greil, Johann ^a   Mier, Walter ^a   Becker, Luis E ^a   Lang, Peter ^c   Opelz, Gerhard ^a   Terness, Peter ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b VICTOR BABES UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cell therapy; Organ transplantation; Suppressive cells; Transplant tolerance

Indexed keywords

BIOLOGICAL MARKER; CD4 ANTIGEN; COMPLEMENT COMPONENT C4D; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, RAT; IMMUNOSUPPRESSIVE AGENT; MITOMYCIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CELL; CARDIAC GRAFT REJECTION; DENDRITIC CELL; FEMALE; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; KIDNEY ALLOGRAFT; KIDNEY GRAFT REJECTION; LYMPHOID ORGAN; MALE; MONOCYTE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PIG; PRIORITY JOURNAL; RAT; REGULATORY T LYMPHOCYTE; SPLEEN CELL; ADVERSE EFFECTS; ALLOGRAFT; ANIMAL; BROWN NORWAY RAT; CASE REPORT; CELL CULTURE; CELL SEPARATION; CHILD; DRUG EFFECTS; HUMAN; IMMUNOLOGY; KIDNEY TRANSPLANTATION; LEWIS RAT; METABOLISM; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROCEDURES; SWINE; TIME; TRANSPLANTATION; TRANSPLANTATION TOLERANCE; TREATMENT OUTCOME;

ALLOGRAFTS; ANIMALS; BIOLOGICAL MARKERS; CELL SEPARATION; CELLS, CULTURED; CHILD; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; KIDNEY TRANSPLANTATION; MALE; MITOMYCIN; MONOCYTES; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RATS, INBRED BN; RATS, INBRED LEW; SWINE; T-LYMPHOCYTES, REGULATORY; TIME FACTORS; TRANSPLANTATION TOLERANCE; TREATMENT OUTCOME;

EID: 84927170726     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20140258     Document Type: Article

References (52)

1. Ruiz, P., Maldonado, P., Hidalgo, Y., Gleisner, A., Sauma, D., Silva, C., Saez, J.J., Nunez, S., Rosemblatt, M. and Bono, M.R. (2013) Transplant tolerance: new insights and strategies for long-term allograft acceptance. Clin. Dev. Immunol. 2013, 210506
2. Page, E.K., Dar, W.A. and Knechtle, S.J. (2012) Tolerogenic therapies in transplantation. Front. Immunol. 3, 198
3. Verweij, J. and Pinedo, H.M. (1990) Mitomycin C: mechanism of action, usefulness and limitations. Anticancer Drugs 1, 5-13
4. Jiga, L.P., Ehser, S., Kleist, C., Opelz, G. and Terness, P. (2007) Inhibition of heart allograft rejection with mitomycin C-treated donor dendritic cells. Transplantation 83, 347-350
5. Terness, P., Oelert, T., Ehser, S., Chuang, J.J., Lahdou, I., Kleist, C., Velten, F., Hammerling, G.J., Arnold, B. and Opelz, G. (2008) Mitomycin C-treated dendritic cells inactivate autoreactive T cells: toward the development of a tolerogenic vaccine in autoimmune diseases. Proc. Natl. Acad. Sci. U.S.A. 105, 18442-18447
6. Ueno, H., Klechevsky, E., Morita, R., Aspord, C., Cao, T., Matsui, T., Di Pucchio, T., Connolly, J., Fay, J.W., Pascual, V. et al. (2007) Dendritic cell subsets in health and disease. Immunol. Rev. 219, 118-142
7. Jiga, L.P., Cristian, H., Blidisel, A., Sandra, F., Nistor, A., Hoinoiu, B., Dornean, V. and Ionac, M. (2008) Thoracoscopic approach of the internal mammary artery (IMA): a training model in pigs. Microsurgery 28, 375-379
8. Ono, K. and Lindsey, E.S. (1969) Improved technique of heart transplantation in rats. J. Thorac. Cardiovasc. Surg. 57, 225-229
9. Wang, D., Opelz, G. and Terness, P. (2006) A simplified technique for heart transplantation in rats: abdominal vessel branch-sparing and modified venotomy. Microsurgery 26, 470-472
10. Racusen, L.C., Solez, K., Colvin, R.B., Bonsib, S.M., Castro, M.C., Cavallo, T., Croker, B.P., Demetris, A.J., Drachenberg, C.B., Fogo, A.B. et al. (1999) The Banff 97 working classification of renal allograft pathology. Kidney Int. 55, 713-723
11. Roca, M., de Vries, E.F., Jamar, F., Israel, O. and Signore, A. (2010) Guidelines for the labelling of leucocytes with (111)In-oxine. Inflammation/Infection Taskgroup of the European Association of Nuclear Medicine. Eur. J. Nucl. Med. Mol. Imaging 37, 835-841
12. Thakur, M.L., Lavender, J.P., Arnot, R.N., Silvester, D.J. and Segal, A.W. (1977) Indium-111-labeled autologous leukocytes in man. J. Nucl. Med. 18, 1014-1021
13. Lang, P., Mueller, I., Greil, J., Bader, P., Schumm, M., Pfeiffer, M., Hoelle, W., Klingebiel, T., Heinzelmann, F., Belka, C. et al. (2008) Retransplantation with stem cells from mismatched related donors after graft rejection in pediatric patients. Blood Cells Mol. Dis. 40, 33-39
14. Liu, K., Iyoda, T., Saternus, M., Kimura, Y., Inaba, K. and Steinman, R.M. (2002) Immune tolerance after delivery of dying cells to dendritic cells in situ. J. Exp. Med. 196, 1091-1097
15. Kushwah, R. and Hu, J. (2010) Dendritic cell apoptosis: regulation of tolerance versus immunity. J. Immunol. 185, 795-802
16. Opelz, G., Sengar, D.P., Mickey, M.R. and Terasaki, P.I. (1973) Effect of blood transfusions on subsequent kidney transplants. Transplant. Proc. 5, 253-259
17. Bittencourt, M.C., Perruche, S., Contassot, E., Fresnay, S., Baron, M.H., Angonin, R., Aubin, F., Herve, P., Tiberghien, P. and Saas, P. (2001) Intravenous injection of apoptotic leukocytes enhances bone marrow engraftment across major histocompatibility barriers. Blood 98, 224-230
18. Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G.M., Apetoh, L., Perfettini, J.L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N. et al. (2007) Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat. Med. 13, 54-61
19. Chernysheva, A.D., Kirou, K.A. and Crow, M.K. (2002) T cell proliferation induced by autologous non-T cells is a response to apoptotic cells processed by dendritic cells. J. Immunol. 169, 1241-1250
20. Ip, W.K. and Lau, Y.L. (2004) Distinct maturation of, but not migration between, human monocyte-derived dendritic cells upon ingestion of apoptotic cells of early or late phases. J. Immunol. 173, 189-196
21. Ronchetti, A., Rovere, P., Iezzi, G., Galati, G., Heltai, S., Protti, M.P., Garancini, M.P., Manfredi, A.A., Rugarli, C. and Bellone, M. (1999) Immunogenicity of apoptotic cells in vivo: role of antigen load, antigen-presenting cells, and cytokines. J. Immunol. 163, 130-136
22. Feng, H., Zeng, Y., Graner, M.W., Likhacheva, A. and Katsanis, E. (2003) Exogenous stress proteins enhance the immunogenicity of apoptotic tumor cells and stimulate antitumor immunity. Blood 101, 245-252
23. Skoberne, M., Beignon, A.S., Larsson, M. and Bhardwaj, N. (2005) Apoptotic cells at the crossroads of tolerance and immunity. Curr. Top. Microbiol. Immunol. 289, 259-292
24. Marti, H.P., Henschkowski, J., Laux, G., Vogt, B., Seiler, C., Opelz, G. and Frey, F.J. (2006) Effect of donor-specific transfusions on the outcome of renal allografts in the cyclosporine era. Transpl. Int. 19, 19-26
25. Opelz, G., Vanrenterghem, Y., Kirste, G., Gray, D.W., Horsburgh, T., Lachance, J.G., Largiader, F., Lange, H., Vujaklija-Stipanovic, K., Alvarez-Grande, J. et al. (1997) Prospective evaluation of pretransplant blood transfusions in cadaver kidney recipients. Transplantation 63, 964-967
26. Terness, P., Schiffl, R., Susal, C. and Opelz, G. (1988) Induction of a suppressive serum factor, prevention of sensitization, and prolongation of kidney graft survival in rats by transfusion with antibody-coated blood cells. Transplantation 46, 812-819
27. Demirkiran, A., Hendrikx, T.K., Baan, C.C. and van der Laan, L.J. (2008) Impact of immunosuppressive drugs on CD4+CD25+FOXP3+ regulatory T cells: does in vitro evidence translate to the clinical setting? Transplantation 85, 783-789
28. Just, U., Dimou, E., Knobler, R., Klosner, G., Ivancic-Brandenberger, E., Greinix, H., Becherer, A. and Trautinger, F. (2012) Leucocyte scintigraphy with 111In-oxine for assessment of cell trafficking after extracorporeal photopheresis. Exp. Dermatol. 21, 443-447
29. Kawai, T., Cosimi, A.B., Spitzer, T.R., Tolkoff-Rubin, N., Suthanthiran, M., Saidman, S.L., Shaffer, J., Preffer, F.I., Ding, R., Sharma, V. et al. (2008) HLA-mismatched renal transplantation without maintenance immunosuppression. N. Engl. J. Med. 358, 353-361
30. Sachs, D.H., Sykes, M., Kawai, T. and Cosimi, A.B. (2011) Immuno-intervention for the induction of transplantation tolerance through mixed chimerism. Semin. Immunol. 23, 165-173
31. Scandling, J.D., Busque, S., Dejbakhsh-Jones, S., Benike, C., Sarwal, M., Millan, M.T., Shizuru, J.A., Lowsky, R., Engleman, E.G. and Strober, S. (2012) Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants. Am. J. Transplant. 12, 1133-1145
32. Spitzer, T.R., Sykes, M., Tolkoff-Rubin, N., Kawai, T., McAfee, S.L., Dey, B.R., Ballen, K., Delmonico, F., Saidman, S., Sachs, D.H. and Cosimi, A.B. (2011) Long-term follow-up of recipients of combined human leukocyte antigen-matched bone marrow and kidney transplantation for multiple myeloma with end-stage renal disease. Transplantation 91, 672-676
33. Brunstein, C.G., Miller, J.S., Cao, Q., McKenna, D.H., Hippen, K.L., Curtsinger, J., Defor, T., Levine, B.L., June, C.H., Rubinstein, P. et al. (2011) Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 117, 1061-1070
34. Di Ianni, M., Falzetti, F., Carotti, A., Terenzi, A., Castellino, F., Bonifacio, E., Del Papa, B., Zei, T., Ostini, R.I., Cecchini, D. et al. (2011) Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 117, 3921-3928
35. Trzonkowski, P., Bieniaszewska, M., Juscinska, J., Dobyszuk, A., Krzystyniak, A., Marek, N., Mysliwska, J. and Hellmann, A. (2009) First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells. Clin. Immunol. 133, 22-26
36. Tang, Q., Bluestone, J.A. and Kang, S.M. (2012) CD4(+)Foxp3(+) regulatory T cell therapy in transplantation. J. Mol. Cell. Biol. 4, 11-21
37. Zheng, Y., Josefowicz, S., Chaudhry, A., Peng, X.P., Forbush, K. and Rudensky, A.Y. (2010) Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463, 808-812
38. Wang, L., de Zoeten, E.F., Greene, M.I. and Hancock, W.W. (2009) Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells. Nat. Rev. Drug Discov. 8, 969-981
39. Xiao, Y., Li, B., Zhou, Z., Hancock, W.W., Zhang, H. and Greene, M.I. (2010) Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function. Curr. Opin. Immunol. 22, 583-591
40. Moreau, A., Varey, E., Beriou, G., Hill, M., Bouchet-Delbos, L., Segovia, M. and Cuturi, M.C. (2012) Tolerogenic dendritic cells and negative vaccination in transplantation: from rodents to clinical trials. Front. Immunol. 3, 218
41. van Kooten, C., Lombardi, G., Gelderman, K.A., Sagoo, P., Buckland, M., Lechler, R. and Cuturi, M.C. (2011) Dendritic cells as a tool to induce transplantation tolerance: obstacles and opportunities. Transplantation 91, 2-7
42. Le Blanc, K., Frassoni, F., Ball, L., Locatelli, F., Roelofs, H., Lewis, I., Lanino, E., Sundberg, B., Bernardo, M.E., Remberger, M. et al. (2008) Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 371, 1579-1586
43. Allison, M. (2009) Genzyme backs Osiris, despite Prochymal flop. Nat. Biotechnol. 27, 966-967
44. Ankrum, J. and Karp, J.M. (2010) Mesenchymal stem cell therapy: two steps forward, one step back. Trends Mol. Med. 16, 203-209
45. Hutchinson, J.A., Riquelme, P., Brem-Exner, B.G., Schulze, M., Matthai, M., Renders, L., Kunzendorf, U., Geissler, E.K. and Fandrich, F. (2008) Transplant acceptance-inducing cells as an immune-conditioning therapy in renal transplantation. Transpl. Int. 21, 728-741
46. Hutchinson, J.A., Brem-Exner, B.G., Riquelme, P., Roelen, D., Schulze, M., Ivens, K., Grabensee, B., Witzke, O., Philipp, T., Renders, L. et al. (2008) A cell-based approach to the minimization of immunosuppression in renal transplantation. Transpl. Int. 21, 742-754
47. Bluestone, J.A., Thomson, A.W., Shevach, E.M. and Weiner, H.L. (2007) What does the future hold for cell-based tolerogenic therapy? Nat. Rev. Immunol. 7, 650-654
48. Grochowiecki, T., Gotoh, M., Dono, K., Takeda, Y., Nishihara, M., Ohta, Y., Kimura, F., Ohzato, H., Umeshita, K., Sakon, M. and Monden, M. (1998) Pretreatment of crude pancreatic islets with mitomycin C (MMC) prolongs islet graft survival in a xenogeneic rat-to-mouse model. Cell Transplant. 7, 411-412
49. Liu, L., Wang, F., Zheng, Y., Yuan, X., Wang, D., Zeng, W., He, X., Wang, C. and Deng, S. (2014) Pretreatment of transfused donor splenocytes and allografts with mitomycin C attenuates acute rejection in heart transplantation in mice. Transplant. Proc. 46, 1169-1174
50. Wang, D., Kleist, C., Ehser, S., Opelz, G. and Terness, P. (2006) Ex vivo perfusion with mitomycin C containing solution prolongs heart graft survival in rats. Transplantation 82, 1537-1540
51. Yamaguchi, Y., Harland, R., Wyble, C., Mori, K. and Bollinger, R.R. (1989) Variable allograft responses to pretreatment with donor splenocytes treated with mitomycin C in the rat. Transplantation 47, 360-363
52. Radu, C.A., Kiefer, J., Horn, D., Kleist, C., Dittmar, L., Sandra, F., Rebel, M., Ryssel, H., Koellensperger, E., Gebhard, M.M. et al. (2012) Mitomycin-C-treated peripheral blood mononuclear cells (PBMCs) prolong allograft survival in composite tissue allotransplantation. J. Surg. Res. 176, e95-e101