Single perioperative dose of tranexamic acid in primary hip and knee arthroplasty

European Journal of Orthopaedic Surgery and Traumatology

Volumn 25, Issue 1, 2015, Pages 129-133

  George, D A ^a   Sarraf, K M ^a   Nwaboku, H ^a  

^a BARNET HOSPITAL   (United Kingdom)

Author keywords

Blood loss; Hip arthroplasty; Knee arthroplasty; Perioperative; Single dose; Tranexamic acid

Indexed keywords

TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; COHORT ANALYSIS; COST EFFECTIVENESS ANALYSIS; DRUG EFFECT; ERYTHROCYTE VOLUME; FEMALE; HIP ARTHROPLASTY; HUMAN; KNEE ARTHROPLASTY; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; OPERATIVE BLOOD LOSS; OUTCOME ASSESSMENT; PERIOPERATIVE PERIOD; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SINGLE DRUG DOSE; THROMBOEMBOLISM; TREATMENT INDICATION; ADVERSE EFFECTS; BLOOD LOSS, SURGICAL; BLOOD VOLUME; CHEMICALLY INDUCED; DRUG EFFECTS; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; PROCEDURES; VEIN THROMBOSIS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; BLOOD VOLUME; ERYTHROCYTE VOLUME; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; LENGTH OF STAY; MALE; MIDDLE AGED; PERIOPERATIVE CARE; RETROSPECTIVE STUDIES; TRANEXAMIC ACID; VENOUS THROMBOSIS;

EID: 84927129701     PISSN: 16338065     EISSN: 14321068     Source Type: Journal    
DOI: 10.1007/s00590-014-1457-5     Document Type: Article

References (26)

1. Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, (CRASH-2 collaborators) et al (2010) Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage: a randomised, placebo-controlled trial. Lancet 376:23-32
2. Roberts I, Shakur H, Ker K, Coats T, (CRASH-2 collaborators) (2011) Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev 1:CD004896
3. Marti DN, Schaller J, Llinas M (1999) Solution structure and dynamics of the plasminogen kringle 2-AMCHA complex: 3(1)-helix in homologous domains. Biochemistry 38(48):15741-15755
4. Okamoto S, Hijikata-Okunomiya A, Wanaka K, Okada Y, Okamoto U (1997) Enzyme controlling medicines. Semin Thromb Hemost 23(6):493-501
5. Sukeik M, Alshryda S, Haddad FS, Mason JM (2001) Systematic review and meta-analysis of the use of tranexamic acid in total hip replacement. J Bone Joint Surg 93(1):39-46
6. Henry DA, Carless PA, Moxey AJ et al (2007) Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 4:CD001886
7. Ker K, Edwards P, Perel P, Shakur H, Roberts I (2012) Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 344:e3054
8. Bradshaw AR, Monoghan J, Campbell D (2012) Oral tranexamic acid reduces blood loss in total knee replacement arthroplasty. Curr Orthop Pract 23(3):209-212
9. Wong J, Abrishami A, El Beheiry H, Mahomed NN, Davey JR, Gandhi R, Syed KA et al (2010) Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg Am 92(15):2503-2513
10. Elwatidy S, Jamjoom Z, Elgamal E, Zakaria A, Turkistani A, El-Dawlatly A (2008) Efficacy and safety of prophylactic large dose of tranexamic acid in spine surgery: a prospective, randomized, double-blind, placebo-controlled study. Spine 33(24):2577-2580
11. Nadler SB, Hidalgo JU, Bloch T (1962) Prediction of blood volume in normal human adults. Surgery 51:224-232
12. March GM, Elfatori S, Beaule´ PE (2013) Clinical experience with tranexamic acid during primary total hip arthroplasty. Hip Int 23(1):72-79
13. Yamasaki S, Masuhara K, Fuji T (2004) Tranexamic acid reduces blood loss after cementless total hip arthroplasty-prospective randomized study in 40 cases. Int Orthop 28(2):69-73
14. Claeys MA, Vermeersch N, Haentjens P (2007) Reduction of blood loss with tranexamic acid in primary total hip replacement surgery. Acta Chir Belg 107:397-401
15. Ralley FE, Berta D, Binns V, Howard J, Naudie DDR (2010) One Intraoperative dose of tranexamic acid for patients having primary hip or knee arthroplasty. Clin Orthop Relat Res 468(7):1905-1911
16. MacGillivray RG, Tarabichi SA, Hawari MF, Raoof NT (2011) Tranexamic acid to reduce blood loss after bilateral total knee arthroplasty: a prospective, randomized double blind study. J Arthroplast 26(1):24-28
17. Benoni G, Björkman S, Fredin H (1995) Application of pharmacokinetic data from healthy volunteers for the prediction of plasma concentrations of tranexamic acid in surgical patients. Clin Drug Invest 10(5):280-287
18. Horrow JC, Van Riper DF, Strong MD, Grunewald KE, Parmet JL (1995) The dose-response relationship of tranexamic acid. Anesthesiology 82(2):383-392
19. Meda Pharmaceuticals, Cyklokapron Tablets (2013) Summary of product characteristics. Updated 3 June 2013. http://www.medi cines.org.uk/. Visited 3 July 2013
20. Tanaka N, Sakahashi H, Sato E, Hirose K, Ishima T, Gorinbashi S, Ishii S (2001) Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. JBJS Br 83B(5):702-705
21. Imai N, Dohmae Y, Suda K, Miyasaka D, Ito T, Endo N (2012) Tranexamic acid for reduction of blood loss during total hip arthroplasty. J Arthroplast 27(10):1838-1843
22. Benoni G, Lethagen S, Nilsson P, Fredin H (2000) Tranexamic acid, given at the end of the operation, does not reduce postoperative blood loss in hip arthroplasty. Acta Orthop Scand 71(3):250-254
23. NHS Blood and Transplant (2013) Blood and Components. Price list. 2013/14. http://hospital.blood.co.uk/library/pdf/price:list_2013_14.pdf. Accessed 16 November 2013
24. BNF (British National Formulary) (2013) Tranexamic acid. BMJ Group/Royal Pharmaceutical Society of Great Britain. BMJ Publishing Group Ltd/RCPCH Publications Ltd, London
25. Guerriero C, Cairns J, Perel P, Shakur H, Roberts I (2011) Clinical randomization of an antifibrinolytic in significant hemorrhage 2 trial collaborators. Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial. PLoS One 6(5):e18987
26. Guerriero C, Cairns J, Jayaraman S, Roberts I, Perel P, Shakur H (2010) Giving tranexamic acid to reduce surgical bleeding in sub-Saharan Africa: an economic evaluation. Cost Eff Resour Alloc 8:1