An oncogenic enhancer enemy (N-Me) in T-ALL

Cell Cycle

Volumn 14, Issue 2, 2015, Pages 167-168

  Herranz, Daniel ^a   Ferrando, Adolfo A ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR; NOTCH1 RECEPTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; BONE MARROW PROGENITOR CELL; CELL GROWTH; DNA SEQUENCE; EDITORIAL; ENHANCER REGION; HUMAN; LEUKEMIA CELL; NONHUMAN; ONCOGENE MYC; ONCOGENIC ENHANCER ENEMY; T CELL ACUTE LYMPHOBLASTIC LEUKEMIA; T CELL LEUKEMIA; T LYMPHOCYTE; ANIMAL; FEMALE; GENETICS; MALE;

ANIMALS; ENHANCER ELEMENTS, GENETIC; FEMALE; GENES, MYC; HUMANS; MALE; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECEPTOR, NOTCH1;

EID: 84927124456     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/15384101.2014.989129     Document Type: Editorial

References (8)

1. Tzoneva G, Ferrando AA. Recent advances on NOTCH signaling in T-ALL. Curr Top Microbiol Immunol 2012; 360:163-82; PMID:22673746; http://dx.doi.org/10.1007/82-2012-232
2. Palomero T, Lim WK, Odom DT, Sulis ML, Real PJ, Margolin A, Barnes KC, O'Neil J, Neuberg D, Weng AP, et al. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A 2006; 103:18261-6; PMID:17114293, http://dx.doi.org/10.1073/pnas.0606108103
3. Herranz D, Ambesi-Impiombato A, Palomero T, Schnell SA, Belver L, Wendorff AA, Xu L, Castillo-Martin M, Llobet-Navás D, Cordon-Cardo C, et al. A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. Nat Med 2014; 20:1130-7); PMID:25194570, http://dx.doi.org/10.1038/nm.3665
4. Dose, M., Khan I, Guo Z, Kovalovsky D, Krueger A, von Boehmer H, Khazaie K, Gounari F. c-Myc mediates pre-TCR-induced proliferation but not developmental progression. Blood 2006; 108:2669-77; PMID:16788099, http://dx.doi.org/10.1182/blood-2006-02-005900
5. Shi, J, Whyte WA, Zepeda-Mendoza CJ, Milazzo JP, Shen C, Roe JS, Minder JL, Mercan F, Wang E, Eckersley-Maslin MA, et al. Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev 2013; 27:2648-62; PMID:24285714, http://dx.doi.org/10.1101/gad.232710.113
6. Sur, IK, Hallikas O, Vähärautio A, Yan J, Turunen M, Enge M, Taipale M, Karhu A, Aaltonen LA, Taipale J. Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors. Science 2012; 338:1360-3; PMID:23118011, http://dx.doi.org/10.1126/science.1228606
7. Allen TD, Rodriguez EM, Jones KD, Bishop JM. Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung adenocarcinoma. Cancer Res 2011; 71, 6010-8; PMID:21803744, http://dx.doi.org/10.1158/0008-5472.CAN-11-0595
8. Klinakis A., Szabolcs M, Politi K, Kiaris H, Artavanis-Tsakonas S, Efstratiadis A. Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc Natl Acad Sci U S A 2006; 103, 9262-7; PMID:16751266, http://dx.doi.org/10.1073/pnas.0603371103