Evaluation of detection sensitivity in comprehensive two-dimensional liquid chromatography separations of an active pharmaceutical ingredient and its degradants

Analytical and Bioanalytical Chemistry

Volumn 407, Issue 1, 2015, Pages 265-277

  Stoll, Dwight R ^a   Talus, Eric S ^a   Harmes, David C ^a   Zhang, Kelly ^b  

^a GUSTAVUS ADOLPHUS COLLEGE   (United States)

^b GENENTECH INC   (United States)

Author keywords

Comprehensive; Degradation; Liquid chromatography; Pharmaceutical analysis; Sensitivity; Two dimensional

Indexed keywords

DEGRADATION; EFFLUENTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LIQUIDS; SENSITIVITY ANALYSIS; SEPARATION; TRANSPORT PROPERTIES; TWO DIMENSIONAL; WATER INJECTION;

ACTIVE PHARMACEUTICAL INGREDIENTS; COMPREHENSIVE; COMPREHENSIVE TWO-DIMENSIONAL; COMPREHENSIVE TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY; DETECTION SENSITIVITY; PHARMACEUTICAL ANALYSIS; SECOND-DIMENSION COLUMN; SENSITIVITY;

CHROMATOGRAPHY;

DRUG;

CHEMISTRY; DEVICES; EVALUATION STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROCEDURES; SENSITIVITY AND SPECIFICITY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; PHARMACEUTICAL PREPARATIONS; SENSITIVITY AND SPECIFICITY;

EID: 84926678971     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-014-8036-9     Document Type: Article

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