Mucosal-associated invariant T cells in inflammatory bowel diseases: Bystanders, defenders, or offenders?

Frontiers in Immunology

Volumn 6, Issue FEB, 2015, Pages

  Treiner, Emmanuel ^a  

^a France   (France)

Author keywords

Cytokines; Inflammation; Inflammatory bowel diseases; Innate lymphocytes; MAIT cells

Indexed keywords

CD161 ANTIGEN; CRYOPYRIN; DIPEPTIDYL PEPTIDASE IV; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR BETA2; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 18 RECEPTOR ALPHA; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; SECUKINUMAB; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

CD8+ T LYMPHOCYTE; CELL MIGRATION; CELL SURVIVAL; CYTOKINE PRODUCTION; GENETIC POLYMORPHISM; IMMUNE RESPONSE; INFLAMMATION; INFLAMMATORY BOWEL DISEASE; INTESTINE FLORA; INTESTINE MUCOSA; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MUCOSAL ASSOCIATED INVARIANT T CELL; NOTE; T LYMPHOCYTE;

EID: 84926678405     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00027     Document Type: Note

References (12)

1. Tilloy F, Treiner E, Park SH, Garcia C, Lemonnier F, de la Salle H, et al. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. J Exp Med (1999) 189(12):1907-21. doi: 10.1084/jem.189.12.1907
2. Dusseaux M, Martin E, Serriari N, Peguillet I, Premel V, Louis D, et al. Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood (2011) 117(4):1250-9. doi:10.1182/blood-2010-08-303339
3. Patel O, Kjer-Nielsen L, Le Nours J, Eckle SB, Birkinshaw R, Beddoe T, et al. Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nat Commun (2013) 4:2142. doi:10.1038/ncomms3142
4. Ussher JE, Klenerman P, Willberg CB. Mucosal-associated invariant T-cells: new players in anti-bacterial immunity. Front Immunol (2014) 5:450. doi:10.3389/fimmu.2014.00450
5. Serriari NE, Eoche M, Lamotte L, Lion J, Fumery M, Marcelo P, et al. Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases. Clin Exp Immunol (2014) 176(2):266-74. doi:10.1111/cei.12277
6. Ussher JE, Bilton M, Attwod E, Shadwell J, Richardson R, de Lara C, et al. CD161++ CD8+ T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner. Eur J Immunol (2014) 44(1):195-203. doi:10.1002/eji.201343509
7. Jo J, Tan AT, Ussher JE, Sandalova E, Tang XZ, Tan-Garcia A, et al. Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver. PLoS Pathog (2014) 10(6):e1004210. doi:10.1371/journal.ppat.1004210
8. Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology (2011) 140(6):1756-67. doi:10.1053/j.gastro.2011.02.016
9. O'Connor W Jr, Zenewicz LA, Flavell RA. The dual nature of T(H)17 cells: shifting the focus to function. Nat Immunol (2010) 11(6):471-6. doi:10.1038/ni.1882
10. O'Connor W Jr, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, et al. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol (2009) 10(6):603-9. doi:10.1038/ni.1736
11. Hueber W, Sands BE, Lewitzky S, Vandemeulebroecke M, Reinisch W, Higgins PD, et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut (2012) 61(12):1693-700. doi:10.1136/gutjnl-2011-301668
12. Dige A, Stoy S, Rasmussen TK, Kelsen J, Hvas CL, Sandahl TD, et al. Increased levels of circulating Th17 cells in quiescent versus active Crohn's disease. J Crohns Colitis (2013) 7(3):248-55. doi:10.1016/j.crohns.2012.06.015