메뉴 건너뛰기




Volumn 5, Issue NOV, 2014, Pages

Quantitative systems pharmacology can reduce attrition and improve productivity in pharmaceutical research and development

Author keywords

Drug discovery and development; Modeling and simulation; Pharmaceutical R D; Pharmacometrics; Quantitative systems pharmacology; Systems biology

Indexed keywords

ARTICLE; COMPUTER MODEL; COMPUTER SIMULATION; DECISION SUPPORT SYSTEM; DRUG APPROVAL; DRUG DEVELOPMENT; MEDICAL RESEARCH; METHODOLOGY; PHARMACEUTICAL RESEARCH AND DEVELOPMENT; PROCESS DEVELOPMENT; PROCESS MODEL; QUANTITATIVE SYSTEMS PHARMACOLOGY; SYSTEM ANALYSIS;

EID: 84926673199     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2014.00247     Document Type: Article
Times cited : (57)

References (22)
  • 1
    • 82255183162 scopus 로고    scopus 로고
    • Integration not isolation: arguing the case for quantitative and systems pharmacology in drug discovery and development
    • Agoram, B. M., and Demin, O. (2011). Integration not isolation: arguing the case for quantitative and systems pharmacology in drug discovery and development. Drug Discov. Today 16, 1031-1036. doi: 10.1016/j.drudis.2011.10.001
    • (2011) Drug Discov. Today , vol.16 , pp. 1031-1036
    • Agoram, B.M.1    Demin, O.2
  • 2
    • 0021441822 scopus 로고
    • Pharmacognosy: the oldest modern science
    • de Pasquale, A. (1984). Pharmacognosy: the oldest modern science. J. Ethnopharmacol. 11, 1-16. doi: 10.1016/0378-8741(84)90092-8
    • (1984) J. Ethnopharmacol. , vol.11 , pp. 1-16
    • de Pasquale, A.1
  • 3
    • 34548324706 scopus 로고    scopus 로고
    • The cost of biopharmaceutical R&D: is biotech different?
    • DiMasi, J. A., and Grabowski, H. (2007). The cost of biopharmaceutical R&D: is biotech different? MDE Manage. Decis. Econ. 28, 469-479. doi: 10.1002/mde.1360
    • (2007) MDE Manage. Decis. Econ , vol.28 , pp. 469-479
    • DiMasi, J.A.1    Grabowski, H.2
  • 4
    • 0034677966 scopus 로고    scopus 로고
    • Drug discovery: a historical perspective
    • Drews, J. (2000). Drug discovery: a historical perspective. Science 287, 1960-1964. doi: 10.1126/science.287.5460.1960
    • (2000) Science , vol.287 , pp. 1960-1964
    • Drews, J.1
  • 5
    • 52649130373 scopus 로고    scopus 로고
    • Whole body physiologically-based pharmacokinetic models: their use in clinical drug development
    • Edginton, A. N., Theil, F. P., Schmitt, W., and Willmann, S. (2008). Whole body physiologically-based pharmacokinetic models: their use in clinical drug development. Expert Opin. Drug Metab. Toxicol. 4, 1143-1152. doi: 10.1517/17425255.4.9.1143
    • (2008) Expert Opin. Drug Metab. Toxicol. , vol.4 , pp. 1143-1152
    • Edginton, A.N.1    Theil, F.P.2    Schmitt, W.3    Willmann, S.4
  • 6
    • 80054718671 scopus 로고    scopus 로고
    • A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks
    • Eissing, T., Kuepfer, L., Becker, C., Block, M., Coboeken, K., Gaub, T., et al. (2011). A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks. Front. Physiol. 2:4. doi: 10.3389/fphys.2011.00004
    • (2011) Front. Physiol , vol.2 , pp. 4
    • Eissing, T.1    Kuepfer, L.2    Becker, C.3    Block, M.4    Coboeken, K.5    Gaub, T.6
  • 7
    • 84881149060 scopus 로고    scopus 로고
    • A quantitative system pharmacology computer model for cognitive deficits in schizophrenia
    • Geerts, H., Roberts, P., and Spiros, A. (2013a). A quantitative system pharmacology computer model for cognitive deficits in schizophrenia. CPT Pharmacometrics Syst. Pharmacol. 2:e36. doi: 10.1038/psp.2013.12
    • (2013) CPT Pharmacometrics Syst. Pharmacol , vol.2 , pp. e36
    • Geerts, H.1    Roberts, P.2    Spiros, A.3
  • 8
    • 84881511797 scopus 로고    scopus 로고
    • A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer's disease
    • Geerts, H., Roberts, P., Spiros, A., and Carr, R. (2013b). A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer's disease. Front. Pharmacol. 4:47. doi: 10.3389/fphar.2013.00047
    • (2013) Front. Pharmacol , vol.4 , pp. 47
    • Geerts, H.1    Roberts, P.2    Spiros, A.3    Carr, R.4
  • 11
    • 28444451169 scopus 로고    scopus 로고
    • A strategy for preclinical formulation development using GastroPlus as pharmacokinetic simulation tool and a statistical screening design applied to a dog study
    • Kuentz, M., Nick, S., Parrott, N., and Rothlisberger, D. (2006). A strategy for preclinical formulation development using GastroPlus as pharmacokinetic simulation tool and a statistical screening design applied to a dog study. Eur. J. Pharm. Sci. 27, 91-99. doi: 10.1016/j.ejps.2005.08.011
    • (2006) Eur. J. Pharm. Sci. , vol.27 , pp. 91-99
    • Kuentz, M.1    Nick, S.2    Parrott, N.3    Rothlisberger, D.4
  • 12
    • 84926686878 scopus 로고    scopus 로고
    • [online]. Available at: [accessed October 13, 2014].
    • Merrimack Pharmaceuticals Inc. (2014). Science [online]. Available at: http://merrimackpharma.com/science[accessed October 13, 2014].
    • (2014) Science
  • 13
    • 79957889347 scopus 로고    scopus 로고
    • The productivity crisis in pharmaceutical R&D
    • Pammolli, F., Magazzini, L., and Riccaboni, M. (2011). The productivity crisis in pharmaceutical R&D. Nat. Rev. Drug Discov. 10, 428-438. doi: 10.1038/nrd3405
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 428-438
    • Pammolli, F.1    Magazzini, L.2    Riccaboni, M.3
  • 15
    • 77954637421 scopus 로고    scopus 로고
    • The Type 1 Diabetes PhysioLab Platform: a validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse
    • Shoda, L., Kreuwel, H., Gadkar, K., Zheng, Y., Whiting, C., Atkinson, M., et al. (2010). The Type 1 Diabetes PhysioLab Platform: a validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse. Clin. Exp. Immunol. 161, 250-267. doi: 10.1111/j.1365-2249.2010.04166.x
    • (2010) Clin. Exp. Immunol. , vol.161 , pp. 250-267
    • Shoda, L.1    Kreuwel, H.2    Gadkar, K.3    Zheng, Y.4    Whiting, C.5    Atkinson, M.6
  • 17
    • 84861483762 scopus 로고    scopus 로고
    • First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development
    • Strougo, A., Eissing, T., Yassen, A., Willmann, S., Danhof, M., and Freijer, J. (2012). First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development. J. Pharmacokinet. Pharmacodyn. 39, 195-203. doi: 10.1007/s10928-012-9241-9
    • (2012) J. Pharmacokinet. Pharmacodyn. , vol.39 , pp. 195-203
    • Strougo, A.1    Eissing, T.2    Yassen, A.3    Willmann, S.4    Danhof, M.5    Freijer, J.6
  • 18
    • 84926621903 scopus 로고    scopus 로고
    • Pharmacometrics at FDA [online]. Available at: [accessed October 13, 2014].
    • U.S. Food and Drug Administration. (2013a). Pharmacometrics at FDA [online]. Available at: http://www.fda.gov/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/ucm167032.htm[accessed October 13, 2014].
    • (2013)
  • 19
    • 84926682148 scopus 로고    scopus 로고
    • 1938 to the Present [online]. U.S. Food and Drug Administration. Available at: [accessed October 13, 2014].
    • U.S. Food and Drug Administration. (2013b). Summary of NDA Approvals & Receipts, 1938 to the Present [online]. U.S. Food and Drug Administration. Available at: http://www.fda.gov/AboutFDA/WhatWeDo/History/ProductRegulation/SummaryofNDAApprovalsReceipts1938tothepresent/default.htm[accessed October 13, 2014].
    • (2013) Summary of NDA Approvals & Receipts
  • 20
    • 84881146279 scopus 로고    scopus 로고
    • Quantitative Systems Pharmacology model of NO metabolome and methemoglobin following long-term infusion of sodium nitrite in humans
    • Vega-Villa, K., Pluta, R., Lonser, R., and Woo, S. (2013). Quantitative Systems Pharmacology model of NO metabolome and methemoglobin following long-term infusion of sodium nitrite in humans. CPT Pharmacometrics Syst. Pharmacol. 2:e60. doi: 10.1038/psp.2013.35
    • (2013) CPT Pharmacometrics Syst. Pharmacol. , vol.2 , pp. e60
    • Vega-Villa, K.1    Pluta, R.2    Lonser, R.3    Woo, S.4
  • 21
    • 84857453874 scopus 로고    scopus 로고
    • If we designed airplanes like we design drugs
    • Woltosz, W. S. (2012). If we designed airplanes like we design drugs. J. Comput. Aided Mol. Des. 26, 159-163. doi: 10.1007/s10822-011-9490-5
    • (2012) J. Comput. Aided Mol. Des. , vol.26 , pp. 159-163
    • Woltosz, W.S.1
  • 22
    • 39649084919 scopus 로고    scopus 로고
    • The FDA critical path initiative and its influence on new drug development
    • Woodcock, J., and Woosley, R. (2008). The FDA critical path initiative and its influence on new drug development. Annu. Rev. Med. 59, 1-12. doi: 10.1146/annurev.med.59.090506.155819
    • (2008) Annu. Rev. Med. , vol.59 , pp. 1-12
    • Woodcock, J.1    Woosley, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.