An inflammatory tale from 3 fatty depots

Journal of the American College of Cardiology

Volumn 58, Issue 3, 2011, Pages 256-257

  Dandona, Paresh ^a   Ghanim, Husam ^a   Chaudhuri, Ajay ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

endothelium; inflammation; obesity; vasculature; vasodilation

Indexed keywords

C REACTIVE PROTEIN; CD163 ANTIGEN; CD68 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GELATINASE B; GLUCOSE; GLYCOPROTEIN P 15095; INSULIN RECEPTOR; INTERLEUKIN 10; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ABDOMINAL FAT; ADIPOSE TISSUE; BODY MASS; CORONARY ARTERY ATHEROSCLEROSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME INDUCTION; HUMAN; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIPID PEROXIDATION; MACROPHAGE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NOTE; OBESITY; OXIDATIVE STRESS; PATHOGENESIS; PERIVASCULAR FAT; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; VASODILATATION; WAIST CIRCUMFERENCE;

EID: 79960037912     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.02.056     Document Type: Editorial

References (16)

1. G.S. Hotamisligil, N.S. Shargill, and B.M. Spiegelman Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance Science 259 1993 87 91 (Pubitemid 23036092)
2. S. Moncada, and A. Higgs The L-arginine-nitric oxide pathway N Engl J Med 329 1993 2002 2012 (Pubitemid 24015045)
3. G. Zeng, and M.J. Quon Insulin-stimulated production of nitric oxide is inhibited by wortmannin Direct measurement in vascular endothelial cells J Clin Invest 98 1996 894 898 (Pubitemid 26293305)
4. A. Aljada, and P. Dandona Effect of insulin on human aortic endothelial nitric oxide synthase Metabolism 49 2000 147 150 (Pubitemid 30090874)
5. A. Aljada, H. Ghanim, E. Assian, and P. Dandona Tumor necrosis factor-alpha inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells Metabolism 51 2002 487 491 (Pubitemid 34406567)
6. P. Dandona, P. Mohanty, and H. Ghanim The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation J Clin Endocrinol Metab 86 2001 355 362 (Pubitemid 32109818)
7. P. Dandona, R. Weinstock, K. Thusu, E. Abdel-Rahman, A. Aljada, and T. Wadden Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss J Clin Endocrinol Metab 83 1998 2907 2910 (Pubitemid 28493796)
8. S.P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R.L. Leibel, and A.W. Ferrante Jr Obesity is associated with macrophage accumulation in adipose tissue J Clin Invest 112 2003 1796 1808 (Pubitemid 38063703)
9. A. Virdis, F. Santini, and R. Coluccio Vascular generation of tumor necrosis factor-α reduces nitric oxide availability in small arteries from visceral fat of obese patients J Am Coll Cardiol 58 2011 238 247
10. M.G. Farb, S. Bigornia, and M. Mott Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity J Am Coll Cardiol 58 2011 232 237
11. Y. Hirata, M. Tabata, and H. Kurobe Coronary atherosclerosis is associated with macrophage polarization in epicardial adipose tissue J Am Coll Cardiol 58 2011 248 255
12. P.R. Moreno, K.R. Purushothaman, V. Fuster, and W.N. O'Connor Intimomedial interface damage and adventitial inflammation is increased beneath disrupted atherosclerosis in the aorta: implications for plaque vulnerability Circulation 105 2002 2504 2511 (Pubitemid 34568972)
13. H. Ghanim, A. Aljada, D. Hofmeyer, S. Tufail, P. Mohanty, and P. Dandona The circulating mononuclear cells in the obese are in a pro-inflammatory state Circulation 110 2004 1564 1571 (Pubitemid 39297977)
14. S.P. Weisberg, D. Hunter, and R. Huber CCR2 modulates inflammatory and metabolic effects of high-fat feeding J Clin Invest 116 2006 115 124 (Pubitemid 43121796)
15. A.E. Obstfeld, E. Sugaru, and M. Thearle C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis Diabetes 59 2010 916 925
16. H. Ghanim, K. Korzeniewski, and C.L. Sia Suppressive effect of insulin infusion on chemokines and chemokine receptors Diabetes Care 33 2010 1103 1108