Autoantibodies in systemic sclerosis: Unanswered questions

Frontiers in Immunology

Volumn 6, Issue MAR, 2015, Pages

  Kayser, Cristiane ^a   Fritzler, Marvin J ^b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Anti nuclear antibodies; Autoantibodies; Autoimmune diseases; Scleroderma; Systemic sclerosis

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; AUTOANTIBODY; CASPASE 3; CENTROMERE ANTIBODY; COLLAGEN TYPE 1; ENZYME ANTIBODY; EPITOPE; FIBRILLARIN; FIBRILLIN 1; IMMUNOGLOBULIN G; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; KU ANTIBODY; NOR 90 ANTIBODY; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PM SCL ANTIBODY; REACTIVE OXYGEN METABOLITE; RIBONUCLEOPROTEIN ANTIBODY; RNA POLYMERASE I ANTIBODY; RNA POLYMERASE II ANTIBODY; RNA POLYMERASE III ANTIBODY; RO52 ANTIBODY; RO60 ANTIBODY; STROMELYSIN; TH TO ANTIBODY; TOPOISOMERASE I ANTIBODY; U11 RIBONUCLEOPROTEIN ANTIBODY; U12 RIBONUCLEOPROTEIN ANTIBODY; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CHEMOLUMINESCENCE; COLLAGEN DEGRADATION; DISEASE COURSE; HUMAN; IMMUNOASSAY; IMMUNOBLOTTING; IMMUNODIFFUSION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYSTEMIC SCLEROSIS;

EID: 84926663785     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00167     Document Type: Article

References (31)

1. LeRoy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, Medsger TA Jr, et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol (1988) 15:202-5.
2. Mehra S, Walker J, Patterson K, Fritzler MJ. Autoantibodies in systemic sclerosis. Autoimmun Rev (2013) 12:340-54. doi: 10.1016/j.autrev.2012.05.011.
3. Arnett FC. Is scleroderma an autoantibody mediated disease? Curr Opin Rheumatol (2006) 18:579-81.
4. van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum (2013) 65:2737-47. doi: 10.1002/art.38098.
5. Villalta D, Imbastaro T, Di Giovanni S, Lauriti C, Gabini M, Turi MC, et al. Diagnostic accuracy and predictive value of extended autoantibody profile in systemic sclerosis. Autoimmun Rev (2012) 12:114-20. doi: 10.1016/j.autrev.2012.07.005.
6. Gabrielli A, Svegliati S, Moroncini G, Avvedimento EV. Pathogenic autoantibodies in systemic sclerosis. Curr Opin Immunol (2007) 19:640-5. doi:10.1016/j.coi.2007.11.004.
7. Riemekasten G, Philippe A, Näther M, Slowinski T, Müller DN, Heidecke H, et al. Involvement of functional autoantibodies against vascular receptors in systemic sclerosis. Ann Rheum Dis (2011) 70:530-6. doi: 10.1136/ard.2010.135772.
8. Ho K, Reveille JD. The clinical relevance of autoantibodies in scleroderma. Arthritis Res Ther (2003) 5:80-93. doi:10.1186/ar628.
9. Steen VD. Autoantibodies in systemic sclerosis. Semin Arthritis Rheum (2005) 35:35-42. doi: http://dx.doi.org/10.1016/j.semarthrit.2005.03.005.
10. Hamaguchi Y. Autoantibody profiles in systemic sclerosis: predictive value for clinical evaluation and prognosis. J Dermatol (2010) 37:42-53. doi: 10.1111/j.1346-8138.2009.00762.x.
11. Sobanski V, Dauchet L, Lefèvre G, Lambert M, Morell-Dubois S, Sy T, et al. Prevalence of anti-RNA polymerase III antibodies in systemic sclerosis: New data from a French cohort and a systematic review and meta-analysis. Arthritis Rheumatol (2014) 66:407-17. doi: 10.1002/art.38219.
12. Fertig N, Domsic RT, Rodriguez-Reyna T, Kuwana M, Lucas M, Medsger TA Jr, et al. Anti-U11/U12 RNP antibodies in systemic sclerosis: a new serologic marker associated with pulmonary fibrosis. Arthritis Rheum (2009) 61:958-65. doi: 10.1002/art.24586.
13. Tramposch HD, Smith CD, Senecal JL, Rothfield N. A long-term longitudinal study of anticentromere antibodies. Arthritis Rheum (1984) 27:121-4.
14. Perera A, Fertig N, Lucas M, Rodriguez-Reyna TS, Hu P, Steen VD, et al. Clinical subsets, skin thickness progression rate, and serum antibody levels in systemic sclerosis patients with anti-topoisomerase I antibody. Arthritis Rheum (2007) 56:2740-6. doi: 10.1002/art.22747.
15. Kuwana M, Kaburaki J, Mimori T, Kawakami Y, Tojo T. Longitudinal analysis of autoantibody response to topoisomerase I in systemic sclerosis. Arthritis Rheum (2000) 43:1074-84. doi: 10.1002/1529-0131(200005)43:5<1074::AID-ANR18>3.0.CO;2-E.
16. Kuwana M, Okano Y, Pandey JP, Silver RM, Fertig N, Medsger TA Jr. Enzyme-linked immunosorbent assay for detection of anti-RNA polymerase III antibody: analytical accuracy and clinical associations in systemic sclerosis. Arthritis Rheum (2005) 52:2425-32. doi: 10.1002/art.21232.
17. Nihtyanova SI, Parker JC, Black CM, Bunn CC, Denton CP. A longitudinal study of anti-RNA polymerase III antibody levels in systemic sclerosis. Rheumatology (Oxford) (2009) 48:1218-21. doi: 10.1093/rheumatology/kep215.
18. Jarzabek-Chorzelska M, Blaszczyk M, Kolacinska-Strasz Z, Jablonska S, Chorzelski T, Maul GG. Are ACA and Scl 70 antibodies mutually exclusive? Br J Dermatol (1990) 122:201-8.
19. Heijnen IA, Foocharoen C, Bannert B, Carreira PE, Caporali R, Smith V, et al. Clinical significance of coexisting antitopoisomerase I and anticentromere antibodies in patients with systemic sclerosis: a EUSTAR group-based study. Clin Exp Rheumatol (2013) 31(2 Suppl 76):96-102.
20. Op De Beéck K, Vermeersch P, Verschueren P, Westhovens R, Mariën G, Blockmans D, et al. Antinuclear antibody detection by automated multiplex immunoassay in untreated patients at the time of diagnosis. Autoimmun Rev (2012) 12:137-43. doi: 10.1016/j.autrev.2012.02.013.
21. Senécal JL, Hénault J, Raymond Y. The pathogenic role of autoantibodies to nuclear autoantigens in systemic sclerosis (scleroderma). J Rheumatol (2005) 32:1643-9.
22. Hénault J, Tremblay M, Clément I, Raymond Y, Senécal JL. Direct binding of anti-DNA topoisomerase I autoantibodies to the cell surface of fibroblasts in patients with systemic sclerosis. Arthritis Rheum (2004) 50:3265-74. doi: 10.1002/art.20515.
23. Hénault J, Robitaille G, Senécal JL, Raymond Y. DNA topoisomerase I binding to fibroblasts induces monocyte adhesion and activation in the presence of anti-topoisomerase I autoantibodies from systemic sclerosis patients. Arthritis Rheum (2006) 54:963-73. doi: 10.1002/art.21646.
24. Abraham DJ, Krieg T, Distler J, Distler O. Overview of pathogenesis of systemic sclerosis. Rheumatology (Oxford) (2009) 48 Suppl 3:iii3-7. doi: 10.1093/rheumatology/ken481.
25. Chizzolini C, Raschi E, Rezzonico R, Testoni C, Mallone R, Gabrielli A, et al. Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis. Arthritis Rheum (2002) 46:1602-13. doi: 10.1002/art.10361.
26. Fineschi S, Cozzi F, Burger D, Dayer JM, Meroni PL, Chizzolini C. Anti-fibroblast antibodies detected by cell-based ELISA in systemic sclerosis enhance the collagenolytic activity and matrix metalloproteinase-1 production in dermal fibroblasts. Rheumatolology (Oxford) (2007) 46:1779-85. doi: 10.1093/rheumatology/kem241.
27. Brinckmann J, Hunzelmann N, El-Hallous E, Krieg T, Sakai LY, Krengel S, et al. Absence of autoantibodies against correctly folded recombinant fibrillin-1 protein in systemic sclerosis patients. Arthritis Res Ther (2005) 7:R1221-6. doi:10.1186/ar1813.
28. Ahmed SS, Tan FK, Arnett FC, Jin L, Geng YJ. Induction of apoptosis and fibrillin 1 expression in human dermal endothelial cells by scleroderma sera containing anti-endothelial cell antibodies. Arthritis Rheum (2006) 54:2250-62. doi: 10.1002/art.21952.
29. Baroni SS, Santillo M, Bevilacqua F, Luchetti M, Spadoni T, Mancini M, et al. Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med (2006) 354:2667-76. doi: 10.1056/NEJMoa052955.
30. Kill A, Tabeling C, Undeutsch R, Kühl AA, Günther J, Radic M, et al. Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis. Arthritis Res Ther (2014) 16:R29. doi: 10.1186/ar4457.
31. Zhou X, Tan FK, Xiong M, Milewicz DM, Feghali CA, Fritzler MJ, et al. Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts. J Immunol (2001)167:7126-33. doi:10.4049/jimmunol.167.12.7126.