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Volumn 19, Issue 6, 2007, Pages 640-645

Pathogenic autoantibodies in systemic sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CENTROMERE ANTIBODY; DNA TOPOISOMERASE INHIBITOR; ENDOTHELIAL CELL ANTIBODY; NUCLEAR CENTROMERIC PROTEIN C; NUCLEAR PROTEIN; PLATELET DERIVED GROWTH FACTOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

EID: 44649085694     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2007.11.004     Document Type: Review
Times cited : (41)

References (34)
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    • This study highlights the links between Ras protein levels and ROS. In vivo this circuitry is amplified in fibroblasts derived from scleroderma lesions that produce vast excess of ROS and undergo rapid senescence. The authors propose that stabilization of Ras protein by ROS and ERK1/2 amplifies the response of primary fibroblasts to growth factors and represents a crucial factor in the onset and progression of systemic sclerosis.
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