Caffeic acid phenethyl ester inhibits liver fibrosis in rats

World Journal of Gastroenterology

Volumn 21, Issue 13, 2015, Pages 3893-3903

  Li, Mei ^a   Wang, Xiu Fang ^a   Shi, Juan Juan ^a   Li, Ya Ping ^a   Yang, Ning ^a   Zhai, Song ^a   Dang, Shuang Suo ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Caffeic acid phenethyl ester; Liver fibrosis; NF E2 related factor 2; Oxidative stress; smooth

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALPHA SMOOTH MUSCLE ACTIN; ALPHA TOCOPHEROL; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CAFFEIC ACID PHENETHYL ESTER; CARBON TETRACHLORIDE; CATALASE; FAT; GLUTATHIONE; MALONALDEHYDE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; BIOLOGICAL MARKER; CAFFEIC ACID DERIVATIVE; NFE2L2 PROTEIN, RAT; PHENETHYL ALCOHOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA PROTEIN COMPLEX; ENZYME INHIBITION; FEEDING BEHAVIOR; FORAGE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER FIBROSIS; LIVER PARENCHYMA; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; SPRAGUE DAWLEY RAT; STELLATE CELL; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CELL PROTECTION; CHEMICAL AND DRUG INDUCED LIVER INJURY; CHEMICALLY INDUCED; DOSE RESPONSE; DRINKING BEHAVIOR; DRUG EFFECTS; HEPATIC STELLATE CELL; LIPID DIET; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; METABOLISM; PATHOLOGY;

ALCOHOL DRINKING; ANIMALS; ANTIOXIDANTS; BIOMARKERS; CAFFEIC ACIDS; CARBON TETRACHLORIDE; CHEMICAL AND DRUG INDUCED LIVER INJURY; CYTOPROTECTION; DIET, HIGH-FAT; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATIC STELLATE CELLS; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHENYLETHYL ALCOHOL; RATS, SPRAGUE-DAWLEY;

EID: 84926649837     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v21.i13.3893     Document Type: Article

References (39)

1. Türkez H, Yousef MI, Geyikoglu F. Propolis prevents aluminiuminduced genetic and hepatic damages in rat liver. Food Chem Toxicol 2010; 48: 2741-2746 [PMID: 20637254 DOI:10.1016/j.fct.2010.06.049].
2. Simões LM, Gregório LE, Da Silva Filho AA, de Souza ML, Azzolini AE, Bastos JK, Lucisano-Valim YM. Effect of Brazilian green propolis on the production of reactive oxygen species by stimulated neutrophils. J Ethnopharmacol 2004; 94: 59-65 [PMID: 15261964 DOI:10.1016/j.jep.2004.04.026].
3. Nakamura T, Ohta Y, Ohashi K, Ikeno K, Watanabe R, Tokunaga K, Harada N. Protective effect of Brazilian propolis against hepatic oxidative damage in rats with water-immersion restraint stress. Phytother Res 2012; 26: 1482-1489 [PMID: 22298415 DOI:10.1002/ptr.4601].
4. Kus I, Colakoglu N, Pekmez H, Seckin D, Ogeturk M, Sarsilmaz M. Protective effects of caffeic acid phenethyl ester (CAPE) on carbon tetrachloride-induced hepatotoxicity in rats. Acta Histochem 2004; 106: 289-297 [PMID: 15350811 DOI:10.1016/j.acthis.2004.05.002].
5. Pekmez H, Kus I, Colakoglu N, Ogeturk M, Ozyurt H, Turkoglu AO, Sarsilmaz M. The protective effects of caffeic acid phenethyl ester (CAPE) against liver damage induced by cigarette smoke inhalation in rats. Cell Biochem Funct 2007; 25: 395-400 [PMID: 16370025 DOI:10.1002/cbf.1312].
6. Coban S, Yildiz F, Terzi A, Al B, Ozgor D, Ara C, Polat A, Esrefoglu M. The effect of caffeic acid phenethyl ester (CAPE) against cholestatic liver injury in rats. J Surg Res 2010; 159: 674-679 [PMID: 19535096].
7. Michaluart P, Masferrer JL, Carothers AM, Subbaramaiah K, Zweifel BS, Koboldt C, Mestre JR, Grunberger D, Sacks PG, Tanabe T, Dannenberg AJ. Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res 1999; 59: 2347-2352 [PMID: 10344742].
8. Wu WM, Lu L, Long Y, Wang T, Liu L, Chen Q, Wang R. Free radical scavenging and antioxidative activities of caffeic acid phenethyl ester (CAPE) and its related compounds in solution and membranes: A structure-activity insight. Food Chemistry 2007; 105: 107-115 [DOI:10.1016/j.foodchem.2007.03.049].
9. Macías-Pérez JR, Beltrán-Ramírez O, Vásquez-Garzón VR, Salcido-Neyoy ME, Martínez-Soriano PA, Ruiz-Sánchez MB, Angeles E, Villa-Treviño S. The effect of caffeic acid phenethyl ester analogues in a modified resistant hepatocyte model. Anticancer Drugs 2013; 24: 394-405 [PMID: 23388162 DOI:10.1097/CAD.0b013e32835e9743].
10. Onori P, DeMorrow S, Gaudio E, Franchitto A, Mancinelli R, Venter J, Kopriva S, Ueno Y, Alvaro D, Savage J, Alpini G, Francis H. Caffeic acid phenethyl ester decreases cholangiocarcinoma growth by inhibition of NF-kappaB and induction of apoptosis. Int J Cancer 2009; 125: 565-576 [PMID: 19358267 DOI:10.1002/ijc.24271].
11. Hess A, Wijayanti N, Neuschäfer-Rube AP, Katz N, Kietzmann T, Immenschuh S. Phorbol ester-dependent activation of peroxiredoxin I gene expression via a protein kinase C, Ras, p38 mitogen-activated protein kinase signaling pathway. J Biol Chem 2003; 278: 45419-45434 [PMID: 12960165].
12. Natarajan K, Singh S, Burke TR, Grunberger D, Aggarwal BB. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci USA 1996; 93: 9090-9095 [PMID: 8799159].
13. Ha J, Choi HS, Lee Y, Lee ZH, Kim HH. Caffeic acid phenethyl ester inhibits osteoclastogenesis by suppressing NF kappaB and downregulating NFATc1 and c-Fos. Int Immunopharmacol 2009; 9: 774-780 [PMID: 19285574 DOI:10.1016/j.intimp.2009.03.001].
14. Bezerra RM, Veiga LF, Caetano AC, Rosalen PL, Amaral ME, Palanch AC, de Alencar SM. Caffeic acid phenethyl ester reduces the activation of the nuclear factor κB pathway by high-fat dietinduced obesity in mice. Metabolism 2012; 61: 1606-1614 [PMID: 22575582 DOI:10.1016/j.metabol.2012.04.006].
15. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005; 115: 209-218 [PMID: 15690074 DOI:10.1172/JCI200524282].
16. Svegliati Baroni G, D'Ambrosio L, Ferretti G, Casini A, Di Sario A, Salzano R, Ridolfi F, Saccomanno S, Jezequel AM, Benedetti A. Fibrogenic effect of oxidative stress on rat hepatic stellate cells. Hepatology 1998; 27: 720-726 [PMID: 9500700 DOI:10.1002/hep.510270313].
17. Ghatak S, Biswas A, Dhali GK, Chowdhury A, Boyer JL, Santra A. Oxidative stress and hepatic stellate cell activation are key events in arsenic induced liver fibrosis in mice. Toxicol Appl Pharmacol 2011; 251: 59-69 [PMID: 21134390 DOI:10.1016/j.taap.2010.11.016].
18. Kaspar JW, Niture SK, Jaiswal AK. Nrf2: INrf2 (Keap1) signaling in oxidative stress. Free Radic Biol Med 2009; 47: 1304-1309 [PMID: 19666107 DOI10.1016/j.freeradbiomed.2009.07.035].
19. Kobayashi M, Yamamoto M. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal 2005; 7: 385-394 [PMID: 15706085 DOI:10.1089/ars.2005.7.385].
20. Aleksunes LM, Manautou JE. Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease. Toxicol Pathol 2007; 35: 459-473 [PMID: 17562481 DOI:10.1080/01926230701311344].
21. Sedmak JJ, Grossberg SE. A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. Anal Biochem 1977; 79: 544-552 [PMID: 68686 DOI:10.1016/0003-2697(77)90428-6].
22. Edwards CA, O'Brien WD. Modified assay for determination of hydroxyproline in a tissue hydrolyzate. Clin Chim Acta 1980; 104: 161-167 [PMID: 7389130 DOI:10.1016/0009-8981(80)90192-8].
23. Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978; 86: 271-278 [PMID: 655387 DOI:10.1016/0003-2697(78)90342-1].
24. Lee KJ, Jeong HG. Protective effect of Platycodi radix on carbon tetrachloride-induced hepatotoxicity. Food Chem Toxicol 2002; 40: 517-525 [PMID: 11893410 DOI:10.1016/S0278-6915(01)00104-1].
25. Lee KJ, Panzera A, Rogawski D, Greene LE, Eisenberg E. Cellular prion protein (PrPC) protects neuronal cells from the effect of huntingtin aggregation. J Cell Sci 2007; 120: 2663-2671 [PMID: 17635996 DOI:10.1242/jcs.004598].
26. Zhang J, Wang H, Yu H. Thioacetamide-induced cirrhosis in selenium-adequate mice displays rapid and persistent abnormity of hepatic selenoenzymes which are mute to selenium supplementation. Toxicol Appl Pharmacol 2007; 224: 81-88 [PMID: 17643461 DOI:10.1016/j.taap.2007.06.013].
27. Zhu XD, Zhang JB, Zhuang PY, Zhu HG, Zhang W, Xiong YQ, Wu WZ, Wang L, Tang ZY, Sun HC. High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma. J Clin Oncol 2008; 26: 2707-2716 [PMID: 18509183 DOI:10.1200/JCO.2007.15.6521].
28. Dey A, Cederbaum AI. Alcohol and oxidative liver injury. Hepatology 2006; 43: S63-S74 [PMID: 16447273 DOI:10.1002/hep.20957].
29. Russo A, Longo R, Vanella A. Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia 2002; 73 Suppl 1: S21-S29 [PMID: 12495706 DOI:10.1016/S0367-326X(02)00187-9].
30. Bai H, Liu R, Chen HL, Zhang W, Wang X, Zhang XD, Li WL, Hai CX. Enhanced antioxidant effect of caffeic acid phenethyl ester and Trolox in combination against radiation induced-oxidative stress. Chem Biol Interact 2014; 207: 7-15 [PMID: 24211618 DOI:10.1016/j.cbi.2013.10.022].
31. Jollow DJ, Mitchell JR, Potter WZ, Davis DC, Gillette JR, Brodie BB. Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. J Pharmacol Exp Ther 1973; 187: 195-202 [PMID: 4746327].
32. Basu S. Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients. Toxicology 2003; 189: 113-127 [PMID: 12821287 DOI:10.1016/S0300-483X(03)00157-4].
33. Pascual C, Gonzalez R, Torricella RG. Scavenging action of propolis extract against oxygen radicals. J Ethnopharmacol 1994; 41: 9-13 [PMID: 8170165 DOI:10.1016/0378-8741(94)90052-3].
34. Hünkar T, Aktan F, Ceylan A, Karasu C. Effects of cod liver oil on tissue antioxidant pathways in normal and streptozotocindiabetic rats. Cell Biochem Funct 2002; 20: 297-302 [PMID: 12415563 DOI:10.1002/cbf.977].
35. Itoh K, Tong KI, Yamamoto M. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med 2004; 36: 1208-1213 [PMID: 15110385 DOI:10.1016/j.freeradbiomed.2004.02.075].
36. Xu W, Hellerbrand C, Köhler UA, Bugnon P, Kan YW, Werner S, Beyer TA. The Nrf2 transcription factor protects from toxininduced liver injury and fibrosis. Lab Invest 2008; 88: 1068-1078 [PMID: 18679376 DOI:10.1038/labinvest.2008.75].
37. Borrelli F, Maffia P, Pinto L, Ianaro A, Russo A, Capasso F, Ialenti A. Phytochemical compounds involved in the anti-inflammatory effect of propolis extract. Fitoterapia 2002; 73 Suppl 1: S53-S63 [PMID: 12495710 DOI:10.1016/S0367-326X(02)00191-0].
38. Celik S, Erdogan S. Caffeic acid phenethyl ester (CAPE) protects brain against oxidative stress and inflammation induced by diabetes in rats. Mol Cell Biochem 2008; 312: 39-46 [PMID: 18265948 DOI:10.1007/s11010-008-9719-3].
39. Petrosillo G, Moro N, Paradies V, Ruggiero FM, Paradies G. Increased susceptibility to Ca(2+)-induced permeability transition and to cytochrome c release in rat heart mitochondria with aging: effect of melatonin. J Pineal Res 2010; 48: 340-346 [PMID: 20345745 DOI:10.1111/j.1600-079X.2010.00758.x].