Trends in and correlates of CD4+ cell count at antiretroviral therapy initiation after changes in national ART guidelines in Rwanda

AIDS

Volumn 29, Issue 1, 2015, Pages 67-76

  Mutimura, Eugene ^a   Addison, Diane ^b   Anastos, Kathryn ^c   Hoover, Donald ^d   Dusingize, Jean Claude ^a   Karenzie, Ben ^e   Izimukwiye, Isabelle ^f   Mutesa, Leo ^g   Nsanzimana, Sabin ^h   Nash, Denis ⁱ  

^a Regional Alliance for Sustainable Development   (Rwanda)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d RUTGERS UNIVERSITY   (United States)

^e RWANDA MILITARY HOSPITAL   (Rwanda)

^f Masaka District Hospital   (Rwanda)

^g UNIVERSITY OF RWANDA   (Rwanda)

^h RWANDA BIOMEDICAL CENTER   (Rwanda)

ⁱ CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Antiretroviral therapy national guidelines; CD4+; Determinants; HIV treatment; Rwanda

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIRETROVIRUS AGENT;

ADOLESCENT; ADULT; ANTIVIRAL THERAPY; CD4 LYMPHOCYTE COUNT; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRACTICE GUIDELINE; PRIORITY JOURNAL; RWANDA; RWANDAN; SEX DIFFERENCE; TREND STUDY; VERTICAL TRANSMISSION; AFRICA SOUTH OF THE SAHARA; AGE DISTRIBUTION; EPIDEMIOLOGY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV INFECTIONS; PREGNANCY; PREGNANCY COMPLICATION; SEX RATIO; STATISTICS AND NUMERICAL DATA; YOUNG ADULT;

ADOLESCENT; ADULT; AFRICA SOUTH OF THE SAHARA; AGE DISTRIBUTION; ANTI-HIV AGENTS; ANTI-RETROVIRAL AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; PRACTICE GUIDELINES AS TOPIC; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; RWANDA; SEX DISTRIBUTION; YOUNG ADULT;

EID: 84926645441     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000000520     Document Type: Conference Paper

References (32)

1. Ojikutu B, Makadzange AT, Gaolathe T. Scaling up ART treatment capacity: lessons learned from South Africa, Zimbabwe, and Botswana. Curr HIV/AIDS Rep 2008; 5:94-98
2. WHO. Towards universal access: scaling up priority HIV/AIDS interventions in the health sector: progress report 2010. Geneva, Switzerland: WHO; October 2010
3. Nash D, Katyal M, Brinkhof MW, Keiser O, May M, Hughes R, et al. Long-term immunologic response to antiretroviral therapy in low-income countries: a collaborative analysis of prospective studies. AIDS 2008; 22:2291-2302
4. Jahn A, Floyd S, Crampin AC, Mwaungulu F, Mvula H, Munthali F, et al. Population-level effect of HIV on adult mortality and early evidence of reversal after introduction of antiretroviral therapy in Malawi. Lancet 2008; 371:1603-1611
5. Reniers G, Araya T, Davey G, Nagelkerke N, Berhane Y, Coutinho R, et al. Steep declines in population level AIDS mortality following the introduction of antiretroviral therapy in Addis Ababa. AIDS 2009; 23:511-518
6. Dlodlo RA, Fujiwara PI, Hwalima ZE, Mungofa S, Harries AD. Adult mortality in the cities of Bulawayo and Harare, Zimbabwe: 1979-2008. J Int AIDS Soc 2011; 14 (Suppl 1): S2
7. Lahuerta M, Ue F, Hoffman S, Elul B, Kulkarni SG, Wu Y, et al. The problem of late ART initiation in sub-Saharan Africa: a transient aspect of scale-up or a long-term phenomenon? J Healthcare Poor Underserved 2013; 24:359-383
8. Brinkhof MW, Boulle A, Weigel R, Messou E, Mathers C, Orrell C, et al. Mortality of HIV-infected patients starting antiretroviral therapy in sub-Saharan Africa: comparison with HIVunrelated mortality. PloS Med 2009; 6:e1000066
9. Nash D, Wu Y, Elul B, Hoos D, El Sadr W. Program-level and contextual-level determinants of low-median CD4R cell count in cohorts of persons initiating ART in eight sub-Saharan African countries. AIDS 2011; 25:1523-1533
10. Lahuerta M, Lima J, Nuwagaba-Biribonwaha H, Okamura M, Alvim MF, Fernandes R, et al. Factors associated with late antiretroviral therapy initiation among adults in Mozambique. PLoS One 2012; 7:e37125
11. Rwanda Demographic and Health Survey 2014 Final Report. National Institute of Statistics of Rwanda. Ministry of Finance and Economic Planning, Kigali, Rwanda; February 2012, pp. 15-18
12. Nsanzimana S, Ruton H, Lowrance DW, Cishahayo S, Nyemazi JP, Muhayimpundu R, et al. Cell phone-based and internetbased monitoring and evaluation of the national antiretroviral treatment program during rapid scale-up in Rwanda: TRACnet, 2004-2010. J Acquir Immune Defic Syndr 2012; 59:e17-e23
13. Lowrance DW, Ndamage F, Kayirangwa E, Ndagije F, Lo W, Hoover DR, et al. Adult clinical and immunologic outcomes of the national antiretroviral treatment program in Rwanda during 2004-2005. J Acquir Immune Defic Syndr 2009; 52:49-55
14. Elul B, Basinga P, Nuwagaba-Biribonwaha H, Saito S, Horowitz D, Nash D, et al. High levels of adherence and viral suppression in a nationally representative sample of HIV-infected adults on antiretroviral therapy for 6, 12 and 18 months in Rwanda. PLoS One 2013; 8:e53586
15. Geng EH, Hunt PW, Diero LO, Kimaiyo S, Somi GR, Okong P, et al. Trends in the clinical characteristics of HIV-infected patients initiating antiretroviral therapy in Kenya, Uganda and Tanzania between 2002 and 2009. J Int AIDS Soc 2011; 14:46
16. Cornell M, Grimsrud A, Fairall L, Fox MP, van Cutsem G, Giddy J, et al. Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002-2007. AIDS 2010; 24:2263-2270
17. Mugglin C, Althoff K, Wools-Kaloustian K, Sterne J, Nash D, Dabis F, et al. Immunodeficiency at the start of ART: global view. In: 19th Conference on Retroviruses and Opportunistic Infections (CROI); 3-8 March 2012; Seattle
18. Avila D, Althoff KN, Mugglin C, Wools-Kaloustian K, Koller M, Dabis F, et al. Immunodeficiency at the start of combination antiretroviral therapy in low-, middle-, and high-income countries. J Acquir Immune Defic Syndr 2014; 65:e8-e16
19. Binagwaho A, Farmer PE, Nsanzimana S, Karema C, Gasana M, de Dieu Ngirabega J, et al. Rwanda 20 years on: investing in life. Lancet 2014; 384:371-375
20. Lahuerta M, Wu Y, Hoffman S, Elul B, Kulkarni SG, Remien RH, et al. Advanced HIV disease at entry into HIV care and initiation of antiretroviral therapy during 2006-2011: findings from four sub-Saharan African countries. Clin Infect Dis 2014; 58:432-441
21. Johansson KA, Robberstad B, Norheim OF. Further benefits by early start of HIV treatment in low income countries: survival estimates of early versus deferred antiretroviral therapy. AIDS Res Ther 2010; 7:3
22. Taylor-Smith K, Tweya H, Harries A, Schoutene E, Jahn A. Gender differences in retention and survival on antiretroviral therapy of HIV-1 infected adults in Malawi. Malawi Med J 2010; 22:49-56
23. Hawkins C, Chalamilla G, Okuma J, Spiegelman D, Hertzmark E, Aris E, et al. Sex differences in antiretroviral treatment outcomes among HIV-infected adults in an urban Tanzanian setting. AIDS 2011; 25:1189-1197
24. Alibhai A, Kipp W, Saunders LD, Senthilselvan A, Kaler A, Houston S, et al. Gender-related mortality for HIV-infected patients on highly active antiretroviral therapy (HAART) in rural Uganda. Int J Womens Health 2010; 2:45-52
25. Maman D, Pujades-Rodriguez M, Subtil F, Pinoges L, McGuire M, Ecochard R, et al. Gender differences in immune reconstitution: a multicentric cohort analysis in sub-Saharan Africa. PLoS One 2012; 7:e31078
26. Logie DE, Rowson M, Ndagije F. Innovations in Rwanda's health system: looking to the future. Lancet 2008; 372:256-261
27. Twahira A. Sharing the burden of sickness: mutual health insurance inRwanda. BullWorld HealthOrgan 2008; 86:823-824
28. Lu C, Chin B, Lewandowski JL, Basinga P, Hirschhorn LR, Hill K, et al. Towards universal health coverage: an evaluation of Rwanda mutuelles in its first eight years. PLoS One 2012; 7: e39282
29. Bucagu M, Kagubare JM, Basinga P, Ngabo F, Timmons BK, Lee AC. Impact of health systems strengthening on coverage of maternal health services in Rwanda, 2000-2010: a systematic review. Reprod Health Matters 2012; 20:50-61
30. Rodriquez PR, Samuels F. Rwanda's progress in health: leadership, performance and insurance. London: ODI publications, 111 Westminster Bridge Road, London SE1 7JD, UK Overseas Development Institute, 2011
31. Demographic and Health Surveys. 2014. http://www.measuredhs.com/[Accessed 25 April 2014]
32. The World Bank. Data: Poverty headcount ratio at $1.25 a day (PPP) (% of population). (n.d.) Washington, DC. Retrieved November 10, 2014, from http://data.worldbank.org/indicator/SI.POV.DDAY.