High Levels of Adherence and Viral Suppression in a Nationally Representative Sample of HIV-Infected Adults on Antiretroviral Therapy for 6, 12 and 18 Months in Rwanda

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Elul, Batya ^a   Basinga, Paulin ^b,c   Nuwagaba Biribonwoha, Harriet ^a   Saito, Suzue ^a   Horowitz, Deborah ^a   Nash, Denis ^a,d   Mugabo, Jules ^e   Mugisha, Veronicah ^a   Rugigana, Etienne ^b   Nkunda, Richard ^f   Asiimwe, Anita ^e  

^a Mailman School of Public Health ^*  (United States)

^b UNIVERSITY OF RWANDA   (Rwanda)

^c BILL AND MELINDA GATES FOUNDATION   (United States)

^d CITY UNIVERSITY OF NEW YORK   (United States)

^e RWANDA BIOMEDICAL CENTER   (Rwanda)

^f National Reference Laboratory   (Rwanda)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; EFAVIRENZ; NEVIRAPINE;

ADULT; ALCOHOL CONSUMPTION; ANTIVIRAL THERAPY; ARTICLE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PATIENT ATTITUDE; PATIENT COMPLIANCE; PATIENT PARTICIPATION; PROFESSIONAL PRACTICE; RWANDA; SELF REPORT; TREATMENT DURATION; VIRUS DETECTION; VIRUS INHIBITION; VIRUS LOAD;

ADOLESCENT; ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATIENT COMPLIANCE; PATIENT SELECTION; RWANDA; SELF REPORT; TIME FACTORS; VIRAL LOAD; YOUNG ADULT;

EID: 84872226306     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053586     Document Type: Article

References (44)

1. Abaasa AM, Todd J, Ekoru K, Kalyango JN, Levin J, et al. (2008) Good adherence to HAART and improved survival in a community HIV/AIDS treatment and care programme: the experience of The AIDS Support Organization (TASO), Kampala, Uganda. BMC Health Serv Res. 2008/11/22 ed. pp. 241.
2. Nachega JB, Hislop M, Nguyen H, Dowdy DW, Chaisson RE, et al. (2009) Antiretroviral therapy adherence, virologic and immunologic outcomes in adolescents compared with adults in southern Africa. J Acquir Immune Defic Syndr 51: 65-71.
3. Graham SM, Masese L, Gitau R, Jalalian-Lechak Z, Richardson BA, et al. (2010) Antiretroviral adherence and development of drug resistance are the strongest predictors of genital HIV-1 shedding among women initiating treatment. J Infect Dis 202: 1538-1542.
4. El-Khatib Z, Delong AK, Katzenstein D, Ekstrom AM, Ledwaba J, et al. (2011) Drug resistance patterns and virus re-suppression among HIV-1 subtype C infected patients receiving non-nucleoside reverse transcriptase inhibitors in South Africa. J AIDS Clin Res 2: 1-23.
5. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, et al. (2011) Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 365: 493-505.
6. Kashuba AD, Patterson KB, Dumond JB, Cohen MS (2011) Pre-exposure prophylaxis for HIV prevention: how to predict success. Lancet. 2011/12/14 ed.
7. Bussmann H, Wester CW, Ndwapi N, Grundmann N, Gaolathe T, et al. (2008) Five-year outcomes of initial patients treated in Botswana's National Antiretroviral Treatment Program. AIDS 22: 2303-2311.
8. Brinkhof MW, Pujades-Rodriguez M, Egger M (2009) Mortality of patients lost to follow-up in antiretroviral treatment programmes in resource-limited settings: systematic review and meta-analysis. PLoS One. 2009/06/06 ed. pp. e5790.
9. Lowrance DW, Ndamage F, Kayirangwa E, Ndagije F, Lo W, et al. (2009) Adult clinical and immunologic outcomes of the national antiretroviral treatment program in Rwanda during 2004-2005. J Acquir Immune Defic Syndr 52: 49-55.
10. Somi G, Matee M, Makene CL, Van Den Hombergh J, Kilama B, et al. (2009) Three years of HIV/AIDS care and treatment services in Tanzania: achievements and challenges. Tanzan J Health Res 11: 136-143.
11. Mills EJ, Nachega JB, Buchan I, Orbinski J, Attaran A, et al. (2006) Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA 296: 679-690.
12. Amberbir A, Woldemichael K, Getachew S, Girma B, Deribe K (2008) Predictors of adherence to antiretroviral therapy among HIV-infected persons: a prospective study in Southwest Ethiopia. BMC Public Health. 2008/08/01 ed. pp. 265.
13. Uzochukwu BS, Onwujekwe OE, Onoka AC, Okoli C, Uguru NP, et al. (2009) Determinants of non-adherence to subsidized anti-retroviral treatment in southeast Nigeria. Health Policy Plan 24: 189-196.
14. Unge C, Sodergard B, Marrone G, Thorson A, Lukhwaro A, et al. (2010) Long-term adherence to antiretroviral treatment and program drop-out in a high-risk urban setting in sub-Saharan Africa: a prospective cohort study. PLoS One. 2010/11/05 ed. pp. e13613.
15. Barth RE, van der Loeff MF, Schuurman R, Hoepelman AI, Wensing AM, (2010) Virological follow-up of adult patients in antiretroviral treatment programmes in sub-Saharan Africa: a systematic review. Lancet Infect Dis 10: 155-166.
16. National Institute of Statistics of Rwanda (NISR) RMoH, ICF International (2012) Rwanda Demographic and Health Survey 2010. Calverton, Maryland, USA: NISR, MOH, and ICF International.
17. UNAIDS JUNPoHA, WHO, World Health Organization, UNICEF, United Nations Children's Fund (2011) Global HIV/AIDS response: epidemic update and health sector progress towards universal access: progress report 2011. Geneva, Switzerland: WHO.
18. Ministry of Health GoR (2011) Annual report July 2010-June 2011. Kigali, Rwanda: Ministry of Health, Government of Rwanda.
19. Rwanda Go (2010) United Nations General Assembly Special Session on HIV and AIDS. Country Progress Report January 2008-December 2009. New York, USA: United Nations.
20. Musiime S, Muhairwe F, Rutagengwa A, Mutimura E, Anastos K, et al. (2011) Adherence to highly active antiretroviral treatment in HIV-infected Rwandan women. PLoS One. 2011/11/25 ed. pp. e27832.
21. Demeester R, Omes C, Karasi JC, Schneider S, Mugabo J, et al. (2005) Adherence to first-line antiretroviral regimens in Rwanda [Letter]. J Acquir Immune Defic Syndr 40: 113-114.
22. Chesney MA, Ickovics JR, Chambers DB, Gifford AL, Neidig J, et al. (2000) Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient Care Committee & Adherence Working Group of the Outcomes Committee of the Adult AIDS Clinical Trials Group (AACTG). AIDS Care 12: 255-266.
23. Oyugi JH, Byakika-Tusiime J, Charlebois ED, Kityo C, Mugerwa R, et al. (2004) Multiple validated measures of adherence indicate high levels of adherence to generic HIV antiretroviral therapy in a resource-limited setting. J Acquir Immune Defic Syndr 36: 1100-1102.
24. Peltzer K, Friend-du Preez N, Ramlagan S, Anderson J (2010) Antiretroviral treatment adherence among HIV patients in KwaZulu-Natal, South Africa. BMC Public Health. 2010/03/09 ed. pp. 111.
25. Watt MH, Maman S, Golin CE, Earp JA, Eng E, et al. (2010) Factors associated with self-reported adherence to antiretroviral therapy in a Tanzanian setting. AIDS Care 22: 381-389.
26. Walsh JC, Mandalia S, Gazzard BG, (2002) Responses to a 1 month self-report on adherence to antiretroviral therapy are consistent with electronic data and virological treatment outcome. AIDS 16: 269-277.
27. Brambatti LP (2007) Sharing views, dialogues and ways: adhesion to anti-retroviral treatment and quality of life in people living with HIV/AIDS in Maputo, Mozambique. Psychology-Program of Processes of Human Development and Health. Brasilia: University of Brasilia.
28. Kip E, Ehlers VJ, van der Wal DM, (2009) Patients' adherence to anti-retroviral therapy in Botswana. J Nurs Scholarsh 41: 149-157.
29. Shumbusho F, van Griensven J, Lowrance D, Turate I, Weaver MA, et al. (2009) Task shifting for scale-up of HIV care: evaluation of nurse-centered antiretroviral treatment at rural health centers in Rwanda. PLoS Med. 2009/10/14 ed. pp. e1000163.
30. Osborn CY, Davis TC, Bailey SC, Wolf MS, (2008) Health literacy in the context of HIV treatment: introducing the Brief Estimate of Health Knowledge and Action (BEHKA)-HIV version. AIDS Behav 14: 181-188.
31. Kalichman SC, Pope H, White D, Cherry C, Amaral CM, et al. (2008) Association between health literacy and HIV treatment adherence: further evidence from objectively measured medication adherence. J Int Assoc Physicians AIDS Care (Chic) 7: 317-323.
32. Mascolini M, Zuniga JM, (2008) Perceptions of health, HIV disease, and HIV treatment by patients in 6 regions: analysis of the 2555-person AIDS treatment for life international survey. J Int Assoc Physicians AIDS Care (Chic) 7: 160-177.
33. Etienne M, Hossain M, Redfield R, Stafford K, Amoroso A, (2010) Indicators of adherence to antiretroviral therapy treatment among HIV/AIDS patients in 5 African countries. J Int Assoc Physicians AIDS Care (Chic) 9: 98-103.
34. Bhat VG, Ramburuth M, Singh M, Titi O, Antony AP, et al. (2010) Factors associated with poor adherence to anti-retroviral therapy in patients attending a rural health centre in South Africa. Eur J Clin Microbiol Infect Dis 29: 947-953.
35. Dahab M, Charalambous S, Hamilton R, Fielding K, Kielmann K, et al. (2008) "That is why I stopped the ART": patients' & providers' perspectives on barriers to and enablers of HIV treatment adherence in a South African workplace programme. BMC Public Health. 2008/02/20 ed. pp. 63.
36. Hendershot CS, Stoner SA, Pantalone DW, Simoni JM, (2009) Alcohol use and antiretroviral adherence: review and meta-analysis. J Acquir Immune Defic Syndr 52: 180-202.
37. WHO (2008) Essential prevention and care interventions for adults and adolescents living with HIV in resource-limited settings. Geneva, Switzerland: WHO.
38. Perrine R, Kouanfack C, Cohen J, Marcellin F, Boyer S, et al. (2011) Adherence to Antiretroviral Treatment in HIV-Positive Patients in the Cameroon Context: Promoting the Use of Medication Reminder Methods. J Acquir Immune Defic Syndr 57: S40-S43.
39. Pop-Eleches C, Thirumurthy H, Habyarimana JP, Zivin JG, Goldstein MP, et al. (2011) Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders. AIDS 25: 825-834.
40. Wise J, Operario D, (2008) Use of electronic reminder devices to improve adherence to antiretroviral therapy: a systematic review. AIDS Patient Care STDS 22: 495-504.
41. Kipp W, Alibhai A, Saunders LD, Senthilselvan A, Kaler A, et al. (2010) Gender differences in antiretroviral treatment outcomes of HIV patients in rural Uganda. AIDS Care 22: 271-278.
42. Simoni JM, Chen WT, Huh D, Fredriksen-Goldsen KI, Pearson C, et al. (2011) A preliminary randomized controlled trial of a nurse-delivered medication adherence intervention among HIV-positive outpatients initiating antiretroviral therapy in Beijing, China. AIDS Behav 15: 919-929.
43. Pearson CR, Micek MA, Simoni JM, Hoff PD, Matediana E, et al. (2007) Randomized control trial of peer-delivered, modified directly observed therapy for HAART in Mozambique. J Acquir Immune Defic Syndr 46: 238-244.
44. Chang LW, Kagaayi J, Nakigozi G, Ssempijja V, Packer AH, et al. (2010) Effect of peer health workers on AIDS care in Rakai, Uganda: a cluster-randomized trial. PLoS One. 2010/06/10 ed. pp. e10923.