Chinese herbal medicine-induced liver injury

Journal of Clinical and Translational Hepatology

Volumn 2, Issue 3, 2014, Pages 170-175

  Ma, Xin ^a   Peng, Jing Hua ^a,b   Hu, Yi Yang ^a,b,c  

^a SHUGUANG HOSPITAL AFFILIATED TO SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c Shanghai Key Laboratory of Traditional Chinese Clinical Medicine   (China)

Author keywords

Chinese herbal medicine; Liver injury

Indexed keywords

EID: 84926639680     PISSN: 22250719     EISSN: 23108819     Source Type: Journal    
DOI: 10.14218/JCTH.2014.00009     Document Type: Review

References (85)

1. Tachjian A, Maria V, Jahangir A. Use Of Herbal Products And Potential Interactions In Patients With Cardiovascular Diseases. J Am Coll Cardiol 2010;55:515–525. doi: 10.1016/j.jacc.2009.07.074.
2. Die junge Generation wendet sich den Naturheilmitteln zu. Allensbacher Berichte, Nr. 17, 1989.
3. Yao F, Wang YY. Statistic analysis of the 9355 patients with drug induced liver injury. Anhui Medical and Pharmaceutical Journal 2011;15:1312–1314.
4. Sun J, Yu F, Wang J. Clinical Characteristics and Drug Analysis in 337 Cases of Drug induced Liver Injury. Pharmaceutical and Clinical Research 2013;4: 383–387. (Article in Chinese)
5. Teschke R, Wolff A, Frenzel C, Schulze J, Eickhoff A. Herbal hepatotoxicity: a tabular compilation of reported cases. Liver Int 2012;32:1543–1556. doi: 10.1111/j.1478-3231.2012.02864.x.
6. Bunchorntavakul C, Reddy K. Review article: herbal and dietary supplement hepatotoxicity. Aliment Pharmacol Ther 2013;37:3–17. doi: 10.1111/apt.12109.
7. Shao Y, Li DS. Clinical Analysis of Patients with medicine Induced and Traditional Medicine-Induced Liver Injury. Journal of Clinical Internal Medicine 2010;27:827–828. (Article in Chinese)
8. Teng Guangju, Sun Ying, Chang Binxia. The clinical features and prognosis analysis of 418 patients with drug-induced liver injury. Chinese Hepatology 2013;18:11–14. (Article in Chinese)
9. Kessler RC, Davis RB, Foster DF, Van Rompay MI, Walters EE, Wilkey SA, et al. Long-term trends in the use of complementary and alternative medical therapies in the United States. Annals Of Internal Medicine 2001;135:262– 268.
10. Lucena MI, Andrade RJ, Kaplowitz N, García-Cortes M, Fernández MC, Romero-Gomez M, et al. Phenotypic characterization of idiosyncratic drug induced liver injury: the influence of age and sex. Hepatology 2009;49: 2001–2009. doi: 10.1002/hep.22895.
11. Tajiri K, Shimizu Y. Practical guideline for diagnosis and early management of drug-induced liver injury. World J Gastroenterol 2008;14:6774–6785.
12. Teschke R, Schulze J, Schwarzenboeck A, Eickhoff A, Frenzel C. Herbal hepatotoxicity: suspected cases assessed for alternative causes. Eur J Gastroenterol Hepatol 2013;25:1093–1098
13. Teschke R, Eickhoff A, Schulze J. Drug and herb induced liver injury in clinical and translational hepatology: Causality assessment methods, quo vadis? J Clin Translat Hepatol 2013;1:59–74. doi: 10.14218/JCTH.2013.D002X
14. Maria VA, Victorino RM. Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis. Hepatology 1997;26:664–669. doi: 10.1002/hep.510260319.
15. Aithal PG, Day CP. The natural history of histologically proved drug induced liver disease. Gut 1999;44:731–735. doi: 10.1136/gut.44.5.731.
16. Aithal GP, Rawlins MD, Day CP. Accuracy of hepatic adverse drug reaction reporting in one English health region. BMJ 1999;319:1541. doi: 10.1136/bmj.319.7224.1541.
17. Takikawa H, Takamori Y, Kumagi T, Onji M, Watanabe M, Shibuya A, et al. Assessment of 287 Japanese cases of drug induced liver injury by the diagnostic scale of the International Consensus Meeting. Hepatol Res 2003; 27:192–195. doi: 10.1016/S1386-6346(03)00232-8.
18. Teschke R, Wolff A, Frenzel C, Schwarzenboeck A, Schulze J, Eickhoff A. Drug and herb induced liver injury: Council for International Organizations of Medical Sciences scale for causality asse ssment. World J Hepatol 2014;6: 17–32. Doi: 10.4254/wjh.v6.i1.17.
19. Agarwal VK, McHutchison JG, Hoofnagle JH, Drug-Induced Liver Injury Network (DILIN). Imp ortant elements for the diagnosis of drug-induced liver injury. Clin Gastroenterol Hepatol 2010;8:463–470. doi: 10.1016/j.cgh.2010.02.008.
20. Kleiner DE, Chalasani NP, Lee WM, Fontana RJ, Bonkovsky HL, Watkins PB, et al. Hepatic histological findings in suspected drug-induced liver injury: Systematic evaluation and clinical associations. Hepatology 2014;59:661– 670. doi: 10.1002/hep.26709.
21. Xu LM, Lin QX. Hepatic toxicity of Chinese herbal medicine. Chinese Journal of Hepatology. 2007;15:534–535. (Article in Chinese)
22. Hu YY, Huang F. Chinese herb and drug-induced liver injury. Chinese Journal of Hepatology 2012;2:173–175. (Article in Chinese)
23. Kaplowitz N. Biochemical and cellular mechanisms of toxic liver injury. Semin Liver Dis 2002;22:137–144. doi: 10.1055/s-2002-30100
24. Grattagliano I, Bonfrate L, Diogo CV, Wang HH, Wang DQ, Portincasa P. Biochemical mechanisms in drug-induced liver injury:Certainties and doubts. World J Gastroenterol 2009,39:4865–4876.
25. Holt MP, Ju C. Mechanisms of drug-induced liver injury. AAPS J 2006;8: E48– E54. doi: 10.1208/aapsj080106.
26. Malhi H, Gores GJ, Lemasters JJ. Apoptosis and necrosis inthe liver: a tale of two deaths? Hepatology 2006;43:S31–S44. doi: 10.1002/hep.21062.
27. Tarantino G, Di Minno MN, Capone D. Drug-induced liver injury:Is it somehow foreseeable? World J Gastroenterol 2009;23:2817–2833.
28. Liu NN, Xu L, Shi L, Li Y, Lin LF. Advances in toxicology of saponins-contained traditional chinese medicine. Central South Pharmacy 2010;8:916–919. (Article in Chinese)
29. Wang J, Ji L, Liu H, Wang Z. Study of the hepatotoxicity induced by Dioscorea bulbifera L. rhizome in mice. Bioscience trends 2010;4:79–85.
30. Pacifici RE, Davies KJ. Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited. Gerontology 1991;37:166– 180. doi: 10.1159/000213257.
31. Li Chen. Research progress of Chinese herbal medicine induced liver damage. Journal of Clinical Hepatology 2013;16:278–281. (Article in Chinese)
32. Cai HD, Sun FX. Pyrrolizidine alkaloids-containing plants and hepatic veno-occlusive disease. Adverse drug reactions Journal 2007;9:229. (Article in Chinese)
33. Huang JF, Jiang ZZ, Wang T, Yao JC, Zhang LY. Overview of Research on Drug-induced Liver Injury. Progress in Pharmaceutical Sciences 2008;32:357– 362. (Article in Chinese)
34. Xia JQ, Xi ZH. Prevention of traditional Chinese medicine-induced liver damage during the treatment of liver disease. Chinese Journal Of General Practice 2010;08:1287–1288. (Article in Chinese)
35. Chen YF, Cai HD. Investigation of liver damage associate with traditional Chinese medicine. Adverse Drug Reactions Journal 1999;1:27–32. (Article in Chinese)
36. Jung KA, Min HJ, Yoo SS, Kim HJ, Choi SN, Ha CY, et al. Drug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb. Gut And Liver 2011;5:493–499. doi: 10.5009/gnl.2011.5.4.493.
37. Zhang L, Yan J, Liu X, Ye Z, Yang X, Meyboom R, et al. Pharmacovigilance practice and risk control of Traditional Chinese Medicine drugs in China: Current status and futur e perspective. J Ethnopharmacol 2012;140:519– 525. doi: 10.1016/j.jep.2012.01.058
38. Jin CS, Wu DL, Zhang JS. Effects of different processing methods on constituents and pharmacological action of fructus xanthii. Journal of anhui traditional chinese medical college 2000;19:54–56. Doi: 10.3969/j.issn.1000-2219.2013.00.000
39. Liu DZ, Zhao XG. The study developments on etiological factor pathome-chanism and TCM treatment of hepatic injury. Forumon Traditional Chinese Medicine 2006;21:53–55. (Article in Chinese)
40. Teschke R, Glass X, Schulze J, Eickhoff A. Suspected Greater Celandine Hepatotoxicity: Liver-Specific Causality Evaluation Of Published Case Reports From Europe. Eur J Gastroenterol Hepatol 2012;24:270–280. doi: 10.1097/MEG.0b013e32834f993f
41. Teschke R, Frenzel C, Gl ass X, Schul ze J, Ei ckhoff A. Herbal hepatotoxicity: A critical review. Br J Clin Pharmacol 2013;75:630–636. Doi: 10.1111/j.1365-2125.2012.04395.x.
42. http://www.ema.europa.eu/docs/en_GB/document_l ibrary/Herbal _-_HMPC_assessment_re port/2010/02/WC500074167.pdf, accessed May 2007.
43. Wang BS. Absinthism. Chinese Journal of Internal Medicine 1955;3:941– 943.
44. Lao A, Fujimoto Y, Tatsuno T. Studies on the constituents of Artemisia argi Levi et Vant. Chem Pharm Bull 1984;32:723–727. doi: 10.1248/cpb.32.723.
45. Judzentiene A, Budiene J, Butkiene R, Kupcinskiene E, Laffont-Schwob I, Masotti V. Caryophyllene oxide-rich essential oils of Lithuanian Artemisia campestris ssp. campestris and their toxicity. Nat Prod Commun 2010;5: 1981–1984.
46. Willco, M. Artemisia species: From traditional medicines to modern antimalarial and back again. J Altern Complement Med 2009;15:101–109. doi: 10.1089/acm.2008.0327
47. Wang JX. Clinical analysis of 56 cases of acute poisoning induced by castor bean. Chinese Community Doctors. 2013;09:205–206. (Article in Chinese)
48. Wedin GP, Neal JS, Everson GW, Krenzelok EP. Castor bean poisoning. Am J Emerg Med. 1986;4:259–261.
49. Scarpa A, Guerci A. Various uses of the castor oil plant (Ricinus communis L.). A review. J Ethnopharmacol 1982;5:117–137. doi: 10.1016/0378-8741(82)90038-1.
50. Nie K, Li YX, Zhao XF, Wang S. Summary of the Liver Toxicity of Traditional Chinese Medicine. Journal Of Practical traditional Chinese Internal medicine 2009;12:112–114.
51. Wu XZ. 14 cases of myocardial damage and liver damage caused by Cang Er Zi. Yi Xue Li Lun Yu Shi Jian. 1996;9:312–312. (Article in Chinese)
52. MacLeod JK, Moeller PD, Franke FP. Two toxic kaurene glycosides from the burrs of Xanthium pungens. J Nat Prod 1990;53:451–455. doi: 10.1021/np50068a025.
53. But P, Chang C. Chinese herbal medicine in the treatment of asthma and allergies. Clin Rev Allergy Immunol 1996;14:253–269.
54. Obatomi DK, Bach PH Biochemistry and toxicology of the diterpenoid glycoside atractyloside. Food Chem Toxicol 1998;36:335–346. doi: 10.1016/S0278-6915(98)00002-7.
55. Li CC, Chen Z. Observation on Hydrangeas role in fighting malaria and its preliminary pharmacological. Fu Jian Yi Xue Yuan Xue Bao. 1959;1:93–97. (Article in Chinese)
56. Keller TL, Zocco D, Sundrud MS, Hendrick M, Edenius M, Yum J, et al. Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol 2012;8:311–317. doi: 10.1038/nchembio.790
57. Arseculeratne SN, Gunatilaka AA, Panabokke RG. Studies on medicinal plants of Sri Lanka: occurrence of pyrrolizidine alkaloids and hepatotoxic properties in some traditional medicinal herbs. J Ethnopharmacol 1981;4:159–177. doi: 10.1016/0378-8741(81)90033-7.
58. Ikeda T, Fujiwara S, Araki K, Kinjo J, Nohara T, Miyoshi T. Cytotoxic glycosides from Albizia julibrissin. J Nat Prod 1997;60:102–107. doi: 10.1021/np960556t.
59. Yeskaliyeva B, Mesaik M A, Abbaskhan A, Kulsoom A, Burasheva GSh, Abilov ZhA, et al. Bioactive flavonoids and saponins from Climacoptera obtusifolia. Phytochemi stry 2006; 67: 2392–2397. doi: 10.1016/j.phytochem. 2006.07.003.
60. Zhang L, Yang X, Sun Z, Qu Y. Retrospective study of adverse events of Polygonum multiflorum and risks control. Zhongguo Zhong Yao Za Zhi 2009; 34:1724–1729. (Abstract in English, article in Chinese)
61. Sun XH, Sun YW, Li H, Sun W. Influence of main component of Heshouwu such as emodin, rhein and toluylene glycoside on hepatic cells and hepatoma carcinoma cell. Modern Journal Of Integrated Traditional Chinese And Western Medicine 2010;11:1315–1317, 1319. (Article in Chinese)
62. Park HJ, Zhang N, Park DK. Topical application of Polygonum multiflorum extract induces hair growth of resting hair follicles through upregulating Shh and b-catenin expression in C57BL/6 mice. J Ethnopharmacol 2011;135: 369–375. doi: 10.1016/j.jep.2011.03.028.
63. Banarova A, Koller T, Payer J. Toxic hepatitis induced by Polygonum multiflorum. Vnitr Lek 2012;58:958–962.
64. Huang ZF, Hua BC, Chen XF, Shi DH, Cheng XL, Wang YH, et al. Analysis of Liver Injury in 78 Cases Caused by Rhizoma Dioscoreae Bulbiferae and Related Preparation. Chinese Journal of Experimental Traditional Medical Formulae 2013;23:295–297.
65. Komoif T. Glycosides from Dioscorea btflbifera. Toxicon 1997;35:1531– 1535. doi: 10.1016/S0041-0101(97)00032-9.
66. Teponno R B, Tapondjou A L, Gatsing D, Djoukeng JD, Abou-Mansour E, Tabacchi R, et al. Bafoudiosbulbins A, and B, two anti-salmonellal clerodane diterpenoids from Dioscorea bulbifera L. var sativa. Phytochemistry 2006; 67:1957–1963. doi: 10.1016/j.phytochem.2006.06.019.
67. Marc S, Anne-Claire MO, Marie-Aleth LD. The Dioscorea genus: a review of bioactive steroid saponins. J Nat Med 2007;61:91–101.
68. Wang J, Ji L, Liu H, Wang Z. Study of the hepatotoxicity induced by Dioscorea bulbifera L. rhizome in mice. Biosci Trends 2010;4:79–85.
69. Phua DH, Tsai WJ, Ger J, Deng JF, Yang CC. Human Melia azedarach poisoning. Clin Toxicol 2008;46:1067–1070. doi: 10.1080/15563650802310929.
70. Liang WK, Kuang JJ. Liver damage related to triptolide and its preparations: domestic literatures review and analysis. Chinese Journal Of Drug Application And Monitoring 2011;03:169–172. (Article in Chinese)
71. Zhou Y, Zhang L, Liu W. Protective effect of total glucosides of paeony against acute hepatic injury induced by tripterygium glycosides tablet in mice. Tianjin Journal of Traditional Chinese Medicine 2007;1:28. (Article in Chinese)
72. Zhang Y,Jiang Z,Xue M,Zhang S, Wang Y, Zhang L. Toxicogenomic analysis of the gene expression changes in rat liver after a 28-day oral Tripterygium wilfordii multiglycoside exposure. J Ethnopharmacol 2012;141:170–177. doi: 10.1016/j.jep.2012.02.015.
73. Tao X, Lipsky PE. The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F. Rheum Dis Clin North Am 2000; 26:29–50.
74. Peng B, Miao MS, Wang YL. Initial discussion of mice acute hepatic injury caused by Tripterygium glycosides. Zhongguo Zhong Yao Za Zhi 2003;28: 1067–1070. (Article in Chinese)
75. Yeong ML, Clark SP, Waring JM, Wilson RD, Wakefield SJ. The effects of comfrey derived pyrrolizidine alkaloids on rat liver. Pathology 1991;23:35– 38. doi: 10.3109/00313029109061438.
76. Zuckerman M, Steenkamp V, StewartMJ. Hepatic veno-occlusive disease as a result of a traditional remedy: confirmation of toxic pyrrolizidine alkaloids as the cause, using an in vitro technique. J Clin Pathol 2002;55:676–679. doi: 10.1136/jcp.55.9.676.
77. WHO. Environmental Health Criteria 80, pyrrolizidine alkaloid, 1988.
78. Tian XY, Wang YH, Yang QY, Liu X, Fang WS, Yu SS. Jacaranone glycosides from Senecio scandens. J Asian Nat Prod Res 2006;8:125–132. doi: 10.1080/10286020500530912.
79. Guo BK, Zhang FQ, Zhang L, Liu Y. Clinical analysis on 10 cases of acute pokeberry root poisoning. Chinese Journal Of Industrial Medicine 2005;01: 32–33. (Article in Chinese)
80. Lampe, K F., McCann, M A. AMA Handbook of poisonous and injurious plants. Chicago: American Medical Association, 1985.
81. Zhou Q,Yao GT, Jin RM, Xie JJ. Hepatotoxicity induced by esculentoside A. Chinese Traditional Patent Medicine 2014;36:14–18.
82. Zarling JM,Moran PA,Haffar O, Sias J, Richman DD, Spina CA, et al. Inhibition of HIV replication by pokeweed antiviral protein targeted to CD + 4 cells by monoclonal antibodies. Nature 1990;347:92–95. doi: 10.1038/347092a0
83. Silva AL, Goto LS, Dinarte AR, Hansen D, Moreira RA, Beltramini LM, et al. Pulchellin, a highly toxic type 2 ribosome-inactivating protein from Abrus pulchellus. Cloning heterologous expression of A-chain and structural studies. FEBS J 2005;272:1201–1210. doi: 10.1111/j.1742-4658.2005. 04545.x.
84. Wawrzynczak E J, Cumber A J, Henry R V, May J, Newell DR, Parnell GD, et al. Pharmacokinetics in the rat of a panel of immunotoxins made with abrin A chain, ricin A chain, gelonin, and momordin. Cancer res 1990;50:7519– 7526.
85. Bhasker AS, Sant B, Yadav P, Agrawal M, Lakshmana Rao PV. Plant toxin abrin induced oxidative stress mediated neurodegenerative changes in mice. Neurotoxicology 2014;44C:194–203. doi: 10.1016/j.neuro.2014.06.015.