Miniature microwave biosensors: Noninvasive applications

IEEE Microwave Magazine

Volumn 16, Issue 4, 2015, Pages 71-86

  Guarin, Gustavo ^a   Hofmann, Maximilian ^a   Nehring, Johannes ^a   Weigel, Robert ^a   Fischer, Georg ^a   Kissinger, Dietmar ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ECONOMICS; POPULATION STATISTICS;

AGING SOCIETIES; CHRONIC DISEASE; DEMOGRAPHIC SHIFTS; ECONOMIC GROWTHS; INDUSTRIAL COUNTRIES; PRIMARY-CARE PROVIDERS; SOCIAL SECURITY SYSTEMS; TOBACCO CONSUMPTION;

METAL DRAWING;

EID: 84926628728     PISSN: 15273342     EISSN: None     Source Type: Journal    
DOI: 10.1109/MMM.2015.2394024     Document Type: Article

References (65)

1. Health at a Glance: Europe 2012. Paris, France: OECD Publishing, 2012.
2. S. Cavenaghi, "Demographic transformations and inequalities in Latin America," Serie Investigaciones of the Latin American Population Association, vol. 8, pp. 13-14, 2009.
3. K. Linz and S. Stula, "Demographic change in Europe: An overview," in Proc. Observatory Sociopolitical Developments Europe, Aug. 2010, p. 3.
4. D. A. Squires, "Explaining high health care spending in the United States: An international comparison of supply, utilization, prices, and quality," Commonwealth Fund, vol. 10, no. 1595, pp. 1-14, May 2012.
5. B. Korte, "Point-of-care technologies research network," Natl. Inst. Biomed. Imag. Bioeng., Bethesda, MD, Tech. Rep. POCTRN 2013.
6. M. A. Batista and S. M. Gaglani, "Virtual mentor," Amer. Med. Assoc. J. Ethics, vol. 15, no. 11, pp. 947-950, Nov. 2013.
7. F. Kremer and A. Scönhals, Broadband Dielectric Spectroscopy. Berlin Heidelberg, Germany: Springer-Verlag, 2003.
8. M. A. Cooper, Label-Free Biosensors: Techniques and Applications. Cambridge, U.K: Cambridge Univ. Press, 2009.
9. B. Stuart, Infrared Spectroscopy: Fundamentals and Applications. Hoboken, NJ: Wiley, 2004.
10. K. S. Cole and R. H. Cole, "Dispersion and absorption in dielectrics I. Alternating current characteristics," J. Chem. Phys., vol. 9, pp. 341-351, Apr. 1941.
11. D. K. Ghodgaonkar and A. B. Daud, "Calculation of Debye parameter of single Debye relaxation equation for human skin in vivo," in Proc. Nat. Conf. Telecommunications Technologies, Shah Alam, Malaysia, 2003, pp. 71-74.
12. A. P. Gregory and R. N. Clarke, "A review of RF and microwave techniques for dielectric measurements on polar liquids," IEEE Trans. Dielect. Elect. Insul., vol. 13, no. 4, pp. 727-743, 2006.
13. K. B. Yu, S. G. Ogourtsov, V. G. Belenky, A. B. Maslenikov, and A. S. Omar, "Accurate microwave resonant method for complex permittivity measurements of liquids," IEEE Trans. Microwave Theory Tech., vol. 48, no. 11, pp. 2159-2163, 2000.
14. U. Schwerthoeffer, R. Weigel, and D. Kissinger, "A highly sensitive glucose biosensor based on a microstrip ring resonator," in Proc. Int. Microwave Workshop Series RF Wireless Technologies Biomedical Healthcare Applications, Singapore, Dec. 2013, pp. 1-3.
15. U. Schwerthoeffer, C. Warter, R. Weigel, and D. Kissinger, "A microstrip resonant biosensor for aqueous glucose detection in microfluidic medical applications," in Proc. IEEE Topical Conf. Biomedical Wireless Technologies, Networks, Sensing Systems, San Diego, CA, Jan. 2014, pp. 55-57.
16. M. Hofmann, T. Fersch, R. Weigel, G. Fischer, and D. Kissinger, "A novel approach to non-invasive blood glucose measurement based on RF transmission," in Proc. IEEE Int. Workshop Medical Measurements Applications, 2011, pp. 39-42.
17. A. Landoulsi, L. Y. Zhang, C. Dalmay, A. Lacroix, A. Pothier, A. Bessaudou, P. Blondy, S. Battu, F. Laloue, C. Bounaix, and C. Lautrette, "Tunable frequency resonant biosensors dedicated to dielectric permittivity analysis of biological cell cytoplasm," in IEEE MTT-S Int. Microwave Symp. Dig., Seattle, WA, June 2013, pp. 1-4.
18. C. Dalmay, A. Pothier, M. Cheray, F. Lalloue, M. Jauberteau, and P. Blondy, "Microwave biosensors for stem cell identification and discrimination," in IEEE MTT-S Int. Microwave Symp. Dig., Anahaim, CA, May 2010, pp. 620-623.
19. L. Y. Zhang, A. Landoulsi, C. Bounaix, M. du Punch, A. Lacroix, C. Dalmay, A. Bessaudou, C. Lautret, S. Battu, F. Lalloue, M. Jauberteau, P. Blondy, and A. Pothier, "Label-free colorectal cancer cell line bio-sensing using RF resonator," in Proc. Conf. Solid-State Sensors, Actuators Microsystems, Barcelona, Spain, June 2013, pp. 1194-1197.
20. Y. Ning, C. Multari, X. Luo, C. Palego, X. Cheng, J. C. M. Hwang, A. Denzi, C. Merla, F. Apollonio, and M. Liberti, "Broadband electrical detection of individual biological cells," IEEE Trans. Microwave Theory Tech., vol. 62, no. 9, pp. 1905-1911, Sept. 2014.
21. S. Afroz, S. W. Thomas, and S. E. Saddow, "Implantable based RF antenna biosensor for continuous glucose monitoring," in Proc. IEEE Sensors, Baltimore, MD, Nov. 2013, pp. 1-4.
22. M. M. Ahmadi and G. A. Jullien, "A wireless-implantable microsystem for continuous blood glucose monitoring," IEEE Trans. Biomed. Circuits Syst., vol. 3, no. 3, pp. 169-180, June 2009.
23. J. Roelvink, S. Trabelsi, and S. O. Nelson, "A planar transmissionline sensor for measuring the microwave permittivity of liquid and semisolid biological materials," IEEE Trans. Instrum. Meas., vol. 62, no. 11, pp. 2974-2982, Dec. 2012.
24. J. Baker-Jarvis, M. D. Janezic, B. Riddle, R. T. Johnk, P. Kabos, C. L. Holloway, R. G. Geyer, and C. A. Grosvenor, "Measuring the permittivity and permeability of lossy materials: Solids, liquids, metals, building materials, and negative-index materials," Natl. Inst. Standards Technol. Res. Library, Boulder, CO, Tech. Note 1536, 2005.
25. M. D. Janezic and J. A. Jargon, "Complex permittivity determination from propagation constant measurements," IEEE Microwave Guided Wave Lett., vol. 9, no. 2, pp. 76-78, 1999.
26. M. J. Degerstrom, B. K. Gilbert, and E. S. Daniel, "Accurate resistance, inductance, capacitance, and conductance (RLCG) from uniform transmission line measurements," in Proc. Electrical Performance Electronic Packaging, San Jose, CA, Oct. 29, 2008.
27. J. Svacina, "Analysis of multilayer microstrip lines by a conformal mapping method," IEEE Trans. Microwave Theory Tech., vol. 40, no. 4, pp. 769-772, Apr. 1992.
28. W. R. Eisenstadt and Y. Eo, "S-parameter-based IC interconnect transmission line characterization," IEEE Trans. Compon. Packag. Manuf. Technol., vol. 15, no. 4, pp. 483-490, 1992.
29. M. Tofighi and A. S. Daryoush, "Characterization of the complex permittivity of brain tissues up to 50 GHz utilizing a two-port microstrip test fixture," IEEE Trans. Microwave Theory Tech., vol. 50, no. 10, pp. 2217-2225, Oct. 2002.
30. J. Roelvink, S. Trabelsi, and S. O. Nelson, "A planar transmissionline sensor for measuring the microwave permittivity of liquid and semisolid biological materials," IEEE Trans. Instrum. Meas., vol. 62, no. 11, pp. 2974-2982, Nov. 2013.
31. A. Seo, T. Stintzing, I. Block, D. Pavlidis, M. Rieke, and P. G. Layer, "High frequency permittivity measurements of biological substances using coplanar waveguides and application to cell suspensions," in IEEE MTT-S Int. Microwave Symp. Dig., Atlanta, GA, June 2008, pp. 915-918.
32. K. Grenier, D. Dubuc, T. Chen, F. Artis, T. Chretiennot, M. Poupot, and J. Fournie, "Recent advances in microwave-based dielectric spectroscopy at the cellular level for cancer investigations," IEEE Trans. Microwave Theory Tech., vol. 61, no. 5, pp. 2023-2030, May 2013.
33. M. Hofmann, M. Bloss, R. Weigel, G. Fischer, and D. Kissinger, "Non-invasive glucose monitoring using open electromagnetic waveguides," in Proc. European Microwave Conf., Amsterdam, The Netherlands, Oct. 2012, pp. 546-549.
34. B. Laemmle, K. Schmalz, C. Scheytt, R. Weigel, and D. Kissinger, "An integrated 125 GHz sensor with read-out circuit for permittivity measurement of liquids," in IEEE MTT-S Int. Dig., Montreal, QC, Canada, June 2012, pp. 1-3.
35. M. Hofmann, G. Fischer, R. Weigel, and D. Kissinger, "Microwave-based noninvasive concentration measurements for biomedical applications," IEEE Trans. Microwave Theory Tech., vol. 61, no. 5, pp. 2195-2204, May 2013.
36. L. F. Chen, C. K. Ong, C. P. Neo, V. V. Varadan, and V. K. Varadan, Microwave Electronics: Measurements and Materials Characterization. Hoboken, NJ: Wiley, 2004.
37. D. Berube, F. M. Ghannouchi, and P. Savard, "A comparative study of four open-ended coaxial probe models for permittivity measurements of lossy dielectric/biological materials at microwave frequencies," IEEE Trans. Microwave Theory Tech., vol. 44, no. 10, pp. 1928-1934, Oct. 1996.
38. C. L. Pournaropoulos and D. K. Misra, "The co-axial aperture electromagnetic sensor and its application in material characterization," Meas. Sci. Technol., vol. 8, no. 11, pp. 1191-1201, 1997.
39. F. M. Ghannouchi and R. G. Bosisio, "Measurement of microwave permittivity using six-port reflectometer with an open-ended coaxial line," IEEE Trans. Instrum. Meas., vol. 38, no. 2, pp. 505-508, Apr. 1989.
40. S. S. Stuchly, C. L. Sibbald, and J. M. Anderson, "A new aperture admittance model for open-ended waveguides," IEEE Trans. Microwave Theory Tech., vol. 42, pp. 192-198, Feb. 1994.
41. K. Kim, N. Kim, S.-H. Hwang, Y.-K. Kim, and Y. Kwon, "A Miniaturized broadband multi-state reflectometer integrated on a silicon MEMS probe for complex permittivity measurement of biological material," IEEE Trans. Microwave Theory Tech., vol. 61, no. 5, pp. 2205-2214, May 2013.
42. D. Popovic, L. MacCartney, C. Beasley, M. Lazebnik, M. Okoniewski, S. C. Hagness, and J. H. Booske, "Precision open-ended coaxial probes for in vivo and ex vivo dielectric spectroscopy of biological tissues at microwave frequencies," IEEE Trans. Microwave Theory Tech., vol. 53, no. 5, pp. 1713-1722, May 2005.
43. M. J. Kuhn, M. Awida, M. R. Mahfouz, and A. E. Fathy, "Openended coaxial probe measurements for breast cancer detection," in Proc. Radio Wireless Symp., New Orleans, LA, Jan. 2010, pp. 512-515.
44. M. Obol, N. Al-Moayed, S. P. Naber, and M. N. Afsar, "Using coaxial probe for broadband microwave characterization of biological tissues," in Proc. European Microwave Conf., Amsterdam, The Netherlands, Oct. 2008, pp. 416-419.
45. K. Kwon, S. Lim, S. Cho, J. Yoon, J. Cho, C. Cheon, and Y. Kwon, "Planar type probe with multiple-polarization response for invivo permittivity measurements of heterogeneous biological tissues," IEEE Microwave Compon. Lett., vol. 16, no. 1, pp. 1-3, Jan. 2006.
46. P. Mehta, K. Chand, D. Narayanswamy, D. G. Beetner, R. Zoughi, and W. V. Stoecker, "Microwave reflectometry as a novel diagnostic tool for detection of skin cancers," IEEE Trans. Instrum. Meas., vol. 55, no. 4, pp. 1309-1316, Aug. 2006.
47. G. Engen and C. Hoer, "Application of an arbitrary 6-port junction to power-measurement problems," IEEE Trans. Instrum. Meas., vol. IM-21, no. 4, pp. 470-474, Nov. 1972.
48. C. A. Hoer, "The six-port coupler: A new approach to measuring voltage, current, power, impedance, and phase," IEEE Trans. Instrum. Meas., vol. 21, no. 4, pp. 466-470, Nov. 1972.
49. G. Engen, "The six-port reflectometer: An alternative network analyzer," IEEE Trans. Microwave Theory Tech., vol. 25, no. 12, pp. 1075-1080, Dec. 1977.
50. A. Koelpin, G. Vinci, B. Laemmle, D. Kissinger, and R. Weigel, "The six port in modern society," IEEE Microwave Mag., vol. 11, no. 7, pp. 35-43, Dec. 2010.
51. F. M. Ghannouchi and A. Mohammadi, The Six-Port Technique with Microwave and Wireless Applications. Norwood, MA: Artech House, 2009.
52. B. Laemmle, K. Schmalz, C. Scheytt, D. Kissinger, and R. Weigel, "A 62 GHz reflectometer for biomedical sensor readout in SiGe BiCMOS technology," in Proc. IEEE 12th Topical Meeting Silicon Monolithic Integrated Circuits RF Systems, Santa Clara, CA, Jan. 2012, pp. 45-48.
53. B. Laemmle, K. Schmalz, C. Scheytt, D. Kissinger, and R. Weigel, "A 122 GHz multiprobe reflectometer for dielectric sensor readout in SiGe BiCMOS technology," in IEEE Compound Semiconductor Integrated Circuit Symp. Tech. Dig., Waikoloa, HI, Oct. 2011, pp. 1-4.
54. M. Hofmann, S. Linz, R. Weigel, G. Fischer, and D. Kissinger, "A multiband 2-port VNA for biomedical applications based on two six-port-junctions," in IEEE MTT-S Int. Microwave Symp. Dig., Seattle, WA, June 2013, pp. 1-4.
55. J. Schoukens, Y. Rolain, and R. Pintelon, "Improved frequency response function measurements for random noise excitations," IEEE Trans. Instrum. Meas., vol. 47, no. 1, pp. 322-326, Feb. 1998.
56. M. R. Schroeder, "Integrated-impulse method measuring sound decay without using impulses," J. Acoust. Soc. Amer., vol. 66, no. 2, pp. 497-500, Aug. 1979.
57. M. Martin and A. Lempel, "On fast M-sequence transforms," IEEE Trans. Inform. Theory, vol. 23, no. 1, pp. 135-137, Jan. 1977.
58. J. Sachs and P. Peyerl, "Integrated network analyser module for microwave moisture sensors," in Proc. 4th Int. Conf. Electromagnetic Wave Interaction with Water Moist Substances, May 2001, pp. 165-172.
59. B. Sewiolo, B. Laemmle, and R. Weigel, "Ultra-wideband transmitters based on M-sequences for high resolution radar and sensing applications," in Proc. Conf. Ph.D. Research Microelectronics Electronics (PRIME), 2010, pp. 1-4.
60. G. Guarin, M. Hofmann, R. Weigel, G. Fischer, and D. Kissinger, "Determination of sugar concentration in aqueous solutions using ultra-wideband microwave impedance spectroscopy," in IEEE MTT-S Int. Microwave Symp. Dig., Seattle, WA, June 2013, pp. 1-4.
61. J. Nehring, I. Nasr, K. Borutta, R. Weigel, and D. Kissinger, "A silicon integrated microwave vector network analyzer for biomedical sensor read-out applications," in IEEE MTT-S Int. Microwave Symp. Dig., Tampa, FL, June 2014, pp. 1-6.
62. M. Hofmann, A. Oborovski, R. Weigel, G. Fischer, and D. Kissinger, "A microwave VNA for biomedical in-line concentration measurements," in Proc. IEEE Topical Conf. Biomedical Wireless Technologies, Networks, Sensing Systems, Austin, TX, Jan. 2013, pp. 61-63.
63. M. Fujii, R. Fujii, R. Yotzuki, T. Wuren, T. Takai, and I. Sakagami, "Exploration of whole human body and UWB radiation interaction by efficient and accurate two-Debye-pole tissue models," IEEE Trans. Antennas Propagat., vol. 58, no. 2, pp. 515-524, Feb. 2010.
64. M. Lazebnik, M. Okoniewski, J. H. Booske, and S. C. Hagness, "Highly accurate Debye models for normal and malignant breast tissue dielectric properties at microwave frequencies," IEEE Microwave Compon. Lett., vol. 17, no. 12, pp. 822-824, Dec. 2007.
65. A. Mustafa, A. M. Abbosh, and P. T. Nguyen, "Modelling human head tissues using fourth-order Debye model in convolution-based three-dimensional finite-difference time-domain," IEEE Trans. Antennas Propagat., vol. 62, no. 3, pp. 1354-1361, Mar. 2014.